product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human ICAM-1/CD54 Antibody
catalog :
BBA3
quantity :
100 ug
price :
469 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
BBIG-I1 (11C81)
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section
more info or order :
citations: 80
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:3000; loading ...; fig 1s1a
Yang D, Haemmig S, Zhou H, Pérez Cremades D, Sun X, Chen L, et al. Methotrexate attenuates vascular inflammation through an adenosine-microRNA-dependent pathway. elife. 2021;10: pubmed publisher
Liang N, Wilson C, Davis B, Wolf I, Qyli T, Moy J, et al. Modeling lung endothelial dysfunction in sepsis-associated ARDS using a microphysiological system. Physiol Rep. 2024;12:e16134 pubmed publisher
Chien Y, Huang X, Yarmishyn A, Chien C, Liu Y, Hsiao Y, et al. Paracrinal regulation of neutrophil functions by coronaviral infection in iPSC-derived alveolar type II epithelial cells. Virus Res. 2024;345:199391 pubmed publisher
Cacho Navas C, L xf3 pez Pujante C, Reglero Real N, Col xe1 s Algora N, Cuervo A, Conesa J, et al. ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin. elife. 2024;12: pubmed publisher
Kintos D, Salagiannis K, Sgouros A, Nikolaropoulos S, Topouzis S, Fousteris M. Identification of new multi-substituted 1H-pyrazolo[3,4-c]pyridin-7(6H)-ones as soluble guanylyl cyclase (sGC) stimulators with vasoprotective and anti-inflammatory activities. Bioorg Chem. 2024;144:107170 pubmed publisher
Howard C, Joof F, Hu R, Smith J, Zheng Y. Probing cerebral malaria inflammation in 3D human brain microvessels. Cell Rep. 2023;42:113253 pubmed publisher
Geyer M, Gaul L, D Agosto S, Corbo V, Queiroz K. The tumor stroma influences immune cell distribution and recruitment in a PDAC-on-a-chip model. Front Immunol. 2023;14:1155085 pubmed publisher
Ehlers H, Nicolas A, Schavemaker F, Heijmans J, Bulst M, Trietsch S, et al. Vascular inflammation on a chip: A scalable platform for trans-endothelial electrical resistance and immune cell migration. Front Immunol. 2023;14:1118624 pubmed publisher
Constant O, Maarifi G, Barthelemy J, Martin M, Tinto B, Savini G, et al. Differential effects of Usutu and West Nile viruses on neuroinflammation, immune cell recruitment and blood-brain barrier integrity. Emerg Microbes Infect. 2023;12:2156815 pubmed publisher
Akoto C, Willis A, Banas C, Bell J, Bryant D, Blume C, et al. IL-33 Induces an Antiviral Signature in Mast Cells but Enhances Their Permissiveness for Human Rhinovirus Infection. Viruses. 2022;14: pubmed publisher
Delprat V, Huart C, Feron O, Soncin F, Michiels C. The impact of macrophages on endothelial cells is potentiated by cycling hypoxia: Enhanced tumor inflammation and metastasis. Front Oncol. 2022;12:961753 pubmed publisher
Pediaditakis I, Kodella K, Manatakis D, Le C, Barthakur S, Sorets A, et al. A microengineered Brain-Chip to model neuroinflammation in humans. iScience. 2022;25:104813 pubmed publisher
Kosta A, Mekhloufi A, Lucantonio L, Zingoni A, Soriani A, Cippitelli M, et al. GAS6/TAM signaling pathway controls MICA expression in multiple myeloma cells. Front Immunol. 2022;13:942640 pubmed publisher
Singhatanadgit W, Kitpakornsanti S, Toso M, Pavasant P. IFNγ-primed periodontal ligament cells regulate T-cell responses via IFNγ-inducible mediators and ICAM-1-mediated direct cell contact. R Soc Open Sci. 2022;9:220056 pubmed publisher
Cacho Navas C, Reglero Real N, Colás Algora N, Barroso S, de Rivas G, Stamatakis K, et al. Plasmolipin regulates basolateral-to-apical transcytosis of ICAM-1 and leukocyte adhesion in polarized hepatic epithelial cells. Cell Mol Life Sci. 2022;79:61 pubmed publisher
Schimmel L, Chew K, Stocks C, Yordanov T, Essebier P, Kulasinghe A, et al. Endothelial cells are not productively infected by SARS-CoV-2. Clin Transl Immunology. 2021;10:e1350 pubmed publisher
Piechocka I, Keary S, Sosa Costa A, Lau L, Mohan N, Stanisavljevic J, et al. Shear forces induce ICAM-1 nanoclustering on endothelial cells that impact on T-cell migration. Biophys J. 2021;120:2644-2656 pubmed publisher
Tong O, Duette G, O Neil T, Royle C, Rana H, Johnson B, et al. Plasmacytoid dendritic cells have divergent effects on HIV infection of initial target cells and induce a pro-retention phenotype. PLoS Pathog. 2021;17:e1009522 pubmed publisher
Russo E, Runge P, Jahromi N, Naboth H, Landtwing A, Montecchi R, et al. CD112 Regulates Angiogenesis and T Cell Entry into the Spleen. Cells. 2021;10: pubmed publisher
Takeuchi M, Vidigal P, Guerra M, Hundt M, Robert M, Olave Martinez M, et al. Neutrophils interact with cholangiocytes to cause cholestatic changes in alcoholic hepatitis. Gut. 2021;70:342-356 pubmed publisher
Simion V, Zhou H, Pierce J, Yang D, Haemmig S, Tesmenitsky Y, et al. LncRNA VINAS regulates atherosclerosis by modulating NF-κB and MAPK signaling. JCI Insight. 2020;5: pubmed publisher
Israelov H, Ravid O, Atrakchi D, Rand D, Elhaik S, Bresler Y, et al. Caspase-1 has a critical role in blood-brain barrier injury and its inhibition contributes to multifaceted repair. J Neuroinflammation. 2020;17:267 pubmed publisher
Clé M, Desmetz C, Barthelemy J, Martin M, Constant O, Maarifi G, et al. Zika Virus Infection Promotes Local Inflammation, Cell Adhesion Molecule Upregulation, and Leukocyte Recruitment at the Blood-Brain Barrier. MBio. 2020;11: pubmed publisher
Chen Y, Tang D, Zhu L, Yuan T, Jiao Y, Yan H, et al. hnRNPA2/B1 Ameliorates LPS-Induced Endothelial Injury through NF-κB Pathway and VE-Cadherin/β-Catenin Signaling Modulation In Vitro. Mediators Inflamm. 2020;2020:6458791 pubmed publisher
Nishihara H, Soldati S, Mossu A, Rosito M, Rudolph H, Muller W, et al. Human CD4+ T cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro. Fluids Barriers CNS. 2020;17:3 pubmed publisher
Davies S, Reynolds G, Wilkinson A, Li X, Rose R, Leekha M, et al. Hepatocytes Delete Regulatory T Cells by Enclysis, a CD4+ T Cell Engulfment Process. Cell Rep. 2019;29:1610-1620.e4 pubmed publisher
Poussin C, Kramer B, Lanz H, van den Heuvel A, Laurent A, Olivier T, et al. 3D human microvessel-on-a-chip model for studying monocyte-to-endothelium adhesion under flow - application in systems toxicology. ALTEX. 2020;37:47-63 pubmed publisher
Guo P, Yang J, Liu D, Huang L, Fell G, Huang J, et al. Dual complementary liposomes inhibit triple-negative breast tumor progression and metastasis. Sci Adv. 2019;5:eaav5010 pubmed publisher
Blatchley M, Hall F, Wang S, Pruitt H, Gerecht S. Hypoxia and matrix viscoelasticity sequentially regulate endothelial progenitor cluster-based vasculogenesis. Sci Adv. 2019;5:eaau7518 pubmed publisher
Cho J, Kweon H, Huh S, Sadra A. Augmented reduction in colonic inflammatory markers of dextran sulfate sodium-induced colitis with a combination of 5-aminosalicylic acid and AD-lico™ from Glycyrrhiza inflata. Anim Cells Syst (Seoul). 2018;22:189-196 pubmed publisher
Ecklu Mensah G, Olsen R, Bengtsson A, Ofori M, Hviid L, Jensen A, et al. Blood outgrowth endothelial cells (BOECs) as a novel tool for studying adhesion of Plasmodium falciparum-infected erythrocytes. PLoS ONE. 2018;13:e0204177 pubmed publisher
Raschi E, Chighizola C, Cesana L, Privitera D, Ingegnoli F, Mastaglio C, et al. Immune complexes containing scleroderma-specific autoantibodies induce a profibrotic and proinflammatory phenotype in skin fibroblasts. Arthritis Res Ther. 2018;20:187 pubmed publisher
Liu B, Xu L, Yu X, Li W, Sun X, Xiao S, et al. Protective effect of KLF15 on vascular endothelial dysfunction induced by TNF‑α. Mol Med Rep. 2018;18:1987-1994 pubmed publisher
Su Q, Sun Y, Ye Z, Yang H, Kong B, Li L. Pinocembrin protects endothelial cells from oxidized LDL-induced injury. Cytokine. 2018;111:475-480 pubmed publisher
Weiler J, Mohr M, Zanker K, Dittmar T. Matrix metalloproteinase-9 (MMP9) is involved in the TNF-α-induced fusion of human M13SV1-Cre breast epithelial cells and human MDA-MB-435-pFDR1 cancer cells. Cell Commun Signal. 2018;16:14 pubmed publisher
Kroon J, Schaefer A, van Rijssel J, Hoogenboezem M, van Alphen F, Hordijk P, et al. Inflammation-Sensitive Myosin-X Functionally Supports Leukocyte Extravasation by Cdc42-Mediated ICAM-1-Rich Endothelial Filopodia Formation. J Immunol. 2018;200:1790-1801 pubmed publisher
Liu C, Zhao Z, Chen Z, Che C, Zou Z, Wu X, et al. DL-3-n-butylphthalide protects endothelial cells against advanced glycation end product-induced injury by attenuating oxidative stress and inflammation responses. Exp Ther Med. 2017;14:2241-2248 pubmed publisher
Malara N, Trunzo V, Musolino G, Aprigliano S, Rotta G, Macrina L, et al. Soluble CD54 induces human endothelial cells ex vivo expansion useful for cardiovascular regeneration and tissue engineering application. Int J Cardiol Heart Vasc. 2015;6:48-53 pubmed publisher
Schaefer A, van Duijn T, Majolee J, Burridge K, Hordijk P. Endothelial CD2AP Binds the Receptor ICAM-1 To Control Mechanosignaling, Leukocyte Adhesion, and the Route of Leukocyte Diapedesis In Vitro. J Immunol. 2017;198:4823-4836 pubmed publisher
Guo P, Yang J, Bielenberg D, Dillon D, Zurakowski D, Moses M, et al. A quantitative method for screening and identifying molecular targets for nanomedicine. J Control Release. 2017;263:57-67 pubmed publisher
Espagnolle N, Balguerie A, Arnaud E, Sensebe L, Varin A. CD54-Mediated Interaction with Pro-inflammatory Macrophages Increases the Immunosuppressive Function of Human Mesenchymal Stromal Cells. Stem Cell Reports. 2017;8:961-976 pubmed publisher
Lyck R, Lécuyer M, Abadier M, Wyss C, Matti C, Rosito M, et al. ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood-brain barrier. J Cereb Blood Flow Metab. 2017;37:2894-2909 pubmed publisher
Arebro J, Ekstedt S, Hjalmarsson E, Winqvist O, Kumlien Georén S, Cardell L. A possible role for neutrophils in allergic rhinitis revealed after cellular subclassification. Sci Rep. 2017;7:43568 pubmed publisher
Ganesan M, Finsterwalder R, Leb H, Resch U, Neumüller K, de Martin R, et al. Three-Dimensional Coculture Model to Analyze the Cross Talk Between Endothelial and Smooth Muscle Cells. Tissue Eng Part C Methods. 2017;23:38-49 pubmed publisher
Galore Haskel G, Nemlich Y, Greenberg E, Ashkenazi S, Hakim M, Itzhaki O, et al. A novel immune resistance mechanism of melanoma cells controlled by the ADAR1 enzyme. Oncotarget. 2015;6:28999-9015 pubmed publisher
Zhang P, Fu C, Hu Y, Dong C, Song Y, Song E. C6-ceramide nanoliposome suppresses tumor metastasis by eliciting PI3K and PKCζ tumor-suppressive activities and regulating integrin affinity modulation. Sci Rep. 2015;5:9275 pubmed publisher
Mukherjee S, Kim J, Mooren O, Shahan S, Cohan M, Cooper J. Role of cortactin homolog HS1 in transendothelial migration of natural killer cells. PLoS ONE. 2015;10:e0118153 pubmed publisher
Tellier C, Desmet D, Petit L, Finet L, Graux C, Raes M, et al. Cycling hypoxia induces a specific amplified inflammatory phenotype in endothelial cells and enhances tumor-promoting inflammation in vivo. Neoplasia. 2015;17:66-78 pubmed publisher
Onken M, Li J, Cooper J. Uveal melanoma cells utilize a novel route for transendothelial migration. PLoS ONE. 2014;9:e115472 pubmed publisher
Mooren O, Li J, Nawas J, Cooper J. Endothelial cells use dynamic actin to facilitate lymphocyte transendothelial migration and maintain the monolayer barrier. Mol Biol Cell. 2014;25:4115-29 pubmed publisher
Roe K, Orillo B, Verma S. West Nile virus-induced cell adhesion molecules on human brain microvascular endothelial cells regulate leukocyte adhesion and modulate permeability of the in vitro blood-brain barrier model. PLoS ONE. 2014;9:e102598 pubmed publisher
Spilioti E, Jaakkola M, Tolonen T, Lipponen M, Virtanen V, Chinou I, et al. Phenolic acid composition, antiatherogenic and anticancer potential of honeys derived from various regions in Greece. PLoS ONE. 2014;9:e94860 pubmed publisher
Noviello M, Tedesco F, Bondanza A, Tonlorenzi R, Rosaria Carbone M, Gerli M, et al. Inflammation converts human mesoangioblasts into targets of alloreactive immune responses: implications for allogeneic cell therapy of DMD. Mol Ther. 2014;22:1342-1352 pubmed publisher
Ohnuma K, Fujiki A, Yanagihara K, Tachikawa S, Hayashi Y, Ito Y, et al. Enzyme-free passage of human pluripotent stem cells by controlling divalent cations. Sci Rep. 2014;4:4646 pubmed publisher
Park S, Kim K, Kim W, Cho C. Interaction of mesenchymal stem cells with fibroblast-like synoviocytes via cadherin-11 promotes angiogenesis by enhanced secretion of placental growth factor. J Immunol. 2014;192:3003-10 pubmed publisher
Gakhar G, Navarro V, Jurish M, Lee G, Tagawa S, Akhtar N, et al. Circulating tumor cells from prostate cancer patients interact with E-selectin under physiologic blood flow. PLoS ONE. 2013;8:e85143 pubmed publisher
Lin Y, Huang C, Chen Y, Shih C, Tsao N, Lin C, et al. GroEL1, a heat shock protein 60 of Chlamydia pneumoniae, impairs neovascularization by decreasing endothelial progenitor cell function. PLoS ONE. 2013;8:e84731 pubmed publisher
Lauridsen H, Pober J, Gonzalez A. A composite model of the human postcapillary venule for investigation of microvascular leukocyte recruitment. FASEB J. 2014;28:1166-80 pubmed publisher
Schellerer V, Langheinrich M, Hohenberger W, Croner R, Merkel S, Rau T, et al. Tumor-associated fibroblasts isolated from colorectal cancer tissues exhibit increased ICAM-1 expression and affinity for monocytes. Oncol Rep. 2014;31:255-61 pubmed publisher
Tsai S, Huang P, Peng Y, Chang W, Tsai H, Leu H, et al. Zoledronate attenuates angiotensin II-induced abdominal aortic aneurysm through inactivation of Rho/ROCK-dependent JNK and NF-?B pathway. Cardiovasc Res. 2013;100:501-10 pubmed publisher
Trachootham D, Chen G, Zhang W, Lu W, Zhang H, Liu J, et al. Loss of p53 in stromal fibroblasts promotes epithelial cell invasion through redox-mediated ICAM1 signal. Free Radic Biol Med. 2013;58:1-13 pubmed publisher
Xu W, Joo H, Clayton S, Dullaers M, Herve M, Blankenship D, et al. Macrophages induce differentiation of plasma cells through CXCL10/IP-10. J Exp Med. 2012;209:1813-23, S1-2 pubmed
Wilhelmsen K, Mesa K, Lucero J, Xu F, Hellman J. ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes. J Biol Chem. 2012;287:26478-94 pubmed publisher
Stroka K, Levitan I, Aranda Espinoza H. OxLDL and substrate stiffness promote neutrophil transmigration by enhanced endothelial cell contractility and ICAM-1. J Biomech. 2012;45:1828-34 pubmed publisher
Wilhelmsen K, Mesa K, Prakash A, Xu F, Hellman J. Activation of endothelial TLR2 by bacterial lipoprotein upregulates proteins specific for the neutrophil response. Innate Immun. 2012;18:602-16 pubmed publisher
Stroka K, Aranda Espinoza H. Endothelial cell substrate stiffness influences neutrophil transmigration via myosin light chain kinase-dependent cell contraction. Blood. 2011;118:1632-40 pubmed publisher
Zhao Y, Howatt D, Gizard F, Nomiyama T, Findeisen H, Heywood E, et al. Deficiency of the NR4A orphan nuclear receptor NOR1 decreases monocyte adhesion and atherosclerosis. Circ Res. 2010;107:501-11 pubmed publisher
Pennino D, Eyerich K, Scarponi C, Carbone T, Eyerich S, Nasorri F, et al. IL-17 amplifies human contact hypersensitivity by licensing hapten nonspecific Th1 cells to kill autologous keratinocytes. J Immunol. 2010;184:4880-8 pubmed publisher
Crosby H, Lalor P, Ross E, Newsome P, Adams D. Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4. J Hepatol. 2009;51:734-49 pubmed publisher
Rajesh M, Mukhopadhyay P, Bátkai S, Haskó G, Liaudet L, Drel V, et al. Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption. Am J Physiol Heart Circ Physiol. 2007;293:H610-9 pubmed
Bae E, Kim W, Kang Y, Suk K, Koh E, Cha H, et al. Glucocorticoid-induced tumour necrosis factor receptor-related protein-mediated macrophage stimulation may induce cellular adhesion and cytokine expression in rheumatoid arthritis. Clin Exp Immunol. 2007;148:410-8 pubmed
Kelly K, Allport J, Yu A, Sinh S, Sage E, Gerszten R, et al. SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration. J Leukoc Biol. 2007;81:748-56 pubmed
Filer A, Parsonage G, Smith E, Osborne C, Thomas A, Curnow S, et al. Differential survival of leukocyte subsets mediated by synovial, bone marrow, and skin fibroblasts: site-specific versus activation-dependent survival of T cells and neutrophils. Arthritis Rheum. 2006;54:2096-108 pubmed
Ramachandran R, Morice A, Compton S. Proteinase-activated receptor2 agonists upregulate granulocyte colony-stimulating factor, IL-8, and VCAM-1 expression in human bronchial fibroblasts. Am J Respir Cell Mol Biol. 2006;35:133-41 pubmed
Amin M, Haas C, Zhu K, Mansfield P, Kim M, Lackowski N, et al. Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NFkappaB. Blood. 2006;107:2252-61 pubmed
Domeij H, Modeer T, Quezada H, Yucel Lindberg T. Cell expression of MMP-1 and TIMP-1 in co-cultures of human gingival fibroblasts and monocytes: the involvement of ICAM-1. Biochem Biophys Res Commun. 2005;338:1825-33 pubmed
Tamai R, Asai Y, Ogawa T. Requirement for intercellular adhesion molecule 1 and caveolae in invasion of human oral epithelial cells by Porphyromonas gingivalis. Infect Immun. 2005;73:6290-8 pubmed
Dardik A, Chen L, Frattini J, Asada H, Aziz F, Kudo F, et al. Differential effects of orbital and laminar shear stress on endothelial cells. J Vasc Surg. 2005;41:869-80 pubmed
Yamamoto H, Nagata M, Sakamoto Y. CC chemokines and transmigration of eosinophils in the presence of vascular cell adhesion molecule 1. Ann Allergy Asthma Immunol. 2005;94:292-300 pubmed
Helantera I, Loginov R, Koskinen P, Tornroth T, Gronhagen Riska C, Lautenschlager I. Persistent cytomegalovirus infection is associated with increased expression of TGF-beta1, PDGF-AA and ICAM-1 and arterial intimal thickening in kidney allografts. Nephrol Dial Transplant. 2005;20:790-6 pubmed
product information
brand :
R&D Systems
master code :
BBA3
SKU :
BBA3
product name :
Human ICAM-1/CD54 Antibody
unit size :
100 ug
seo description :
The Human ICAM-1/CD54 Antibody from R&D Systems is a mouse monoclonal antibody to ICAM-1/CD54. This antibody reacts with human,mouse,rat. The Human ICAM-1/CD54 Antibody has been validated for the following applications: Immunocytochemistry,Neutralization,Western Blot,Immunoprecipitation,Bead-based Bioassay,Bioassay,Cell-based ELISA,ELISA Development,ELISA Development (Capture),Inhibition,Flow Cytometry,Functional Assay,ELISA Capture,Immunohistochemistry,Immunohistochemistry-Frozen,Immunofluorescence,Adhesion Blockade.
target :
ICAM-1/CD54
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose.
clonality :
Monoclonal
clone :
BBIG-I1 (11C81)
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 2 ug/mL, Flow Cytometry 0.25 ug/10^6 cells, Immunoprecipitation, Adhesion Blockade, Immunocytochemistry 5-25 ug/mL
host :
Mouse
immunogen :
Activated HUVEC human umbilical vein endothelial cells
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse,Rat
specificity :
This antibody was selected for its ability to stain human ICAM-1/CD54 transfected COS cells. It does not stain COS cells transfected with human E-Selectin, VCAM-1, or PECAM-1.
gene symbol :
ICAM1
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
applications :
Adhesion Blockade,Bead-based Bioassay,Bioassay,Cell-based ELISA,ELISA Development,ELISA Development (Capture),Inhibition,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Frozen,Neutralization,Immunofluorescence,Immunocytochemistry,Functional Assay,ELISA Capture
USD :
469 USD
alt names :
BB2, CD54, CD54 antigen, cell surface glycoprotein P3.58, human rhinovirus receptor, ICAM1, ICAM-1, intercellular adhesion molecule 1, intercellular adhesion molecule 1 (CD54), human rhinovirus receptor, Major group rhinovirus receptor, P3.58
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.