Human Integrin alpha 4/CD49d Antibody | R&D Systems BBA37 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Integrin alpha 4/CD49d Antibody

catalog :

BBA37

quantity :

200 ug

price :

519 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2B4

reactivity :

human, mouse

application :

immunocytochemistry, neutralization, flow cytometry

more info or order :

R&D Systems product webpage

citations: 11

Reference
Lertjuthaporn S, Cicala C, Van Ryk D, Liu M, Yolitz J, Wei D, et al. Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7. PLoS Pathog. 2018;14:e1007278 pubmed publisher
Kebir H, Carmant L, Fontaine F, Beland K, Bosoi C, Sanon N, et al. Humanized mouse model of Rasmussen's encephalitis supports the immune-mediated hypothesis. J Clin Invest. 2018;128:2000-2009 pubmed publisher
Kobori T, Hamasaki S, Kitaura A, Yamazaki Y, Nishinaka T, Niwa A, et al. Interleukin-18 Amplifies Macrophage Polarization and Morphological Alteration, Leading to Excessive Angiogenesis. Front Immunol. 2018;9:334 pubmed publisher
Vogel M, Idelman G, Konaniah E, Zucker S. Bilirubin Prevents Atherosclerotic Lesion Formation in Low-Density Lipoprotein Receptor-Deficient Mice by Inhibiting Endothelial VCAM-1 and ICAM-1 Signaling. J Am Heart Assoc. 2017;6: pubmed publisher
Yoon S, Lee I, Zhang X, Zapata M, Choi Y. CD9 may contribute to the survival of human germinal center B cells by facilitating the interaction with follicular dendritic cells. FEBS Open Bio. 2014;4:370-6 pubmed publisher
Kang I, Yoon D, Braun K, Wight T. Expression of versican V3 by arterial smooth muscle cells alters tumor growth factor ? (TGF?)-, epidermal growth factor (EGF)-, and nuclear factor ?B (NF?B)-dependent signaling pathways, creating a microenvironment that resists monocyte adhesion. J Biol Chem. 2014;289:15393-404 pubmed publisher
Jelicic K, Cimbro R, Nawaz F, Huang D, Zheng X, Yang J, et al. The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-Î²1 production and FcRL4 expression. Nat Immunol. 2013;14:1256-65 pubmed publisher
Ludwig R, Hardt K, Hatting M, Bistrian R, Diehl S, Radeke H, et al. Junctional adhesion molecule (JAM)-B supports lymphocyte rolling and adhesion through interaction with alpha4beta1 integrin. Immunology. 2009;128:196-205 pubmed publisher
Riou S, Mees B, Esposito B, Merval R, Vilar J, Stengel D, et al. High pressure promotes monocyte adhesion to the vascular wall. Circ Res. 2007;100:1226-33 pubmed
Abe Y, Fornage M, Yang C, Bui Thanh N, Wise V, Chen H, et al. L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesion. Atherosclerosis. 2007;192:56-66 pubmed
Bug G, Rossmanith T, Henschler R, Kunz Schughart L, Schroder B, Kampfmann M, et al. Rho family small GTPases control migration of hematopoietic progenitor cells into multicellular spheroids of bone marrow stroma cells. J Leukoc Biol. 2002;72:837-45 pubmed

product information

brand :

R&D Systems

master code :

BBA37

SKU :

BBA37

product name :

Human Integrin alpha 4/CD49d Antibody

unit size :

200 ug

seo description :

The Human Integrin alpha 4/CD49d Antibody from R&D Systems is a mouse monoclonal antibody to Integrin alpha 4/CD49d. This antibody reacts with human,mouse. The Human Integrin alpha 4/CD49d Antibody has been validated for the following applications: Blocking,Flow Cytometry,Neutralization,Immunocytochemistry,Adhesion Blockade.

target :

Integrin alpha 4/CD49d

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose.

clonality :

Monoclonal

clone :

2B4

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Adhesion Blockade

host :

Mouse

immunogen :

U937 human histiocytic lymphoma cell line

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse

specificity :

Detects human Integrin alpha 4 subunit (Needham, L.A. et al . (1994) Cell Adhesion and Communication 2 :87).

gene symbol :

ITGA4

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

applications :

Adhesion Blockade,Blocking,Flow Cytometry,Neutralization,Immunocytochemistry

USD :

519 USD

alt names :

269C wild type, CD49 antigen-like family member D, CD49d, CD49d antigen, CD49Dantigen CD49D, alpha-4 subunit of VLA-4 receptor, IA4, integrin alpha 4, integrin alpha-4, integrin alpha-4 subunit, Integrin alpha-IV, integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor), ITGA4, MGC90518, very late activation protein 4 receptor, alpha 4 subunit, VLA-4, VLA-4 subunit alpha

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage