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product summary
company name :
R&D Systems
product type :
ELISA/assay
product name :
Human SLPI Quantikine ELISA Kit
catalog :
DPI00
quantity :
1 Kit
price :
655 USD
citations: 37
Reference
Nasr M, Aldous A, Daniels J, Joy C, Capozzi E, Yang M, et al. Effect of progestin-based contraceptives on HIV-associated vaginal immune biomarkers and microbiome in adolescent girls. PLoS ONE. 2024;19:e0306237 pubmed publisher
Knipping K, Kartaram S, Teunis M, Zuithoff N, Buurman N, M Rabet L, et al. Salivary concentrations of secretory leukocyte protease inhibitor and matrix metallopeptidase-9 following a single bout of exercise are associated with intensity and hydration status. PLoS ONE. 2023;18:e0291297 pubmed publisher
Flerlage T, Crawford J, Allen E, Severns D, Tan S, Surman S, et al. Single cell transcriptomics identifies distinct profiles in pediatric acute respiratory distress syndrome. Nat Commun. 2023;14:3870 pubmed publisher
Miyazaki Y, Goto T, Li X, Nakayama K, Okasho K, Takeda M, et al. Up-regulation of secretory leukocyte protease inhibitor in human samples might have a potential role of predicting prostate cancer recurrence and progression after surgery and hormonal therapy. Cancer Med. 2023;12:3328-3342 pubmed publisher
Sawicki K, Nannini D, Bielinski S, Larson N, Lloyd Jones D, Psaty B, et al. Secretory leukocyte protease inhibitor and risk of heart failure in the Multi-Ethnic Study of Atherosclerosis. Sci Rep. 2023;13:604 pubmed publisher
Frey D, Bridson C, Dittrich S, Graeber S, Stahl M, Wege S, et al. Changes in Microbiome Dominance Are Associated With Declining Lung Function and Fluctuating Inflammation in People With Cystic Fibrosis. Front Microbiol. 2022;13:885822 pubmed publisher
Sibila O, Perea L, Albacar N, Mois xe9 s J, Cruz T, Mendoza N, et al. Elevated plasma levels of epithelial and endothelial cell markers in COVID-19 survivors with reduced lung diffusing capacity six months after hospital discharge. Respir Res. 2022;23:37 pubmed publisher
Dickey B, Sirak B, Martín Gómez L, Reich R, Abrahamsen M, Isaacs Soriano K, et al. Oral secretory leukocyte protease inhibitor (SLPI): Associations with oropharyngeal cancer and treatment outcome. PLoS ONE. 2021;16:e0254161 pubmed publisher
Samejima T, Nagamatsu T, Akiba N, Fujii T, Sayama S, Kawana K, et al. Secretory leukocyte protease inhibitor and progranulin as possible regulators of cervical remodeling in pregnancy. J Reprod Immunol. 2021;143:103241 pubmed publisher
Stanton A, Mowbray C, Lanz M, Brown K, Hilton P, Tyson Capper A, et al. Topical Estrogen Treatment Augments the Vaginal Response to Escherichia coli Flagellin. Sci Rep. 2020;10:8473 pubmed publisher
Whitwell H, Worthington J, Blyuss O, Gentry Maharaj A, Ryan A, Gunu R, et al. Improved early detection of ovarian cancer using longitudinal multimarker models. Br J Cancer. 2020;122:847-856 pubmed publisher
Averdunk L, Fitzner C, Levkovich T, Leaf D, Sobotta M, Vieten J, et al. Secretory Leukocyte Protease Inhibitor (SLPI)-A Novel Predictive Biomarker of Acute Kidney Injury after Cardiac Surgery: A Prospective Observational Study. J Clin Med. 2019;8: pubmed publisher
Kongpol K, Nernpermpisooth N, Prompunt E, Kumphune S. Endothelial-Cell-Derived Human Secretory Leukocyte Protease Inhibitor (SLPI) Protects Cardiomyocytes against Ischemia/Reperfusion Injury. Biomolecules. 2019;9: pubmed publisher
Smith McCune K, Chen J, Greenblatt R, Shanmugasundaram U, Shacklett B, Hilton J, et al. Unexpected Inflammatory Effects of Intravaginal Gels (Universal Placebo Gel and Nonoxynol-9) on the Upper Female Reproductive Tract: A Randomized Crossover Study. PLoS ONE. 2015;10:e0129769 pubmed publisher
Raundhal M, Morse C, Khare A, Oriss T, Milosevic J, Trudeau J, et al. High IFN-γ and low SLPI mark severe asthma in mice and humans. J Clin Invest. 2015;125:3037-50 pubmed publisher
Påhlman L, Jögi A, Gram M, Mori M, Egesten A. Hypoxia down-regulates expression of secretory leukocyte protease inhibitor in bronchial epithelial cells via TGF-β1. BMC Pulm Med. 2015;15:19 pubmed publisher
Wilflingseder J, Sunzenauer J, Toronyi E, Heinzel A, Kainz A, Mayer B, et al. Molecular pathogenesis of post-transplant acute kidney injury: assessment of whole-genome mRNA and miRNA profiles. PLoS ONE. 2014;9:e104164 pubmed publisher
Klimenkova O, Ellerbeck W, Klimiankou M, Unalan M, Kandabarau S, Gigina A, et al. A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation. Blood. 2014;123:1239-49 pubmed publisher
Suh H, Choi N, Tarassishin L, Lee S. Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12). PLoS ONE. 2012;7:e35115 pubmed publisher
Tse K, Wu C, Hsueh C, Chang K, Hao S, Chang Y, et al. The relationship between secretory leukocyte protease inhibitor expression and Epstein-Barr virus status among patients with nasopharyngeal carcinoma. Anticancer Res. 2012;32:1299-307 pubmed
Wen J, Nikitakis N, Chaisuparat R, Greenwell Wild T, Gliozzi M, Jin W, et al. Secretory leukocyte protease inhibitor (SLPI) expression and tumor invasion in oral squamous cell carcinoma. Am J Pathol. 2011;178:2866-78 pubmed publisher
Keller M, Madan R, Torres N, Fazzari M, Cho S, Kalyoussef S, et al. A randomized trial to assess anti-HIV activity in female genital tract secretions and soluble mucosal immunity following application of 1% tenofovir gel. PLoS ONE. 2011;6:e16475 pubmed publisher
Cheng W, Wang C, Huang Y, Liang Y, Lin P, Hsueh C, et al. Overexpression of a secretory leukocyte protease inhibitor in human gastric cancer. Int J Cancer. 2008;123:1787-96 pubmed publisher
Mitchell C, Balkus J, Agnew K, Cohn S, Luque A, Lawler R, et al. Bacterial vaginosis, not HIV, is primarily responsible for increased vaginal concentrations of proinflammatory cytokines. AIDS Res Hum Retroviruses. 2008;24:667-71 pubmed publisher
Nicol G, Han M, Kim J, Birse C, Brand E, Nguyen A, et al. Use of an immunoaffinity-mass spectrometry-based approach for the quantification of protein biomarkers from serum samples of lung cancer patients. Mol Cell Proteomics. 2008;7:1974-82 pubmed publisher
Jacobsen L, Sørensen O, Cowland J, Borregaard N, Theilgaard Monch K. The secretory leukocyte protease inhibitor (SLPI) and the secondary granule protein lactoferrin are synthesized in myelocytes, colocalize in subcellular fractions of neutrophils, and are coreleased by activated neutrophils. J Leukoc Biol. 2008;83:1155-64 pubmed publisher
Cummins J, Denniston M, Mayer K, Pickard R, Novak R, Graham P, et al. Mucosal innate immune factors in secretions from high-risk individuals immunized with a bivalent gp120 vaccine. AIDS Res Hum Retroviruses. 2007;23:748-54 pubmed
Keller M, Guzman E, Hazrati E, Kasowitz A, Cheshenko N, Wallenstein S, et al. PRO 2000 elicits a decline in genital tract immune mediators without compromising intrinsic antimicrobial activity. AIDS. 2007;21:467-76 pubmed
Meinhold Heerlein I, Bauerschlag D, Zhou Y, Sapinoso L, Ching K, Frierson H, et al. An integrated clinical-genomics approach identifies a candidate multi-analyte blood test for serous ovarian carcinoma. Clin Cancer Res. 2007;13:458-66 pubmed
Into T, Inomata M, Kanno Y, Matsuyama T, Machigashira M, Izumi Y, et al. Arginine-specific gingipains from Porphyromonas gingivalis deprive protective functions of secretory leucocyte protease inhibitor in periodontal tissue. Clin Exp Immunol. 2006;145:545-54 pubmed
Simpson J, Scott R, Boyle M, Gibson P. Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma. Am J Respir Crit Care Med. 2005;172:559-65 pubmed
Chattopadhyay A, Gray L, Patton L, Caplan D, Slade G, Tien H, et al. Salivary secretory leukocyte protease inhibitor and oral candidiasis in human immunodeficiency virus type 1-infected persons. Infect Immun. 2004;72:1956-63 pubmed
Kamal A, Corrigan C, Tetley T, Alaghband Zadeh J, Smith S. Effect of fluticasone on the elastase:antielastase profile of the normal lung. Eur J Clin Invest. 2002;32:713-9 pubmed
Farquhar C, VanCott T, Mbori Ngacha D, Horani L, Bosire R, Kreiss J, et al. Salivary secretory leukocyte protease inhibitor is associated with reduced transmission of human immunodeficiency virus type 1 through breast milk. J Infect Dis. 2002;186:1173-6 pubmed
Watt G, Kantipong P, Jongsakul K, de Souza M, Burnouf T. Passive transfer of scrub typhus plasma to patients with AIDS: a descriptive clinical study. QJM. 2001;94:599-607 pubmed
Gompertz S, Bayley D, Hill S, Stockley R. Relationship between airway inflammation and the frequency of exacerbations in patients with smoking related COPD. Thorax. 2001;56:36-41 pubmed
Hocini H, Becquart P, Bouhlal H, Adle Biassette H, Kazatchkine M, Belec L. Secretory leukocyte protease inhibitor inhibits infection of monocytes and lymphocytes with human immunodeficiency virus type 1 but does not interfere with transcytosis of cell-associated virus across tight epithelial barriers. Clin Diagn Lab Immunol. 2000;7:515-8 pubmed
product information
master code :
DPI00
SKU :
DPI00
product name :
Human SLPI Quantikine ELISA Kit
unit size :
1 Kit
description :
The Human SLPI Quantikine ELISA Kit from R&D Systems is a Solid Phase Sandwich ELISA that quantifies human SLPI in cell culture supernates (100 ul), serum (10 ul), edta plasma (10 ul), heparin plasma (10 ul), citrate plasma (10 ul), urine (20 ul).
target :
SLPI
category :
ELISAs
species :
Human
specificity :
Natural and recombinant human SLPI
gene symbol :
SLPI
kit type :
Solid Phase Sandwich ELISA
assay length :
4.5 hours
elisaSampleTypes :
Cell Culture Supernates (100 uL), Serum (10 uL), EDTA Plasma (10 uL), Heparin Plasma (10 uL), Citrate Plasma (10 uL), Urine (20 uL)
elisaSensitivity :
25 pg/mL
elisaRange :
62.50 - 4000 pg/mL
top caption :
Human SLPI ELISA Standard Curve
applications :
ELISA
USD :
655 USD
product details :
The Quantikine Human SLPI Immunoassay is a 4.5 hour solid phase ELISA designed to measure SLPI in cell culture supernates, serum, plasma, and urine. It contains E. coli -expressed recombinant human SLPI and antibodies raised against the recombinant factor. The kit has been shown to accurately quantitate recombinant human SLPI. Results obtained using natural human SLPI showed linear curves that were parallel to the curves obtained using the recombinant kit standards. These results indicate that this kit can be used to determine relative mass values for natural human SLPI.
alt names :
ALK1, ALPProtease inhibitor WAP4, antileukoproteinase, BLPISeminal proteinase inhibitor, HUSI, HUSI-I, Mucus proteinase inhibitor, secretory leukocyte peptidase inhibitor, Secretory leukocyte protease inhibitor, secretory leukocyte protease inhibitor (antileukoproteinase), WAP four-disulfide core domain protein 4, WAP4HUSI-1, WFDC4MPI
storage :
Store the unopened product at 2 - 8 ░C. Do not use past expiration date.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.