This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
ELISA/assay
product name :
Human Total MMP-3 Quantikine ELISA Kit
catalog :
DMP300
quantity :
1 Kit (also 1 Pack (50 Plates), 1 Pack (6 Plates))
price :
655 USD
citations: 55
Reference
Kowalska M, Tylicka M, Koper Lenkiewicz O, Kami x144 ska J, Dorf J, Matuszczak E. Plasma concentration of MMP-17 is elevated in boys with cryptorchidism and correlates with HSP-70. Sci Rep. 2025;15:474 pubmed publisher
Monroe T, Hertzel A, Dickey D, Hagen T, Santibanez S, Berdaweel I, et al. Lipid peroxidation products induce carbonyl stress, mitochondrial dysfunction, and cellular senescence in human and murine cells. Aging Cell. 2025;24:e14367 pubmed publisher
Partan R, Putra K, Kusuma N, Darma S, Reagan M, Muthia P, et al. Umbilical Cord Mesenchymal Stem Cell Secretome Improves Clinical Outcomes and Changes Biomarkers in Knee Osteoarthritis. J Clin Med. 2023;12: pubmed publisher
Pl xfc mers R, Lindenkamp C, Osterhage M, Knabbe C, Hendig D. Matrix Metalloproteinases Contribute to the Calcification Phenotype in Pseudoxanthoma Elasticum. Biomolecules. 2023;13: pubmed publisher
O Callaghan J, Delaney C, O Connor M, van Batenburg Sherwood J, Schicht M, L xfc tjen Drecoll E, et al. Matrix metalloproteinase-3 (MMP-3)-mediated gene therapy for glaucoma. Sci Adv. 2023;9:eadf6537 pubmed publisher
Kim T, Kim A, Lee K, Hwang M, Choi H. Microfluidic Electroceuticals Platform for Therapeutic Strategies of Intervertebral Disc Degeneration: Effects of Electrical Stimulation on Human Nucleus Pulposus Cells under Inflammatory Conditions. Int J Mol Sci. 2022;23: pubmed publisher
Shin J, Park S, Cho H, Kim J, Choi H. Adipokine human Resistin promotes obesity-associated inflammatory intervertebral disc degeneration via pro-inflammatory cytokine cascade activation. Sci Rep. 2022;12:8936 pubmed publisher
Dreiner M, Munk T, Zaucke F, Liphardt A, Niehoff A. Relationship between different serum cartilage biomarkers in the acute response to running and jumping in healthy male individuals. Sci Rep. 2022;12:6434 pubmed publisher
Jung B, Samten B, Dean K, Wallace R, Brown Elliott B, Tucker T, et al. Early IL-17A production helps establish Mycobacterium intracellulare infection in mice. PLoS Pathog. 2022;18:e1010454 pubmed publisher
Jarecki J, Ma x142 ecka Masalska T, Kosior Jarecka E, Widuchowski W, Krasowski P, Gutbier M, et al. Concentration of Selected Metalloproteinases and Osteocalcin in the Serum and Synovial Fluid of Obese Women with Advanced Knee Osteoarthritis. Int J Environ Res Public Health. 2022;19: pubmed publisher
S xf8 rensen A, Andersen M, Juul Madsen K, Broks xf8 A, Skej xf8 C, Schmidt H, et al. Tumor necrosis factor alpha neutralization attenuates immune checkpoint inhibitor-induced activation of intermediate monocytes in synovial fluid mononuclear cells from patients with inflammatory arthritis. Arthritis Res Ther. 2022;24:43 pubmed publisher
Rademacher J, Siderius M, Gellert L, Wink F, Verba M, Maas F, et al. Baseline serum biomarkers of inflammation, bone turnover and adipokines predict spinal radiographic progression in ankylosing spondylitis patients on TNF inhibitor therapy. Semin Arthritis Rheum. 2022;53:151974 pubmed publisher
Kudelski J, Młynarczyk G, Gudowska Sawczuk M, Mroczko B, Darewicz B, Bruczko Goralewska M, et al. Enhanced Expression but Decreased Specific Activity of Matrix Metalloproteinase 10 (MMP-10) in Comparison with Matrix Metalloproteinase 3 (MMP-3) in Human Urinary Bladder Carcinoma. J Clin Med. 2021;10: pubmed publisher
Pak H, Kim Y, Nam B, Lee A, Roh J, Gil M, et al. The Migration of Human Follicular Dendritic Cell-Like Cell Is Facilitated by Matrix Metalloproteinase 3 Expression That Is Mediated through TNFα-ERK1/2-AP1 Signaling. J Immunol Res. 2021;2021:8483938 pubmed publisher
Chihara K, Hattori N, Ichikawa N, Matsuda T, Saito T. Re-evaluation of serum leptin and adiponectin concentrations normalized by body fat mass in patients with rheumatoid arthritis. Sci Rep. 2020;10:15932 pubmed publisher
Liu Y, Wang S, Li Y, Bian W, Zhang L, Li Y, et al. Activity of fibroblast-like synoviocytes in rheumatoid arthritis was impaired by dickkopf-1 targeting siRNA. Chin Med J (Engl). 2020;:679-686 pubmed publisher
Zhang D, Peng Y, Zhang H, Ma J, Zhao M, Yin S, et al. Basilar Artery Tortuosity Is Associated With White Matter Hyperintensities by TIMP-1. Front Neurosci. 2019;13:836 pubmed publisher
Muñoz D, Yannone S, Daemen A, Sun Y, Vakar Lopez F, Kawahara M, et al. Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging. JCI Insight. 2019;5: pubmed publisher
Kollar B, Shubin A, Borges T, Tasigiorgos S, Win T, Lian C, et al. Increased levels of circulating MMP3 correlate with severe rejection in face transplantation. Sci Rep. 2018;8:14915 pubmed publisher
Hulme C, Wilson E, Fuller H, Roberts S, Richardson J, Gallacher P, et al. Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation. Arthritis Res Ther. 2018;20:87 pubmed publisher
Audo R, Deckert V, Daïen C, Che H, Elhmioui J, Lemaire S, et al. PhosphoLipid transfer protein (PLTP) exerts a direct pro-inflammatory effect on rheumatoid arthritis (RA) fibroblasts-like-synoviocytes (FLS) independently of its lipid transfer activity. PLoS ONE. 2018;13:e0193815 pubmed publisher
Robinson C, Tsang L, Solomon A, Woodiwiss A, Gunter S, Mer M, et al. Nesfatin-1 and visfatin expression is associated with reduced atherosclerotic disease risk in patients with rheumatoid arthritis. Peptides. 2018;102:31-37 pubmed publisher
Hou S, Hou C, Liu J. CX3CL1 promotes MMP-3 production via the CX3CR1, c-Raf, MEK, ERK, and NF-κB signaling pathway in osteoarthritis synovial fibroblasts. Arthritis Res Ther. 2017;19:282 pubmed publisher
Jadon D, Sengupta R, Nightingale A, Lu H, Dunphy J, Green A, et al. Serum bone-turnover biomarkers are associated with the occurrence of peripheral and axial arthritis in psoriatic disease: a prospective cross-sectional comparative study. Arthritis Res Ther. 2017;19:210 pubmed publisher
Mechmeche R, Zaroui A, Aloui S, Boukhris M, Allal Elasmi M, Kaabachi N, et al. Late mitral restenosis after percutaneous commissurotomy: Predictive value of inflammation and extracellular matrix remodeling biomarkers. Heart Lung. 2017;46:258-264 pubmed publisher
Bchir S, Nasr H, Bouchet S, Benzarti M, Garrouch A, Tabka Z, et al. Concomitant elevations of MMP-9, NGAL, proMMP-9/NGAL and neutrophil elastase in serum of smokers with chronic obstructive pulmonary disease. J Cell Mol Med. 2017;21:1280-1291 pubmed publisher
Weinmann D, Schlangen K, Andre S, Schmidt S, Walzer S, Kubista B, et al. Galectin-3 Induces a Pro-degradative/inflammatory Gene Signature in Human Chondrocytes, Teaming Up with Galectin-1 in Osteoarthritis Pathogenesis. Sci Rep. 2016;6:39112 pubmed publisher
Qin W, Tsukasaki Y, Dasgupta S, Mukhopadhyay N, Ikebe M, Sauter E. Exosomes in Human Breast Milk Promote EMT. Clin Cancer Res. 2016;22:4517-24 pubmed publisher
Kmiecik A, Pula B, Suchanski J, Olbromski M, Gomulkiewicz A, Owczarek T, et al. Metallothionein-3 Increases Triple-Negative Breast Cancer Cell Invasiveness via Induction of Metalloproteinase Expression. PLoS ONE. 2015;10:e0124865 pubmed publisher
Zhao R, Chen N, Zhou X, Miao P, Hu C, Qian L, et al. Exogenous IFN-beta regulates the RANKL-c-Fos-IFN-beta signaling pathway in the collagen antibody-induced arthritis model. J Transl Med. 2014;12:330 pubmed publisher
Symeonidis C, Papakonstantinou E, Androudi S, Tsaousis K, Tsinopoulos I, Brazitikos P, et al. Interleukin-6 and matrix metalloproteinase expression in the subretinal fluid during proliferative vitreoretinopathy: correlation with extent, duration of RRD and PVR grade. Cytokine. 2012;59:184-90 pubmed publisher
Jaedicke K, Taylor J, Preshaw P. Validation and quality control of ELISAs for the use with human saliva samples. J Immunol Methods. 2012;377:62-5 pubmed publisher
Symeonidis C, Papakonstantinou E, Androudi S, Rotsos T, Diza E, Brazitikos P, et al. Interleukin-6 and the matrix metalloproteinase response in the vitreous during proliferative vitreoretinopathy. Cytokine. 2011;54:212-7 pubmed publisher
Yamakawa N, Uchida T, Matthay M, Makita K. Proteolytic release of the receptor for advanced glycation end products from in vitro and in situ alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011;300:L516-25 pubmed publisher
Verma S, Kumar M, Nerurkar V. Cyclooxygenase-2 inhibitor blocks the production of West Nile virus-induced neuroinflammatory markers in astrocytes. J Gen Virol. 2011;92:507-15 pubmed publisher
Hashizume M, Mihara M. High molecular weight hyaluronic acid inhibits IL-6-induced MMP production from human chondrocytes by up-regulating the ERK inhibitor, MKP-1. Biochem Biophys Res Commun. 2010;403:184-9 pubmed publisher
Kawut S, Barr R, Johnson W, Chahal H, Tandri H, Jain A, et al. Matrix metalloproteinase-9 and plasminogen activator inhibitor-1 are associated with right ventricular structure and function: the MESA-RV Study. Biomarkers. 2010;15:731-8 pubmed publisher
van Kuijk A, Degroot J, Koeman R, Sakkee N, Baeten D, Gerlag D, et al. Soluble biomarkers of cartilage and bone metabolism in early proof of concept trials in psoriatic arthritis: effects of adalimumab versus placebo. PLoS ONE. 2010;5: pubmed publisher
Buralli S, Dini F, Ballo P, Conti U, Fontanive P, Duranti E, et al. Circulating matrix metalloproteinase-3 and metalloproteinase-9 and tissue Doppler measures of diastolic dysfunction to risk stratify patients with systolic heart failure. Am J Cardiol. 2010;105:853-6 pubmed publisher
Reikvam H, Hatfield K, Oyan A, Kalland K, Kittang A, Bruserud O. Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation. Eur J Haematol. 2010;84:239-51 pubmed publisher
Karapanagiotidis G, Antonitsis P, Charokopos N, Foroulis C, Anastasiadis K, Rouska E, et al. Serum levels of matrix metalloproteinases -1,-2,-3 and -9 in thoracic aortic diseases and acute myocardial ischemia. J Cardiothorac Surg. 2009;4:59 pubmed publisher
Hayer S, Pundt N, Peters M, Wunrau C, Kühnel I, Neugebauer K, et al. PI3Kgamma regulates cartilage damage in chronic inflammatory arthritis. FASEB J. 2009;23:4288-98 pubmed publisher
Wunrau C, Schnaeker E, Freyth K, Pundt N, Wendholt D, Neugebauer K, et al. Establishment of a matrix-associated transepithelial resistance invasion assay to precisely measure the invasive potential of synovial fibroblasts. Arthritis Rheum. 2009;60:2606-11 pubmed publisher
Yeh Y, Sheu B, Cheng H, Wang Y, Yang H, Wu J. Elevated serum matrix metalloproteinase-3 and -7 in H. pylori-related gastric cancer can be biomarkers correlating with a poor survival. Dig Dis Sci. 2010;55:1649-57 pubmed publisher
Lee Y, Kweon S, Kwon K, Park J, Yoon T, Park B. Inhibition of IL-1beta-mediated inflammatory responses by the IkappaB alpha super-repressor in human fibroblast-like synoviocytes. Biochem Biophys Res Commun. 2009;378:90-4 pubmed publisher
Agarwal A, Covic L, Sevigny L, Kaneider N, Lazarides K, Azabdaftari G, et al. Targeting a metalloprotease-PAR1 signaling system with cell-penetrating pepducins inhibits angiogenesis, ascites, and progression of ovarian cancer. Mol Cancer Ther. 2008;7:2746-57 pubmed publisher
Wendling D, Cedoz J, Racadot E. Serum levels of MMP-3 and cathepsin K in patients with ankylosing spondylitis: effect of TNFalpha antagonist therapy. Joint Bone Spine. 2008;75:559-62 pubmed publisher
Samnegard A, Hulthe J, Silveira A, Ericsson C, Hamsten A, Eriksson P. Gender specific associations between matrix metalloproteinases and inflammatory markers in post myocardial infarction patients. Atherosclerosis. 2009;202:550-6 pubmed publisher
Naveau A, Reinald N, Fournier B, Durand E, Lafont A, Coulomb B, et al. Gingival fibroblasts inhibit MMP-1 and MMP-3 activities in an ex-vivo artery model. Connect Tissue Res. 2007;48:300-8 pubmed
McLennan S, Kelly D, Schache M, Waltham M, Dy V, Langham R, et al. Advanced glycation end products decrease mesangial cell MMP-7: a role in matrix accumulation in diabetic nephropathy?. Kidney Int. 2007;72:481-8 pubmed
Zhao Z, McCloud B, Fleming R, Klempner M. Borrelia burgdorferi-induced monocyte chemoattractant protein-1 production in vivo and in vitro. Biochem Biophys Res Commun. 2007;358:528-33 pubmed
Nah S, Choi I, Yoo B, Kim Y, Moon H, Lee C. Advanced glycation end products increases matrix metalloproteinase-1, -3, and -13, and TNF-alpha in human osteoarthritic chondrocytes. FEBS Lett. 2007;581:1928-32 pubmed
Bodet C, Andrian E, Tanabe S, Grenier D. Actinobacillus actinomycetemcomitans lipopolysaccharide regulates matrix metalloproteinase, tissue inhibitors of matrix metalloproteinase, and plasminogen activator production by human gingival fibroblasts: a potential role in connective tissue destr. J Cell Physiol. 2007;212:189-94 pubmed
Li D, Chen Z, Song X, Luo L, Pflugfelder S. Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2004;45:4302-11 pubmed
Marx N, Froehlich J, Siam L, Ittner J, Wierse G, Schmidt A, et al. Antidiabetic PPAR gamma-activator rosiglitazone reduces MMP-9 serum levels in type 2 diabetic patients with coronary artery disease. Arterioscler Thromb Vasc Biol. 2003;23:283-8 pubmed
product information
master code :
DMP300
SKU :
DMP300
product name :
Human Total MMP-3 Quantikine ELISA Kit
unit size :
1 Kit (also 1 Pack (50 Plates), 1 Pack (6 Plates))
description :
The Human Total MMP-3 Quantikine ELISA Kit from R&D Systems is a Solid Phase Sandwich ELISA that quantifies human MMP-3 in cell culture supernates (50 ul), serum (10 ul), heparin plasma (10 ul).
target :
MMP-3
category :
ELISAs
species :
Human
specificity :
Natural and recombinant human total MMP-3
gene symbol :
MMP3
kit type :
Solid Phase Sandwich ELISA
assay length :
4.5 hours
elisaSampleTypes :
Cell Culture Supernates (50 uL), Serum (10 uL), Heparin Plasma (10 uL)
elisaSensitivity :
0.045 ng/mL
elisaRange :
0.16 - 10 ng/mL
top caption :
Human Total MMP-3 ELISA Standard Curve
applications :
ELISA
USD :
655 USD
product details :
The Quantikine Human Total MMP-3 Immunoassay is a 4.5 hour solid phase immunoassay designed to measure total MMP-3 (pro- and active MMP-3) in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human Pro-MMP-3 and antibodies raised against the recombinant factor. Both antibodies also recognize recombinant human active MMP-3. Natural human MMP-3 showed dose-response curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards, indicating that this kit can be used to determine relative levels of natural human MMP-3.
alt names :
CHDS6, EC 3.4.24, EC 3.4.24.17, matrix metallopeptidase 3 (stromelysin 1, progelatinase), matrix metalloproteinase 3 (stromelysin 1, progelatinase), Matrix metalloproteinase-3, MGC126102, MGC126103, MMP3, MMP-3, proteoglycanase, SL-1, STMY, STMY1MGC126104, STR1, Stromelysin 1, stromelysin-1, Transin-1
storage :
Store the unopened product at 2 - 8 ░C. Do not use past expiration date.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.