This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
ELISA/assay
product name :
Human IL-6R alpha DuoSet ELISA
catalog :
DY227
quantity :
1 Kit (for 15 Plates)
price :
850 USD
citations: 19
Reference
Zhang W, Chua B, Selva K, Kedzierski L, Ashhurst T, Haycroft E, et al. SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity. Nat Commun. 2022;13:2774 pubmed publisher
Machcińska M, Kierasińska M, Michniowska M, Maruszewska Cheruiyot M, Szewczak L, Rola R, et al. Reduced Expression of PD-1 in Circulating CD4+ and CD8+ Tregs Is an Early Feature of RRMS. Int J Mol Sci. 2022;23: pubmed publisher
Chou C, Hua K, Chen M, Wu C, Hsu C, Wang J, et al. Discovery and characterization of a monoclonal antibody targeting a conformational epitope of IL-6/IL-6Rα to inhibit IL-6/ IL-6Rα/gp130 hexameric signaling complex formation. MAbs. 2022;14:2029675 pubmed publisher
Zhang W, Chua B, Selva K, Kedzierski L, Ashhurst T, Haycroft E, et al. Immune responses in COVID-19 respiratory tract and blood reveal mechanisms of disease severity. Res Sq. 2021;: pubmed publisher
Georgieva E, Leber S, Wex C, Garbers C. Perturbation of the Actin Cytoskeleton in Human Hepatoma Cells Influences Interleukin-6 (IL-6) Signaling, but Not Soluble IL-6 Receptor Generation or NF-κB Activation. Int J Mol Sci. 2021;22: pubmed publisher
Flynn C, Kespohl B, Daunke T, Garbers Y, Düsterhöft S, Rose John S, et al. Interleukin-6 controls recycling and degradation, but not internalization of its receptors. J Biol Chem. 2021;296:100434 pubmed publisher
Flynn C, Garbers Y, Düsterhöft S, Wichert R, Lokau J, Lehmann C, et al. Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro. Sci Rep. 2020;10:21612 pubmed publisher
Werner Klein M, Grujovic A, Irlbeck C, Obradovic M, Hoffmann M, Koerkel Qu H, et al. Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency. Nat Commun. 2020;11:4977 pubmed publisher
Gupta S, Junquera G, Nicassio L, Becknell B, Ching C. Trans IL-6 signaling does not appear to play a role in renal scarring after urinary tract infection. J Pediatr Urol. 2020;16:586-591 pubmed publisher
Flynn C, Garbers Y, Lokau J, Wesch D, Schulte D, Laudes M, et al. Activation of Toll-like Receptor 2 (TLR2) induces Interleukin-6 trans-signaling. Sci Rep. 2019;9:7306 pubmed publisher
Prenissl N, Lokau J, Rose John S, Haybaeck J, Garbers C. Therapeutic blockade of the interleukin-6 receptor (IL-6R) allows sIL-6R generation by proteolytic cleavage. Cytokine. 2019;114:1-5 pubmed publisher
Arcidiacono P, Webb C, Brooke M, Zhou H, Delaney P, Ng K, et al. p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response. Nat Commun. 2018;9:1021 pubmed publisher
Dogan M, Shields B, Cutrona C, Gao L, Gibbons F, SIMONS R, et al. The effect of smoking on DNA methylation of peripheral blood mononuclear cells from African American women. BMC Genomics. 2014;15:151 pubmed publisher
Richards F, Tape C, Jodrell D, Murphy G. Anti-tumour effects of a specific anti-ADAM17 antibody in an ovarian cancer model in vivo. PLoS ONE. 2012;7:e40597 pubmed publisher
Ikeda H, Hideshima T, Fulciniti M, Perrone G, Miura N, Yasui H, et al. PI3K/p110{delta} is a novel therapeutic target in multiple myeloma. Blood. 2010;116:1460-8 pubmed publisher
Zhao S, Gu Y, Dong Q, Fan R, Wang Y. Altered interleukin-6 receptor, IL-6R and gp130, production and expression and decreased SOCS-3 expression in placentas from women with pre-eclampsia. Placenta. 2008;29:1024-8 pubmed publisher
Ahmed S, Marotte H, Kwan K, Ruth J, Campbell P, Rabquer B, et al. Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production. Proc Natl Acad Sci U S A. 2008;105:14692-7 pubmed publisher
Briso E, Dienz O, Rincon M. Cutting edge: soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells. J Immunol. 2008;180:7102-6 pubmed
Ishitsuka K, Hideshima T, Neri P, Vallet S, Shiraishi N, Okawa Y, et al. p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications. Br J Haematol. 2008;141:598-606 pubmed publisher
product information
master code :
DY227
SKU :
DY227
product name :
Human IL-6R alpha DuoSet ELISA
unit size :
1 Kit (for 15 Plates)
description :
The Human IL-6R alpha DuoSet ELISA from R&D Systems is a Solid Phase Sandwich ELISA that quantifies human IL-6R alpha.
target :
IL-6R alpha
category :
ELISAs
species :
Human
gene symbol :
IL6R
kit type :
Solid Phase Sandwich ELISA
elisaRange :
15.60 - 1000 pg/mL
top caption :
Human IL-6 R alpha ELISA Standard Curve
applications :
ELISA
USD :
850 USD
alt names :
CD126, gp80, IL-6 R alpha, IL6Q, IL6R, IL6R alpha, IL-6R-1, IL6RA, IL-6RA, IL6RQ, interleukin 6 receptor
storage :
Store the unopened product at 2 - 8 ░C. Do not use past expiration date.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.