Human Soluble gp130 Quantikine ELISA Kit | R&D Systems DGP00 product information

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product summary

company name :

R&D Systems

product type :

ELISA/assay

product name :

Human Soluble gp130 Quantikine ELISA Kit

catalog :

DGP00

quantity :

1 Kit

price :

655 USD

citations: 14

Reference
M xfc ller S, Shmueli M, Feng X, T xfc shaus J, Schumacher N, Clark R, et al. The Alzheimer's disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130. Mol Neurodegener. 2023;18:13 pubmed publisher
Bratseth V, Nordeng J, Helseth R, Solheim S, xc5 kra S, Arnesen H, et al. Circulating Microvesicles in Association with the NLRP3 Inflammasome in Coronary Thrombi from STEMI Patients. Biomedicines. 2022;10: pubmed publisher
Salemi R, Gattuso G, Tomasello B, Lavoro A, Gaudio A, Libra M, et al. Co-Occurrence of Interleukin-6 Receptor Asp358Ala Variant and High Plasma Levels of IL-6: An Evidence of IL-6 Trans-Signaling Activation in Deep Vein Thrombosis (DVT) Patients. Biomolecules. 2022;12: pubmed publisher
Nordeng J, Schandiz H, Solheim S, Akra S, Hoffman P, Roald B, et al. The Inflammasome Signaling Pathway Is Actively Regulated and Related to Myocardial Damage in Coronary Thrombi from Patients with STEMI. Mediators Inflamm. 2021;2021:5525917 pubmed publisher
Osuka K, Watanabe Y, Usuda N, Aoyama M, Iwami K, Takeuchi M, et al. Inhibitory Mechanism of the Outer Membrane Growth of Chronic Subdural Hematomas. J Neurotrauma. 2017;34:1996-2000 pubmed publisher
Holmlund U, Amoudruz P, Johansson M, Haileselassie Y, Ongoiba A, Kayentao K, et al. Maternal country of origin, breast milk characteristics and potential influences on immunity in offspring. Clin Exp Immunol. 2010;162:500-9 pubmed publisher
Nikolajuk A, Kowalska I, Karczewska Kupczewska M, Adamska A, Otziomek E, Wolczynski S, et al. Serum soluble glycoprotein 130 concentration is inversely related to insulin sensitivity in women with polycystic ovary syndrome. Diabetes. 2010;59:1026-9 pubmed publisher
Perez Andres M, Almeida J, Martin Ayuso M, de las Heras N, Moro M, Martín Nuñez G, et al. Soluble and membrane levels of molecules involved in the interaction between clonal plasma cells and the immunological microenvironment in multiple myeloma and their association with the characteristics of the disease. Int J Cancer. 2009;124:367-75 pubmed publisher
Richards P, Nowell M, Horiuchi S, McLoughlin R, Fielding C, Grau S, et al. Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. Arthritis Rheum. 2006;54:1662-72 pubmed
Hirota H, Izumi M, Hamaguchi T, Sugiyama S, Murakami E, Kunisada K, et al. Circulating interleukin-6 family cytokines and their receptors in patients with congestive heart failure. Heart Vessels. 2004;19:237-41 pubmed
Lukashevich I, Tikhonov I, Rodas J, Zapata J, Yang Y, Djavani M, et al. Arenavirus-mediated liver pathology: acute lymphocytic choriomeningitis virus infection of rhesus macaques is characterized by high-level interleukin-6 expression and hepatocyte proliferation. J Virol. 2003;77:1727-37 pubmed
Erices A, Conget P, Rojas C, Minguell J. Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. Exp Cell Res. 2002;280:24-32 pubmed
Hampel H, Teipel S, Padberg F, Haslinger A, Riemenschneider M, Schwarz M, et al. Discriminant power of combined cerebrospinal fluid tau protein and of the soluble interleukin-6 receptor complex in the diagnosis of Alzheimer's disease. Brain Res. 1999;823:104-12 pubmed
Stubner S, Schön T, Padberg F, Teipel S, Schwarz M, Haslinger A, et al. Interleukin-6 and the soluble IL-6 receptor are decreased in cerebrospinal fluid of geriatric patients with major depression: no alteration of soluble gp130. Neurosci Lett. 1999;259:145-8 pubmed

product information

master code :

DGP00

SKU :

DGP00

product name :

Human Soluble gp130 Quantikine ELISA Kit

unit size :

1 Kit

description :

The Human Soluble gp130 Quantikine ELISA Kit from R&D Systems is a Solid Phase Sandwich ELISA that quantifies human gp130/CD130 in cell culture supernates (100 ul), serum (10 ul), edta plasma (10 ul), heparin plasma (10 ul), citrate plasma (10 ul).

target :

gp130

category :

ELISAs

species :

Human

specificity :

Natural and recombinant human sgp130

gene symbol :

IL6ST

kit type :

Solid Phase Sandwich ELISA

assay length :

4.5 hours or 5.5 hours

elisaSampleTypes :

Cell Culture Supernates (100 uL), Serum (10 uL), EDTA Plasma (10 uL), Heparin Plasma (10 uL), Citrate Plasma (10 uL)

elisaSensitivity :

0.05 ng/mL (Cell Culture Supernates), 0.08 ng/mL (Serum, Heparin Plasma, Citrate Plasma, EDTA Plasma)

elisaRange :

0.13 - 8 ng/mL (Cell Culture Supernates), 0.25 - 16 ng/mL (Serum, Heparin Plasma, Citrate Plasma, EDTA Plasma)

top caption :

Human gp130 ELISA Serum/Plasma Standard Curve

applications :

ELISA

USD :

655 USD

product details :

The Quantikine Human soluble gp130 Immunoassay is a 4.5 or 5.5 hour solid phase ELISA designed to measure sgp130 in cell culture supernates, serum, and plasma. It contains soluble insect cell-expressed recombinant human gp130 and antibodies raised against recombinant human gp130 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural gp130 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural gp130.

alt names :

CD130, CD130 antigen, CDw130, DKFZp564F053, gp130, gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form, IL-6 receptor subunit beta, IL-6R subunit beta, IL-6RB, IL-6R-beta, IL6ST, interleukin 6 signal transducer (gp130, oncostatin M receptor), interleukin receptor beta chain, interleukin-6 receptor subunit beta, Interleukin-6 signal transducer, Membrane glycoprotein 130, membrane glycoprotein gp130, Oncostatin-M receptor subunit alpha

storage :

Store the unopened product at 2 - 8 ░C. Do not use past expiration date.