product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human CD31/PECAM-1 Antibody
catalog :
BBA7
quantity :
100 ug
price :
459 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
9G11
reactivity :
human, mouse, rat, rhesus macaque
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 63
Reference
Vazana Netzarim R, Elmalem Y, Sofer S, Bruck H, Danino N, Sarig U. Distinct HAND2/HAND2-AS1 Expression Levels May Fine-Tune Mesenchymal and Epithelial Cell Plasticity of Human Mesenchymal Stem Cells. Int J Mol Sci. 2023;24: pubmed publisher
McQueen L, Ladak S, Layton G, Wadey K, George S, Angelini G, et al. Osteopontin Activation and Microcalcification in Venous Grafts Can Be Modulated by Dexamethasone. Cells. 2023;12: pubmed publisher
Fayed H, Bakleh M, Ashraf J, Howarth A, Ebner D, Al Haj Zen A. Selective ROCK Inhibitor Enhances Blood Flow Recovery after Hindlimb Ischemia. Int J Mol Sci. 2023;24: pubmed publisher
Nakamura Y, Shimizu Y, Fujimaki Shiraishi M, Uchida N, Takemasa A, Niho S. A Protective Effect of Pirfenidone in Lung Fibroblast-Endothelial Cell Network via Inhibition of Rho-Kinase Activity. Biomedicines. 2023;11: pubmed publisher
Chen Y, Chauhan S, Gong C, Dayton H, Xu C, De La Cruz E, et al. Scalable projected Light Sheet Microscopy for high-resolution imaging of living and cleared samples. bioRxiv. 2023;: pubmed publisher
Thakar M, Noumbissi M, Stins M. Microvascular Environment Influences Brain Microvascular Heterogeneity: Relative Roles of Astrocytes and Oligodendrocytes for the EPCR Expression in the Brain Endothelium. Int J Mol Sci. 2023;24: pubmed publisher
Park S, Kook M, Kim S, Lee J, Park C, Oh B, et al. Development of cell-laden multimodular Lego-like customizable endometrial tissue assembly for successful tissue regeneration. Biomater Res. 2023;27:33 pubmed publisher
Johnson S, Karpova Y, Guo D, Ghatak A, Markov D, Tulin A. PARG suppresses tumorigenesis and downregulates genes controlling angiogenesis, inflammatory response, and immune cell recruitment. BMC Cancer. 2022;22:557 pubmed publisher
Nawrot D, Ozer L, Al Haj Zen A. A Novel High Content Angiogenesis Assay Reveals That Lacidipine, L-Type Calcium Channel Blocker, Induces In Vitro Vascular Lumen Expansion. Int J Mol Sci. 2022;23: pubmed publisher
Ye L, Liu Y, Zhu X, Duan T, Wang C, Fu X, et al. Digital Spatial Profiling of Individual Glomeruli From Patients With Anti-Neutrophil Cytoplasmic Autoantibody-Associated Glomerulonephritis. Front Immunol. 2022;13:831253 pubmed publisher
Jaeschke A, Eckert H, Bray L. Qiber3D-an open-source software package for the quantitative analysis of networks from 3D image stacks. Gigascience. 2022;11: pubmed publisher
Saito N, Shirado T, Funabashi Eto H, Wu Y, Mori M, Asahi R, et al. Purification and characterization of human adipose-resident microvascular endothelial progenitor cells. Sci Rep. 2022;12:1775 pubmed publisher
Sun X, Perl A, Li R, Bell S, Sajti E, Kalinichenko V, et al. A census of the lung: CellCards from LungMAP. Dev Cell. 2022;57:112-145.e2 pubmed publisher
Zhang Z, Na H, Gan Q, Tao Q, Alekseyev Y, Hu J, et al. Monomeric C-reactive protein via endothelial CD31 for neurovascular inflammation in an ApoE genotype-dependent pattern: A risk factor for Alzheimer's disease?. Aging Cell. 2021;20:e13501 pubmed publisher
Urbantat R, Jelgersma C, Brandenburg S, Nieminen Kelhä M, Kremenetskaia I, Zollfrank J, et al. Tumor-Associated Microglia/Macrophages as a Predictor for Survival in Glioblastoma and Temozolomide-Induced Changes in CXCR2 Signaling with New Resistance Overcoming Strategy by Combination Therapy. Int J Mol Sci. 2021;22: pubmed publisher
Dayton J, Yuan Y, Pacumio L, Dorflinger B, Yoo S, Olson M, et al. Expression of IL-20 Receptor Subunit β Is Linked to EAE Neuropathology and CNS Neuroinflammation. Front Cell Neurosci. 2021;15:683687 pubmed publisher
Wacker M, Riedel J, Walles H, Scherner M, Awad G, Varghese S, et al. Comparative Evaluation on Impacts of Fibronectin, Heparin-Chitosan, and Albumin Coating of Bacterial Nanocellulose Small-Diameter Vascular Grafts on Endothelialization In Vitro. Nanomaterials (Basel). 2021;11: pubmed publisher
Wang W, Sindrewicz Goral P, Chen C, Duckworth C, Pritchard D, Rhodes J, et al. Appearance of peanut agglutinin in the blood circulation after peanut ingestion promotes endothelial secretion of metastasis-promoting cytokines. Carcinogenesis. 2021;42:1079-1088 pubmed publisher
Goel K, Beatman E, Egersdorf N, Scruggs A, Cao D, Berdyshev E, et al. Sphingosine 1 Phosphate (S1P) Receptor 1 Is Decreased in Human Lung Microvascular Endothelial Cells of Smokers and Mediates S1P Effect on Autophagy. Cells. 2021;10: pubmed publisher
Roy Chowdhury U, Bahler C, Hann C, Holman B, Fautsch M. Isolation and characterization of novel primary cells from the human distal outflow pathway. Sci Rep. 2021;11:4034 pubmed publisher
Santos R, Asensi K, de Barros J, de Menezes R, Cordeiro I, Neto J, et al. Intrinsic Angiogenic Potential and Migration Capacity of Human Mesenchymal Stromal Cells Derived from Menstrual Blood and Bone Marrow. Int J Mol Sci. 2020;21: pubmed publisher
Uchimura K, Wu H, Yoshimura Y, Humphreys B. Human Pluripotent Stem Cell-Derived Kidney Organoids with Improved Collecting Duct Maturation and Injury Modeling. Cell Rep. 2020;33:108514 pubmed publisher
Manferdini C, Saleh Y, Dolzani P, Gabusi E, Trucco D, Filardo G, et al. Impact of Isolation Procedures on the Development of a Preclinical Synovial Fibroblasts/Macrophages in an In Vitro Model of Osteoarthritis. Biology (Basel). 2020;9: pubmed publisher
Qi L, Wu K, Shi S, Ji Q, Miao H, Bin Q. Thrombospondin-2 is upregulated in patients with aortic dissection and enhances angiotensin II-induced smooth muscle cell apoptosis. Exp Ther Med. 2020;20:150 pubmed publisher
Villota S, Toledo Rodriguez M, Leach L. Compromised barrier integrity of human feto-placental vessels from gestational diabetic pregnancies is related to downregulation of occludin expression. Diabetologia. 2021;64:195-210 pubmed publisher
Faulkner A, Tamiato A, Cathery W, Rampin A, Caravaggi C, Jover E, et al. Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus. Diabetologia. 2020;63:2205-2217 pubmed publisher
Mori N, Akagi Y, Imai Y, Takayama Y, Kida Y. Fabrication of Perfusable Vascular Channels and Capillaries in 3D Liver-like Tissue. Sci Rep. 2020;10:5646 pubmed publisher
Assaly R, Giuliano F, Clement P, Laurin M, Favier M, Teo P, et al. Extracorporeal Shock Waves Therapy Delivered by Aries Improves Erectile Dysfunction in Spontaneously Hypertensive Rats Through Penile Tissue Remodeling and Neovascularization. Sex Med. 2019;7:441-450 pubmed publisher
Tsutsumi T, Nagaoka T, Yoshida T, Wang L, Kuriyama S, Suzuki Y, et al. Nintedanib ameliorates experimental pulmonary arterial hypertension via inhibition of endothelial mesenchymal transition and smooth muscle cell proliferation. PLoS ONE. 2019;14:e0214697 pubmed publisher
Spiegler S, Rath M, Much C, Sendtner B, Felbor U. Precise CCM1 gene correction and inactivation in patient-derived endothelial cells: Modeling Knudson's two-hit hypothesis in vitro. Mol Genet Genomic Med. 2019;7:e00755 pubmed publisher
Luzuriaga J, Pastor Alonso O, Encinas J, Unda F, Ibarretxe G, Pineda J. Human Dental Pulp Stem Cells Grown in Neurogenic Media Differentiate Into Endothelial Cells and Promote Neovasculogenesis in the Mouse Brain. Front Physiol. 2019;10:347 pubmed publisher
Dayton J, Franke M, Yuan Y, Cruz Orengo L. Straightforward method for singularized and region-specific CNS microvessels isolation. J Neurosci Methods. 2019;318:17-33 pubmed publisher
Gandhi J, Knudsen T, Hill M, Roy B, Bachman L, Pfannkoch Andrews C, et al. Human Fibrinogen for Maintenance and Differentiation of Induced Pluripotent Stem Cells in Two Dimensions and Three Dimensions. Stem Cells Transl Med. 2019;8:512-521 pubmed publisher
Pattanaik S, Arbra C, Bainbridge H, Dennis S, Fann S, Yost M. Vascular Tissue Engineering Using Scaffold-Free Prevascular Endothelial-Fibroblast Constructs. Biores Open Access. 2019;8:1-15 pubmed publisher
Ecklu Mensah G, Olsen R, Bengtsson A, Ofori M, Hviid L, Jensen A, et al. Blood outgrowth endothelial cells (BOECs) as a novel tool for studying adhesion of Plasmodium falciparum-infected erythrocytes. PLoS ONE. 2018;13:e0204177 pubmed publisher
Stephens C, Orr K, Acton A, Tersey S, Mirmira R, Considine R, et al. In situ type I oligomeric collagen macroencapsulation promotes islet longevity and function in vitro and in vivo. Am J Physiol Endocrinol Metab. 2018;315:E650-E661 pubmed publisher
Gurevich D, Severn C, Twomey C, Greenhough A, Cash J, Toye A, et al. Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression. EMBO J. 2018;37: pubmed publisher
Li S, Nih L, Bachman H, Fei P, Li Y, Nam E, et al. Hydrogels with precisely controlled integrin activation dictate vascular patterning and permeability. Nat Mater. 2017;16:953-961 pubmed publisher
Shimizu F, Schaller K, Owens G, Cotleur A, Kellner D, Takeshita Y, et al. Glucose-regulated protein 78 autoantibody associates with blood-brain barrier disruption in neuromyelitis optica. Sci Transl Med. 2017;9: pubmed publisher
Morgan K, Sklaviadis D, Tochka Z, Fischer K, Hearon K, Morgan T, et al. Multi-Material Tissue Engineering Scaffold with Hierarchical Pore Architecture. Adv Funct Mater. 2016;26:5873-5883 pubmed
Ebrahim N, Leach L. Transendothelial migration of human umbilical mesenchymal stem cells across uterine endothelial monolayers: Junctional dynamics and putative mechanisms. Placenta. 2016;48:87-98 pubmed publisher
Barruet E, Morales B, Lwin W, White M, Theodoris C, Kim H, et al. The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling. Stem Cell Res Ther. 2016;7:115 pubmed publisher
Srivastava S, Shi S, Kanasaki M, Nagai T, Kitada M, He J, et al. Effect of Antifibrotic MicroRNAs Crosstalk on the Action of N-acetyl-seryl-aspartyl-lysyl-proline in Diabetes-related Kidney Fibrosis. Sci Rep. 2016;6:29884 pubmed publisher
Chen Y, Lu L, Shao J. Endothelial Surface Protrusion by a Point Force. Biophys J. 2016;110:1150-7 pubmed publisher
Sreekanthreddy P, Gromnicova R, Davies H, Phillips J, Romero I, Male D. A three-dimensional model of the human blood-brain barrier to analyse the transport of nanoparticles and astrocyte/endothelial interactions. F1000Res. 2015;4:1279 pubmed publisher
Lepelletier F, Mann D, Robinson A, Pinteaux E, Boutin H. Early changes in extracellular matrix in Alzheimer's disease. Neuropathol Appl Neurobiol. 2017;43:167-182 pubmed publisher
Ishikawa T, Takizawa T, Iwaki J, Mishima T, Ui Tei K, Takeshita T, et al. Fc gamma receptor IIb participates in maternal IgG trafficking of human placental endothelial cells. Int J Mol Med. 2015;35:1273-89 pubmed publisher
Weston C, Shepherd E, Claridge L, Rantakari P, Curbishley S, Tomlinson J, et al. Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis. J Clin Invest. 2015;125:501-20 pubmed publisher
Martinelli R, Zeiger A, Whitfield M, Sciuto T, Dvorak A, Van Vliet K, et al. Probing the biomechanical contribution of the endothelium to lymphocyte migration: diapedesis by the path of least resistance. J Cell Sci. 2014;127:3720-34 pubmed publisher
Liu T, Zhang X, Zhang J, Liang Z, Cai W, Huang M, et al. Association between PON1 rs662 polymorphism and coronary artery disease. Eur J Clin Nutr. 2014;68:1029-35 pubmed publisher
Kanasaki K, Shi S, Kanasaki M, He J, Nagai T, Nakamura Y, et al. Linagliptin-mediated DPP-4 inhibition ameliorates kidney fibrosis in streptozotocin-induced diabetic mice by inhibiting endothelial-to-mesenchymal transition in a therapeutic regimen. Diabetes. 2014;63:2120-31 pubmed publisher
Berger S, Turner L, Wang C, Petersen J, Kraft M, Lusingu J, et al. Plasmodium falciparum expressing domain cassette 5 type PfEMP1 (DC5-PfEMP1) bind PECAM1. PLoS ONE. 2013;8:e69117 pubmed publisher
Turner L, Lavstsen T, Berger S, Wang C, Petersen J, Avril M, et al. Severe malaria is associated with parasite binding to endothelial protein C receptor. Nature. 2013;498:502-5 pubmed publisher
Napione L, Strasly M, Meda C, Mitola S, Alvaro M, Doronzo G, et al. IL-12-dependent innate immunity arrests endothelial cells in G0-G1 phase by a p21(Cip1/Waf1)-mediated mechanism. Angiogenesis. 2012;15:713-25 pubmed publisher
Jensen B, Swigart P, Montgomery M, Simpson P. Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2010;382:475-82 pubmed publisher
Williamson M, Shuttleworth A, Canfield A, Black R, Kielty C. The role of endothelial cell attachment to elastic fibre molecules in the enhancement of monolayer formation and retention, and the inhibition of smooth muscle cell recruitment. Biomaterials. 2007;28:5307-18 pubmed
Dentelli P, Rosso A, Balsamo A, Colmenares Benedetto S, Zeoli A, Pegoraro M, et al. C-KIT, by interacting with the membrane-bound ligand, recruits endothelial progenitor cells to inflamed endothelium. Blood. 2007;109:4264-71 pubmed
Neria F, Caramelo C, Peinado H, Gonzalez Pacheco F, Deudero J, De Solis A, et al. Mechanisms of endothelial cell protection by blockade of the JAK2 pathway. Am J Physiol Cell Physiol. 2007;292:C1123-31 pubmed
Manchio J, Gu J, Romar L, Brown J, Gammie J, Pierson R, et al. Disruption of graft endothelium correlates with early failure after off-pump coronary artery bypass surgery. Ann Thorac Surg. 2005;79:1991-8 pubmed
Carman C, Springer T. A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them. J Cell Biol. 2004;167:377-88 pubmed
Wei H, Song J, Fang L, Li G, Chatterjee S. Identification of a novel transcript of human PECAM-1 and its role in the transendothelial migration of monocytes and Ca2+ mobilization. Biochem Biophys Res Commun. 2004;320:1228-35 pubmed
Satchell S, Anderson K, Mathieson P. Angiopoietin 1 and vascular endothelial growth factor modulate human glomerular endothelial cell barrier properties. J Am Soc Nephrol. 2004;15:566-74 pubmed
Gomez D, Reich N. Stimulation of primary human endothelial cell proliferation by IFN. J Immunol. 2003;170:5373-81 pubmed
product information
brand :
R&D Systems
master code :
BBA7
SKU :
BBA7
product name :
Human CD31/PECAM-1 Antibody
unit size :
100 ug
seo description :
The Human CD31/PECAM-1 Antibody from R&D Systems is a mouse monoclonal antibody to CD31/PECAM-1. This antibody reacts with human,mouse,porcine,primate - macaca mulatta (rhesus macaque),rat. The Human CD31/PECAM-1 Antibody has been validated for the following applications: Immunocytochemistry,Immunohistochemistry,Bioassay,Flow Cytometry,Western Blot,Functional Assay,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunofluorescence,Immunocytochemistry/ Immunofluorescence,Immunoprecipitation,Knockout Validated.
target :
CD31/PECAM-1
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose.
clonality :
Monoclonal
clone :
9G11
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 1 ug/mL, Immunohistochemistry 5-25 ug/mL, Immunoprecipitation, Immunocytochemistry 8-25 ug/mL, Knockout Validated 8-25 ug/mL
host :
Mouse
immunogen :
Activated HUVEC human umbilical vein endothelial cells
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse,Porcine,Primate - Macaca mulatta (Rhesus Macaque),Rat
specificity :
Detects human CD31/PEACAM-1. In Western blots, no cross-reactivity with recombinant human (rh) E-Selectin, rhICAM-1, -2, -3, rhVCAM-1, or recombinant mouse VCAM-1 was observed.
gene symbol :
PECAM1
top caption :
Detection of Human CD31/PECAM-1 antibody by Western Blot.
applications :
Immunoprecipitation,Knockout Validated,Bioassay,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunofluorescence,Immunocytochemistry,Functional Assay,Immunocytochemistry/ Immunofluorescence
USD :
459 USD
alt names :
adhesion molecule, CD31, CD31 antigen, CD31/EndoCAM, EndoCAM, FLJ34100, FLJ58394, GPIIA', PECA1, PECAM1, PECAM-1, PECAM-1, CD31/EndoCAM, platelet endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1, platelet/endothelial cell adhesion molecule
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.