This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
ELISA/assay
product name :
Human Caspase-1/ICE Quantikine ELISA Kit
catalog :
DCA100
quantity :
1 Kit
price :
655 USD
citations: 44
Reference
Thirugnanam S, Wang C, Zheng C, Grasperge B, Datta P, Rappaport J, et al. The Association between IL-1β and IL-18 Levels, Gut Barrier Disruption, and Monocyte Activation during Chronic Simian Immunodeficiency Virus Infection and Long-Term Suppressive Antiretroviral Therapy. Int J Mol Sci. 2024;25: pubmed publisher
Matsumoto H, Yoshida S, Koga T, Fujita Y, Sumichika Y, Saito K, et al. Increased serum caspase-1 in adult-onset Still's disease. PLoS ONE. 2024;19:e0307908 pubmed publisher
Elovitz M, Anton L, Cristancho A, Ferguson B, Joseph A, Ravel J. Vaginal microbes alter epithelial transcriptome and induce epigenomic modifications providing insight into mechanisms for susceptibility to adverse reproductive outcomes. Res Sq. 2024;: pubmed publisher
Mohammed O, Saber S, Abdel Reheim M, Alamri M, Alfaifi J, Adam M, et al. Tracking the therapeutic efficacy of a ketone mono ester and β-hydroxybutyrate for ulcerative colitis in rats: New perspectives. Toxicol Appl Pharmacol. 2024;486:116943 pubmed publisher
Elovitz M, Anton L, Cristancho A, Ferguson B, Joseph A, Ravel J. Vaginal microbes alter epithelial transcriptomic and epigenomic modifications providing insight into the molecular mechanisms for susceptibility to adverse reproductive outcomes. Res Sq. 2023;: pubmed publisher
Nieto Veloza A, Hong S, Reeder M, Sula M, D Souza D, Zhong Q, et al. Lunasin reduces the susceptibility of IL-10 deficient mice to inflammatory bowel disease and modulates the activation of the NLRP3 inflammasome. J Nutr Biochem. 2023;119:109383 pubmed publisher
Schnittman S, Kitch D, Swartz T, Burdo T, Fitch K, McCallum S, et al. Coronary Artery Plaque Composition and Severity Relate to the Inflammasome in People With Treated Human Immunodeficiency Virus. Open Forum Infect Dis. 2023;10:ofad106 pubmed publisher
Mokhtari T, Yue L, Hu L. Exogenous melatonin alleviates neuropathic pain-induced affective disorders by suppressing NF-κB/ NLRP3 pathway and apoptosis. Sci Rep. 2023;13:2111 pubmed publisher
La Rosa F, Zoia C, Bazzini C, Bolognini A, Saresella M, Conti E, et al. Modulation of MAPK- and PI3/AKT-Dependent Autophagy Signaling by Stavudine (D4T) in PBMC of Alzheimer's Disease Patients. Cells. 2022;11: pubmed publisher
Alfian I, Chakraborty A, Yong H, Saini S, Lau R, Kalionis B, et al. The Placental NLRP3 Inflammasome and Its Downstream Targets, Caspase-1 and Interleukin-6, Are Increased in Human Fetal Growth Restriction: Implications for Aberrant Inflammation-Induced Trophoblast Dysfunction. Cells. 2022;11: pubmed publisher
Bhattarai N, Korhonen E, Mysore Y, Kaarniranta K, Kauppinen A. Hydroquinone Induces NLRP3-Independent IL-18 Release from ARPE-19 Cells. Cells. 2021;10: pubmed publisher
Wu C, Fan W, Chiu Y, Yang H, Lee W, Huang J. Lipopolysaccharide stimulation test on cultured PBMCs assists the discrimination of cryopyrin-associated periodic syndrome from systemic juvenile idiopathic arthritis. Sci Rep. 2021;11:11903 pubmed publisher
Chen Y, Fujuan Q, Chen E, Yu B, Zuo F, Yuan Y, et al. Expression of AIM2 in Rheumatoid Arthritis and Its Role on Fibroblast-Like Synoviocytes. Mediators Inflamm. 2020;2020:1693730 pubmed publisher
Toribio M, Burdo T, Fulda E, Cetlin M, Chu S, Feldpausch M, et al. Effects of Integrase Inhibitor-Based ART on the NLRP3 Inflammasome Among ART-Naïve People With HIV. Open Forum Infect Dis. 2020;7:ofaa459 pubmed publisher
Fujita Y, Matsuoka N, Temmoku J, Furuya Yashiro M, Asano T, Sato S, et al. JAK inhibitors impair GM-CSF-mediated signaling in innate immune cells. BMC Immunol. 2020;21:35 pubmed publisher
Lavallard V, Cottet Dumoulin D, Wassmer C, Rouget C, Parnaud G, Brioudes E, et al. NLRP3 Inflammasome is Activated in Rat Pancreatic Islets by Transplantation and Hypoxia. Sci Rep. 2020;10:7011 pubmed publisher
de Carvalho R, Lima Júnior D, da Silva M, Dilucca M, Rodrigues T, Horta C, et al. Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition. Nat Commun. 2019;10:5273 pubmed publisher
Wu M, Shu C, Wang J, Yan B, Lai H, Chiang B, et al. NLRP3 inflammasome is attenuated in patients with Mycobacterium avium complex lung disease and correlated with decreased interleukin-1β response and host susceptibility. Sci Rep. 2019;9:12534 pubmed publisher
Weis G, Assmann C, Cadoná F, Bonadiman B, Alves A, Machado A, et al. Immunomodulatory effect of mancozeb, chlorothalonil, and thiophanate methyl pesticides on macrophage cells. Ecotoxicol Environ Saf. 2019;182:109420 pubmed publisher
Furuya M, Asano T, Sumichika Y, Sato S, Kobayashi H, Watanabe H, et al. Tofacitinib inhibits granulocyte-macrophage colony-stimulating factor-induced NLRP3 inflammasome activation in human neutrophils. Arthritis Res Ther. 2018;20:196 pubmed publisher
Ho V, Hirohashi N, Kong W, Yun G, Ota K, Itai J, et al. Sera from Septic Patients Contain the Inhibiting Activity of the Extracellular ATP-Dependent Inflammasome Pathway. Tohoku J Exp Med. 2018;245:193-204 pubmed publisher
Wakamatsu T, Yamamoto S, Ito T, Sato Y, Matsuo K, Takahashi Y, et al. Indoxyl Sulfate Promotes Macrophage IL-1β Production by Activating Aryl Hydrocarbon Receptor/NF-κ/MAPK Cascades, but the NLRP3 inflammasome Was Not Activated. Toxins (Basel). 2018;10: pubmed publisher
Bandera A, Masetti M, Fabbiani M, Biasin M, Muscatello A, Squillace N, et al. The NLRP3 Inflammasome Is Upregulated in HIV-Infected Antiretroviral Therapy-Treated Individuals with Defective Immune Recovery. Front Immunol. 2018;9:214 pubmed publisher
Dubey S, Yoon H, COHEN M, Nagarkatti P, Nagarkatti M, Karan D. Withaferin A Associated Differential Regulation of Inflammatory Cytokines. Front Immunol. 2018;9:195 pubmed publisher
Han Y, Xu X, Tang C, Gao P, Chen X, Xiong X, et al. Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis. Redox Biol. 2018;16:32-46 pubmed publisher
Dabo S, Maillard P, Collados Rodriguez M, Hansen M, Mazouz S, Bigot D, et al. Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT. Sci Rep. 2017;7:16129 pubmed publisher
Burger D, Fickentscher C, de Moerloose P, Brandt K. F-actin dampens NLRP3 inflammasome activity via Flightless-I and LRRFIP2. Sci Rep. 2016;6:29834 pubmed publisher
Kim J, Sohn H, Yoo J, Kang H, Seong G, Chwae Y, et al. NLRP3 Inflammasome Activation in THP-1 Target Cells Triggered by Pathogenic Naegleria fowleri. Infect Immun. 2016;84:2422-8 pubmed publisher
Shamaa O, Mitra S, Gavrilin M, Wewers M. Monocyte Caspase-1 Is Released in a Stable, Active High Molecular Weight Complex Distinct from the Unstable Cell Lysate-Activated Caspase-1. PLoS ONE. 2015;10:e0142203 pubmed publisher
Deng Q, Wang Y, Zhang Y, Li M, Li D, Huang X, et al. Pseudomonas aeruginosa Triggers Macrophage Autophagy To Escape Intracellular Killing by Activation of the NLRP3 Inflammasome. Infect Immun. 2016;84:56-66 pubmed publisher
Cox R, Phillips O, Fukumoto J, Fukumoto I, Tamarapu Parthasarathy P, Mandry M, et al. Resolvins Decrease Oxidative Stress Mediated Macrophage and Epithelial Cell Interaction through Decreased Cytokine Secretion. PLoS ONE. 2015;10:e0136755 pubmed publisher
Datta Mitra A, Kundu Raychaudhuri S, Mitra A, Raychaudhuri S. Cross talk between neuroregulatory molecule and monocyte: nerve growth factor activates the inflammasome. PLoS ONE. 2015;10:e0121626 pubmed publisher
Shenker B, Ojcius D, Walker L, Zekavat A, Scuron M, Boesze Battaglia K. Aggregatibacter actinomycetemcomitans cytolethal distending toxin activates the NLRP3 inflammasome in human macrophages, leading to the release of proinflammatory cytokines. Infect Immun. 2015;83:1487-96 pubmed publisher
Westbom C, Shukla A, Macpherson M, Yasewicz E, Miller J, Beuschel S, et al. CREB-induced inflammation is important for malignant mesothelioma growth. Am J Pathol. 2014;184:2816-27 pubmed publisher
Exline M, Justiniano S, Hollyfield J, Berhe F, BESECKER B, Das S, et al. Microvesicular caspase-1 mediates lymphocyte apoptosis in sepsis. PLoS ONE. 2014;9:e90968 pubmed publisher
Wu M, Chen S, Yang A, Lin W, Lin Y, Chen N, et al. CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages. Blood. 2013;121:95-106 pubmed publisher
Huang T, Ojcius D, Young J, Wu Y, Ko Y, Wong T, et al. The anti-tumorigenic mushroom Agaricus blazei Murill enhances IL-1β production and activates the NLRP3 inflammasome in human macrophages. PLoS ONE. 2012;7:e41383 pubmed publisher
Beynon V, Quintana F, Weiner H. Activated human CD4+CD45RO+ memory T-cells indirectly inhibit NLRP3 inflammasome activation through downregulation of P2X7R signalling. PLoS ONE. 2012;7:e39576 pubmed publisher
Kuijk L, Beekman J, Koster J, Waterham H, Frenkel J, Coffer P. HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB-dependent caspase-1 activation. Blood. 2008;112:3563-73 pubmed publisher
Blankenberg S, Godefroy T, Poirier O, Rupprecht H, Barbaux S, Bickel C, et al. Haplotypes of the caspase-1 gene, plasma caspase-1 levels, and cardiovascular risk. Circ Res. 2006;99:102-8 pubmed
Yamanaka K, Clark R, Dowgiert R, Hurwitz D, Shibata M, Rich B, et al. Expression of interleukin-18 and caspase-1 in cutaneous T-cell lymphoma. Clin Cancer Res. 2006;12:376-82 pubmed
Grandjean Laquerriere A, Laquerriere P, Laurent Maquin D, Guenounou M, Phillips T. The effect of the physical characteristics of hydroxyapatite particles on human monocytes IL-18 production in vitro. Biomaterials. 2004;25:5921-7 pubmed
Dziankowska Bartkowiak B, Waszczykowska E, Zalewska A, Sysa Jedrzejowska A. Evaluation of caspase 1 and sFas serum levels in patients with systemic sclerosis: correlation with lung dysfunction, joint and bone involvement. Mediators Inflamm. 2003;12:339-43 pubmed
Cloëz Tayarani I, Petit Bertron A, Venters H, Cavaillon J. Differential effect of serotonin on cytokine production in lipopolysaccharide-stimulated human peripheral blood mononuclear cells: involvement of 5-hydroxytryptamine2A receptors. Int Immunol. 2003;15:233-40 pubmed
product information
master code :
DCA100
SKU :
DCA100
product name :
Human Caspase-1/ICE Quantikine ELISA Kit
unit size :
1 Kit
description :
The Human Caspase-1/ICE Quantikine ELISA Kit from R&D Systems is a Solid Phase Sandwich ELISA that quantifies human Caspase-1 in cell culture supernates (100 ul).
target :
Caspase-1
category :
ELISAs
species :
Human
specificity :
Natural and recombinant human Caspase-1
gene symbol :
CASP1
kit type :
Solid Phase Sandwich ELISA
assay length :
3 hours
elisaSampleTypes :
Cell Culture Supernates (100 uL)
elisaSensitivity :
1.24 pg/mL
elisaRange :
6.25 - 400 pg/mL
top caption :
Human Caspase-1 ELISA Standard Curve
applications :
ELISA
USD :
655 USD
product details :
The Quantikine Human Caspase-1 Immunoassay is a 3 hour solid phase ELISA designed to measure Caspase-1 in cell culture supernates. It contains recombinant human Caspase-1 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtained measuring natural human Caspase-1 showed dose-response curves that were parallel to the standard curves obtained using the recombinant Caspase-1. These results indicate that this kit can be used to determine relative mass values for natural human Caspase-1.
alt names :
CASP1, CASP-1, CASP1 nirs variant 1, caspase 1, apoptosis-related cysteine peptidase, caspase-1, Caspase1, Caspase-1 subunit p10, Caspase-1 subunit p20, EC 3.4.22.36, EC:3.4.22.36, ICE, IL-1 beta-converting enzyme, IL1BC, IL-1BC, IL1BCE, IL1B-convertase, interleukin 1, beta, convertase, interleukin 1-B converting enzyme, Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, p45
storage :
Store the unopened product at 2 - 8 ░C. Do not use past expiration date.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.