product summary
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company name :
R&D Systems
product type :
ELISA/assay
product name :
Human CD40 Ligand/TNFSF5 Quantikine ELISA Kit
catalog :
DCDL40
quantity :
1 Kit (also 1 Pack (50 Plates), 1 Pack (6 Plates))
price :
655 USD
more info or order :
R&D Systems product webpage
citations: 44
Reference
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Buschmann K, Gramlich Y, Chaban R, Oelze M, Hink U, Munzel T, et al. Disturbed Lipid Metabolism in Diabetic Patients with Manifest Coronary Artery Disease Is Associated with Enhanced Inflammation. Int J Environ Res Public Health. 2021;18: pubmed publisher
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Martínez Fernández D, Padilla Gutiérrez J, Casillas Muñoz F, Valdés Alvarado E, Parra Reyna B, Aceves Ramírez M, et al. Analysis of Genetic Variation in CD40 and CD40L: Relationship with mRNA Relative Expression and Soluble Proteins in Acute Coronary Syndrome. J Immunol Res. 2019;2019:8063983 pubmed publisher
Liu Z, Hu J, Xiao X, Peng Y, Zhao S, Xiao X, et al. The CD40 rs1883832 Polymorphism Affects Sepsis Susceptibility and sCD40L Levels. Biomed Res Int. 2018;2018:7497314 pubmed publisher
Ruediger C, John B, Kumar S, Lim H, Rangnekar G, Roberts Thomson K, et al. Influence of ethnic background on left atrial markers of inflammation, endothelial function and tissue remodelling. Indian Pacing Electrophysiol J. 2018;18:1-5 pubmed publisher
Szentpéteri A, Zsíros N, Varga V, Lőrincz H, Katko M, Seres I, et al. Paraoxonase-1 and myeloperoxidase correlate with vascular biomarkers in overweight patients with newly diagnosed untreated hyperlipidaemia. Vasa. 2017;46:370-376 pubmed publisher
Lorente L, Martín M, Pérez Cejas A, Ferreres J, Sole Violan J, Labarta L, et al. Non-survivor septic patients have persistently higher serum sCD40L levels than survivors. J Crit Care. 2017;41:177-182 pubmed publisher
Blaha V, Blaha M, Lanska M, Solichova D, Kujovska Krcmova L, Havel E, et al. Lipoprotein apheresis in the treatment of dyslipidaemia - the Czech Republic experience. Physiol Res. 2017;66:S91-S100 pubmed
Chang L, Li Y, Kaplan D. Endotoxemia contributes to CD27+ memory B-cell apoptosis via enhanced sensitivity to Fas ligation in patients with Cirrhosis. Sci Rep. 2016;6:36862 pubmed publisher
Azzariti A, Brunetti O, Porcelli L, Graziano G, Iacobazzi R, Signorile M, et al. Potential predictive role of chemotherapy-induced changes of soluble CD40 ligand in untreated advanced pancreatic ductal adenocarcinoma. Onco Targets Ther. 2016;9:4681-6 pubmed publisher
Fuentes E, Pereira J, Mezzano D, Alarcón M, Caballero J, Palomo I. Inhibition of platelet activation and thrombus formation by adenosine and inosine: studies on their relative contribution and molecular modeling. PLoS ONE. 2014;9:e112741 pubmed publisher
Silliman C, Kelher M, Khan S, LaSarre M, West F, Land K, et al. Experimental prestorage filtration removes antibodies and decreases lipids in RBC supernatants mitigating TRALI in vivo. Blood. 2014;123:3488-95 pubmed publisher
Kageyama Y, Doi T, Matsushima Nishiwaki R, Iida Y, Akamatsu S, Kondo A, et al. Involvement of Rac in thromboxane A2?induced human platelet activation: regulation of sCD40 ligand release and PDGF?AB secretion. Mol Med Rep. 2014;10:107-12 pubmed publisher
Fuentes E, Caballero J, Alarcon M, Rojas A, Palomo I. Chlorogenic acid inhibits human platelet activation and thrombus formation. PLoS ONE. 2014;9:e90699 pubmed publisher
Dickinson R, Milne P, Jardine L, Zandi S, Swierczek S, McGovern N, et al. The evolution of cellular deficiency in GATA2 mutation. Blood. 2014;123:863-74 pubmed publisher
Fuentes E, Alarcon M, Astudillo L, Valenzuela C, Gutierrez M, Palomo I. Protective mechanisms of guanosine from Solanum lycopersicum on agonist-induced platelet activation: role of sCD40L. Molecules. 2013;18:8120-35 pubmed publisher
Johansson P, Sørensen A, Perner A, Welling K, Wanscher M, Larsen C, et al. Elderly trauma patients have high circulating noradrenaline levels but attenuated release of adrenaline, platelets, and leukocytes in response to increasing injury severity. Crit Care Med. 2012;40:1844-50 pubmed publisher
Feng X, Scheinberg P, Samsel L, Rios O, Chen J, McCoy J, et al. Decreased plasma cytokines are associated with low platelet counts in aplastic anemia and immune thrombocytopenic purpura. J Thromb Haemost. 2012;10:1616-23 pubmed publisher
Johansson P, Sørensen A, Perner A, Welling K, Wanscher M, Larsen C, et al. High sCD40L levels early after trauma are associated with enhanced shock, sympathoadrenal activation, tissue and endothelial damage, coagulopathy and mortality. J Thromb Haemost. 2012;10:207-16 pubmed publisher
Jefferis B, Whincup P, Welsh P, Wannamethee S, Rumley A, Lawlor D, et al. Prospective study of circulating soluble CD40 ligand concentrations and the incidence of cardiovascular disease in a nested prospective case-control study of older men and women. J Thromb Haemost. 2011;9:1452-9 pubmed publisher
Kawut S, Barr R, Johnson W, Chahal H, Tandri H, Jain A, et al. Matrix metalloproteinase-9 and plasminogen activator inhibitor-1 are associated with right ventricular structure and function: the MESA-RV Study. Biomarkers. 2010;15:731-8 pubmed publisher
Ray M, Calabro L, Sirisena T, Crawford S, Crawford R, Walters D. Pre-operative platelet-bound CD40 ligand is probably associated with peri-operative cardiac events in hip and knee arthroplasty. Eur J Clin Invest. 2010;40:497-503 pubmed publisher
Dossus L, Becker S, Achaintre D, Kaaks R, Rinaldi S. Validity of multiplex-based assays for cytokine measurements in serum and plasma from "non-diseased" subjects: comparison with ELISA. J Immunol Methods. 2009;350:125-32 pubmed publisher
Plat J, Brufau G, Dallinga Thie G, Dasselaar M, Mensink R. A plant stanol yogurt drink alone or combined with a low-dose statin lowers serum triacylglycerol and non-HDL cholesterol in metabolic syndrome patients. J Nutr. 2009;139:1143-9 pubmed publisher
Arellano Rodrigo E, Alvarez Larran A, Reverter J, Colomer D, Villamor N, Bellosillo B, et al. Platelet turnover, coagulation factors, and soluble markers of platelet and endothelial activation in essential thrombocythemia: relationship with thrombosis occurrence and JAK2 V617F allele burden. Am J Hematol. 2009;84:102-8 pubmed publisher
Trøseid M, Seljeflot I, Hjerkinn E, Arnesen H. Interleukin-18 is a strong predictor of cardiovascular events in elderly men with the metabolic syndrome: synergistic effect of inflammation and hyperglycemia. Diabetes Care. 2009;32:486-92 pubmed publisher
Beres B, Toth Zsamboki E, Vargova K, László A, Masszi T, Kerecsen G, et al. Analysis of platelet alpha2-adrenergic receptor activity in stable coronary artery disease patients on dual antiplatelet therapy. Thromb Haemost. 2008;100:829-38 pubmed
Lengellé J, Panopoulos E, Betsou F. Soluble CD40 ligand as a biomarker for storage-related preanalytic variations of human serum. Cytokine. 2008;44:275-82 pubmed publisher
Dai D, Thajeb P, Tu C, Chiang F, Chen C, Yang R, et al. Plasma concentration of SCUBE1, a novel platelet protein, is elevated in patients with acute coronary syndrome and ischemic stroke. J Am Coll Cardiol. 2008;51:2173-80 pubmed publisher
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Undas A, Wiek I, Stepien E, Zmudka K, Tracz W. Hyperglycemia is associated with enhanced thrombin formation, platelet activation, and fibrin clot resistance to lysis in patients with acute coronary syndrome. Diabetes Care. 2008;31:1590-5 pubmed publisher
Choudhury A, Freestone B, Patel J, Lip G. Relationship of soluble CD40 ligand to vascular endothelial growth factor, angiopoietins, and tissue factor in atrial fibrillation: a link among platelet activation, angiogenesis, and thrombosis?. Chest. 2007;132:1913-9 pubmed
Khanolkar M, Morris R, Thomas A, Bolusani H, Roberts A, Geen J, et al. Rosiglitazone produces a greater reduction in circulating platelet activity compared with gliclazide in patients with type 2 diabetes mellitus--an effect probably mediated by direct platelet PPARgamma activation. Atherosclerosis. 2008;197:718-24 pubmed
Altwegg L, Neidhart M, Hersberger M, Müller S, Eberli F, Corti R, et al. Myeloid-related protein 8/14 complex is released by monocytes and granulocytes at the site of coronary occlusion: a novel, early, and sensitive marker of acute coronary syndromes. Eur Heart J. 2007;28:941-8 pubmed
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Wang T, Chen W, Cheng W, Lin J, Chen M, Lee Y. Relation of improvement in endothelium-dependent flow-mediated vasodilation after rosiglitazone to changes in asymmetric dimethylarginine, endothelin-1, and C-reactive protein in nondiabetic patients with the metabolic syndrome. Am J Cardiol. 2006;98:1057-62 pubmed
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Chu C, Lee K, Lee M, Su H, Voon W, Sheu S, et al. Effects of rosiglitazone alone and in combination with atorvastatin on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus. Am J Cardiol. 2006;97:646-50 pubmed
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image
image 1 :
R&D Systems DCDL40 image 1
Human CD40 Ligand/TNFSF5 ELISA Standard Curve
product information
brand :
R&D Systems
master code :
DCDL40
SKU :
DCDL40
product name :
Human CD40 Ligand/TNFSF5 Quantikine ELISA Kit
unit size :
1 Kit (also 1 Pack (50 Plates), 1 Pack (6 Plates))
seo description :
The Human CD40 Ligand/TNFSF5 Quantikine ELISA Kit from R&D Systems is a Solid Phase Sandwich ELISA that quantifies human CD40 Ligand/TNFSF5 in cell culture supernates (100 ul), serum (20 ul), platelet-poor edta plasma (100 ul), platelet-poor heparin plasma (100 ul).
target :
CD40 Ligand/TNFSF5
category :
ELISAs
dilution :
ELISA
species :
Human
specificity :
Natural and recombinant human CD40 Ligand
gene symbol :
CD40LG
kit type :
Solid Phase Sandwich ELISA
assay length :
4.5 hours
elisaSampleTypes :
Cell Culture Supernates (100 uL), Serum (20 uL), Platelet-poor EDTA Plasma (100 uL), Platelet-poor Heparin Plasma (100 uL)
elisaSensitivity :
10.1 pg/mL
elisaRange :
62.50 - 4000 pg/mL
top caption :
Human CD40 Ligand/TNFSF5 ELISA Standard Curve
applications :
ELISA
USD :
655 USD
product details :
The Quantikine Human CD40 Ligand Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human CD40 Ligand in cell culture supernates, serum, and plasma. It contains E. coli -expressed recombinant human CD40 Ligand and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human CD40 Ligand showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human CD40 Ligand.
alt names :
CD154, CD154 antigen, CD40 antigen ligand, CD40 ligand, CD40L, CD40-L, CD40LG, CD40LIGM, gp39, hCD40L, HIGM1, T-B cell-activating molecule, T-BAM, T-cell antigen Gp39, TNF-related activation protein, TNFSF5, TNFSF5IMD3, TRAP, TRAPtumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome), tumor necrosis factor (ligand) superfamily member 5, Tumor necrosis factor ligand superfamily member 5
storage :
Store the unopened product at 2 - 8 ░C. Do not use past expiration date.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.