Human CD44v6 Antibody | R&D Systems BBA13 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CD44v6 Antibody

catalog :

BBA13

quantity :

200 ug

price :

499 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2F10

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 31

Reference
Jian F, Bao P, Li W, Cui Y, Hong H. Negative regulation of CD44st by miR-138-5p affects the invasive ability of breast cancer cells and patient prognosis after breast cancer surgery. BMC Cancer. 2023;23:269 pubmed publisher
Lin Z, Chung C, Liu Y, Chang C, Liu H, Liang Y, et al. EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression. elife. 2023;12: pubmed publisher
Ghatak S, Hascall V, Karamanos N, Markwald R, Misra S. Chemotherapy induces feedback up-regulation of CD44v6 in colorectal cancer initiating cells through β-catenin/MDR1 signaling to sustain chemoresistance. Front Oncol. 2022;12:906260 pubmed publisher
Ghatak S, Hascall V, Karamanos N, Markwald R, Misra S. Interplay Between Chemotherapy-Activated Cancer Associated Fibroblasts and Cancer Initiating Cells Expressing CD44v6 Promotes Colon Cancer Resistance. Front Oncol. 2022;12:906415 pubmed publisher
De Angelis M, Francescangeli F, Nicolazzo C, Xhelili E, La Torre F, Colace L, et al. An Orthotopic Patient-Derived Xenograft (PDX) Model Allows the Analysis of Metastasis-Associated Features in Colorectal Cancer. Front Oncol. 2022;12:869485 pubmed publisher
Di Franco S, Bianca P, Sardina D, Turdo A, Gaggianesi M, Veschi V, et al. Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery. Nat Commun. 2021;12:5006 pubmed publisher
Manic G, Musella M, Corradi F, Sistigu A, Vitale S, Soliman Abdel Rehim S, et al. Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51. Cell Death Differ. 2021;28:2060-2082 pubmed publisher
Hu S, Cao M, He Y, Zhang G, Liu Y, Du Y, et al. CD44v6 Targeted by miR-193b-5p in the Coding Region Modulates the Migration and Invasion of Breast Cancer Cells. J Cancer. 2020;11:260-271 pubmed publisher
Veschi V, Mangiapane L, Nicotra A, Di Franco S, Scavo E, Apuzzo T, et al. Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant. Oncogene. 2020;39:987-1003 pubmed publisher
Wang D, Fu L, Wei J, Xiong Y, DuBois R. PPARδ Mediates the Effect of Dietary Fat in Promoting Colorectal Cancer Metastasis. Cancer Res. 2019;79:4480-4490 pubmed publisher
Giampieri R, Piva F, Occhipinti G, Bittoni A, Righetti A, Pagliaretta S, et al. Clinical impact of different exosomes' protein expression in pancreatic ductal carcinoma patients treated with standard first line palliative chemotherapy. PLoS ONE. 2019;14:e0215990 pubmed publisher
Tirella A, Kloc Muniak K, Good L, Ridden J, Ashford M, Puri S, et al. CD44 targeted delivery of siRNA by using HA-decorated nanotechnologies for KRAS silencing in cancer treatment. Int J Pharm. 2019;561:114-123 pubmed publisher
Turano M, Costabile V, Cerasuolo A, Duraturo F, Liccardo R, Delrio P, et al. Characterisation of mesenchymal colon tumour-derived cells in tumourspheres as a model for colorectal cancer progression. Int J Oncol. 2018;53:2379-2396 pubmed publisher
Navas T, Pfister T, Colantonio S, Aziz A, Dieckman L, Saul R, et al. Novel antibody reagents for characterization of drug- and tumor microenvironment-induced changes in epithelial-mesenchymal transition and cancer stem cells. PLoS ONE. 2018;13:e0199361 pubmed publisher
Chiou G, Yang T, Huang C, Tang C, Yen J, Tsai M, et al. Musashi-1 promotes a cancer stem cell lineage and chemoresistance in colorectal cancer cells. Sci Rep. 2017;7:2172 pubmed publisher
Whelan K, Chandramouleeswaran P, Tanaka K, Natsuizaka M, Guha M, Srinivasan S, et al. Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance. Oncogene. 2017;36:4843-4858 pubmed publisher
Hanke Roos M, Fuchs K, Maleschlijski S, Sleeman J, Orian Rousseau V, Rosenhahn A. CD44 mediates the catch-bond activated rolling of HEPG2Iso epithelial cancer cells on hyaluronan. Cell Adh Migr. 2017;11:476-487 pubmed publisher
Yoo S, Leng L, Kim B, Du X, Tilstam P, Kim K, et al. MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2016;113:E7917-E7926 pubmed
Teye K, Numata S, Ishii N, Krol R, Tsuchisaka A, Hamada T, et al. Isolation of All CD44 Transcripts in Human Epidermis and Regulation of Their Expression by Various Agents. PLoS ONE. 2016;11:e0160952 pubmed publisher
Eom B, Joo J, Park B, Jo M, Choi S, Cho S, et al. Nomogram Incorporating CD44v6 and Clinicopathological Factors to Predict Lymph Node Metastasis for Early Gastric Cancer. PLoS ONE. 2016;11:e0159424 pubmed publisher
Francescangeli F, Contavalli P, de Angelis M, Baiocchi M, Gambara G, Pagliuca A, et al. Dynamic regulation of the cancer stem cell compartment by Cripto-1 in colorectal cancer. Cell Death Differ. 2015;22:1700-13 pubmed publisher
Marzese D, Liu M, Huynh J, Hirose H, Donovan N, Huynh K, et al. Brain metastasis is predetermined in early stages of cutaneous melanoma by CD44v6 expression through epigenetic regulation of the spliceosome. Pigment Cell Melanoma Res. 2015;28:82-93 pubmed publisher
Bailon E, Ugarte Berzal E, Amigo Jiménez I, Van den Steen P, Opdenakker G, Garcia Marco J, et al. Overexpression of progelatinase B/proMMP-9 affects migration regulatory pathways and impairs chronic lymphocytic leukemia cell homing to bone marrow and spleen. J Leukoc Biol. 2014;96:185-99 pubmed publisher
Rowehl R, Burke S, Bialkowska A, Pettet D, Rowehl L, Li E, et al. Establishment of highly tumorigenic human colorectal cancer cell line (CR4) with properties of putative cancer stem cells. PLoS ONE. 2014;9:e99091 pubmed publisher
Rizzardi A, Rosener N, Koopmeiners J, Isaksson Vogel R, Metzger G, Forster C, et al. Evaluation of protein biomarkers of prostate cancer aggressiveness. BMC Cancer. 2014;14:244 pubmed publisher
Todaro M, Gaggianesi M, Catalano V, Benfante A, Iovino F, Biffoni M, et al. CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis. Cell Stem Cell. 2014;14:342-56 pubmed publisher
Baccelli I, Schneeweiss A, Riethdorf S, Stenzinger A, Schillert A, Vogel V, et al. Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay. Nat Biotechnol. 2013;31:539-44 pubmed publisher
Zhang J, Espinoza L, Kinders R, Lawrence S, Pfister T, Zhou M, et al. NANOG modulates stemness in human colorectal cancer. Oncogene. 2013;32:4397-405 pubmed publisher
Barbour A, Reeder J, Walsh M, Fawcett J, Antalis T, Gotley D. Expression of the CD44v2-10 isoform confers a metastatic phenotype: importance of the heparan sulfate attachment site CD44v3. Cancer Res. 2003;63:887-92 pubmed
Herrera Gayol A, Jothy S. Effect of hyaluronan on xenotransplanted breast cancer. Exp Mol Pathol. 2002;72:179-85 pubmed
Dingemans K, Ramkema M, Pals S. CD44 is exposed to the extracellular matrix at invasive sites in basal cell carcinomas. Lab Invest. 2002;82:313-22 pubmed

product information

brand :

R&D Systems

master code :

BBA13

SKU :

BBA13

product name :

Human CD44v6 Antibody

unit size :

200 ug

seo description :

The Human CD44v6 Antibody from R&D Systems is a mouse monoclonal antibody to CD44. This antibody reacts with human,mouse,xenograft. The Human CD44v6 Antibody has been validated for the following applications: Bioassay,Immunogold Electron Microscopy,Flow Cytometry,Immunoprecipitation,Western Blot,Neutralization,ELISA Detection,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry,CyTOF-ready.

target :

CD44

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose.

clonality :

Monoclonal

clone :

2F10

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, Flow Cytometry 0.25 ug/10^6 cells, Immunohistochemistry 1-25 ug/mL, Immunoprecipitation, Immunocytochemistry 8-25 ug/mL, CyTOF-ready

host :

Mouse

immunogen :

Recombinant human CD44 v3-10

isotype :

IgG1

purity :

Protein A or G purified from ascites

species :

Human,Mouse,Xenograft

specificity :

Detects human CD44v6 in Western blots. By flow cytometry analysis using a panel of CD44-transfected COS cells (9), monoclonal antibody clone 2F10 was deduced to be specific for human CD44 protein isoforms containing variant exon 6 (CD44v6).

gene symbol :

CD44

top caption :

Detection of CD44 antibody in Human Blood Monocytes antibody by Flow Cytometry.

applications :

CyTOF-ready,Bioassay,Immunogold Electron Microscopy,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Neutralization,Immunocytochemistry,ELISA Detection

USD :

499 USD

alt names :

CD44, CD44 antigen, CD44 molecule (Indian blood group), CD44R, CDw44, cell surface glycoprotein CD44, chondroitin sulfate proteoglycan 8, CSPG8, ECMR-III, Epican, Extracellular matrix receptor III, GP90 lymphocyte homing/adhesion receptor, HCAM, HCELL, hematopoietic cell E- and L-selectin ligand, Heparan sulfate proteoglycan, Hermes antigen, homing function and Indian blood group system, HUTCH-I, Hyaluronate receptor, IN, LHR, MC56, MDU2, MDU2CD44 antigen (homing function and Indian blood group system), MDU3, MDU3CDW44, MIC4, MIC4MGC10468, MUTCH-I, Pgp1, PGP-1, PGP-I, Phagocytic glycoprotein 1, Phagocytic glycoprotein I

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage