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product summary
company name :
R&D Systems
product type :
ELISA/assay
product name :
Human PlGF Quantikine ELISA Kit
catalog :
DPG00
quantity :
1 Kit (also 1 Pack (50 Plates), 1 Pack (6 Plates))
price :
655 USD
citations: 79
Reference
Yang Z, Jia X, Deng Q, Luo M, Hou Y, Yue J, et al. Human umbilical cord mesenchymal stem cell-derived extracellular vesicles loaded with TFCP2 activate Wnt/β-catenin signaling to alleviate preeclampsia. Int Immunopharmacol. 2023;115:109732 pubmed publisher
Sch xf6 nborn M, Gregorczyk Maga I, Batko K, Maga M, Bogucka K, Gawlik K, et al. Angiogenic and Microvascular Status Alterations after Endovascular Revascularization of Lower Limb Arteries among Patients with Diabetic Foot Syndrome: A Prospective 12-Month Follow-Up Study. J Clin Med. 2023;12: pubmed publisher
Komaki R, Miyagaki T, Tanaka M, Nakajima K, Okano T, Takeuchi S, et al. Increased Interleukin-36β Expression Promotes Angiogenesis in Japanese Atopic Dermatitis. Int J Mol Sci. 2023;24: pubmed publisher
Sch xf6 nborn M, Gregorczyk Maga I, Batko K, Bogucka K, Maga M, P x142 otek A, et al. Circulating Angiogenic Factors and Ischemic Diabetic Foot Syndrome Advancement-A Pilot Study. Biomedicines. 2023;11: pubmed publisher
Huang X, Jia L, Jia Y, Xu X, Wang R, Wei M, et al. sFlt-1-enriched exosomes induced endothelial cell dysfunction and a preeclampsia-like phenotype in mice. Cytokine. 2023;166:156190 pubmed publisher
Kurlak L, Scaife P, Briggs L, Broughton Pipkin F, Gardner D, Mistry H. Alterations in Antioxidant Micronutrient Concentrations in Placental Tissue, Maternal Blood and Urine and the Fetal Circulation in Pre-eclampsia. Int J Mol Sci. 2023;24: pubmed publisher
Dymara Konopka W, Laskowska M, Grywalska E, Hymos A, B x142 a x17c ewicz A, Leszczy x144 ska Gorzelak B. Similar Pro- and Antiangiogenic Profiles Close to Delivery in Different Clinical Presentations of Two Pregnancy Syndromes: Preeclampsia and Fetal Growth Restriction. Int J Mol Sci. 2023;24: pubmed publisher
Tsai T, Alwees M, Asaad M, Theile J, Kakkassery V, Dick H, et al. Increased Angiopoietin-1 and -2 levels in human vitreous are associated with proliferative diabetic retinopathy. PLoS ONE. 2023;18:e0280488 pubmed publisher
Darmochwal Kolarz D, Chara A. The Association of IL-17 and PlGF/sENG Ratio in Pre-Eclampsia and Adverse Pregnancy Outcomes. Int J Environ Res Public Health. 2022;20: pubmed publisher
Klaassen I, Avery P, Schlingemann R, Steel D. Vitreous protein networks around ANG2 and VEGF in proliferative diabetic retinopathy and the differential effects of aflibercept versus bevacizumab pre-treatment. Sci Rep. 2022;12:21062 pubmed publisher
Kuriyama S, Yamada T, Matsuda A, Takahashi G, Iwai T, Takeda K, et al. Biomarkers for anti-vascular endothelial growth factor drugs. Oncol Lett. 2022;24:463 pubmed publisher
Anto E, Coall D, Asiamah E, Afriyie O, Addai Mensah O, Wiafe Y, et al. Placental lesions and differential expression of pro-and anti-angiogenic growth mediators and oxidative DNA damage marker in placentae of Ghanaian suboptimal and optimal health status pregnant women who later developed preeclampsia. PLoS ONE. 2022;17:e0265717 pubmed publisher
Wada H, Shinozaki T, Suzuki M, Sakagami S, Ajiro Y, Funada J, et al. Impact of Chronic Kidney Disease on the Associations of Cardiovascular Biomarkers With Adverse Outcomes in Patients With Suspected or Known Coronary Artery Disease: The EXCEED-J Study. J Am Heart Assoc. 2022;11:e023464 pubmed publisher
Yagi K, Mimura K, Tomimatsu T, Matsuyama T, Kawanishi Y, Kakigano A, et al. Potency of Tokishakuyakusan in treating preeclampsia: Drug repositioning method by in vitro screening of the Kampo library. PLoS ONE. 2020;15:e0244684 pubmed publisher
Parchem J, Kanasaki K, Lee S, Kanasaki M, Yang J, Xu Y, et al. STOX1 deficiency is associated with renin-mediated gestational hypertension and placental defects. JCI Insight. 2021;6: pubmed publisher
Kim S, Park M, Kim J, Kim T, Hwang J, Ha K, et al. Circulating miRNAs Associated with Dysregulated Vascular and Trophoblast Function as Target-Based Diagnostic Biomarkers for Preeclampsia. Cells. 2020;9: pubmed publisher
Wilson D, Howard M, Fung A, O Donoghue F, Barnes M, Lappas M, et al. Sleep-disordered breathing does not impact maternal outcomes in women with hypertensive disorders of pregnancy. PLoS ONE. 2020;15:e0232287 pubmed publisher
Nikuei P, Rajaei M, Roozbeh N, Mohseni F, Poordarvishi F, Azad M, et al. Diagnostic accuracy of sFlt1/PlGF ratio as a marker for preeclampsia. BMC Pregnancy Childbirth. 2020;20:80 pubmed publisher
Jiao W, Ji J, Xu W, Bu W, Zheng Y, Ma A, et al. Distinct downstream signaling and the roles of VEGF and PlGF in high glucose-mediated injuries of human retinal endothelial cells in culture. Sci Rep. 2019;9:15339 pubmed publisher
Unger H, Hansa A, Buffet C, Hasang W, Teo A, Randall L, et al. Sulphadoxine-pyrimethamine plus azithromycin may improve birth outcomes through impacts on inflammation and placental angiogenesis independent of malarial infection. Sci Rep. 2019;9:2260 pubmed publisher
Nakada Y, Kawakami R, Matsui M, Ueda T, Nakano T, Nakagawa H, et al. Value of Placental Growth Factor as a Predictor of Adverse Events During the Acute Phase of Acute Decompensated Heart Failure. Circ J. 2019;83:395-400 pubmed publisher
Tsai T, Kuehn S, Tsiampalis N, Vu M, Kakkassery V, Stute G, et al. Anti-inflammatory cytokine and angiogenic factors levels in vitreous samples of diabetic retinopathy patients. PLoS ONE. 2018;13:e0194603 pubmed publisher
Perrotta M, Lori A, Carnevale L, Fardella S, Cifelli G, Iacobucci R, et al. Deoxycorticosterone acetate-salt hypertension activates placental growth factor in the spleen to couple sympathetic drive and immune system activation. Cardiovasc Res. 2018;114:456-467 pubmed publisher
Lamm K, Johnson M, Baker Phillips J, Muntifering M, JAMES J, Jones H, et al. Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome. elife. 2018;7: pubmed publisher
O Brien M, Baczyk D, Kingdom J. Endothelial Dysfunction in Severe Preeclampsia is Mediated by Soluble Factors, Rather than Extracellular Vesicles. Sci Rep. 2017;7:5887 pubmed publisher
Dutta A, Brito K, Khramstova G, Mueller A, Chinthala S, Alexander D, et al. Household air pollution and angiogenic factors in pregnant Nigerian women: A randomized controlled ethanol cookstove intervention. Sci Total Environ. 2017;599-600:2175-2181 pubmed publisher
Li X, Yao Q, Liu H, Jin Q, Xu B, Zhang S, et al. Placental growth factor silencing ameliorates liver fibrosis and angiogenesis and inhibits activation of hepatic stellate cells in a murine model of chronic liver disease. J Cell Mol Med. 2017;21:2370-2385 pubmed publisher
Senapati S, Sammel M, Butts S, Takacs P, Chung K, Barnhart K. Predicting first trimester pregnancy outcome: derivation of a multiple marker test. Fertil Steril. 2016;106:1725-1732.e3 pubmed publisher
Wu D, Lai T, Yuan Y, Chen M, Xia J, Li W, et al. Elevated expression of placental growth factor is associated with airway-wall vascular remodelling and thickening in smokers with asthma. Sci Rep. 2017;7:43017 pubmed publisher
Jammalamadaga V, Abraham P. Spectrum of Factors Triggering Endothelial Dysfunction in PIH. J Clin Diagn Res. 2016;10:BC14-BC17 pubmed publisher
Weel I, Baergen R, Romão Veiga M, Borges V, Ribeiro V, Witkin S, et al. Association between Placental Lesions, Cytokines and Angiogenic Factors in Pregnant Women with Preeclampsia. PLoS ONE. 2016;11:e0157584 pubmed publisher
Dauwe D, Pelacho B, Wibowo A, Walravens A, Verdonck K, Gillijns H, et al. Neovascularization Potential of Blood Outgrowth Endothelial Cells From Patients With Stable Ischemic Heart Failure Is Preserved. J Am Heart Assoc. 2016;5:e002288 pubmed publisher
Bessho H, Wong B, Huang D, Siew E, Huang D, Tan J, et al. Inhibition of placental growth factor in renal cell carcinoma. Anticancer Res. 2015;35:531-41 pubmed
Hou H, Cheng S, Chung K, Kuo M, Yeh C, Chang B, et al. Elastase induces lung epithelial cell autophagy through placental growth factor: a new insight of emphysema pathogenesis. Autophagy. 2014;10:1509-21 pubmed publisher
Calcaterra F, Taddeo A, Colombo E, Cappelletti M, Martinelli A, Calabrese S, et al. Reduction of maternal circulating endothelial progenitor cells in human pregnancies with intrauterine growth restriction. Placenta. 2014;35:431-6 pubmed publisher
White W, Garrett A, Craici I, Wagner S, Fitz Gibbon P, Butters K, et al. Persistent urinary podocyte loss following preeclampsia may reflect subclinical renal injury. PLoS ONE. 2014;9:e92693 pubmed publisher
Liu L, Yang T, Ji J, Wen Q, Morgan A, Jin B, et al. Integrating multiple 'omics' analyses identifies serological protein biomarkers for preeclampsia. BMC Med. 2013;11:236 pubmed publisher
El Tarhouny S, Almasry S, Elfayomy A, Baghdadi H, Habib F. Placental growth factor and soluble Fms-like tyrosine kinase 1 in diabetic pregnancy: A possible relation to distal villous immaturity. Histol Histopathol. 2014;29:259-72 pubmed publisher
Huang Q, Wang S, Zhang M, Huang L, Tian J, Yu Y, et al. Advanced oxidation protein products enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts: a possible link between oxidative stress and preeclampsia. Placenta. 2013;34:949-52 pubmed publisher
Chaturvedi P, Gilkes D, Wong C, Luo W, Zhang H, Wei H, et al. Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. J Clin Invest. 2013;123:189-205 pubmed publisher
Sleijfer S, Gorlia T, Lamers C, Burger H, Blay J, Le Cesne A, et al. Cytokine and angiogenic factors associated with efficacy and toxicity of pazopanib in advanced soft-tissue sarcoma: an EORTC-STBSG study. Br J Cancer. 2012;107:639-45 pubmed publisher
Yamashita Kashima Y, Fujimoto Ouchi K, Yorozu K, Kurasawa M, Yanagisawa M, Yasuno H, et al. Biomarkers for antitumor activity of bevacizumab in gastric cancer models. BMC Cancer. 2012;12:37 pubmed publisher
Rahbari N, Schmidt T, Falk C, Hinz U, Herber M, Bork U, et al. Expression and prognostic value of circulating angiogenic cytokines in pancreatic cancer. BMC Cancer. 2011;11:286 pubmed publisher
DuBois S, Shusterman S, Ingle A, Ahern C, Reid J, Wu B, et al. Phase I and pharmacokinetic study of sunitinib in pediatric patients with refractory solid tumors: a children's oncology group study. Clin Cancer Res. 2011;17:5113-22 pubmed publisher
de Groot J, Piao Y, Tran H, Gilbert M, Wu H, Liu J, et al. Myeloid biomarkers associated with glioblastoma response to anti-VEGF therapy with aflibercept. Clin Cancer Res. 2011;17:4872-81 pubmed publisher
Loupakis F, Cremolini C, Fioravanti A, Orlandi P, Salvatore L, Masi G, et al. Pharmacodynamic and pharmacogenetic angiogenesis-related markers of first-line FOLFOXIRI plus bevacizumab schedule in metastatic colorectal cancer. Br J Cancer. 2011;104:1262-9 pubmed publisher
Horne A, Shaw J, Murdoch A, McDonald S, Williams A, Jabbour H, et al. Placental growth factor: a promising diagnostic biomarker for tubal ectopic pregnancy. J Clin Endocrinol Metab. 2011;96:E104-8 pubmed publisher
Jeyabalan A, Powers R, Clifton R, Van Dorsten P, Hauth J, Klebanoff M, et al. Effect of smoking on circulating angiogenic factors in high risk pregnancies. PLoS ONE. 2010;5:e13270 pubmed publisher
Brave S, Eberlein C, Shibuya M, Wedge S, Barry S. Placental growth factor neutralising antibodies give limited anti-angiogenic effects in an in vitro organotypic angiogenesis model. Angiogenesis. 2010;13:337-47 pubmed publisher
Powers R, Jeyabalan A, Clifton R, Van Dorsten P, Hauth J, Klebanoff M, et al. Soluble fms-Like tyrosine kinase 1 (sFlt1), endoglin and placental growth factor (PlGF) in preeclampsia among high risk pregnancies. PLoS ONE. 2010;5:e13263 pubmed publisher
Jaffe I, Newfell B, Aronovitz M, Mohammad N, McGraw A, Perreault R, et al. Placental growth factor mediates aldosterone-dependent vascular injury in mice. J Clin Invest. 2010;120:3891-900 pubmed publisher
Ha C, Wu J, Irmak S, Lisboa F, Dizon A, Warren J, et al. Human pregnancy specific beta-1-glycoprotein 1 (PSG1) has a potential role in placental vascular morphogenesis. Biol Reprod. 2010;83:27-35 pubmed publisher
Brittain J, Hulkower B, Jones S, Strayhorn D, De Castro L, Telen M, et al. Placenta growth factor in sickle cell disease: association with hemolysis and inflammation. Blood. 2010;115:2014-20 pubmed publisher
Verlohren S, Galindo A, Schlembach D, Zeisler H, Herraiz I, Moertl M, et al. An automated method for the determination of the sFlt-1/PIGF ratio in the assessment of preeclampsia. Am J Obstet Gynecol. 2010;202:161.e1-161.e11 pubmed publisher
Cassidy A, Chiuve S, Manson J, Rexrode K, Girman C, Rimm E. Potential role for plasma placental growth factor in predicting coronary heart disease risk in women. Arterioscler Thromb Vasc Biol. 2009;29:134-9 pubmed publisher
Rini B, Michaelson M, Rosenberg J, Bukowski R, Sosman J, Stadler W, et al. Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma. J Clin Oncol. 2008;26:3743-8 pubmed publisher
FINDLEY C, Mitchell R, Duscha B, Annex B, Kontos C. Plasma levels of soluble Tie2 and vascular endothelial growth factor distinguish critical limb ischemia from intermittent claudication in patients with peripheral arterial disease. J Am Coll Cardiol. 2008;52:387-93 pubmed publisher
Manaster I, Mizrahi S, Goldman Wohl D, Sela H, Stern Ginossar N, Lankry D, et al. Endometrial NK cells are special immature cells that await pregnancy. J Immunol. 2008;181:1869-76 pubmed
Jeyabalan A, Powers R, Durica A, Harger G, Roberts J, Ness R. Cigarette smoke exposure and angiogenic factors in pregnancy and preeclampsia. Am J Hypertens. 2008;21:943-7 pubmed publisher
Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, et al. Isolation and characterization of CD146+ multipotent mesenchymal stromal cells. Exp Hematol. 2008;36:1035-46 pubmed publisher
Gutman G, Barak V, Maslovitz S, Amit A, Lessing J, Geva E. Regulation of vascular endothelial growth factor-A and its soluble receptor sFlt-1 by luteinizing hormone in vivo: implication for ovarian follicle angiogenesis. Fertil Steril. 2008;89:922-6 pubmed publisher
Kissel C, Lehmann R, Assmus B, Aicher A, Honold J, Fischer Rasokat U, et al. Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure. J Am Coll Cardiol. 2007;49:2341-9 pubmed
Apple F, Pearce L, Chung A, Ler R, Murakami M. Multiple biomarker use for detection of adverse events in patients presenting with symptoms suggestive of acute coronary syndrome. Clin Chem. 2007;53:874-81 pubmed
Cianfarani F, Zambruno G, Brogelli L, Sera F, Lacal P, Pesce M, et al. Placenta growth factor in diabetic wound healing: altered expression and therapeutic potential. Am J Pathol. 2006;169:1167-82 pubmed
Levine R, Lam C, Qian C, Yu K, Maynard S, Sachs B, et al. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med. 2006;355:992-1005 pubmed
Wallner W, Sengenberger R, Strick R, Strissel P, Meurer B, Beckmann M, et al. Angiogenic growth factors in maternal and fetal serum in pregnancies complicated by intrauterine growth restriction. Clin Sci (Lond). 2007;112:51-7 pubmed
Iwama H, Uemura S, Naya N, Imagawa K, Takemoto Y, Asai O, et al. Cardiac expression of placental growth factor predicts the improvement of chronic phase left ventricular function in patients with acute myocardial infarction. J Am Coll Cardiol. 2006;47:1559-67 pubmed
Moreno M, Ball M, Andrade M, McDermid A, Stanimirovic D. Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells. Glia. 2006;53:845-57 pubmed
Briguori C, Testa U, Colombo A, Petrucci E, Condorelli G, Airoldi F, et al. Relation of various plasma growth factor levels in patients with stable angina pectoris and total occlusion of a coronary artery to the degree of coronary collaterals. Am J Cardiol. 2006;97:472-6 pubmed
Masuyama H, Suwaki N, Nakatsukasa H, Masumoto A, Tateishi Y, Hiramatrsu Y. Circulating angiogenic factors in preeclampsia, gestational proteinuria, and preeclampsia superimposed on chronic glomerulonephritis. Am J Obstet Gynecol. 2006;194:551-6 pubmed
Buhimschi C, Norwitz E, Funai E, Richman S, Guller S, Lockwood C, et al. Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia. Am J Obstet Gynecol. 2005;192:734-41 pubmed
Levine R, Thadhani R, Qian C, Lam C, Lim K, Yu K, et al. Urinary placental growth factor and risk of preeclampsia. JAMA. 2005;293:77-85 pubmed
Nishishita T, Ouchi K, Zhang X, Inoue M, Inazawa T, Yoshiura K, et al. A potential pro-angiogenic cell therapy with human placenta-derived mesenchymal cells. Biochem Biophys Res Commun. 2004;325:24-31 pubmed
Levine R, Maynard S, Qian C, Lim K, England L, Yu K, et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med. 2004;350:672-83 pubmed
Tsao P, Su Y, Li H, Huang P, Chien C, Lai Y, et al. Overexpression of placenta growth factor contributes to the pathogenesis of pulmonary emphysema. Am J Respir Crit Care Med. 2004;169:505-11 pubmed
Maynard S, Min J, Merchan J, Lim K, Li J, Mondal S, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest. 2003;111:649-58 pubmed
Oura H, Bertoncini J, Velasco P, Brown L, Carmeliet P, Detmar M. A critical role of placental growth factor in the induction of inflammation and edema formation. Blood. 2003;101:560-7 pubmed
Chappell L, Seed P, Briley A, Kelly F, Hunt B, Charnock Jones D, et al. A longitudinal study of biochemical variables in women at risk of preeclampsia. Am J Obstet Gynecol. 2002;187:127-36 pubmed
Zhou Y, McMaster M, Woo K, Janatpour M, Perry J, Karpanen T, et al. Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. Am J Pathol. 2002;160:1405-23 pubmed
product information
master code :
DPG00
SKU :
DPG00
product name :
Human PlGF Quantikine ELISA Kit
unit size :
1 Kit (also 1 Pack (50 Plates), 1 Pack (6 Plates))
description :
The Human PlGF Quantikine ELISA Kit from R&D Systems is a Solid Phase Sandwich ELISA that quantifies human PLGF in cell culture supernates (100 ul), serum (100 ul), edta plasma (100 ul), heparin plasma (100 ul), citrate plasma (100 ul), urine (100 ul).
target :
PlGF
category :
ELISAs
species :
Human
specificity :
Natural and recombinant human PlGF
gene symbol :
PGF
kit type :
Solid Phase Sandwich ELISA
assay length :
3.5 hours or 4.5 hours
elisaSampleTypes :
Cell Culture Supernates (100 uL), Serum (100 uL), EDTA Plasma (100 uL), Heparin Plasma (100 uL), Citrate Plasma (100 uL), Urine (100 uL)
elisaSensitivity :
7 pg/mL
elisaRange :
15.60 - 1000 pg/mL
top caption :
Human PlGF ELISA Cell Culture Supernate Standard Curve
applications :
ELISA
USD :
655 USD
product details :
The Quantikine Human PlGF Immunoassay is a 3.5 or 4.5 hour solid phase ELISA designed to measure human PlGF in cell culture supernates, serum, plasma, and urine. The immunoassay kit contains E. coli -expressed recombinant human PlGF and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate recombinant human PlGF accurately. Results obtained using natural human PlGF showed dose curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human PlGF.
alt names :
D12S1900, PGF, PGFL, placenta growth factor, placental growth factor, placental growth factor, vascular endothelial growth factor-related protein, PlGF, PlGF-2, PLGFplacental growth factor-like, SHGC-10760
storage :
Store the unopened product at 2 - 8 ░C. Do not use past expiration date.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.