Human IGFBP-3 Quantikine ELISA Kit | R&D Systems DGB300 product information

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product summary

company name :

R&D Systems

product type :

ELISA/assay

product name :

Human IGFBP-3 Quantikine ELISA Kit

catalog :

DGB300

quantity :

1 Kit (also 1 Pack (50 Plates), 1 Pack (6 Plates))

price :

655 USD

citations: 48

Reference
Monroe T, Hertzel A, Dickey D, Hagen T, Santibanez S, Berdaweel I, et al. Lipid peroxidation products induce carbonyl stress, mitochondrial dysfunction, and cellular senescence in human and murine cells. Aging Cell. 2025;24:e14367 pubmed publisher
Kang D, Field C, Patel D, Fairey A, Boul xe9 N, Dieli Conwright C, et al. Effects of high-intensity interval training on cardiometabolic biomarkers in patients with prostate cancer undergoing active surveillance: a randomized controlled trial. Prostate Cancer Prostatic Dis. 2024;: pubmed publisher
Bakhashab S, O Neill J, Barber R, Arden C, Weaver J. Upregulation of Anti-Angiogenic miR-106b-3p Correlates Negatively with IGF-1 and Vascular Health Parameters in a Model of Subclinical Cardiovascular Disease: Study with Metformin Therapy. Biomedicines. 2024;12: pubmed publisher
Alrashid M, Al Serri A, Hussain R, Al Bustan S, Al Barrak J. Association Study of IGF-1 rs35767 and rs6214 Gene Polymorphisms with Cancer Susceptibility and Circulating Levels of IGF-1, IGFBP-2, and IGFBP-3 in Colorectal Cancer Patients. Biomedicines. 2023;11: pubmed publisher
Gil Mart xed nez M, Lorente Sorolla C, Rodrigo Mu xf1 oz J, Naharro S, Garc xed a de Castro Z, Sastre J, et al. Obese Asthma Phenotype Is Associated with hsa-miR-26a-1-3p and hsa-miR-376a-3p Modulating the IGF Axis. Int J Mol Sci. 2023;24: pubmed publisher
Strzelczyk J, W xf3 jcik Giertuga M, Strzelczyk J, Se x144 kowska A, Biernacki K, Kos Kud x142 a B. Selected Parameters of Bone Turnover in Neuroendocrine Tumors-A Potential Clinical Use?. J Clin Med. 2023;12: pubmed publisher
x15a widerska M, Mostowska A, Skrypnik D, Jagodzi x144 ski P, Bogda x144 ski P, Grzegorzewska A. Energy Homeostasis Gene Nucleotide Variants and Survival of Hemodialysis Patients-A Genetic Cohort Study. J Clin Med. 2022;11: pubmed publisher
Stuard W, Guner M, Robertson D. IGFBP-3 Regulates Mitochondrial Hyperfusion and Metabolic Activity in Ocular Surface Epithelia during Hyperosmolar Stress. Int J Mol Sci. 2022;23: pubmed publisher
Goldsmith J, Lai R, Garten R, Chen Q, Lesnefsky E, Perera R, et al. Visceral Adiposity, Inflammation, and Testosterone Predict Skeletal Muscle Mitochondrial Mass and Activity in Chronic Spinal Cord Injury. Front Physiol. 2022;13:809845 pubmed publisher
Bogdan E, Stuard W, Titone R, Robertson D. IGFBP-3 Mediates Metabolic Homeostasis During Hyperosmolar Stress in the Corneal Epithelium. Invest Ophthalmol Vis Sci. 2021;62:11 pubmed publisher
Yang J, Yang C, Shen H, Wu W, Tian Z, Xu Q, et al. Discovery and validation of PZP as a novel serum biomarker for screening lung adenocarcinoma in type 2 diabetes mellitus patients. Cancer Cell Int. 2021;21:162 pubmed publisher
Monson K, Goldberg M, Wu H, Santella R, Chung W, Terry M. Circulating growth factor concentrations and breast cancer risk: a nested case-control study of IGF-1, IGFBP-3, and breast cancer in a family-based cohort. Breast Cancer Res. 2020;22:109 pubmed publisher
F B, L P C, V M, M D, G H, G G, et al. High intensity interval training combined with L-citrulline supplementation: Effects on physical performance in healthy older adults. Exp Gerontol. 2020;140:111036 pubmed publisher
Fahlbusch P, Knebel B, H xf6 rbelt T, Barbosa D, Nikolic A, Jacob S, et al. Physiological Disturbance in Fatty Liver Energy Metabolism Converges on IGFBP2 Abundance and Regulation in Mice and Men. Int J Mol Sci. 2020;21: pubmed publisher
Zeng Z, Huo X, Wang Q, Wang C, Hylkema M, Xu X. PM2.5-bound PAHs exposure linked with low plasma insulin-like growth factor 1 levels and reduced child height. Environ Int. 2020;138:105660 pubmed publisher
Sakata J, Hirosue A, Yoshida R, Matsuoka Y, Kawahara K, Arita H, et al. Enhanced Expression of IGFBP-3 Reduces Radiosensitivity and Is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma. Cancers (Basel). 2020;12: pubmed publisher
Malin Igra A, Vahter M, Raqib R, Kippler M. Early-Life Cadmium Exposure and Bone-Related Biomarkers: A Longitudinal Study in Children. Environ Health Perspect. 2019;127:37003 pubmed publisher
Bartels R, Chimwezi E, Watson V, Pei L, Potani I, Allubha B, et al. Hypoallergenic and anti-inflammatory feeds in children with complicated severe acute malnutrition: an open randomised controlled 3-arm intervention trial in Malawi. Sci Rep. 2019;9:2304 pubmed publisher
Krause M, Crognale D, Cogan K, Contarelli S, Egan B, Newsholme P, et al. The effects of a combined bodyweight-based and elastic bands resistance training, with or without protein supplementation, on muscle mass, signaling and heat shock response in healthy older people. Exp Gerontol. 2019;115:104-113 pubmed publisher
DeBoer M, Lee A, Herbert K, Long J, Thayu M, Griffin L, et al. Increases in IGF-1 After Anti-TNF-α Therapy Are Associated With Bone and Muscle Accrual in Pediatric Crohn Disease. J Clin Endocrinol Metab. 2018;103:936-945 pubmed publisher
Annibalini G, Lucertini F, Agostini D, Vallorani L, Gioacchini A, Barbieri E, et al. Concurrent Aerobic and Resistance Training Has Anti-Inflammatory Effects and Increases Both Plasma and Leukocyte Levels of IGF-1 in Late Middle-Aged Type 2 Diabetic Patients. Oxid Med Cell Longev. 2017;2017:3937842 pubmed publisher
Gee J, Saltzstein D, Kim K, Kolesar J, Huang W, Havighurst T, et al. A Phase II Randomized, Double-blind, Presurgical Trial of Polyphenon E in Bladder Cancer Patients to Evaluate Pharmacodynamics and Bladder Tissue Biomarkers. Cancer Prev Res (Phila). 2017;10:298-307 pubmed publisher
Olszanecka A, Dragan A, Kawecka Jaszcz K, Fedak D, Czarnecka D. Relationships of insulin-like growth factor-1, its binding proteins, and cardiometabolic risk in hypertensive perimenopausal women. Metabolism. 2017;69:96-106 pubmed publisher
Sakimoto S, Marchetti V, Aguilar E, Lee K, Usui Y, Murinello S, et al. CD44 expression in endothelial colony-forming cells regulates neurovascular trophic effect. JCI Insight. 2017;2:e89906 pubmed publisher
Cao Q, Liang C, Xue J, Li P, Li J, Wang M, et al. Genetic variation in IGF1 predicts renal cell carcinoma susceptibility and prognosis in Chinese population. Sci Rep. 2016;6:39014 pubmed publisher
Cheng G, Zhang Y, Zhang T, He L, Wang X. Bone marrow-derived mesenchymal stem cells modified with IGFBP-3 inhibit the proliferation of pulmonary artery smooth muscle cells. Int J Mol Med. 2017;39:223-230 pubmed publisher
Jarrard D, Konety B, Huang W, Downs T, Kolesar J, Kim K, et al. Phase IIa, randomized placebo-controlled trial of single high dose cholecalciferol (vitamin D3) and daily Genistein (G-2535) versus double placebo in men with early stage prostate cancer undergoing prostatectomy. Am J Clin Exp Urol. 2016;4:17-27 pubmed
Rowan M, Beckman D, Rizzo J, Isbell C, White C, Cohn S, et al. Elevations in growth hormone and glucagon-like peptide-2 levels on admission are associated with increased mortality in trauma patients. Scand J Trauma Resusc Emerg Med. 2016;24:119 pubmed
Burley S, Whittingham Dowd J, Allen J, Grosset J, Onambele Pearson G. The Differential Hormonal Milieu of Morning versus Evening May Have an Impact on Muscle Hypertrophic Potential. PLoS ONE. 2016;11:e0161500 pubmed publisher
Svalina M, Kikuchi K, Abraham J, Lal S, Davare M, Settelmeyer T, et al. IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma. Sci Rep. 2016;6:27012 pubmed publisher
Kim H, Suzuki T, Kim M, Kojima N, Ota N, Shimotoyodome A, et al. Effects of exercise and milk fat globule membrane (MFGM) supplementation on body composition, physical function, and hematological parameters in community-dwelling frail Japanese women: a randomized double blind, placebo-controlled, follow-up trial. PLoS ONE. 2015;10:e0116256 pubmed publisher
Nguyen K, Yao X, Erickson A, Mishra S, Nyomba B. Glucose intolerance in aging male IGFBP-3 transgenic mice: differential effects of human IGFBP-3 and its mutant IGFBP-3 devoid of IGF binding ability. Endocrinology. 2015;156:462-74 pubmed publisher
Choi Y, Park G, Rho J, Kim S, So G, Kim H, et al. Role of IGF-binding protein 3 in the resistance of EGFR mutant lung cancer cells to EGFR-tyrosine kinase inhibitors. PLoS ONE. 2013;8:e81393 pubmed publisher
Braicu E, Fotopoulou C, Chekerov R, Richter R, Blohmer J, Kummel S, et al. Role of serum concentration of VEGFR1 and TIMP2 on clinical outcome in primary cervical cancer: results of a companion protocol of the randomized, NOGGO-AGO phase III adjuvant trial of simultaneous cisplatin-based radiochemotherapy vs. carboplatin an. Cytokine. 2013;61:755-8 pubmed publisher
Imamura Y, Sakamoto S, Endo T, Utsumi T, Fuse M, Suyama T, et al. FOXA1 promotes tumor progression in prostate cancer via the insulin-like growth factor binding protein 3 pathway. PLoS ONE. 2012;7:e42456 pubmed publisher
Elzi D, Lai Y, Song M, Hakala K, Weintraub S, Shiio Y. Plasminogen activator inhibitor 1--insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence. Proc Natl Acad Sci U S A. 2012;109:12052-7 pubmed publisher
Signori C, Dubrock C, Richie J, Prokopczyk B, Demers L, Hamilton C, et al. Administration of omega-3 fatty acids and Raloxifene to women at high risk of breast cancer: interim feasibility and biomarkers analysis from a clinical trial. Eur J Clin Nutr. 2012;66:878-84 pubmed publisher
Higgins M, Russell N, Crossey P, Nyhan K, Brazil D, McAuliffe F. Maternal and fetal placental growth hormone and IGF axis in type 1 diabetic pregnancy. PLoS ONE. 2012;7:e29164 pubmed publisher
Weimer A, Madry H, Venkatesan J, Schmitt G, Frisch J, Wezel A, et al. Benefits of recombinant adeno-associated virus (rAAV)-mediated insulinlike growth factor I (IGF-I) overexpression for the long-term reconstruction of human osteoarthritic cartilage by modulation of the IGF-I axis. Mol Med. 2012;18:346-58 pubmed publisher
Landt S, Wehling M, Heidecke H, Jeschke S, Korlach S, Stöblen F, et al. Prognostic significance of angiogenic factors in uterine cervical cancer. Anticancer Res. 2011;31:2589-95 pubmed
Morgan K, Dennis N, Ruffman T, Bilkey D, McLennan I. The stature of boys is inversely correlated to the levels of their sertoli cell hormones: do the testes restrain the maturation of boys?. PLoS ONE. 2011;6:e20533 pubmed publisher
Sesso R, Franco M. Abnormalities in metalloproteinase pathways and IGF-I axis: a link between birth weight, hypertension, and vascular damage in childhood. Am J Hypertens. 2010;23:6-11 pubmed publisher
Veraldi K, Gibson B, Yasuoka H, MYERBURG M, Kelly E, Balzar S, et al. Role of insulin-like growth factor binding protein-3 in allergic airway remodeling. Am J Respir Crit Care Med. 2009;180:611-7 pubmed publisher
Oy G, Slipicevic A, Davidson B, Solberg Faye R, Maelandsmo G, Flørenes V. Biological effects induced by insulin-like growth factor binding protein 3 (IGFBP-3) in malignant melanoma. Int J Cancer. 2010;126:350-61 pubmed publisher
Akhtar S, Meeran S, Katiyar N, Katiyar S. Grape seed proanthocyanidins inhibit the growth of human non-small cell lung cancer xenografts by targeting insulin-like growth factor binding protein-3, tumor cell proliferation, and angiogenic factors. Clin Cancer Res. 2009;15:821-31 pubmed publisher
Schoyer K, Liu H, Witkin S, Rosenwaks Z, Spandorfer S. Serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3) in IVF patients with polycystic ovary syndrome: correlations with outcome. Fertil Steril. 2007;88:139-44 pubmed
Yin D, Vreeland F, Schaaf L, Millham R, Duncan B, Sharma A. Clinical pharmacodynamic effects of the growth hormone receptor antagonist pegvisomant: implications for cancer therapy. Clin Cancer Res. 2007;13:1000-9 pubmed
Wang T, Chang C, Wu H, Chiu Y, Chen C, Wang H. Insulin-like growth factor-II (IGF-II), IGF-binding protein-3 (IGFBP-3), and IGFBP-4 in follicular fluid are associated with oocyte maturation and embryo development. Fertil Steril. 2006;86:1392-401 pubmed

product information

master code :

DGB300

SKU :

DGB300

product name :

Human IGFBP-3 Quantikine ELISA Kit

unit size :

1 Kit (also 1 Pack (50 Plates), 1 Pack (6 Plates))

description :

The Human IGFBP-3 Quantikine ELISA Kit from R&D Systems is a Solid Phase Sandwich ELISA that quantifies human IGFBP-3 in cell culture supernates (100 ul), serum (10 ul), edta plasma (10 ul), heparin plasma (10 ul).

target :

IGFBP-3

category :

ELISAs

species :

Human

specificity :

Natural and recombinant human IGFBP-3

gene symbol :

IGFBP3

kit type :

Solid Phase Sandwich ELISA

assay length :

4.5 hours

elisaSampleTypes :

Cell Culture Supernates (100 uL), Serum (10 uL), EDTA Plasma (10 uL), Heparin Plasma (10 uL)

elisaSensitivity :

0.14 ng/mL

elisaRange :

0.78 - 50 ng/mL

top caption :

Human IGFBP-3 ELISA Standard Curve

applications :

ELISA

USD :

655 USD

product details :

The Quantikine Human IGFBP-3 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human IGFBP-3 in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human IGFBP-3 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human IGFBP-3 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human IGFBP-3.

alt names :

acid stable subunit of the 140 K IGF complex, binding protein 29, binding protein 53, growth hormone-dependent binding protein, IBP-3, IBP3BP-53, IGF-binding protein 3, IGFBP3, IGFBP-3, insulin-like growth factor binding protein 3, insulin-like growth factor-binding protein 3

storage :

Store the unopened product at 2 - 8 ░C. Do not use past expiration date.