This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
ELISA/assay
product name :
Human/Mouse/Rat Activin A Quantikine ELISA Kit
catalog :
DAC00B
quantity :
1 Kit
price :
655 USD
citations: 64
Reference
Sinn K, Elbeialy A, Mosleh B, Aigner C, Schelch K, László V, et al. High circulating activin A plasma levels are associated with tumour stage and poor survival in treatment-naive lung squamous cell cancer patients. Transl Oncol. 2025;51:102153 pubmed publisher
Moqaddam M, Nemati M, Dara M, Hoteit M, Sadek Z, Ramezani A, et al. Exploring the Impact of Astaxanthin Supplementation in Conjunction with a 12-Week CrossFit Training Regimen on Selected Adipo-Myokines Levels in Obese Males. Nutrients. 2024;16: pubmed publisher
Nieuwenhuizen N, Nouailles G, Sutherland J, Zyla J, Pasternack A, Heyckendorf J, et al. Activin A levels are raised during human tuberculosis and blockade of the activin signaling axis influences murine responses to M. tuberculosis infection. MBio. 2024;15:e0340823 pubmed publisher
Aversa Z, White T, Heeren A, Hulshizer C, Saul D, Zhang X, et al. Calorie restriction reduces biomarkers of cellular senescence in humans. Aging Cell. 2024;23:e14038 pubmed publisher
St Sauver J, Weston S, Atkinson E, Mc Gree M, Mielke M, White T, et al. Biomarkers of cellular senescence and risk of death in humans. Aging Cell. 2023;22:e14006 pubmed publisher
Yang Y, Lin C, Ma H, Xie J, Kaplan F, Gao G, et al. AAV-Mediated Targeting of the Activin A-ACVR1R206H Signaling in Fibrodysplasia Ossificans Progressiva. Biomolecules. 2023;13: pubmed publisher
Koczo A, Hauspurg A, Countouris M, Berlacher K, xd6 zbay B, Hanley Yanez K, et al. Immune Markers, Blood Pressure Severity, and Cardiac Remodeling 1 to 2 Years After Hypertensive Disorders of Pregnancy. J Am Heart Assoc. 2023;12:e030759 pubmed publisher
Mendis B, He Z, Li X, Wang J, Li C, Li P. Acoustic Atomization-Induced Pumping Based on a Vibrating Sharp-Tip Capillary. Micromachines (Basel). 2023;14: pubmed publisher
Aversa Z, Atkinson E, Carmona E, White T, Heeren A, Jachim S, et al. Biomarkers of cellular senescence in idiopathic pulmonary fibrosis. Respir Res. 2023;24:101 pubmed publisher
Queiroz A, Dantas E, Ramsamooj S, Murthy A, Ahmed M, Zunica E, et al. Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer. Nat Commun. 2022;13:4633 pubmed publisher
McAleavy M, Zhang Q, Ehmann P, Xu J, Wipperman M, Ajithdoss D, et al. The Activin/FLRG Pathway Associates with Poor COVID-19 Outcomes in Hospitalized Patients. Mol Cell Biol. 2022;42:e0046721 pubmed publisher
Cho K, Choi D, Kim Y, Kim J, Ryu K, Woo S. Mesenchymal Stem Cell-Derived Exosomes Protect Muscle Loss by miR-145-5p Activity Targeting Activin A Receptors. Cells. 2021;10: pubmed publisher
Mori D, Miyagawa S, Kido T, Hata H, Ueno T, Toda K, et al. Adipose-derived mesenchymal stem cells preserve cardiac function via ANT-1 in dilated cardiomyopathy hamster model. Regen Ther. 2021;18:182-190 pubmed publisher
Mancinelli G, Torres C, Krett N, Bauer J, Castellanos K, McKinney R, et al. Role of stromal activin A in human pancreatic cancer and metastasis in mice. Sci Rep. 2021;11:7986 pubmed publisher
Terpos E, Ntanasis Stathopoulos I, Katodritou E, Kyrtsonis M, Douka V, Spanoudakis E, et al. Carfilzomib Improves Bone Metabolism in Patients with Advanced Relapsed/Refractory Multiple Myeloma: Results of the CarMMa Study. Cancers (Basel). 2021;13: pubmed publisher
Li K, Zhang Z, Mei Y, Yang Q, Qiao S, Ni C, et al. Metallothionein-1G suppresses pancreatic cancer cell stemness by limiting activin A secretion via NF-κB inhibition. Theranostics. 2021;11:3196-3212 pubmed publisher
Mehta N, Li R, Zhang D, Soomro A, He J, Zhang I, et al. miR299a-5p promotes renal fibrosis by suppressing the antifibrotic actions of follistatin. Sci Rep. 2021;11:88 pubmed publisher
Werner C, Mitra S, Auerbach B, Wang Z, Martin J, Stewart A, et al. Neuroadaptations in the dorsal hippocampus underlie cocaine seeking during prolonged abstinence. Proc Natl Acad Sci U S A. 2020;117:26460-26469 pubmed publisher
Soler Palacios B, Nieto C, Fajardo P, Gonz xe1 lez de la Aleja A, Andr xe9 s N, Dominguez Soto x, et al. Growth Hormone Reprograms Macrophages toward an Anti-Inflammatory and Reparative Profile in an MAFB-Dependent Manner. J Immunol. 2020;205:776-788 pubmed publisher
Schafer M, Zhang X, Kumar A, Atkinson E, Zhu Y, Jachim S, et al. The senescence-associated secretome as an indicator of age and medical risk. JCI Insight. 2020;5: pubmed publisher
Thomas A, Castellanos K, Mancinelli G, Xia Y, Bauer J, Yazici C, et al. Activin A Modulates Inflammation in Acute Pancreatitis and Strongly Predicts Severe Disease Independent of Body Mass Index. Clin Transl Gastroenterol. 2020;11:e00152 pubmed publisher
Rahman R, Murthi P, Singh H, Gurungsinghe S, Leaw B, Mockler J, et al. Hydroxychloroquine Mitigates the Production of 8-Isoprostane and Improves Vascular Dysfunction: Implications for Treating Preeclampsia. Int J Mol Sci. 2020;21: pubmed publisher
Tsai Y, Chou R, Lu Y, Liu C, Huang P, Lin S. Serum Activin A Levels and Renal Outcomes After Coronary Angiography. Sci Rep. 2020;10:3365 pubmed publisher
Pan C, Jaiswal Agrawal N, Zulia Y, Singh S, Sha K, Mohler J, et al. Prostate tumor-derived GDF11 accelerates androgen deprivation therapy-induced sarcopenia. JCI Insight. 2020;5: pubmed publisher
Bauer J, Emon M, Staudacher J, Thomas A, Zessner Spitzenberg J, Mancinelli G, et al. Increased stiffness of the tumor microenvironment in colon cancer stimulates cancer associated fibroblast-mediated prometastatic activin A signaling. Sci Rep. 2020;10:50 pubmed publisher
Oppezzo A, Bourseguin J, Renaud E, Pawlikowska P, Rosselli F. Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia. J Clin Invest. 2020;130:1377-1391 pubmed publisher
Takei Y, Takahashi S, Nakasatomi M, Sakairi T, Ikeuchi H, Kaneko Y, et al. Urinary Activin A is a novel biomarker reflecting renal inflammation and tubular damage in ANCA-associated vasculitis. PLoS ONE. 2019;14:e0223703 pubmed publisher
Lepletier A, Hun M, Hammett M, Wong K, Naeem H, Hedger M, et al. Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging. Cell Rep. 2019;27:3887-3901.e4 pubmed publisher
Kim J, Lee J, Choi S, Lee J, Park Y, Lee C, et al. Diagnostic and prognostic values of serum activin-a levels in patients with acute respiratory distress syndrome. BMC Pulm Med. 2019;19:115 pubmed publisher
Tsai C, Tsai C, Yi J, Kao H, Huang Y, Wang C, et al. Activin A regulates the epidermal growth factor receptor promoter by activating the PI3K/SP1 pathway in oral squamous cell carcinoma cells. Sci Rep. 2019;9:5197 pubmed publisher
Fujiki K, Inamura H, Sugaya T, Matsuoka M. Blockade of ALK4/5 signaling suppresses cadmium- and erastin-induced cell death in renal proximal tubular epithelial cells via distinct signaling mechanisms. Cell Death Differ. 2019;: pubmed publisher
Rentsch P, Stayte S, Morris G, Vissel B. Time dependent degeneration of the nigrostriatal tract in mice with 6-OHDA lesioned medial forebrain bundle and the effect of activin A on L-Dopa induced dyskinesia. BMC Neurosci. 2019;20:5 pubmed publisher
Justice J, Nambiar A, Tchkonia T, Lebrasseur N, Pascual R, Hashmi S, et al. Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study. EBioMedicine. 2019;40:554-563 pubmed publisher
Barruet E, Morales B, Cain C, Ton A, Wentworth K, Chan T, et al. NF-κB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification. JCI Insight. 2018;3: pubmed publisher
Barrios Silva L, Parnell M, Shinwari Z, Chaudhary G, Xenofontos T, van Bekhoven A, et al. Activin subfamily peptides predict chronological age in humans. Physiol Rep. 2018;6:e13823 pubmed publisher
Rodrigues C, Serrano E, Patrício M, Val M, Albuquerque P, Fonseca J, et al. Stroma-derived IL-6, G-CSF and Activin-A mediated dedifferentiation of lung carcinoma cells into cancer stem cells. Sci Rep. 2018;8:11573 pubmed publisher
Shoji M, Minato H, Ogaki S, Seki M, Suzuki Y, Kume S, et al. Different murine-derived feeder cells alter the definitive endoderm differentiation of human induced pluripotent stem cells. PLoS ONE. 2018;13:e0201239 pubmed publisher
Hu J, Wang X, Tang Y, Shan Y, Zou Q, Wang Z, et al. Activin A inhibition attenuates sympathetic neural remodeling following myocardial infarction in rats. Mol Med Rep. 2018;17:5074-5080 pubmed publisher
Barreto R, Kitase Y, Matsumoto T, Pin F, Colston K, Couch K, et al. ACVR2B/Fc counteracts chemotherapy-induced loss of muscle and bone mass. Sci Rep. 2017;7:14470 pubmed publisher
Staudacher J, Yazici C, Carroll T, Bauer J, Pang J, Krett N, et al. Activin in acute pancreatitis: Potential risk-stratifying marker and novel therapeutic target. Sci Rep. 2017;7:12786 pubmed publisher
Cepika A, Banchereau R, Segura E, Ohouo M, Cantarel B, Goller K, et al. A multidimensional blood stimulation assay reveals immune alterations underlying systemic juvenile idiopathic arthritis. J Exp Med. 2017;214:3449-3466 pubmed publisher
Sallustio F, Curci C, Aloisi A, Toma C, Marulli E, Serino G, et al. Inhibin-A and Decorin Secreted by Human Adult Renal Stem/Progenitor Cells Through the TLR2 Engagement Induce Renal Tubular Cell Regeneration. Sci Rep. 2017;7:8225 pubmed publisher
Amarasekera A, Assadi Khansari B, Liu S, Black M, Dymmott G, Rogers N, et al. Vitamin D supplementation lowers thrombospondin-1 levels and blood pressure in healthy adults. PLoS ONE. 2017;12:e0174435 pubmed publisher
Latres E, Mastaitis J, Fury W, Miloscio L, Trejos J, Pangilinan J, et al. Activin A more prominently regulates muscle mass in primates than does GDF8. Nat Commun. 2017;8:15153 pubmed publisher
Senapati S, Sammel M, Butts S, Takacs P, Chung K, Barnhart K. Predicting first trimester pregnancy outcome: derivation of a multiple marker test. Fertil Steril. 2016;106:1725-1732.e3 pubmed publisher
Wang Z, Martin J, Gancarz A, Adank D, Sim F, Dietz D. Activin A is increased in the nucleus accumbens following a cocaine binge. Sci Rep. 2017;7:43658 pubmed publisher
Abdalmula A, Dooley L, Kaufman C, Washington E, House J, Blacklaws B, et al. Immunoselected STRO-3+ mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis. Stem Cell Res Ther. 2017;8:22 pubmed publisher
Stayte S, Rentsch P, Tröscher A, Bamberger M, Li K, Vissel B. Activin A Inhibits MPTP and LPS-Induced Increases in Inflammatory Cell Populations and Loss of Dopamine Neurons in the Mouse Midbrain In Vivo. PLoS ONE. 2017;12:e0167211 pubmed publisher
List E, Jensen E, Kowalski J, Buchman M, Berryman D, Kopchick J. Diet-induced weight loss is sufficient to reduce senescent cell number in white adipose tissue of weight-cycled mice. Nutr Healthy Aging. 2016;4:95-99 pubmed publisher
Olguin Alor R, de la Fuente Granada M, Bonifaz L, Antonio Herrera L, Garcia Zepeda E, Soldevila G. A Key Role for Inhibins in Dendritic Cell Maturation and Function. PLoS ONE. 2016;11:e0167813 pubmed publisher
Hildebrand L, Gaber T, Kühnen P, Morhart R, Unterbörsch H, Schomburg L, et al. Trace element and cytokine concentrations in patients with Fibrodysplasia Ossificans Progressiva (FOP): A case control study. J Trace Elem Med Biol. 2017;39:186-192 pubmed publisher
Kadiombo A, Maeshima A, Kayakabe K, Ikeuchi H, Sakairi T, Kaneko Y, et al. Involvement of infiltrating macrophage-derived activin A in the progression of renal damage in MRL-lpr mice. Am J Physiol Renal Physiol. 2017;312:F297-F304 pubmed publisher
Holtan S, Khera N, Levine J, Chai X, Storer B, Liu H, et al. Late acute graft-versus-host disease: a prospective analysis of clinical outcomes and circulating angiogenic factors. Blood. 2016;128:2350-2358 pubmed publisher
Locci M, Wu J, Arumemi F, Mikulski Z, Dahlberg C, Miller A, et al. Activin A programs the differentiation of human TFH cells. Nat Immunol. 2016;17:976-84 pubmed publisher
Watt F, Paterson E, Freidin A, Kenny M, Judge A, Saklatvala J, et al. Acute Molecular Changes in Synovial Fluid Following Human Knee Injury: Association With Early Clinical Outcomes. Arthritis Rheumatol. 2016;68:2129-40 pubmed publisher
Wilson C, Ottewell P, Coleman R, Holen I. The differential anti-tumour effects of zoledronic acid in breast cancer - evidence for a role of the activin signaling pathway. BMC Cancer. 2015;15:55 pubmed publisher
Ungefroren H, Hyder A, Hinz H, Groth S, Lange H, El Sayed K, et al. Pluripotency gene expression and growth control in cultures of peripheral blood monocytes during their conversion into programmable cells of monocytic origin (PCMO): evidence for a regulatory role of autocrine activin and TGF-β. PLoS ONE. 2015;10:e0118097 pubmed publisher
Näf S, Escote X, Ballesteros M, Yañez R, Simón Muela I, Gil P, et al. Serum activin A and follistatin levels in gestational diabetes and the association of the Activin A-Follistatin system with anthropometric parameters in offspring. PLoS ONE. 2014;9:e92175 pubmed publisher
Li C, Peart N, Xuan Z, Lewis D, Xia Y, Jin J. PMA induces SnoN proteolysis and CD61 expression through an autocrine mechanism. Cell Signal. 2014;26:1369-78 pubmed publisher
Chen L, Zhang W, Liang H, Zhou Q, Ding Z, Yang H, et al. Activin A induces growth arrest through a SMAD- dependent pathway in hepatic progenitor cells. Cell Commun Signal. 2014;12:18 pubmed publisher
Chen W, Greulich S, van der Meer R, Rijzewijk L, Lamb H, de Roos A, et al. Activin A is associated with impaired myocardial glucose metabolism and left ventricular remodeling in patients with uncomplicated type 2 diabetes. Cardiovasc Diabetol. 2013;12:150 pubmed publisher
Pitetti J, Calvel P, Zimmermann C, Conne B, Papaioannou M, Aubry F, et al. An essential role for insulin and IGF1 receptors in regulating sertoli cell proliferation, testis size, and FSH action in mice. Mol Endocrinol. 2013;27:814-27 pubmed publisher
Rufo A, Del Fattore A, Capulli M, Carvello F, De Pasquale L, Ferrari S, et al. Mechanisms inducing low bone density in Duchenne muscular dystrophy in mice and humans. J Bone Miner Res. 2011;26:1891-903 pubmed publisher
Sierra Filardi E, Puig Kröger A, Blanco F, Nieto C, Bragado R, Palomero M, et al. Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers. Blood. 2011;117:5092-101 pubmed publisher
product information
master code :
DAC00B
SKU :
DAC00B
product name :
Human/Mouse/Rat Activin A Quantikine ELISA Kit
unit size :
1 Kit
description :
The Human/Mouse/Rat Activin A Quantikine ELISA Kit from R&D Systems quantifies human, mouse, rat Activin A in cell culture supernates (100 ul), serum (50 ul), edta plasma (50 ul), heparin plasma (50 ul), saliva (50 ul).
target :
Activin A
category :
ELISAs
species :
Human, Mouse, Rat
specificity :
Natural and recombinant human, mouse, and rat Activin A
gene symbol :
INHBA
assay length :
5 hours
elisaSampleTypes :
Cell Culture Supernates (100 uL), Serum (50 uL), EDTA Plasma (50 uL), Heparin Plasma (50 uL), Saliva (50 uL)
elisaSensitivity :
7.85 pg/mL
elisaRange :
15.60 - 1000 pg/mL
top caption :
Human/Mouse/Rat Activin A ELISA Standard Curve
applications :
ELISA
USD :
655 USD
product details :
The Quantikine Human/Mouse/Rat Activin A Immunoassay is a 5.0 hour solid-phase ELISA designed to measure Activin A in human, mouse, or rat cell culture supernates, serum, plasma, and saliva. It contains CHO cell-expressed recombinant human/mouse/rat Activin A and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human/mouse/rat Activin A showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally expressed Activin A.
alt names :
activin AB alpha polypeptide, Activin beta-A chain, erythroid differentiation factor, Erythroid differentiation protein, follicle-stimulating hormone-releasing protein, FSH-releasing protein, inhibin beta A chain, inhibin beta A subunit, Inhibin, beta-1
storage :
Store the unopened product at 2 - 8 ░C. Do not use past expiration date.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.