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product summary
company name :
R&D Systems
product type :
ELISA/assay
product name :
Human IL-12/IL-23 p40 Quantikine ELISA Kit
catalog :
DP400
quantity :
1 Kit (also 1 Pack (50 Plates), 1 Pack (6 Plates))
price :
655 USD
citations: 28
Reference
Orts B, Gutierrez A, Madero L, Sempere L, Francés R, Zapater P. Clinical and Immunological Factors Associated with Recommended Trough Levels of Adalimumab and Infliximab in Patients with Crohn's Disease. Front Pharmacol. 2021;12:795272 pubmed publisher
Avila L, Neves M, Abreu A, Fiuza C, Fukusawa L, Meziat Filho N, et al. Cognitive functional therapy (CFT) compared with core training exercise (CTE) in patients with failed back surgery syndrome (FBSS): A study protocol for a randomized controlled trial. J Bodyw Mov Ther. 2021;26:428-434 pubmed publisher
Banga J, Srinivasan D, Sun C, Thompson C, Milletti F, Huang K, et al. Inhibition of IRF5 cellular activity with cell-penetrating peptides that target homodimerization. Sci Adv. 2020;6:eaay1057 pubmed publisher
Abumaree M, Bahattab E, Alsadoun A, Al Dosaimani A, Abomaray F, Khatlani T, et al. Characterization of the interaction between human decidua parietalis mesenchymal stem/stromal cells and natural killer cells. Stem Cell Res Ther. 2018;9:102 pubmed publisher
Gonda K, Shibata M, Ohtake T, Matsumoto Y, Tachibana K, Abe N, et al. Myeloid-derived suppressor cells are increased and correlated with type 2 immune responses, malnutrition, inflammation, and poor prognosis in patients with breast cancer. Oncol Lett. 2017;14:1766-1774 pubmed publisher
Shinohara H, Kuranaga Y, Kumazaki M, Sugito N, Yoshikawa Y, Takai T, et al. Regulated Polarization of Tumor-Associated Macrophages by miR-145 via Colorectal Cancer-Derived Extracellular Vesicles. J Immunol. 2017;199:1505-1515 pubmed publisher
Wendling D, Abbas W, Godfrin Valnet M, Kumar A, Guillot X, Khan K, et al. Dysregulated serum IL-23 and SIRT1 activity in peripheral blood mononuclear cells of patients with rheumatoid arthritis. PLoS ONE. 2015;10:e0119981 pubmed publisher
Lees J, Duffy S, Perera C, Moalem Taylor G. Depletion of Foxp3+ regulatory T cells increases severity of mechanical allodynia and significantly alters systemic cytokine levels following peripheral nerve injury. Cytokine. 2015;71:207-14 pubmed publisher
Abdi K, Singh N, Spooner E, Kessler B, Radaev S, Lantz L, et al. Free IL-12p40 monomer is a polyfunctional adaptor for generating novel IL-12-like heterodimers extracellularly. J Immunol. 2014;192:6028-36 pubmed publisher
Loubaki L, Hadj Salem I, Fakhfakh R, Jacques E, Plante S, Boisvert M, et al. Co-culture of human bronchial fibroblasts and CD4+ T cells increases Th17 cytokine signature. PLoS ONE. 2013;8:e81983 pubmed publisher
Chase J, Celli J, Bosio C. Direct and indirect impairment of human dendritic cell function by virulent Francisella tularensis Schu S4. Infect Immun. 2009;77:180-95 pubmed publisher
Wang D, Drenker M, Eiz Vesper B, Werfel T, Wittmann M. Evidence for a pathogenetic role of interleukin-18 in cutaneous lupus erythematosus. Arthritis Rheum. 2008;58:3205-15 pubmed publisher
Alvarado Navarro A, Montoya Buelna M, Muñoz Valle J, Lopez Roa R, Guillén Vargas C, Fafutis Morris M. The 3'UTR 1188 A/C polymorphism in the interleukin-12p40 gene (IL-12B) is associated with lepromatous leprosy in the west of Mexico. Immunol Lett. 2008;118:148-51 pubmed publisher
Liu T, Uemura Y, Suzuki M, Narita Y, Hirata S, Ohyama H, et al. Distinct subsets of human invariant NKT cells differentially regulate T helper responses via dendritic cells. Eur J Immunol. 2008;38:1012-23 pubmed publisher
Dudek A, Yunis C, Harrison L, Kumar S, Hawkinson R, Cooley S, et al. First in human phase I trial of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced cancer. Clin Cancer Res. 2007;13:7119-25 pubmed
Mian M, Lauzon N, Stampfli M, Mossman K, Ashkar A. Impairment of human NK cell cytotoxic activity and cytokine release by cigarette smoke. J Leukoc Biol. 2008;83:774-84 pubmed
Vidyarani M, Selvaraj P, Jawahar M, Narayanan P. 1, 25 Dihydroxyvitamin D3 modulated cytokine response in pulmonary tuberculosis. Cytokine. 2007;40:128-34 pubmed
Lin Y, Liang Y, Chiang B. Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells. J Leukoc Biol. 2007;82:1473-80 pubmed
Pockros P, Guyader D, Patton H, Tong M, Wright T, McHutchison J, et al. Oral resiquimod in chronic HCV infection: safety and efficacy in 2 placebo-controlled, double-blind phase IIa studies. J Hepatol. 2007;47:174-82 pubmed
Lepej S, Misic Majerus L, Jeren T, Rode O, Remenar A, Sporec V, et al. Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne encephalitis. Acta Neurol Scand. 2007;115:109-14 pubmed
Wang Z, Yang D, Chen Q, Leifer C, Segal D, Su S, et al. Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways. Exp Hematol. 2006;34:1115-24 pubmed
Vaknin Dembinsky A, Balashov K, Weiner H. IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production. J Immunol. 2006;176:7768-74 pubmed
Spensieri F, Fedele G, Fazio C, Nasso M, Stefanelli P, Mastrantonio P, et al. Bordetella pertussis inhibition of interleukin-12 (IL-12) p70 in human monocyte-derived dendritic cells blocks IL-12 p35 through adenylate cyclase toxin-dependent cyclic AMP induction. Infect Immun. 2006;74:2831-8 pubmed
Chapgier A, Wynn R, Jouanguy E, Filipe Santos O, Zhang S, Feinberg J, et al. Human complete Stat-1 deficiency is associated with defective type I and II IFN responses in vitro but immunity to some low virulence viruses in vivo. J Immunol. 2006;176:5078-83 pubmed
Yoshikawa H, Sato K, Edahiro S, Furukawa Y, Maruta T, Iwasa K, et al. Elevation of IL-12 p40 and its antibody in myasthenia gravis with thymoma. J Neuroimmunol. 2006;175:169-75 pubmed
Bouchama A, Ollivier V, Roberts G, Al Mohanna F, de Prost D, Eldali A, et al. Experimental heatstroke in baboon: analysis of the systemic inflammatory response. Shock. 2005;24:332-5 pubmed
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Mirani M, Elenkov I, Volpi S, Hiroi N, Chrousos G, Kino T. HIV-1 protein Vpr suppresses IL-12 production from human monocytes by enhancing glucocorticoid action: potential implications of Vpr coactivator activity for the innate and cellular immunity deficits observed in HIV-1 infection. J Immunol. 2002;169:6361-8 pubmed
product information
master code :
DP400
SKU :
DP400
product name :
Human IL-12/IL-23 p40 Quantikine ELISA Kit
unit size :
1 Kit (also 1 Pack (50 Plates), 1 Pack (6 Plates))
description :
The Human IL-12/IL-23 p40 Quantikine ELISA Kit from R&D Systems is a Solid Phase Sandwich ELISA that quantifies human IL-12/IL-23 p40 in cell culture supernates (100 ul), serum (100 ul), edta plasma (100 ul), heparin plasma (100 ul), citrate plasma (100 ul).
target :
IL-12/IL-23 p40
category :
ELISAs
species :
Human
specificity :
Natural and recombinant human IL-12 p40
gene symbol :
IL12B
kit type :
Solid Phase Sandwich ELISA
assay length :
3.5 hours or 4.5 hours
elisaSampleTypes :
Cell Culture Supernates (100 uL), Serum (100 uL), EDTA Plasma (100 uL), Heparin Plasma (100 uL), Citrate Plasma (100 uL)
elisaSensitivity :
15 pg/mL
elisaRange :
31.20 - 2000 pg/mL
top caption :
Human IL-12/IL-23 p40 Homodimer ELISA Cell Culture Supernate Standard Curve
applications :
ELISA
USD :
655 USD
product details :
The Quantikine Human IL-12 p40 Immunoassay is a 3.5 or 4.5 hour solid phase ELISA designed to measure IL-12 p40 in cell culture supernates, serum, and plasma. It contains recombinant human IL-12 p40 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate recombinant human IL-12 p40. Results obtained using natural human IL-12 p40 showed dose-response curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human IL-12 p40.
alt names :
CLMF, CLMF p40, CLMF2, Cytotoxic lymphocyte maturation factor 40 kDa subunit, IL12 p40, IL-12 subunit p40, IL12B, IL-12B, IL-12BNK cell stimulatory factor chain 2, interleukin 12, p40, interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocytematuration factor 2, p40), interleukin-12 beta chain, interleukin-12 subunit beta, natural killer cell stimulatory factor, 40 kD subunit, NKSF, NKSF2, NKSF2IL12, subunit p40
storage :
Store the unopened product at 2 - 8 ░C. Do not use past expiration date.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.