Human CXCL13/BLC/BCA-1 Quantikine ELISA Kit | R&D Systems DCX130 product information

product summary

company name :

R&D Systems

product type :

ELISA/assay

product name :

Human CXCL13/BLC/BCA-1 Quantikine ELISA Kit

catalog :

DCX130

quantity :

1 Kit

price :

655 USD

more info or order :

R&D Systems product webpage

citations: 49

Reference
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Erhart D, Klose V, Sch xe4 per T, Tumani H, Senel M. CXCL13 in Cerebrospinal Fluid: Clinical Value in a Large Cross-Sectional Study. Int J Mol Sci. 2023;25: pubmed publisher
Gyllemark P, Sj xf6 wall J, Forsberg P, Ernerudh J, Henningsson A. Intrathecal Th17-driven inflammation is associated with prolonged post-treatment convalescence for patients with Lyme neuroborreliosis. Sci Rep. 2023;13:9722 pubmed publisher
Sandberg J, L xf6 fling M, Varnait x117 R, Emg xe5 rd J, Al Tawil N, Lindquist L, et al. Safety and immunogenicity following co-administration of Yellow fever vaccine with Tick-borne encephalitis or Japanese encephalitis vaccines: Results from an open label, non-randomized clinical trial. PLoS Negl Trop Dis. 2023;17:e0010616 pubmed publisher
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Goubet A, Lordello L, Alves Costa Silva C, Peguillet I, Gazzano M, Mbogning Fonkou M, et al. Escherichia coli-Specific CXCL13-Producing TFH Are Associated with Clinical Efficacy of Neoadjuvant PD-1 Blockade against Muscle-Invasive Bladder Cancer. Cancer Discov. 2022;12:2280-2307 pubmed publisher
Jeon J, Park J, Boo H, Yang K, Lee C, Lee J, et al. Clinical value of urinary cytokines/chemokines as prognostic markers in patients with crescentic glomerulonephritis. Sci Rep. 2022;12:10221 pubmed publisher
Ukita M, Hamanishi J, Yoshitomi H, Yamanoi K, Takamatsu S, Ueda A, et al. CXCL13-producing CD4+ T cells accumulate in the early phase of tertiary lymphoid structures in ovarian cancer. JCI Insight. 2022;7: pubmed publisher
Cox B, Alharshawi K, Mena Palomo I, Lafuse W, Ariza M. EBV/HHV-6A dUTPases contribute to myalgic encephalomyelitis/chronic fatigue syndrome pathophysiology by enhancing TFH cell differentiation and extrafollicular activities. JCI Insight. 2022;7: pubmed publisher
Robinson T, Abdelhak A, Bose T, Meinl E, Otto M, Zettl U, et al. Cerebrospinal Fluid Biomarkers in Relation to MRZ Reaction Status in Primary Progressive Multiple Sclerosis. Cells. 2020;9: pubmed publisher
Sivina M, Xiao L, Kim E, Vaca A, Chen S, Keating M, et al. CXCL13 plasma levels function as a biomarker for disease activity in patients with chronic lymphocytic leukemia. Leukemia. 2021;35:1610-1620 pubmed publisher
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Saberi Hosnijeh F, Kolijn P, Casabonne D, Nieters A, Solans M, Naudin S, et al. Mediating effect of soluble B-cell activation immune markers on the association between anthropometric and lifestyle factors and lymphoma development. Sci Rep. 2020;10:13814 pubmed publisher
Globig A, Sommer N, Wild K, Schardey J, Zoldan K, Thomann A, et al. Ustekinumab Inhibits T Follicular Helper Cell Differentiation in Patients With Crohn's Disease. Cell Mol Gastroenterol Hepatol. 2021;11:1-12 pubmed publisher
Muema D, Akilimali N, Ndumnego O, Rasehlo S, Durgiah R, Ojwach D, et al. Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection. BMC Med. 2020;18:81 pubmed publisher
Miyajima S, Shigehara K, Kamekura R, Takaki H, Yabe H, Ikegami I, et al. Activated circulating T follicular helper cells and skewing of T follicular helper 2 cells are down-regulated by treatment including an inhaled corticosteroid in patients with allergic asthma. Allergol Int. 2020;69:66-77 pubmed publisher
Morou A, Brunet Ratnasingham E, Dubé M, Charlebois R, Mercier E, Darko S, et al. Altered differentiation is central to HIV-specific CD4+ T cell dysfunction in progressive disease. Nat Immunol. 2019;20:1059-1070 pubmed publisher
Ardain A, Domingo Gonzalez R, Das S, Kazer S, Howard N, Singh A, et al. Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis. Nature. 2019;: pubmed publisher
Im E, Lee C, Moon P, Rangaswamy G, Lee B, Lee J, et al. Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A. Nat Commun. 2019;10:1387 pubmed publisher
Richardson S, Chung A, Natarajan H, Mabvakure B, Mkhize N, Garrett N, et al. HIV-specific Fc effector function early in infection predicts the development of broadly neutralizing antibodies. PLoS Pathog. 2018;14:e1006987 pubmed publisher
Pietikäinen A, Oksi J, Hytönen J. Point-of-care testing for CXCL13 in Lyme neuroborreliosis. Diagn Microbiol Infect Dis. 2018;91:226-228 pubmed publisher
Paris R, Milagres L, Moysi E, Okulicz J, Agan B, Ganesan A, et al. Lower Baseline Germinal Center Activity and Preserved Th1 Immunity Are Associated With Hepatitis B Vaccine Response in Treated HIV Infection. Pathog Immun. 2017;2:66-88 pubmed publisher
Wang S, Yang T, Wan J, Zhang Y, Fan Y. Elevated C-X-C motif ligand 13 and B-cell-activating factor levels in neuromyelitis optica during remission. Brain Behav. 2017;7:e00648 pubmed publisher
Gyllemark P, Forsberg P, Ernerudh J, Henningsson A. Intrathecal Th17- and B cell-associated cytokine and chemokine responses in relation to clinical outcome in Lyme neuroborreliosis: a large retrospective study. J Neuroinflammation. 2017;14:27 pubmed publisher
Puthenparampil M, Federle L, Miante S, Zito A, Toffanin E, Ruggero S, et al. BAFF Index and CXCL13 levels in the cerebrospinal fluid associate respectively with intrathecal IgG synthesis and cortical atrophy in multiple sclerosis at clinical onset. J Neuroinflammation. 2017;14:11 pubmed publisher
Havenar Daughton C, Lindqvist M, Heit A, Wu J, Reiss S, Kendric K, et al. CXCL13 is a plasma biomarker of germinal center activity. Proc Natl Acad Sci U S A. 2016;113:2702-7 pubmed publisher
Epeldegui M, Lee J, MartÃnez A, Widney D, Magpantay L, Regidor D, et al. Predictive Value of Cytokines and Immune Activation Biomarkers in AIDS-Related Non-Hodgkin Lymphoma Treated with Rituximab plus Infusional EPOCH (AMC-034 trial). Clin Cancer Res. 2016;22:328-36 pubmed publisher
Stilund M, Gjelstrup M, Petersen T, Møller H, Rasmussen P, Christensen T. Biomarkers of inflammation and axonal degeneration/damage in patients with newly diagnosed multiple sclerosis: contributions of the soluble CD163 CSF/serum ratio to a biomarker panel. PLoS ONE. 2015;10:e0119681 pubmed publisher
Cohen K, Dugast A, Alter G, McElrath M, Stamatatos L. HIV-1 single-stranded RNA induces CXCL13 secretion in human monocytes via TLR7 activation and plasmacytoid dendritic cell-derived type I IFN. J Immunol. 2015;194:2769-75 pubmed publisher
Hytönen J, Kortela E, Waris M, Puustinen J, Salo J, Oksi J. CXCL13 and neopterin concentrations in cerebrospinal fluid of patients with Lyme neuroborreliosis and other diseases that cause neuroinflammation. J Neuroinflammation. 2014;11:103 pubmed publisher
Senel M, Tumani H, Lauda F, Presslauer S, Mojib Yezdani R, Otto M, et al. Cerebrospinal fluid immunoglobulin kappa light chain in clinically isolated syndrome and multiple sclerosis. PLoS ONE. 2014;9:e88680 pubmed publisher
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Tiberti N, Hainard A, Lejon V, Courtioux B, Matovu E, Enyaru J, et al. Cerebrospinal fluid neopterin as marker of the meningo-encephalitic stage of Trypanosoma brucei gambiense sleeping sickness. PLoS ONE. 2012;7:e40909 pubmed publisher
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Singh S, Singh R, Sharma P, Singh U, Rai S, Chung L, et al. Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion. Cancer Lett. 2009;283:29-35 pubmed publisher
Kim M, Romero R, Kim C, Tarca A, Chhauy S, LaJeunesse C, et al. Villitis of unknown etiology is associated with a distinct pattern of chemokine up-regulation in the feto-maternal and placental compartments: implications for conjoint maternal allograft rejection and maternal anti-fetal graft-versus-host disease. J Immunol. 2009;182:3919-27 pubmed publisher
Panse J, Friedrichs K, Marx A, Hildebrandt Y, Luetkens T, Barrels K, et al. Chemokine CXCL13 is overexpressed in the tumour tissue and in the peripheral blood of breast cancer patients. Br J Cancer. 2008;99:930-8 pubmed publisher
Cagigi A, Mowafi F, Phuong Dang L, Tenner Racz K, Atlas A, Grutzmeier S, et al. Altered expression of the receptor-ligand pair CXCR5/CXCL13 in B cells during chronic HIV-1 infection. Blood. 2008;112:4401-10 pubmed publisher
Rioja I, Hughes F, Sharp C, Warnock L, Montgomery D, Akil M, et al. Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor alpha, tumor necrosis factor receptor superfamily member 9, and macrophage colony-stimulating factor. Arthritis Rheum. 2008;58:2257-67 pubmed publisher
Sansonno D, Tucci F, Troiani L, Lauletta G, Montrone M, Conteduca V, et al. Increased serum levels of the chemokine CXCL13 and up-regulation of its gene expression are distinctive features of HCV-related cryoglobulinemia and correlate with active cutaneous vasculitis. Blood. 2008;112:1620-7 pubmed publisher
Aloisi F, Columba Cabezas S, Franciotta D, Rosicarelli B, Magliozzi R, Reynolds R, et al. Lymphoid chemokines in chronic neuroinflammation. J Neuroimmunol. 2008;198:106-12 pubmed publisher
Lim H, Kim C. Loss of IL-7 receptor alpha on CD4+ T cells defines terminally differentiated B cell-helping effector T cells in a B cell-rich lymphoid tissue. J Immunol. 2007;179:7448-56 pubmed
Bürkle A, Niedermeier M, Schmitt Gräff A, Wierda W, Keating M, Burger J. Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia. Blood. 2007;110:3316-25 pubmed
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Corcione A, Casazza S, Ferretti E, Giunti D, Zappia E, Pistorio A, et al. Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis. Proc Natl Acad Sci U S A. 2004;101:11064-9 pubmed
Lisignoli G, Cristino S, Toneguzzi S, Grassi F, Piacentini A, Cavallo C, et al. IL1beta and TNFalpha differently modulate CXCL13 chemokine in stromal cells and osteoblasts isolated from osteoarthritis patients: evidence of changes associated to cell maturation. Exp Gerontol. 2004;39:659-65 pubmed

image

image 1 :

Human CXCL13/BLC/BCA-1 ELISA Standard Curve

product information

brand :

R&D Systems

master code :

DCX130

SKU :

DCX130

product name :

Human CXCL13/BLC/BCA-1 Quantikine ELISA Kit

unit size :

1 Kit

seo description :

The Human CXCL13/BLC/BCA-1 Quantikine ELISA Kit from R&D Systems is a Solid Phase Sandwich ELISA that quantifies human CXCL13/BLC/BCA-1 in cell culture supernates (50 ul), serum (50 ul), edta plasma (50 ul), heparin plasma (50 ul), saliva (25 ul).

target :

CXCL13/BLC/BCA-1

category :

ELISAs

dilution :

ELISA

species :

Human

specificity :

Natural and recombinant human BLC/BCA-1

gene symbol :

CXCL13

kit type :

Solid Phase Sandwich ELISA

assay length :

4.5 hours

elisaSampleTypes :

Cell Culture Supernates (50 uL), Serum (50 uL), EDTA Plasma (50 uL), Heparin Plasma (50 uL), Saliva (25 uL)

elisaSensitivity :

3.97 pg/mL

elisaRange :

7.80 - 500 pg/mL

top caption :

Human CXCL13/BLC/BCA-1 ELISA Standard Curve

applications :

ELISA

USD :

655 USD

product details :

The Quantikine Human BLC/BCA-1 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human BLC/BCA-1 in cell culture supernates, serum, plasma, and saliva. It contains E. coli -expressed recombinant human BLC/BCA-1 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human BLC/BCA-1 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring BLC/BCA-1.

alt names :

ANGIE, ANGIE2, B cell-attracting chemokine 1, B lymphocyte chemoattractant, BCA1, BCA-1, BCA1B-cell chemoattractant, BCA-1CXC chemokine BLC, B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1), BLC, BLCSmall-inducible cytokine B13, BLR1L, B-lymphocyte chemoattractant, chemokine (C-X-C motif) ligand 13, chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant), C-X-C motif chemokine 13, SCYB13, SCYB13B-cell-attracting chemokine 1, small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cellchemoattractant)

storage :

Store the unopened product at 2 - 8 ░C. Do not use past expiration date.

more info or order :

R&D Systems product webpage