Human IL-6R alpha Quantikine ELISA Kit | R&D Systems DR600 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

ELISA/assay

product name :

Human IL-6R alpha Quantikine ELISA Kit

catalog :

DR600

quantity :

1 Kit (also 1 Pack (50 Plates), 1 Pack (6 Plates))

price :

655 USD

citations: 45

Reference
Odell I, Agrawal K, Sefik E, Odell A, Caves E, Kirkiles Smith N, et al. IL-6 trans-signaling in a humanized mouse model of scleroderma. Proc Natl Acad Sci U S A. 2023;120:e2306965120 pubmed publisher
Bratseth V, Nordeng J, Helseth R, Solheim S, xc5 kra S, Arnesen H, et al. Circulating Microvesicles in Association with the NLRP3 Inflammasome in Coronary Thrombi from STEMI Patients. Biomedicines. 2022;10: pubmed publisher
Baran J, Niewiara x, Podolec J, Siedli x144 ski M, J xf3 zefczuk E, Bernacik A, et al. Serum and Vascular Stiffness Biomarkers Associated with the Severity of Degenerative Aortic Valve Stenosis and Cardiovascular Outcomes. J Cardiovasc Dev Dis. 2022;9: pubmed publisher
Siamakpour Reihani S, Cao F, Lyu J, Ren Y, Nixon A, Xie J, et al. Evaluating immune response and metabolic related biomarkers pre-allogenic hematopoietic stem cell transplant in acute myeloid leukemia. PLoS ONE. 2022;17:e0268963 pubmed publisher
Salemi R, Gattuso G, Tomasello B, Lavoro A, Gaudio A, Libra M, et al. Co-Occurrence of Interleukin-6 Receptor Asp358Ala Variant and High Plasma Levels of IL-6: An Evidence of IL-6 Trans-Signaling Activation in Deep Vein Thrombosis (DVT) Patients. Biomolecules. 2022;12: pubmed publisher
Suo L, Wang M. Dexmedetomidine attenuates oxygen-glucose deprivation/ reperfusion-induced inflammation through the miR-17-5p/ TLR4/ NF-κB axis. BMC Anesthesiol. 2022;22:126 pubmed publisher
Ene C, Georgescu S, Tampa M, Matei C, Mitran C, Mitran M, et al. Cellular Response against Oxidative Stress, a Novel Insight into Lupus Nephritis Pathogenesis. J Pers Med. 2021;11: pubmed publisher
Nordeng J, Schandiz H, Solheim S, Akra S, Hoffman P, Roald B, et al. The Inflammasome Signaling Pathway Is Actively Regulated and Related to Myocardial Damage in Coronary Thrombi from Patients with STEMI. Mediators Inflamm. 2021;2021:5525917 pubmed publisher
Ene C, Penescu M, Georgescu S, Tampa M, Nicolae I. Posttranslational Modifications Pattern in Clear Cell Renal Cell Carcinoma. Metabolites. 2020;11: pubmed publisher
Loh K, Tooze J, Nicklas B, Kritchevsky S, Williamson J, Ellis L, et al. Inflammatory biomarkers, geriatric assessment, and treatment outcomes in acute myeloid leukemia. J Geriatr Oncol. 2019;: pubmed publisher
Ishikawa S, Tasaki M, Kuroda T, Kobayashi D, Saito K, Nakagawa Y, et al. Management of Juvenile Idiopathic Arthritis in ABO-incompatible Kidney Transplantation: A Case Report. Transplant Proc. 2018;50:869-872 pubmed publisher
Munir H, Ward L, Sheriff L, Kemble S, Nayar S, Barone F, et al. Adipogenic Differentiation of Mesenchymal Stem Cells Alters Their Immunomodulatory Properties in a Tissue-Specific Manner. Stem Cells. 2017;35:1636-1646 pubmed publisher
Osuka K, Watanabe Y, Usuda N, Aoyama M, Iwami K, Takeuchi M, et al. Inhibitory Mechanism of the Outer Membrane Growth of Chronic Subdural Hematomas. J Neurotrauma. 2017;34:1996-2000 pubmed publisher
Cauley J, Kassem A, Lane N, Thorson S. Prevalent peripheral arterial disease and inflammatory burden. BMC Geriatr. 2016;16:213 pubmed
Uchibori T, Matsuda K, Shimodaira T, Sugano M, Uehara T, Honda T. IL-6 trans-signaling is another pathway to upregulate Osteopontin. Cytokine. 2017;90:88-95 pubmed publisher
Cauley J, Barbour K, Harrison S, Cloonan Y, Danielson M, Ensrud K, et al. Inflammatory Markers and the Risk of Hip and Vertebral Fractures in Men: the Osteoporotic Fractures in Men (MrOS). J Bone Miner Res. 2016;31:2129-2138 pubmed publisher
Srikanth P, Chun R, Hewison M, Adams J, Bouillon R, Vanderschueren D, et al. Associations of total and free 25OHD and 1,25(OH)2D with serum markers of inflammation in older men. Osteoporos Int. 2016;27:2291-2300 pubmed publisher
Zhong H, Davis A, Ouzounova M, Carrasco R, Chen C, Breen S, et al. A Novel IL6 Antibody Sensitizes Multiple Tumor Types to Chemotherapy Including Trastuzumab-Resistant Tumors. Cancer Res. 2016;76:480-90 pubmed publisher
Kawada M, Inoue H, Ohba S, Yoshida J, Masuda T, Yamasaki M, et al. Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFÎ±-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction. PLoS ONE. 2015;10:e0119415 pubmed publisher
Csaszar E, Wang W, Usenko T, Qiao W, Delaney C, Bernstein I, et al. Blood stem cell fate regulation by Delta-1-mediated rewiring of IL-6 paracrine signaling. Blood. 2014;123:650-8 pubmed publisher
Salsano E, Rizzo A, Bedini G, Bernard L, Dall olio V, Volorio S, et al. An autoinflammatory neurological disease due to interleukin 6 hypersecretion. J Neuroinflammation. 2013;10:29 pubmed publisher
Tai Y, Chang B, Kong S, Fulciniti M, Yang G, Calle Y, et al. Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma. Blood. 2012;120:1877-87 pubmed publisher
Barbour K, Boudreau R, Danielson M, Youk A, Wactawski Wende J, Greep N, et al. Inflammatory markers and the risk of hip fracture: the Women's Health Initiative. J Bone Miner Res. 2012;27:1167-76 pubmed publisher
Holmlund U, Amoudruz P, Johansson M, Haileselassie Y, Ongoiba A, Kayentao K, et al. Maternal country of origin, breast milk characteristics and potential influences on immunity in offspring. Clin Exp Immunol. 2010;162:500-9 pubmed publisher
Sadeghi M, Daniel V, Schnitzler P, Lahdou I, Naujokat C, Zeier M, et al. Urinary proinflammatory cytokine response in renal transplant recipients with polyomavirus BK viruria. Transplantation. 2009;88:1109-16 pubmed publisher
Chauhan D, Singh A, Brahmandam M, Carrasco R, Bandi M, Hideshima T, et al. Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: a therapeutic target. Cancer Cell. 2009;16:309-23 pubmed publisher
Fuligni A, Telzer E, Bower J, Irwin M, Kiang L, Cole S. Daily family assistance and inflammation among adolescents from Latin American and European backgrounds. Brain Behav Immun. 2009;23:803-9 pubmed publisher
Ara T, Song L, Shimada H, Keshelava N, Russell H, Metelitsa L, et al. Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells. Cancer Res. 2009;69:329-37 pubmed publisher
Perez Andres M, Almeida J, Martin Ayuso M, de las Heras N, Moro M, Martín Nuñez G, et al. Soluble and membrane levels of molecules involved in the interaction between clonal plasma cells and the immunological microenvironment in multiple myeloma and their association with the characteristics of the disease. Int J Cancer. 2009;124:367-75 pubmed publisher
Egler R, Burlingame S, Nuchtern J, Russell H. Interleukin-6 and soluble interleukin-6 receptor levels as markers of disease extent and prognosis in neuroblastoma. Clin Cancer Res. 2008;14:7028-34 pubmed publisher
Shariat S, Karam J, Walz J, Roehrborn C, Montorsi F, Margulis V, et al. Improved prediction of disease relapse after radical prostatectomy through a panel of preoperative blood-based biomarkers. Clin Cancer Res. 2008;14:3785-91 pubmed publisher
Sadeghi M, Süsal C, Daniel V, Naujokat C, Zimmermann R, Huth Kühne A, et al. Short communication: decreasing soluble CD30 and increasing IFN-gamma plasma levels are indicators of effective highly active antiretroviral therapy. AIDS Res Hum Retroviruses. 2007;23:886-90 pubmed
Chalaris A, Rabe B, Paliga K, Lange H, Laskay T, Fielding C, et al. Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils. Blood. 2007;110:1748-55 pubmed
Cauley J, Danielson M, Boudreau R, Forrest K, Zmuda J, Pahor M, et al. Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition Study. J Bone Miner Res. 2007;22:1088-95 pubmed
Richards P, Nowell M, Horiuchi S, McLoughlin R, Fielding C, Grau S, et al. Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. Arthritis Rheum. 2006;54:1662-72 pubmed
Tsai M, Hanson N, Straka R, Hoke T, Ordovas J, Peacock J, et al. Effect of influenza vaccine on markers of inflammation and lipid profile. J Lab Clin Med. 2005;145:323-7 pubmed
Kaneyama K, Segami N, Sun W, Sato J, Fujimura K. Levels of soluble cytokine factors in temporomandibular joint effusions seen on magnetic resonance images. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:411-8 pubmed
Sadeghi M, Daniel V, Naujokat C, Wiesel M, Hergesell O, Opelz G. Strong inflammatory cytokine response in male and strong anti-inflammatory response in female kidney transplant recipients with urinary tract infection. Transpl Int. 2005;18:177-85 pubmed
Hirota H, Izumi M, Hamaguchi T, Sugiyama S, Murakami E, Kunisada K, et al. Circulating interleukin-6 family cytokines and their receptors in patients with congestive heart failure. Heart Vessels. 2004;19:237-41 pubmed
Petrucci M, Ricciardi M, Gregorj C, Ciapponi L, Savino R, Ciliberto G, et al. Effects of IL-6 variants in multiple myeloma: growth inhibition and induction of apoptosis in primary cells. Leuk Lymphoma. 2002;43:2369-75 pubmed
Lukashevich I, Tikhonov I, Rodas J, Zapata J, Yang Y, Djavani M, et al. Arenavirus-mediated liver pathology: acute lymphocytic choriomeningitis virus infection of rhesus macaques is characterized by high-level interleukin-6 expression and hepatocyte proliferation. J Virol. 2003;77:1727-37 pubmed
Carstanjen D, Regenfus M, Muller C, Salama A. Interleukin-6 is a major effector molecule of short-term G-CSF treatment inducing bone metabolism and an acute-phase response. Exp Hematol. 2001;29:812-21 pubmed
Keller E, Binkley N, Stebler B, Hall D, Johnston G, Zhang J, et al. Ovariectomy does not induce osteopenia through interleukin-6 in rhesus monkeys (Macaca mulatta). Bone. 2000;26:55-62 pubmed
Hampel H, Teipel S, Padberg F, Haslinger A, Riemenschneider M, Schwarz M, et al. Discriminant power of combined cerebrospinal fluid tau protein and of the soluble interleukin-6 receptor complex in the diagnosis of Alzheimer's disease. Brain Res. 1999;823:104-12 pubmed
Stubner S, Schön T, Padberg F, Teipel S, Schwarz M, Haslinger A, et al. Interleukin-6 and the soluble IL-6 receptor are decreased in cerebrospinal fluid of geriatric patients with major depression: no alteration of soluble gp130. Neurosci Lett. 1999;259:145-8 pubmed

product information

master code :

DR600

SKU :

DR600

product name :

Human IL-6R alpha Quantikine ELISA Kit

unit size :

1 Kit (also 1 Pack (50 Plates), 1 Pack (6 Plates))

description :

The Human IL-6R alpha Quantikine ELISA Kit from R&D Systems is a Solid Phase Sandwich ELISA that quantifies human IL-6R alpha in cell culture supernates (100 ul), serum (10 ul), edta plasma (10 ul), heparin plasma (10 ul), citrate plasma (10 ul), urine (50 ul).

target :

IL-6R alpha

category :

ELISAs

species :

Human

specificity :

Natural and recombinant human IL-6 sR

gene symbol :

IL6R

kit type :

Solid Phase Sandwich ELISA

assay length :

4.5 hours

elisaSampleTypes :

Cell Culture Supernates (100 uL), Serum (10 uL), EDTA Plasma (10 uL), Heparin Plasma (10 uL), Citrate Plasma (10 uL), Urine (50 uL)

elisaSensitivity :

15.1 pg/mL

elisaRange :

31.20 - 2000 pg/mL

top caption :

Human IL-6 R alpha ELISA Standard Curve

applications :

ELISA

USD :

655 USD

product details :

The Quantikine Human IL-6 sR Immunoassay is a 4.5 hour solid phase ELISA designed to measure human IL-6 sR in cell culture supernates, serum, plasma, and urine. It contains recombinant human IL-6 sR produced in Sf 21 cells and antibodies raised against this protein. This kit has been shown to accurately quantitate the recombinant soluble IL-6 R. Results obtained using natural IL-6 sR showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural IL-6 sR. Since the measurement of human IL-6 sR by this immunoassay is insensitive to added recombinant human IL-6, it is probable that this measurement corresponds to the total amount of the soluble receptor present in samples ( i.e. the total amount of free receptor plus the total amount of receptor bound to IL-6).

alt names :

CD126, gp80, IL-6 R alpha, IL6Q, IL6R, IL6R alpha, IL-6R-1, IL6RA, IL-6RA, IL6RQ, interleukin 6 receptor

storage :

Store the unopened product at 2 - 8 ░C. Do not use past expiration date.