This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
ELISA/assay
product name :
Human IL-4 Quantikine ELISA Kit
catalog :
D4050
quantity :
1 Kit (also 1 Pack (50 Plates), 1 Pack (6 Plates))
price :
655 USD
citations: 74
Reference
Arita K, Tao H, Crowe P, Thacher S, Otake S, Kobayashi K, et al. Pharmacological Properties of JTE-151; A Novel Orally Available RORγ Antagonist That Suppresses Th17 Cell-Related Responses in Vitro and in Vivo. Biol Pharm Bull. 2024;47:2050-2057 pubmed publisher
Szyma x144 ska B, Knysz B, Ciep x142 ucha H, Piwowar A. Assessment of Metabolic, Inflammatory, and Immunological Disorders Using a New Panel of Plasma Parameters in People Living with HIV Undergoing Antiretroviral Therapy-A Retrospective Study. J Clin Med. 2024;13: pubmed publisher
Freedman P, Schock B, O Reilly S. The Novel Cytokine Interleukin-41/Meteorin-like Is Reduced in Diffuse Systemic Sclerosis. Cells. 2024;13: pubmed publisher
Kütük M, Tufan A, Kilicaslan F, Gokcen C, Aksu G, Yektaş Ç, et al. Cytokine expression profiles in children and adolescents with tic disorders. Sci Rep. 2024;14:15101 pubmed publisher
Ao L, Shi J, Gan J, Yu W, Du H. Effects of dexmedetomidine and ketorolac applied for patient‑controlled analgesia on the balance of Th1/Th2 and level of VEGF in patients undergoing laparoscopic surgery for cervical cancer: A randomized controlled trial. Oncol Lett. 2024;28:379 pubmed publisher
Kim H, Park H, Kim H, Seo D, Hong K, Jang J, et al. The TOX-RAGE axis mediates inflammatory activation and lung injury in severe pulmonary infectious diseases. Proc Natl Acad Sci U S A. 2024;121:e2319322121 pubmed publisher
Scovino A, Dahab E, Diniz Lima I, de Senna Silveira E, Barroso S, Cardoso K, et al. A Comparative Analysis of Innate Immune Responses and the Structural Characterization of Spike from SARS-CoV-2 Gamma Variants and Subvariants. Microorganisms. 2024;12: pubmed publisher
Tomaszewski M, Mertowska P, Janczewska M, Stycze x144 A, Mertowski S, Jonas K, et al. In the Search for Biomarkers of Pulmonary Arterial Hypertension, Are Cytokines IL-2, IL-4, IL-6, IL-10, and IFN-Gamma the Right Indicators to Use?. Int J Mol Sci. 2023;24: pubmed publisher
Song Y, Jiang J, Bai Q, Liu S, Zhang Y, Xu C, et al. Gene expression profiles and bioinformatics analysis in lung samples from ovalbumin-induced asthmatic mice. BMC Pulm Med. 2023;23:50 pubmed publisher
D Arcy Q, Gharaee Kermani M, Zhilin Roth A, Macoska J. The IL-4/IL-13 signaling axis promotes prostatic fibrosis. PLoS ONE. 2022;17:e0275064 pubmed publisher
De Corso E, Baroni S, Settimi S, Onori M, Mastrapasqua R, Troiani E, et al. Sinonasal Biomarkers Defining Type 2-High and Type 2-Low Inflammation in Chronic Rhinosinusitis with Nasal Polyps. J Pers Med. 2022;12: pubmed publisher
Singhatanadgit W, Kitpakornsanti S, Toso M, Pavasant P. IFNγ-primed periodontal ligament cells regulate T-cell responses via IFNγ-inducible mediators and ICAM-1-mediated direct cell contact. R Soc Open Sci. 2022;9:220056 pubmed publisher
Jirapongwattana N, Thongchot S, Chiraphapphaiboon W, Chieochansin T, Sa Nguanraksa D, Warnnissorn M, et al. Mesothelin‑specific T cell cytotoxicity against triple negative breast cancer is enhanced by 40s ribosomal protein subunit 3‑treated self‑differentiated dendritic cells. Oncol Rep. 2022;48: pubmed publisher
Luo S, Wu R, Li Q, Zhang G. Epigenetic Regulation of IFI44L Expression in Monocytes Affects the Functions of Monocyte-Derived Dendritic Cells in Systemic Lupus Erythematosus. J Immunol Res. 2022;2022:4053038 pubmed publisher
Khalaf W, Mahmoud M, Elkhatib W, Hashem H, Soliman W. Phenotypic characterization of NKT-like cells and evaluation of specifically related cytokines for the prediction of unexplained recurrent miscarriage. Heliyon. 2021;7:e08409 pubmed publisher
Gao L, Jiang W, Liu H, Chen Z, Lin Y. Receptor-selective interleukin-4 mutein attenuates laser-induced choroidal neovascularization through the regulation of macrophage polarization in mice. Exp Ther Med. 2021;22:1367 pubmed publisher
Kuzumi A, Yoshizaki A, Matsuda K, Kotani H, Norimatsu Y, Fukayama M, et al. Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis. Nat Commun. 2021;12:5947 pubmed publisher
Sikora B, Skubis Sikora A, Prusek A, Gola J. Paracrine activity of adipose derived stem cells on limbal epithelial stem cells. Sci Rep. 2021;11:19956 pubmed publisher
Maglie R, Ugolini F, De Logu F, Nassini R, Simi S, Nardiello P, et al. Overexpression of helper T cell type 2-related molecules in the skin of patients with eosinophilic dermatosis of hematologic malignancy. J Am Acad Dermatol. 2021;: pubmed publisher
Avila L, Neves M, Abreu A, Fiuza C, Fukusawa L, Meziat Filho N, et al. Cognitive functional therapy (CFT) compared with core training exercise (CTE) in patients with failed back surgery syndrome (FBSS): A study protocol for a randomized controlled trial. J Bodyw Mov Ther. 2021;26:428-434 pubmed publisher
Li R, Li Y, Dong X. Preconditioning mesenchymal stromal cells with flagellin enhances the anti‑inflammatory ability of their secretome against lipopolysaccharide‑induced acute lung injury. Mol Med Rep. 2020;22:2753-2766 pubmed publisher
Gao Y, Sun W, Cha X, Wang H. 'Psoriasis 1' reduces T‑lymphocyte‑mediated inflammation in patients with psoriasis by inhibiting vitamin D receptor‑mediated STAT4 inactivation. Int J Mol Med. 2020;46:1538-1550 pubmed publisher
Park H, Kim H, Kim H, Yoo Y, Shin H, Choi E, et al. Acetylated K676 TGFBIp as a severity diagnostic blood biomarker for SARS-CoV-2 pneumonia. Sci Adv. 2020;6: pubmed publisher
Sałkowska A, Karaś K, Karwaciak I, Walczak Drzewiecka A, Krawczyk M, Sobalska Kwapis M, et al. Identification of Novel Molecular Markers of Human Th17 Cells. Cells. 2020;9: pubmed publisher
Kütük M, Tufan E, Gokcen C, Kilicaslan F, Karadag M, Mutluer T, et al. Cytokine expression profiles in Autism spectrum disorder: A multi-center study from Turkey. Cytokine. 2020;133:155152 pubmed publisher
Al Ayed M, Alshaybari K, Alshehri D, Jamaan A, Nasser I, Alaamri H, et al. Obesity and childhood asthma in male schoolchildren in Saudi Arabia: Is there a role for leptin, interleukin-4, interleukin-5, and interleukin-21?. Ann Saudi Med. 2019;39:295-301 pubmed publisher
Yu H, Cui S, Mei Y, Li Q, Wu L, Duan S, et al. Mesangial Cells Exhibit Features of Antigen-Presenting Cells and Activate CD4+ T Cell Responses. J Immunol Res. 2019;2019:2121849 pubmed publisher
Sun T, Ju M, Dai X, Dong H, Gu W, Gao Y, et al. Multilevel defects in the hematopoietic niche in essential thrombocythemia. Haematologica. 2020;105:661-673 pubmed publisher
Osuji F, Onyenekwe C, Ahaneku J, Ukibe N. The effects of highly active antiretroviral therapy on the serum levels of pro-inflammatory and anti-inflammatory cytokines in HIV infected subjects. J Biomed Sci. 2018;25:88 pubmed publisher
Stanciu A, Stanciu M, Vatasescu R. NT-proBNP and CA 125 levels are associated with increased pro-inflammatory cytokines in coronary sinus serum of patients with chronic heart failure. Cytokine. 2018;111:13-19 pubmed publisher
Rajamanickam A, Munisankar S, Bhootra Y, Dolla C, Thiruvengadam K, Nutman T, et al. Altered levels of memory T cell subsets and common γc cytokines in Strongyloides stercoralis infection and partial reversal following anthelmintic treatment. PLoS Negl Trop Dis. 2018;12:e0006481 pubmed publisher
Sowa P, Misiolek M, Pasinski B, Bartosz G, Soszynski M, Adamczyk Sowa M, et al. Oxidative Stress Markers Patients with Parotid Gland Tumors: A Pilot Study. Biomed Res Int. 2018;2018:4340871 pubmed publisher
Bayık D, Tross D, Klinman D. Factors Influencing the Differentiation of Human Monocytic Myeloid-Derived Suppressor Cells Into Inflammatory Macrophages. Front Immunol. 2018;9:608 pubmed publisher
Jordakieva G, Grabovac I, Valic E, Schmidt K, Graff A, Schuster A, et al. Occupational exposure to ultrafine particles in police officers: no evidence for adverse respiratory effects. J Occup Med Toxicol. 2018;13:5 pubmed publisher
Johdi N, Mazlan L, Sagap I, Jamal R. Profiling of cytokines, chemokines and other soluble proteins as a potential biomarker in colorectal cancer and polyps. Cytokine. 2017;99:35-42 pubmed publisher
Ribeiro V, Romão Veiga M, Romagnoli G, Matias M, Nunes P, Borges V, et al. Association between cytokine profile and transcription factors produced by T-cell subsets in early- and late-onset pre-eclampsia. Immunology. 2017;152:163-173 pubmed publisher
Dijkstra D, Meyer Bahlburg A. Human Basophils Modulate Plasma Cell Differentiation and Maturation. J Immunol. 2017;198:229-238 pubmed
Bu X, Zhang T, Wang C, Ren T, Wen Z. IL-33 reflects dynamics of disease activity in patients with autoimmune hemolytic anemia by regulating autoantibody production. J Transl Med. 2015;13:381 pubmed publisher
Magrinelli F, Briani C, Romano M, Ruggero S, Toffanin E, Triolo G, et al. The Association between Serum Cytokines and Damage to Large and Small Nerve Fibers in Diabetic Peripheral Neuropathy. J Diabetes Res. 2015;2015:547834 pubmed publisher
Aderhold C, Grobschmidt G, Sauter A, Faber A, Hormann K, Schultz J. Interleukin 4, interleukin 6 and osteopontin-serological markers of head and neck malignancy in primary diagnostics: A pilot study. Oncol Lett. 2014;8:1112-1118 pubmed
Zhang Y, Chen H, Sun C, Wang H, Liu M, Li Y, et al. Expression and functional characterization of NOD2 in decidual stromal cells isolated during the first trimester of pregnancy. PLoS ONE. 2014;9:e99612 pubmed publisher
Jun H, Weinstein D, Lee Y, Mansfield B, Chou J. Molecular mechanisms of neutrophil dysfunction in glycogen storage disease type Ib. Blood. 2014;123:2843-53 pubmed publisher
Biancheri P, Di Sabatino A, Ammoscato F, Facciotti F, Caprioli F, Curciarello R, et al. Absence of a role for interleukin-13 in inflammatory bowel disease. Eur J Immunol. 2014;44:370-85 pubmed publisher
Hussein Y, El Shal A, Rezk N, Abdel Galil S, Alzahrani S. Influence of interleukin-4 gene polymorphisms and interleukin-4 serum level on susceptibility and severity of rheumatoid arthritis in Egyptian population. Cytokine. 2013;61:849-55 pubmed publisher
Song W, Tai Y, Tian Z, Hideshima T, Chauhan D, Nanjappa P, et al. HDAC inhibition by LBH589 affects the phenotype and function of human myeloid dendritic cells. Leukemia. 2011;25:161-8 pubmed publisher
Beziat V, Nguyen S, Exley M, Achour A, Simon T, Chevallier P, et al. Shaping of iNKT cell repertoire after unrelated cord blood transplantation. Clin Immunol. 2010;135:364-73 pubmed publisher
Mabilleau G, Sabokbar A. Interleukin-32 promotes osteoclast differentiation but not osteoclast activation. PLoS ONE. 2009;4:e4173 pubmed publisher
Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, et al. IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response. J Allergy Clin Immunol. 2009;123:59-66.e4 pubmed publisher
Yokoi T, Amakawa R, Tanijiri T, Sugimoto H, Torii Y, Amuro H, et al. Mycobacterium bovis Bacillus Calmette-Guérin suppresses inflammatory Th2 responses by inducing functional alteration of TSLP-activated dendritic cells. Int Immunol. 2008;20:1321-9 pubmed publisher
Miller R, Sadhukhan R, Wu C. Development of an in vitro potency bioassay for therapeutic IL-13 antagonists: the A-549 cell bioassay. J Immunol Methods. 2008;334:134-41 pubmed publisher
Liu T, Uemura Y, Suzuki M, Narita Y, Hirata S, Ohyama H, et al. Distinct subsets of human invariant NKT cells differentially regulate T helper responses via dendritic cells. Eur J Immunol. 2008;38:1012-23 pubmed publisher
Miller M, Ramsdell J, Friedman P, Cho J, Renvall M, Broide D. Computed tomographic scan-diagnosed chronic obstructive pulmonary disease-emphysema: eotaxin-1 is associated with bronchodilator response and extent of emphysema. J Allergy Clin Immunol. 2007;120:1118-25 pubmed
Vidyarani M, Selvaraj P, Jawahar M, Narayanan P. 1, 25 Dihydroxyvitamin D3 modulated cytokine response in pulmonary tuberculosis. Cytokine. 2007;40:128-34 pubmed
Lin Y, Liang Y, Chiang B. Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells. J Leukoc Biol. 2007;82:1473-80 pubmed
Sadeghi M, Süsal C, Daniel V, Naujokat C, Zimmermann R, Huth Kühne A, et al. Short communication: decreasing soluble CD30 and increasing IFN-gamma plasma levels are indicators of effective highly active antiretroviral therapy. AIDS Res Hum Retroviruses. 2007;23:886-90 pubmed
Karrar A, Broome U, Uzunel M, Qureshi A, Sumitran Holgersson S. Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction. Gut. 2007;56:243-52 pubmed
Yoshikawa H, Sato K, Edahiro S, Furukawa Y, Maruta T, Iwasa K, et al. Elevation of IL-12 p40 and its antibody in myasthenia gravis with thymoma. J Neuroimmunol. 2006;175:169-75 pubmed
Ehling A, Schaffler A, Herfarth H, Tarner I, Anders S, Distler O, et al. The potential of adiponectin in driving arthritis. J Immunol. 2006;176:4468-78 pubmed
Hartl D, Latzin P, Zissel G, Krane M, Krauss Etschmann S, Griese M. Chemokines indicate allergic bronchopulmonary aspergillosis in patients with cystic fibrosis. Am J Respir Crit Care Med. 2006;173:1370-6 pubmed
Sheikine Y, Olsen B, Gharizadeh B, Jatta K, Tornvall P, Ghaderi M. Influence of eotaxin 67G>A polymorphism on plasma eotaxin concentrations in myocardial infarction survivors and healthy controls. Atherosclerosis. 2006;189:458-63 pubmed
Sheikine Y, Bang C, Nilsson L, Samnegard A, Hamsten A, Jonasson L, et al. Decreased plasma CXCL16/SR-PSOX concentration is associated with coronary artery disease. Atherosclerosis. 2006;188:462-6 pubmed
Kristjansson S, Bjarnarson S, Wennergren G, Palsdottir A, Arnadottir T, Haraldsson A, et al. Respiratory syncytial virus and other respiratory viruses during the first 3 months of life promote a local TH2-like response. J Allergy Clin Immunol. 2005;116:805-11 pubmed
Mistchenko A, Fornari M, Viegas M, Barrero P, Diez R. Detection of interleukin 10 in cerebrospinal fluid of patients with subacute sclerosing panencephalitis. J Neurovirol. 2005;11:66-9 pubmed
Takei M, Umeyama A, Arihara S, Matsumoto H. Effect of piceatannol in human monocyte-derived dendritic cells in vitro. J Pharm Sci. 2005;94:974-82 pubmed
Huang J, Huang J, Duan Z, Wei J, Min J, Luo X, et al. Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome. Microbes Infect. 2005;7:427-36 pubmed
Ciprandi G, Tosca M, Milanese M, Caligo G, Ricca V. Cytokines evaluation in nasal lavage of allergic children after Bacillus clausii administration: a pilot study. Pediatr Allergy Immunol. 2004;15:148-51 pubmed
Basu S, Aballa T, Ferrell S, Lynne C, Brackett N. Inflammatory cytokine concentrations are elevated in seminal plasma of men with spinal cord injuries. J Androl. 2004;25:250-4 pubmed
Giunti D, Borsellino G, Benelli R, Marchese M, Capello E, Valle M, et al. Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS. J Leukoc Biol. 2003;73:584-90 pubmed
Dagna L, Iellem A, Biswas P, Resta D, Tantardini F, Fortis C, et al. Skewing of cytotoxic activity and chemokine production, but not of chemokine receptor expression, in human type-1/-2 gamma delta T lymphocytes. Eur J Immunol. 2002;32:2934-43 pubmed
Marme A, Strauss G, Bastert G, Grischke E, Moldenhauer G. Intraperitoneal bispecific antibody (HEA125xOKT3) therapy inhibits malignant ascites production in advanced ovarian carcinoma. Int J Cancer. 2002;101:183-9 pubmed
Cotler S, Reddy K, McCone J, Wolfe D, Liu A, Craft T, et al. An analysis of acute changes in interleukin-6 levels after treatment of hepatitis C with consensus interferon. J Interferon Cytokine Res. 2001;21:1011-9 pubmed
Albanesi C, Scarponi C, Sebastiani S, Cavani A, Federici M, Sozzani S, et al. A cytokine-to-chemokine axis between T lymphocytes and keratinocytes can favor Th1 cell accumulation in chronic inflammatory skin diseases. J Leukoc Biol. 2001;70:617-23 pubmed
Kadowaki N, Antonenko S, Lau J, Liu Y. Natural interferon alpha/beta-producing cells link innate and adaptive immunity. J Exp Med. 2000;192:219-26 pubmed
Petitto J, Leserman J, Perkins D, Stern R, Silva S, Gettes D, et al. High versus low basal cortisol secretion in asymptomatic, medication-free HIV-infected men: differential effects of severe life stress on parameters of immune status. Behav Med. 2000;25:143-51 pubmed
product information
master code :
D4050
SKU :
D4050
product name :
Human IL-4 Quantikine ELISA Kit
unit size :
1 Kit (also 1 Pack (50 Plates), 1 Pack (6 Plates))
description :
The Human IL-4 Quantikine ELISA Kit from R&D Systems is a Solid Phase Sandwich ELISA that quantifies human IL-4 in cell culture supernates (50 ul), serum (50 ul), edta plasma (50 ul), heparin plasma (50 ul), citrate plasma (50 ul).
target :
IL-4
category :
ELISAs
species :
Human
specificity :
Natural and recombinant human IL-4
gene symbol :
IL4
kit type :
Solid Phase Sandwich ELISA
assay length :
4.5 hours
elisaSampleTypes :
Cell Culture Supernates (50 uL), Serum (50 uL), EDTA Plasma (50 uL), Heparin Plasma (50 uL), Citrate Plasma (50 uL)
elisaSensitivity :
10 pg/mL
elisaRange :
31.20 - 2000 pg/mL
top caption :
Human IL-4 ELISA Cell Culture Supernate Standard Curve
applications :
ELISA
USD :
655 USD
product details :
The Quantikine Human IL-4 Immunoassay is a 4.5 hour solid phase ELISA designed to measure IL-4 levels in cell culture supernates, serum, and plasma. It contains E. coli -expressed recombinant human IL-4 and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant human IL-4 accurately. Results obtained using natural human IL-4 showed dose-response curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human IL-4.
alt names :
B cell growth factor 1, BCDF, B-cell stimulatory factor 1, BCGF1, BCGF-1, binetrakin, BSF1, BSF-1, IL4, IL-4B_cell stimulatory factor 1, IL4E12, interleukin 4, interleukin-4, Lymphocyte stimulatory factor 1, MGC79402, Pitrakinra
storage :
Store the unopened product at 2 - 8 ░C. Do not use past expiration date.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.