product summary
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company name :
R&D Systems
product type :
ELISA/assay
product name :
BMP-2 Quantikine ELISA Kit
catalog :
DBP200
quantity :
1 Kit (also 1 Pack (50 Plates), 1 Pack (6 Plates))
price :
655 USD
more info or order :
citations: 59
Reference
Kim Y, Cidonio G, Kanczler J, Oreffo R, Dawson J. Human bone tissue-derived ECM hydrogels: Controlling physicochemical, biochemical, and biological properties through processing parameters. Bioact Mater. 2025;43:114-128 pubmed publisher
Lee S, Kim J, Kim Y, Hong J, Kim W, Jin S, et al. Sustained BMP-2 delivery via alginate microbeads and polydopamine-coated 3D-Printed PCL/β-TCP scaffold enhances bone regeneration in long bone segmental defects. J Orthop Translat. 2024;49:11-22 pubmed publisher
L xf3 pez Andaluz J, Flores Fraile J, Javier Borrajo -, Blanco Antona L, Garc xed a Carrodeguas R, L xf3 pez Monta xf1 xe9 s D, et al. Assessment of rhBMP-2-loaded bovine hydroxyapatite granules in the guided bone regeneration of critical bone defect in rat mandible bone. J Dent Sci. 2024;19:276-284 pubmed publisher
Tenkumo T, Kruse B, Kostka K, Sokolova V, Ogawa T, Yoda N, et al. Development of triple-functionalized calcium phosphate nanoparticles as an advanced drug delivery system for bone tissue repair. Regen Ther. 2024;25:49-60 pubmed publisher
Zhang R, Jo J, Kanda R, Nishiura A, Hashimoto Y, Matsumoto N. Bioactive Polyetheretherketone with Gelatin Hydrogel Leads to Sustained Release of Bone Morphogenetic Protein-2 and Promotes Osteogenic Differentiation. Int J Mol Sci. 2023;24: pubmed publisher
Bukharova T, Nedorubova I, Mokrousova V, Meglei A, Basina V, Nedorubov A, et al. Adenovirus-Based Gene Therapy for Bone Regeneration: A Comparative Analysis of In Vivo and Ex Vivo BMP2 Gene Delivery. Cells. 2023;12: pubmed publisher
Manzano Lista F, Sanz G xf3 mez M, Gonz xe1 lez Moreno D, Vega Mart xed n E, Gil Ortega M, Schulz A, et al. Imbalance in Bone Morphogenic Proteins 2 and 7 Is Associated with Renal and Cardiovascular Damage in Chronic Kidney Disease. Int J Mol Sci. 2022;24: pubmed publisher
Collon K, Bell J, Gallo M, Chang S, Bougioukli S, Sugiyama O, et al. Influence of donor age and comorbidities on transduced human adipose-derived stem cell in vitro osteogenic potential. Gene Ther. 2022;: pubmed publisher
Nguyen T, Hu C, Sakthivel R, Nabilla S, Huang Y, Yu J, et al. Preparation of gamma poly-glutamic acid/hydroxyapatite/collagen composite as the 3D-printing scaffold for bone tissue engineering. Biomater Res. 2022;26:21 pubmed publisher
Nagel S, Pommerenke C, Meyer C, MacLeod R. The Hematopoietic TALE-Code Shows Normal Activity of IRX1 in Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and IRX5 in Acute Myeloid Leukemia. Int J Mol Sci. 2022;23: pubmed publisher
Ren B, Betz O, Seitz D, Thirion C, Salomon M, Jansson V, et al. Osteogenic Differentiation of Human Adipose-Derived Stem Cells Seeded on a Biomimetic Spongiosa-like Scaffold: Bone Morphogenetic Protein-2 Delivery by Overexpressing Fascia. Int J Mol Sci. 2022;23: pubmed publisher
P xe9 rez Lozano M, Sudre L, van Eegher S, Citadelle D, Pigenet A, Lafage Proust M, et al. Gremlin-1 and BMP-4 Overexpressed in Osteoarthritis Drive an Osteochondral-Remodeling Program in Osteoblasts and Hypertrophic Chondrocytes. Int J Mol Sci. 2022;23: pubmed publisher
Gao X, Cheng H, Sun X, Lu A, Ruzbarsky J, Wang B, et al. Comparison of Autologous Blood Clots with Fibrin Sealant as Scaffolds for Promoting Human Muscle-Derived Stem Cell-Mediated Bone Regeneration. Biomedicines. 2021;9: pubmed publisher
Hsu S, Chou W, Hsu C, Ko J, Jhan S, Wang C, et al. Shockwave Therapy Modulates the Expression of BMP2 for Prevention of Bone and Cartilage Loss in the Lower Limbs of Postmenopausal Osteoporosis Rat Model. Biomedicines. 2020;8: pubmed publisher
Ibrahim A, Hussein K, Wang F, Wan M, Saad N, Essa M, et al. Bone Morphogenetic Protein (BMP)4 But Not BMP2 Disrupts the Barrier Integrity of Retinal Pigment Epithelia and Induces Their Migration: A Potential Role in Neovascular Age-Related Macular Degeneration. J Clin Med. 2020;9: pubmed publisher
Smith D, Daignault Newton S, Grivas P, Reichert Z, Hussain M, Cooney K, et al. Efficacy and Effect of Cabozantinib on Bone Metastases in Treatment-naive Castration-resistant Prostate Cancer. Clin Genitourin Cancer. 2020;18:332-339.e2 pubmed publisher
Gao X, Cheng H, Awada H, Tang Y, Amra S, Lu A, et al. A comparison of BMP2 delivery by coacervate and gene therapy for promoting human muscle-derived stem cell-mediated articular cartilage repair. Stem Cell Res Ther. 2019;10:346 pubmed publisher
Munir A, D xf8 skeland A, Avery S, Fuoco T, Mohamed Ahmed S, Lygre H, et al. Efficacy of copolymer scaffolds delivering human demineralised dentine matrix for bone regeneration. J Tissue Eng. 2019;10:2041731419852703 pubmed publisher
Gorrell R, Totten M, Schoerning L, Newby J, Geyman L, Lawless W, et al. Identification of a bone morphogenetic protein type 2 receptor neutralizing antibody. BMC Res Notes. 2019;12:331 pubmed publisher
Chen C, Chen C, Wang J, Madda R, Tsai S, Wu P, et al. Bone morphogenetic protein activity preservation with extracorporeal irradiation- and liquid nitrogen freezing-treated recycled autografts for biological reconstruction in malignant bone tumor. Cryobiology. 2019;: pubmed publisher
Bougioukli S, Vakhshori V, Ortega B, Sugiyama O, Lieberman J. Regulated ex vivo regional gene therapy for bone repair using an inducible caspase-9 suicide gene system. Gene Ther. 2019;26:230-239 pubmed publisher
Reisbig N, Pinnell E, Scheuerman L, Hussein H, Bertone A. Synovium extra cellular matrices seeded with transduced mesenchymal stem cells stimulate chondrocyte maturation in vitro and cartilage healing in clinically-induced rat-knee lesions in vivo. PLoS ONE. 2019;14:e0212664 pubmed publisher
Ren B, Betz V, Thirion C, Salomon M, Klar R, Jansson V, et al. Gene activated adipose tissue fragments as advanced autologous biomaterials for bone regeneration: osteogenic differentiation within the tissue and implications for clinical translation. Sci Rep. 2019;9:224 pubmed publisher
Wang B, Guo Y, Chen X, Zeng C, Hu Q, Yin W, et al. Nanoparticle-modified chitosan-agarose-gelatin scaffold for sustained release of SDF-1 and BMP-2. Int J Nanomedicine. 2018;13:7395-7408 pubmed publisher
Gao X, Lu A, Tang Y, Schneppendahl J, Liebowitz A, Scibetta A, et al. Influences of donor and host age on human muscle-derived stem cell-mediated bone regeneration. Stem Cell Res Ther. 2018;9:316 pubmed publisher
Ren B, Betz V, Thirion C, Salomon M, Jansson V, Müller P, et al. Osteoinduction within BMP-2 transduced muscle tissue fragments with and without a fascia layer: implications for bone tissue engineering. Gene Ther. 2019;26:16-28 pubmed publisher
Chen C, Li H, Jiang J, Zhang Q, Yan F. Inhibiting PHD2 in bone marrow mesenchymal stem cells via lentiviral vector-mediated RNA interference facilitates the repair of periodontal tissue defects in SD rats. Oncotarget. 2017;8:72676-72699 pubmed publisher
Go Y, Kim S, Cho G, Chae S, Song J. Differential effects of amnion and chorion membrane extracts on osteoblast-like cells due to the different growth factor composition of the extracts. PLoS ONE. 2017;12:e0182716 pubmed publisher
Park S, Kwon J, Lee B, Park J, Lee B, Yun J, et al. BMP2-modified injectable hydrogel for osteogenic differentiation of human periodontal ligament stem cells. Sci Rep. 2017;7:6603 pubmed publisher
Chang H, Yang C, Feng F, Lin F, Wang C, Chang P. Bone morphogenetic protein-2 loaded poly(D,L-lactide-co-glycolide) microspheres enhance osteogenic potential of gelatin/hydroxyapatite/?-tricalcium phosphate cryogel composite for alveolar ridge augmentation. J Formos Med Assoc. 2017;116:973-981 pubmed publisher
Rydén L, Omar O, Johansson A, Jimbo R, Palmquist A, Thomsen P. Inflammatory cell response to ultra-thin amorphous and crystalline hydroxyapatite surfaces. J Mater Sci Mater Med. 2017;28:9 pubmed
Balmayor E, Geiger J, Koch C, Aneja M, van Griensven M, Rudolph C, et al. Modified mRNA for BMP-2 in Combination with Biomaterials Serves as a Transcript-Activated Matrix for Effectively Inducing Osteogenic Pathways in Stem Cells. Stem Cells Dev. 2017;26:25-34 pubmed publisher
Chen X, Guo J, Cai T, Zhang F, Pan S, Zhang L, et al. Targeted next-generation sequencing reveals multiple deleterious variants in OPLL-associated genes. Sci Rep. 2016;6:26962 pubmed publisher
Huang B, Yuan Y, Li T, Ding S, Zhang W, Gu Y, et al. Facilitated receptor-recognition and enhanced bioactivity of bone morphogenetic protein-2 on magnesium-substituted hydroxyapatite surface. Sci Rep. 2016;6:24323 pubmed publisher
Lucaciu O, Soriţău O, Gheban D, Ciuca D, Virtic O, Vulpoi A, et al. Dental follicle stem cells in bone regeneration on titanium implants. BMC Biotechnol. 2015;15:114 pubmed publisher
Choi Y, Ingram P, Yang K, Coffman L, Iyengar M, Bai S, et al. Identifying an ovarian cancer cell hierarchy regulated by bone morphogenetic protein 2. Proc Natl Acad Sci U S A. 2015;112:E6882-8 pubmed publisher
Zhang M, Sara J, Wang F, Liu L, Su L, Zhe J, et al. Increased plasma BMP-2 levels are associated with atherosclerosis burden and coronary calcification in type 2 diabetic patients. Cardiovasc Diabetol. 2015;14:64 pubmed publisher
Pensak M, Hong S, Dukas A, Tinsley B, Drissi H, Tang A, et al. The role of transduced bone marrow cells overexpressing BMP-2 in healing critical-sized defects in a mouse femur. Gene Ther. 2015;22:467-75 pubmed publisher
Chapellier M, Bachelard Cascales E, Schmidt X, Clément F, Treilleux I, Delay E, et al. Disequilibrium of BMP2 levels in the breast stem cell niche launches epithelial transformation by overamplifying BMPR1B cell response. Stem Cell Reports. 2015;4:239-54 pubmed publisher
Cushnie E, Ulery B, Nelson S, Deng M, Sethuraman S, Doty S, et al. Simple signaling molecules for inductive bone regenerative engineering. PLoS ONE. 2014;9:e101627 pubmed publisher
Heinonen A, Rahman M, Dogbevia G, Jakobi H, Wolfl S, Sprengel R, et al. Neuroprotection by rAAV-mediated gene transfer of bone morphogenic protein 7. BMC Neurosci. 2014;15:38 pubmed publisher
Kim J, Kim H, Lim K, Kim Y, Seonwoo H, Park S, et al. Designing nanotopographical density of extracellular matrix for controlled morphology and function of human mesenchymal stem cells. Sci Rep. 2013;3:3552 pubmed publisher
Hang Q, Zhou Y, Hou S, Zhang D, Yang X, Chen J, et al. Asparagine-linked glycosylation of bone morphogenetic protein-2 is required for secretion and osteoblast differentiation. Glycobiology. 2014;24:292-304 pubmed publisher
Talavera Adame D, Gupta A, Kurtovic S, Chaiboonma K, Arumugaswami V, Dafoe D. Bone morphogenetic protein-2/-4 upregulation promoted by endothelial cells in coculture enhances mouse embryoid body differentiation. Stem Cells Dev. 2013;22:3252-60 pubmed publisher
van Houten E, Laven J, Louwers Y, McLuskey A, Themmen A, Visser J. Bone morphogenetic proteins and the polycystic ovary syndrome. J Ovarian Res. 2013;6:32 pubmed publisher
Choi Y, Kim S, Park K, Oh S, Seo J, Shin S, et al. The serum bone morphogenetic protein-2 level in non-small-cell lung cancer patients. Med Oncol. 2012;29:582-8 pubmed publisher
Chen H, Chen C, Lin Y, Chen P, Chen W, Lu C, et al. Association of bone morphogenetic proteins with spinal fusion in ankylosing spondylitis. J Rheumatol. 2010;37:2126-32 pubmed publisher
Dalfino G, Simone S, Porreca S, Cosola C, Balestra C, Manno C, et al. Bone morphogenetic protein-2 may represent the molecular link between oxidative stress and vascular stiffness in chronic kidney disease. Atherosclerosis. 2010;211:418-23 pubmed publisher
Korf Klingebiel M, Kempf T, Sauer T, Brinkmann E, Fischer P, Meyer G, et al. Bone marrow cells are a rich source of growth factors and cytokines: implications for cell therapy trials after myocardial infarction. Eur Heart J. 2008;29:2851-8 pubmed publisher
Chen Y, Chen P, Jeng L, Huang C, Yang L, Chung H, et al. Periodontal regeneration using ex vivo autologous stem cells engineered to express the BMP-2 gene: an alternative to alveolaplasty. Gene Ther. 2008;15:1469-77 pubmed publisher
Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, et al. Isolation and characterization of CD146+ multipotent mesenchymal stromal cells. Exp Hematol. 2008;36:1035-46 pubmed publisher
Potapova I, Gaudette G, Brink P, Robinson R, Rosen M, Cohen I, et al. Mesenchymal stem cells support migration, extracellular matrix invasion, proliferation, and survival of endothelial cells in vitro. Stem Cells. 2007;25:1761-8 pubmed
Yao Y, Zebboudj A, Torres A, Shao E, BOSTROM K. Activin-like kinase receptor 1 (ALK1) in atherosclerotic lesions and vascular mesenchymal cells. Cardiovasc Res. 2007;74:279-89 pubmed
Schmidmaier G, Herrmann S, Green J, Weber T, Scharfenberger A, Haas N, et al. Quantitative assessment of growth factors in reaming aspirate, iliac crest, and platelet preparation. Bone. 2006;39:1156-1163 pubmed publisher
Liu H, Chen C, Tsai C, Hsiue G. Targeted delivery system for juxtacrine signaling growth factor based on rhBMP-2-mediated carrier-protein conjugation. Bone. 2006;39:825-36 pubmed
Egermann M, Baltzer A, Adamaszek S, Evans C, Robbins P, Schneider E, et al. Direct adenoviral transfer of bone morphogenetic protein-2 cDNA enhances fracture healing in osteoporotic sheep. Hum Gene Ther. 2006;17:507-17 pubmed
Zhao M, Zhao Z, Koh J, Jin T, Franceschi R. Combinatorial gene therapy for bone regeneration: cooperative interactions between adenovirus vectors expressing bone morphogenetic proteins 2, 4, and 7. J Cell Biochem. 2005;95:1-16 pubmed
Blum B, Moseley J, Miller L, Richelsoph K, Haggard W. Measurement of bone morphogenetic proteins and other growth factors in demineralized bone matrix. Orthopedics. 2004;27:s161-5 pubmed
Chen Y, Kuo Y, Yang K, Wang C, Huang H, Wang F. Shock wave application enhances pertussis toxin protein-sensitive bone formation of segmental femoral defect in rats. J Bone Miner Res. 2003;18:2169-79 pubmed
image
image 1 :
R&D Systems DBP200 image 1
Human/Mouse/Rat BMP-2 ELISA Standard Curve
product information
master code :
DBP200
SKU :
DBP200
product name :
BMP-2 Quantikine ELISA Kit
unit size :
1 Kit (also 1 Pack (50 Plates), 1 Pack (6 Plates))
description :
The BMP-2 Quantikine ELISA Kit from R&D Systems is a Solid Phase Sandwich ELISA that quantifies human, mouse, rat BMP-2 in cell culture supernates (50 ul), bone extracts (50 ul).
target :
BMP-2
category :
ELISAs
species :
Human, Mouse, Rat
specificity :
Natural and mammalian-expressed recombinant human BMP-2. This assay does not recognize E. coli -expressed BMP-2.
gene symbol :
BMP2
kit type :
Solid Phase Sandwich ELISA
assay length :
4.5 hours
elisaSampleTypes :
Cell Culture Supernates (50 uL), Bone Extracts (50 uL)
elisaSensitivity :
29 pg/mL
elisaRange :
62.50 - 4000 pg/mL
top caption :
Human/Mouse/Rat BMP-2 ELISA Standard Curve
applications :
ELISA
USD :
655 USD
product details :
The Quantikine Human BMP-2 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human BMP-2 in bone tissue extracts and cell culture supernates. It contains CHO cell-expressed recombinant human BMP-2 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural mouse BMP-2 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human BMP-2.
alt names :
BDA2, BMP2, BMP-2, BMP-2A, BMP2ABone morphogenetic protein 2A, bone morphogenetic protein 2, SSFSC
storage :
Store the unopened product at 2 - 8 ░C. Do not use past expiration date.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.