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product summary
company name :
R&D Systems
product type :
ELISA/assay
product name :
Mouse IL-21 DuoSet ELISA
catalog :
DY594-05
quantity :
1 Kit (for 5 Plates) (also 1 Kit (for 15 Plates))
price :
440 USD
citations: 34
Reference
An S, Oh J, Shon H, Song J, Choi Y, Kim D. Co-adjuvanting Nod2-stimulating bacteria with a TLR7 agonist elicits potent protective immunity against respiratory virus infection. Int J Antimicrob Agents. 2024;64:107369 pubmed publisher
Morgaenko K, Arneja A, Ball A, Putelo A, Munson J, Rutkowski M, et al. Ex vivo model of breast cancer cell invasion in live lymph node tissue. bioRxiv. 2024;: pubmed publisher
Landoni E, Woodcock M, Barragan G, Casirati G, Cinella V, Stucchi S, et al. IL-12 reprograms CAR-expressing natural killer T cells to long-lived Th1-polarized cells with potent antitumor activity. Nat Commun. 2024;15:89 pubmed publisher
Liu Y, Fu S, Chien M, Hsu C, Lin M, Dong J, et al. Blimp-1 molds the epigenetic architecture of IL-21-mediated autoimmune diseases through an autoregulatory circuit. JCI Insight. 2022;7: pubmed publisher
Cox B, Alharshawi K, Mena Palomo I, Lafuse W, Ariza M. EBV/HHV-6A dUTPases contribute to myalgic encephalomyelitis/chronic fatigue syndrome pathophysiology by enhancing TFH cell differentiation and extrafollicular activities. JCI Insight. 2022;7: pubmed publisher
Arabpour M, Lebrero Fernández C, Sch xf6 n K, Str xf6 mberg A, B xf6 rjesson V, Lahl K, et al. ADP-ribosylating adjuvant reveals plasticity in cDC1 cells that drive mucosal Th17 cell development and protection against influenza virus infection. Mucosal Immunol. 2022;15:745-761 pubmed publisher
Jang S, Lee J, Hong S, Song Y, Kim M, Kwok S, et al. Niclosamide suppresses the expansion of follicular helper T cells and alleviates disease severity in two murine models of lupus via STAT3. J Transl Med. 2021;19:86 pubmed publisher
Zhou W, Yang Y, Mei C, Dong P, Mu S, Wu H, et al. Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection. Cells. 2019;8: pubmed publisher
Yang J, Kalim K, Li Y, Zheng Y, Guo F. Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation. J Leukoc Biol. 2019;106:1139-1151 pubmed publisher
Spolski R, West E, Li P, Veenbergen S, Yung S, Kazemian M, et al. IL-21/type I interferon interplay regulates neutrophil-dependent innate immune responses to Staphylococcus aureus. elife. 2019;8: pubmed publisher
Ariyaratne A, Szabo E, Bowron J, Finney C. Increases in helminth-induced IL-21 protein levels disappear upon sample freezing. Cytokine. 2018;108:179-181 pubmed publisher
Li B, Wang X, Choi I, Wang Y, Liu S, Pham A, et al. miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity. J Clin Invest. 2017;127:3702-3716 pubmed publisher
Tan L, Han S, Ding S, Xiao W, Ding Y, Qian L, et al. Chitosan nanoparticle-based delivery of fused NKG2D-IL-21 gene suppresses colon cancer growth in mice. Int J Nanomedicine. 2017;12:3095-3107 pubmed publisher
van Gelder M, Vanclée A, Van Elssen C, Hupperets P, Wieten L, Bos G. Bone marrow produces sufficient alloreactive natural killer (NK) cells in vivo to cure mice from subcutaneously and intravascularly injected 4T1 breast cancer. Breast Cancer Res Treat. 2017;161:421-433 pubmed publisher
Brinza L, Djebali S, Tomkowiak M, Mafille J, Loiseau C, Jouve P, et al. Immune signatures of protective spleen memory CD8 T cells. Sci Rep. 2016;6:37651 pubmed publisher
Aggelakopoulou M, Kourepini E, Paschalidis N, Panoutsakopoulou V. ER? in CD4+ T Cells Is Crucial for Ligand-Mediated Suppression of Central Nervous System Autoimmunity. J Immunol. 2016;196:4947-56 pubmed publisher
Nagashima H, Okuyama Y, Asao A, Kawabe T, Yamaki S, Nakano H, et al. The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6. Nat Immunol. 2014;15:449-56 pubmed publisher
Tatano Y, Shimizu T, Tomioka H. Unique macrophages different from M1/M2 macrophages inhibit T cell mitogenesis while upregulating Th17 polarization. Sci Rep. 2014;4:4146 pubmed publisher
Ubel C, Sopel N, Graser A, Hildner K, Reinhardt C, Zimmermann T, et al. The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF-like (BATF), regulates lymphocyte- and mast cell-driven immune responses in the setting of allergic asthma. J Allergy Clin Immunol. 2014;133:198-206.e1-9 pubmed publisher
Yokota Nakatsuma A, Takeuchi H, Ohoka Y, Kato C, Song S, Hoshino T, et al. Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells. Mucosal Immunol. 2014;7:786-801 pubmed publisher
Slight S, Rangel Moreno J, Gopal R, Lin Y, Fallert Junecko B, Mehra S, et al. CXCR5? T helper cells mediate protective immunity against tuberculosis. J Clin Invest. 2013;123:712-26 pubmed publisher
El Behi M, Ciric B, Dai H, Yan Y, Cullimore M, Safavi F, et al. The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat Immunol. 2011;12:568-75 pubmed publisher
Sarra M, Caruso R, Cupi M, Monteleone I, Stolfi C, Campione E, et al. IL-21 promotes skin recruitment of CD4(+) cells and drives IFN-?-dependent epidermal hyperplasia. J Immunol. 2011;186:5435-42 pubmed publisher
Takeuchi H, Yokota A, Ohoka Y, Kagechika H, Kato C, Song S, et al. Efficient induction of CCR9 on T cells requires coactivation of retinoic acid receptors and retinoid X receptors (RXRs): exaggerated T Cell homing to the intestine by RXR activation with organotins. J Immunol. 2010;185:5289-99 pubmed publisher
Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann Koch J, Schirmacher P, et al. Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J Exp Med. 2010;207:1617-24 pubmed publisher
Schraml B, Hildner K, Ise W, Lee W, Smith W, Solomon B, et al. The AP-1 transcription factor Batf controls T(H)17 differentiation. Nature. 2009;460:405-9 pubmed publisher
Dienz O, Eaton S, Bond J, Neveu W, Moquin D, Noubade R, et al. The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. J Exp Med. 2009;206:69-78 pubmed publisher
Kim Schulze S, Kim H, Fan Q, Kim D, Kaufman H. Local IL-21 promotes the therapeutic activity of effector T cells by decreasing regulatory T cells within the tumor microenvironment. Mol Ther. 2009;17:380-8 pubmed publisher
Vogelzang A, McGuire H, Yu D, Sprent J, Mackay C, King C. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity. 2008;29:127-37 pubmed publisher
Uematsu S, Fujimoto K, Jang M, Yang B, Jung Y, Nishiyama M, et al. Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol. 2008;9:769-76 pubmed publisher
Wei L, Laurence A, Elias K, O Shea J. IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem. 2007;282:34605-10 pubmed
Kumano M, Hara I, Furukawa J, Oniki S, Nagai H, Miyake H, et al. Interleukin-21 activates cytotoxic T lymphocytes and natural killer cells to generate antitumor response in mouse renal cell carcinoma. J Urol. 2007;178:1504-9 pubmed
Coquet J, Kyparissoudis K, Pellicci D, Besra G, Berzins S, Smyth M, et al. IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J Immunol. 2007;178:2827-34 pubmed
Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner V, et al. Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet. 2007;39:329-37 pubmed
product information
master code :
DY594
SKU :
DY594-05
product name :
Mouse IL-21 DuoSet ELISA
unit size :
1 Kit (for 5 Plates) (also 1 Kit (for 15 Plates))
description :
The Mouse IL-21 DuoSet ELISA from R&D Systems is a Solid Phase Sandwich ELISA that quantifies mouse IL-21.
target :
IL-21
category :
ELISAs
species :
Mouse
gene symbol :
Il21
kit type :
Solid Phase Sandwich ELISA
elisaRange :
62.50 - 4000 pg/mL
top caption :
Mouse IL-21 ELISA Standard Curve
applications :
ELISA
USD :
440 USD
alt names :
CVID11, IL21, IL-21Za11interleukin-21, interleukin 21, interleukin-21 isoform, Za11
storage :
Store the unopened product at 2 - 8 ░C. Do not use past expiration date.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.