product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human IL-18/IL-1F4 Antibody
catalog :
D043-3
quantity :
100 ug
price :
449 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
25-2G
reactivity :
human
application :
western blot, immunohistochemistry, immunohistochemistry - frozen section
more info or order :
R&D Systems product webpage
citations: 10
Reference
Saha A, Islam M, Kumar R, Ismail A, Garcia E, Gullapali R, et al. Virus and Cell Specific HMGB1 Secretion and Subepithelial Infiltrate Formation in Adenovirus Keratitis. bioRxiv. 2025;: pubmed publisher
Saetang J, Roongsawang N, Sangkhathat S, Voravuthikunchai S, Sangkaew N, Prompat N, et al. Surface cysteine to serine substitutions in IL-18 reduce aggregation and enhance activity. Peerj. 2022;10:e13626 pubmed publisher
Fan Y, Zhang X, Yang L, Wang J, Hu Y, Bian A, et al. Zinc inhibits high glucose-induced NLRP3 inflammasome activation in human peritoneal mesothelial cells. Mol Med Rep. 2017;16:5195-5202 pubmed publisher
Zhang M, Qi Y, Li H, Cui J, Dai L, Frank J, et al. AIM2 inflammasome mediates Arsenic-induced secretion of IL-1 ? and IL-18. Oncoimmunology. 2016;5:e1160182 pubmed publisher
Somanna N, Valente A, Krenz M, McDonald K, Higashi Y, Noda M, et al. Histone deacetyltransferase inhibitors Trichostatin A and Mocetinostat differentially regulate MMP9, IL-18 and RECK expression, and attenuate Angiotensin II-induced cardiac fibroblast migration and proliferation. Hypertens Res. 2016;39:709-716 pubmed publisher
Somanna N, Valente A, Krenz M, Fay W, Delafontaine P, Chandrasekar B. The Nox1/4 Dual Inhibitor GKT137831 or Nox4 Knockdown Inhibits Angiotensin-II-Induced Adult Mouse Cardiac Fibroblast Proliferation and Migration. AT1 Physically Associates With Nox4. J Cell Physiol. 2016;231:1130-41 pubmed publisher
Valente A, Yoshida T, Izadpanah R, Delafontaine P, Siebenlist U, Chandrasekar B. Interleukin-18 enhances IL-18R/Nox1 binding, and mediates TRAF3IP2-dependent smooth muscle cell migration. Inhibition by simvastatin. Cell Signal. 2013;25:1447-56 pubmed publisher
Venkatesan B, Valente A, Reddy V, Siwik D, Chandrasekar B. Resveratrol blocks interleukin-18-EMMPRIN cross-regulation and smooth muscle cell migration. Am J Physiol Heart Circ Physiol. 2009;297:H874-86 pubmed publisher
Piskin G, Tursen U, Sylva Steenland R, Bos J, Teunissen M. Clinical improvement in chronic plaque-type psoriasis lesions after narrow-band UVB therapy is accompanied by a decrease in the expression of IFN-gamma inducers -- IL-12, IL-18 and IL-23. Exp Dermatol. 2004;13:764-72 pubmed
Hessian P, Highton J, Kean A, Sun C, Chin M. Cytokine profile of the rheumatoid nodule suggests that it is a Th1 granuloma. Arthritis Rheum. 2003;48:334-8 pubmed
product information
master code :
D043-3
SKU :
D043-3
product name :
Human IL-18/IL-1F4 Antibody
unit size :
100 ug
description :
The Human IL-18/IL-1F4 Antibody from R&D Systems is a mouse monoclonal antibody to IL-18/IL-1F4. This antibody reacts with human. The Human IL-18/IL-1F4 Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,Immunohistochemistry-Frozen.
target :
IL-18/IL-1F4
category :
Primary Antibodies
buffer :
This antibody is in lyophilized form. After reconstitution, IgG concentration should be 1 mg/mL in PBS (pH 7.2)/1% sucrose. Contains no preservatives.
clonality :
Monoclonal
clone :
25-2G
conjugate :
Unconjugated
host :
Mouse
immunogen :
Human IL-18/IL-1F4
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human
specificity :
This antibody reacts with human IL-18 on Western blotting.
gene symbol :
IL18
applications :
Western Blot,Immunohistochemistry,Immunohistochemistry-Frozen
USD :
449 USD
alt names :
Iboctadekin, IFN-gamma-inducing factor, IGIF, IGIFIL-1 gamma, IL18, IL-18MGC12320, IL-1F4, IL1F4iboctadekin, IL-1g, Interferon gamma-inducing factor, interleukin 18 (interferon-gamma-inducing factor), Interleukin-1 gamma, interleukin-18
storage :
This antibody is stable for one year from the date of purchase when stored at 4░C. After reconstitution, avoid repeated freezing and thawing. For storage, prepare appropriate aliquots and freeze at -20░C.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.