product summary
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company name :
R&D Systems
product type :
ELISA/assay
product name :
GDF-8/Myostatin Quantikine ELISA Kit
catalog :
DGDF80
quantity :
1 Kit
price :
655 USD
more info or order :
citations: 63
Reference
Ishibashi C, Nakanishi K, Nishida M, Shinomiya H, Shinzawa M, Kanayama D, et al. Myostatin as a plausible biomarker for early stage of sarcopenic obesity. Sci Rep. 2024;14:28629 pubmed publisher
P xe9 rez Regalado S, Leon J, Padial P, Benavente C, Almeida F, Bonitch G xf3 ngora J, et al. Exploring the Impact of Resistance Training at Moderate Altitude on Metabolic Cytokines in Humans: Implications for Adipose Tissue Dynamics. Int J Mol Sci. 2024;25: pubmed publisher
Silva Rojas R, P xe9 rez Gu xe0 rdia L, Simon A, Djeddi S, Treves S, Ribes A, et al. ORAI1 inhibition as an efficient preclinical therapy for tubular aggregate myopathy and Stormorken syndrome. JCI Insight. 2024;9: pubmed publisher
Tate B, Van Guilder G, Aly M, Spence L, Díaz Rubio M, Le H, et al. Changes in Choline Metabolites and Ceramides in Response to a DASH-Style Diet in Older Adults. Nutrients. 2023;15: pubmed publisher
Kumar A, Prajapati P, Raj V, Kim S, Mishra V, Raorane C, et al. Salbutamol ameliorates skeletal muscle wasting and inflammatory markers in streptozotocin (STZ)-induced diabetic rats. Int Immunopharmacol. 2023;124:110883 pubmed publisher
Kumar A, Prajapati P, Singh G, Kumar D, Mishra V, Kim S, et al. Salbutamol Attenuates Diabetic Skeletal Muscle Atrophy by Reducing Oxidative Stress, Myostatin/GDF-8, and Pro-Inflammatory Cytokines in Rats. Pharmaceutics. 2023;15: pubmed publisher
Culver A, Hamang M, Wang Y, Jiang H, Yanum J, White E, et al. GDF8 Contributes to Liver Fibrogenesis and Concomitant Skeletal Muscle Wasting. Biomedicines. 2023;11: pubmed publisher
Shin H, Won C, Kim M. Development of multiple biomarker panels for prediction of sarcopenia in community-dwelling older adults. Arch Gerontol Geriatr. 2023;115:105115 pubmed publisher
Walowski C, Herpich C, Enderle J, Braun W, Both M, Hasler M, et al. Determinants of bone mass in older adults with normal- and overweight derived from the crosstalk with muscle and adipose tissue. Sci Rep. 2023;13:5030 pubmed publisher
Tao R, St xf6 hr O, Wang C, Qiu W, COPPS K, White M. Hepatic follistatin increases basal metabolic rate and attenuates diet-induced obesity during hepatic insulin resistance. Mol Metab. 2023;71:101703 pubmed publisher
Saeidi A, Nouri Habashi A, Razi O, Ataeinosrat A, Rahmani H, Mollabashi S, et al. Astaxanthin Supplemented with High-Intensity Functional Training Decreases Adipokines Levels and Cardiovascular Risk Factors in Men with Obesity. Nutrients. 2023;15: pubmed publisher
Lee S, Han M, Kim S, Cha R, Kang S, Kim J, et al. Indoxyl Sulfate Might Play a Role in Sarcopenia, While Myostatin Is an Indicator of Muscle Mass in Patients with Chronic Kidney Disease: Analysis from the RECOVERY Study. Toxins (Basel). 2022;14: pubmed publisher
Yamamoto H, Takeshima F, Haraguchi M, Akazawa Y, Matsushima K, Kitayama M, et al. High serum concentrations of growth differentiation factor-15 and their association with Crohn's disease and a low skeletal muscle index. Sci Rep. 2022;12:6591 pubmed publisher
Perry C, Van Guilder G, Butterick T. Decreased myostatin in response to a controlled DASH diet is associated with improved body composition and cardiometabolic biomarkers in older adults: results from a controlled-feeding diet intervention study. BMC Nutr. 2022;8:24 pubmed publisher
Griffen C, Duncan M, Hattersley J, Weickert M, Dallaway A, Renshaw D. Effects of resistance exercise and whey protein supplementation on skeletal muscle strength, mass, physical function, and hormonal and inflammatory biomarkers in healthy active older men: a randomised, double-blind, placebo-controlled trial. Exp Gerontol. 2022;158:111651 pubmed publisher
Amasene M, Cadenas Sanchez C, Echeverria I, Sanz B, Alonso C, Tobalina I, et al. Effects of Resistance Training Intervention along with Leucine-Enriched Whey Protein Supplementation on Sarcopenia and Frailty in Post-Hospitalized Older Adults: Preliminary Findings of a Randomized Controlled Trial. J Clin Med. 2021;11: pubmed publisher
Micielska K, Flis M, Kortas J, Rodziewicz Flis E, Antosiewicz J, Wochna K, et al. Nordic Walking Rather Than High Intensity Interval Training Reduced Myostatin Concentration More Effectively in Elderly Subjects and the Range of This Drop Was Modified by Metabolites of Vitamin D. Nutrients. 2021;13: pubmed publisher
Nawrocka Millward S, Biegus J, Hurkacz M, Guzik M, Rosiek Biegus M, Jankowska E, et al. Differences in the Biomarker Profile of De Novo Acute Heart Failure versus Decompensation of Chronic Heart Failure. Biomolecules. 2021;11: pubmed publisher
Du Y, Xu C, Shi H, Jiang X, Tang W, Wu X, et al. Serum concentrations of oxytocin, DHEA and follistatin are associated with osteoporosis or sarcopenia in community-dwelling postmenopausal women. BMC Geriatr. 2021;21:542 pubmed publisher
Sato S, Namisaki T, Murata K, Fujimoto Y, Takeda S, Enomoto M, et al. The association between sarcopenia and endotoxin in patients with alcoholic cirrhosis. Medicine (Baltimore). 2021;100:e27212 pubmed publisher
Xu B, Liu C, Zhang H, Zhang R, Tang M, Huang Y, et al. Skeletal muscle-targeted delivery of Fgf6 protects mice from diet-induced obesity and insulin resistance. JCI Insight. 2021;6: pubmed publisher
Liu Y, Lehar A, Rydzik R, Chandok H, Lee Y, Youngstrom D, et al. Local versus systemic control of bone and skeletal muscle mass by components of the transforming growth factor-β signaling pathway. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Tsuchiya Y, Goto K. Myokine secretion following moderate-intensity endurance exercise under different environmental temperatures. Cytokine. 2021;144:155553 pubmed publisher
Miura I, Komine S, Okada K, Wada S, Warabi E, Uchida F, et al. Prevention of non-alcoholic steatohepatitis by long-term exercise via the induction of phenotypic changes in Kupffer cells of hyperphagic obese mice. Physiol Rep. 2021;9:e14859 pubmed publisher
Jerobin J, Ramanjaneya M, Bettahi I, Parammal R, Siveen K, Alkasem M, et al. Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training. Lipids Health Dis. 2021;20:34 pubmed publisher
Kozłowska M, Kortas J, Żychowska M, Antosiewicz J, Żuczek K, Perego S, et al. Beneficial effects of whole-body cryotherapy on glucose homeostasis and amino acid profile are associated with a reduced myostatin serum concentration. Sci Rep. 2021;11:7097 pubmed publisher
Kurose S, Onishi K, Takao N, Miyauchi T, Takahashi K, Kimura Y. Association of serum adiponectin and myostatin levels with skeletal muscle in patients with obesity: A cross-sectional study. PLoS ONE. 2021;16:e0245678 pubmed publisher
Marchildon F, Chi J, O CONNOR S, Bediako H, Cohen P. Beige fat is dispensable for the metabolic benefits associated with myostatin deletion. Mol Metab. 2021;43:101120 pubmed publisher
Lee S, Lehar A, Liu Y, Ly C, Pham Q, Michaud M, et al. Functional redundancy of type I and type II receptors in the regulation of skeletal muscle growth by myostatin and activin A. Proc Natl Acad Sci U S A. 2020;117:30907-30917 pubmed publisher
Mariot V, Le Guiner C, Barthélémy I, Montus M, Blot S, Torelli S, et al. Myostatin Is a Quantifiable Biomarker for Monitoring Pharmaco-gene Therapy in Duchenne Muscular Dystrophy. Mol Ther Methods Clin Dev. 2020;18:415-421 pubmed publisher
Dial A, Monaco C, Grafham G, Romanova N, Simpson J, Tarnopolsky M, et al. Muscle and serum myostatin expression in type 1 diabetes. Physiol Rep. 2020;8:e14500 pubmed publisher
Koch C, Buono S, Menuet A, Robe A, Djeddi S, Kretz C, et al. Myostatin: a Circulating Biomarker Correlating with Disease in Myotubular Myopathy Mice and Patients. Mol Ther Methods Clin Dev. 2020;17:1178-1189 pubmed publisher
Kortas J, Ziemann E, Juszczak D, Micielska K, Kozłowska M, Prusik K, et al. Iron Status in Elderly Women Impacts Myostatin, Adiponectin and Osteocalcin Levels Induced by Nordic Walking Training. Nutrients. 2020;12: pubmed publisher
White D, Harkin K, Roush J, Renberg W, Biller D. Fortetropin inhibits disuse muscle atrophy in dogs after tibial plateau leveling osteotomy. PLoS ONE. 2020;15:e0231306 pubmed publisher
Harish P, Forrest L, Herath S, Dickson G, Malerba A, Popplewell L. Inhibition of Myostatin Reduces Collagen Deposition in a Mouse Model of Oculopharyngeal Muscular Dystrophy (OPMD) With Established Disease. Front Physiol. 2020;11:184 pubmed publisher
Pan C, Jaiswal Agrawal N, Zulia Y, Singh S, Sha K, Mohler J, et al. Prostate tumor-derived GDF11 accelerates androgen deprivation therapy-induced sarcopenia. JCI Insight. 2020;5: pubmed publisher
Esposito P, Battaglia Y, La Porta E, Grignano M, Caramella E, Avella A, et al. Significance of serum Myostatin in hemodialysis patients. BMC Nephrol. 2019;20:462 pubmed publisher
Morena M, Creput C, Bouzernidj M, Rodriguez A, Chalabi L, Seigneuric B, et al. Randomised trial on clinical performances and biocompatibility of four high-flux hemodialyzers in two mode treatments: hemodialysis vs post dilution hemodiafiltration. Sci Rep. 2019;9:18265 pubmed publisher
Tavoian D, Arnold W, Mort S, De Lacalle S. Sex differences in body composition but not neuromuscular function following long-term, doxycycline-induced reduction in circulating levels of myostatin in mice. PLoS ONE. 2019;14:e0225283 pubmed publisher
Lee Y, Kim G, Park S, Lim J. Down-regulation of the mitochondrial i-AAA protease Yme1L induces muscle atrophy via FoxO3a and myostatin activation. J Cell Mol Med. 2020;24:899-909 pubmed publisher
Yamakage H, Tanaka M, Inoue T, Odori S, Kusakabe T, Satoh Asahara N. Effects of dapagliflozin on the serum levels of fibroblast growth factor 21 and myokines and muscle mass in Japanese patients with type 2 diabetes: A randomized, controlled trial. J Diabetes Investig. 2020;11:653-661 pubmed publisher
Sun Y, Xiao Y, Sun H, Zhao Z, Zhu J, Zhang L, et al. miR-27a regulates vascular remodeling by targeting endothelial cells' apoptosis and interaction with vascular smooth muscle cells in aortic dissection. Theranostics. 2019;9:7961-7975 pubmed publisher
He Z, Tian Y, Valenzuela P, Huang C, Zhao J, Hong P, et al. Myokine/Adipokine Response to "Aerobic" Exercise: Is It Just a Matter of Exercise Load?. Front Physiol. 2019;10:691 pubmed publisher
He Z, Tian Y, Valenzuela P, Huang C, Zhao J, Hong P, et al. Myokine Response to High-Intensity Interval vs. Resistance Exercise: An Individual Approach. Front Physiol. 2018;9:1735 pubmed publisher
Jaworska J, Micielska K, Kozłowska M, Wnorowski K, Skrobecki J, Radzimiński L, et al. A 2-Week Specific Volleyball Training Supported by the Whole Body Cryostimulation Protocol Induced an Increase of Growth Factors and Counteracted Deterioration of Physical Performance. Front Physiol. 2018;9:1711 pubmed publisher
Barrios Silva L, Parnell M, Shinwari Z, Chaudhary G, Xenofontos T, van Bekhoven A, et al. Activin subfamily peptides predict chronological age in humans. Physiol Rep. 2018;6:e13823 pubmed publisher
Edington C, Chen W, Geishecker E, Kassis T, Soenksen L, Bhushan B, et al. Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies. Sci Rep. 2018;8:4530 pubmed publisher
Kato H, Masuda S, Ohira T, Ohira L, Takakura H, Ohira Y, et al. Differential response of adipose tissue gene and protein expressions to 4- and 8-week administration of β-guanidinopropionic acid in mice. Physiol Rep. 2018;6: pubmed publisher
Toloza F, Mantilla Rivas J, Pérez Matos M, Ricardo Silgado M, Morales Alvarez M, Pinzón Cortés J, et al. Plasma Levels of Myonectin But Not Myostatin or Fibroblast-Derived Growth Factor 21 Are Associated with Insulin Resistance in Adult Humans without Diabetes Mellitus. Front Endocrinol (Lausanne). 2018;9:5 pubmed publisher
Jones J, Cadena S, Gong C, Wang X, Chen Z, Wang S, et al. Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15. Cell Rep. 2018;22:1522-1530 pubmed publisher
Wu L, Zhu D, Wang B, Lu Y, He P, Zhang Y, et al. Relative abundance of mature myostatin rather than total myostatin is negatively associated with bone mineral density in Chinese. J Cell Mol Med. 2018;22:1329-1336 pubmed publisher
Carvalho L, Basso Vanelli R, Di Thommazo Luporini L, Mendes R, Oliveira Junior M, Vieira R, et al. Myostatin and adipokines: The role of the metabolically unhealthy obese phenotype in muscle function and aerobic capacity in young adults. Cytokine. 2018;107:118-124 pubmed publisher
Périé L, Parente A, Baraige F, Magnol L, Blanquet V. Alterations in Adiposity and Glucose Homeostasis in Adult Gasp-1 Overexpressing Mice. Cell Physiol Biochem. 2017;44:1896-1911 pubmed publisher
Elliott B, Herbert P, Sculthorpe N, Grace F, Stratton D, Hayes L. Lifelong exercise, but not short-term high-intensity interval training, increases GDF11, a marker of successful aging: a preliminary investigation. Physiol Rep. 2017;5: pubmed publisher
Latres E, Mastaitis J, Fury W, Miloscio L, Trejos J, Pangilinan J, et al. Activin A more prominently regulates muscle mass in primates than does GDF8. Nat Commun. 2017;8:15153 pubmed publisher
Fernlund E, Gyllenhammar T, Jablonowski R, Carlsson M, Larsson A, Arnlov J, et al. Serum Biomarkers of Myocardial Remodeling and Coronary Dysfunction in Early Stages of Hypertrophic Cardiomyopathy in the Young. Pediatr Cardiol. 2017;38:853-863 pubmed publisher
Oestreich A, Kamp W, McCray M, Carleton S, Karasseva N, Lenz K, et al. Decreasing maternal myostatin programs adult offspring bone strength in a mouse model of osteogenesis imperfecta. Proc Natl Acad Sci U S A. 2016;113:13522-13527 pubmed
Fang L, Yu Y, Zhang R, He J, Sun Y. Serum GDF-8 levels change dynamically during controlled ovarian hyperstimulation in patients undergoing IVF/ICSI-ET. Sci Rep. 2016;6:28036 pubmed publisher
Chen M, Chen Y, Lee C, Hung C, Chou T. Supplementation of Magnolol Attenuates Skeletal Muscle Atrophy in Bladder Cancer-Bearing Mice Undergoing Chemotherapy via Suppression of FoxO3 Activation and Induction of IGF-1. PLoS ONE. 2015;10:e0143594 pubmed publisher
Yano S, Nagai A, Isomura M, Yamasaki M, Kijima T, Takeda M, et al. Relationship between Blood Myostatin Levels and Kidney Function:Shimane CoHRE Study. PLoS ONE. 2015;10:e0141035 pubmed publisher
Rao S, Fujimura T, Matsunari H, Sakuma T, Nakano K, Watanabe M, et al. Efficient modification of the myostatin gene in porcine somatic cells and generation of knockout piglets. Mol Reprod Dev. 2016;83:61-70 pubmed publisher
Morrison P, Bing C, Harris P, Maltin C, Grove White D, Argo C. Preliminary investigation into a potential role for myostatin and its receptor (ActRIIB) in lean and obese horses and ponies. PLoS ONE. 2014;9:e112621 pubmed publisher
Biesemann N, Mendler L, Wietelmann A, Hermann S, Schäfers M, Kruger M, et al. Myostatin regulates energy homeostasis in the heart and prevents heart failure. Circ Res. 2014;115:296-310 pubmed publisher
image
image 1 :
R&D Systems DGDF80 image 1
Multi-species GDF-8/Myostatin ELISA Standard Curve
product information
master code :
DGDF80
SKU :
DGDF80
product name :
GDF-8/Myostatin Quantikine ELISA Kit
unit size :
1 Kit
description :
The GDF-8/Myostatin Quantikine ELISA Kit from R&D Systems is a Solid Phase Sandwich ELISA that quantifies multi-species GDF-8/Myostatin in cell culture supernates (100 ul), tissue homogenates (20 ul), serum (100 ul), edta plasma (100 ul), heparin plasma (100 ul).
target :
GDF-8/Myostatin
category :
ELISAs
species :
Multi-Species
specificity :
Natural and recombinant human, mouse, rat, canine, porcine, and equine GDF-8.
kit type :
Solid Phase Sandwich ELISA
assay length :
4.5 hours
elisaSampleTypes :
Cell Culture Supernates (100 uL), Tissue Homogenates (20 uL), Serum (100 uL), EDTA Plasma (100 uL), Heparin Plasma (100 uL)
elisaSensitivity :
5.32 pg/mL
elisaRange :
31.30 - 2000 pg/mL
top caption :
Multi-species GDF-8/Myostatin ELISA Standard Curve
applications :
ELISA
USD :
655 USD
product details :
The Quantikine GDF-8/Myostatin Immunoassay is a 4.5 hour solid phase ELISA designed to measure GDF-8 levels in cell culture supernates, tissue homogenates, serum, and plasma. It contains NS0-expressed recombinant GDF-8 and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant GDF-8 accurately. Results obtained using natural GDF-8 showed dose-response curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural GDF-8.
alt names :
GDF8, GDF-8, GDF8growth differentiation factor 8, growth/differentiation factor 8, MSLHP, MSTN, Myostatin
storage :
Store the unopened product at 2 - 8 ░C. Do not use past expiration date.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.