product summary
Loading...
company name :
R&D Systems
product type :
antibody
product name :
Human CD44s Pan Specific Antibody
catalog :
BBA10
quantity :
200 ug
price :
479 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2C5
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry
more info or order :
citations: 50
Reference
Kotian S, Carnes R, Stern J. Enhancing Transcriptional Reprogramming of Mesenchymal Glioblastoma with Grainyhead-like 2 and HDAC Inhibitors Leads to Apoptosis and Cell-Cycle Dysregulation. Genes (Basel). 2023;14: pubmed publisher
Li J, Jaiswal M, Chien J, Kozlenkov A, Jung J, Zhou P, et al. Divergent single cell transcriptome and epigenome alterations in ALS and FTD patients with C9orf72 mutation. Nat Commun. 2023;14:5714 pubmed publisher
Hartl N, J xfc rgens D, Carneiro S, K xf6 nig A, Xiao X, Liu R, et al. Protein corona investigations of polyplexes with varying hydrophobicity - From method development to in vitro studies. Int J Pharm. 2023;643:123257 pubmed publisher
Mohammadalipour A, Showalter C, Muturi H, Farnoud A, Najjar S, Burdick M. Cholesterol depletion decreases adhesion of non-small cell lung cancer cells to E-selectin. Am J Physiol Cell Physiol. 2023;325:C471-C482 pubmed publisher
Jian F, Bao P, Li W, Cui Y, Hong H. Negative regulation of CD44st by miR-138-5p affects the invasive ability of breast cancer cells and patient prognosis after breast cancer surgery. BMC Cancer. 2023;23:269 pubmed publisher
Fukuchi K, Nanai K, Yuita H, Maru C, Tsukada J, Ishigami M, et al. Novel Antibody Exerts Antitumor Effect through Downregulation of CD147 and Activation of Multiple Stress Signals. J Oncol. 2022;2022:3552793 pubmed publisher
Bessy T, Candelas A, Souquet B, Saadallah K, Schaeffer A, Vianay B, et al. Hematopoietic progenitors polarize in contact with bone marrow stromal cells in response to SDF1. J Cell Biol. 2021;220: pubmed publisher
Dastych M, Hubatka F, Turánek Knötigová P, Masek J, Kroupa R, Ra x161 ka M, et al. Overexpression of CD44v8-10 in Colon Polyps-A Possible Key to Early Diagnosis. Pathol Oncol Res. 2021;27:614281 pubmed publisher
Sekino Y, Imaizumi A, Komune N, Ono M, Sato K, Masuda S, et al. Establishment and characterization of a primary cell culture derived from external auditory canal squamous cell carcinoma. FEBS Open Bio. 2021;11:2211-2224 pubmed publisher
Yan X, Han D, Chen Z, Han C, Dong W, Han L, et al. RUNX2 interacts with BRG1 to target CD44 for promoting invasion and migration of colorectal cancer cells. Cancer Cell Int. 2020;20:505 pubmed publisher
Dabelsteen S, Pallesen E, Marinova I, Nielsen M, Adamopoulou M, Rømer T, et al. Essential Functions of Glycans in Human Epithelia Dissected by a CRISPR-Cas9-Engineered Human Organotypic Skin Model. Dev Cell. 2020;54:669-684.e7 pubmed publisher
Todd N, McNally R, Alqudah A, Jerotic D, Suvakov S, Obradović D, et al. Role of A Novel Angiogenesis FKBPL-CD44 Pathway in Preeclampsia Risk Stratification and Mesenchymal Stem Cell Treatment. J Clin Endocrinol Metab. 2021;106:26-41 pubmed publisher
Chen S, Lin M, Tsai J, He P, Luo W, Chiu I, et al. Exosomal 2',3'-CNP from mesenchymal stem cells promotes hippocampus CA1 neurogenesis/neuritogenesis and contributes to rescue of cognition/learning deficiencies of damaged brain. Stem Cells Transl Med. 2020;9:499-517 pubmed publisher
Caslini C, Hong S, Ban Y, Chen X, Ince T. HDAC7 regulates histone 3 lysine 27 acetylation and transcriptional activity at super-enhancer-associated genes in breast cancer stem cells. Oncogene. 2019;38:6599-6614 pubmed publisher
Mikami E, Kudo M, Ohashi R, Kawahara K, Kawamoto Y, Teduka K, et al. Toll‑like receptor 4 plays a tumor‑suppressive role in cutaneous squamous cell carcinoma. Int J Oncol. 2019;54:2179-2188 pubmed publisher
McClements L, Annett S, Yakkundi A, O Rourke M, Valentine A, Moustafa N, et al. FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4. BMC Cancer. 2019;19:351 pubmed publisher
Koura S, Salama M, El Hussiny M, Khalil M, Lotfy A, Hassan S, et al. Fluoxetine induces direct inhibitory effects on mesenchymal stem cell‑derived osteoprogenitor cells independent of serotonin concentration. Mol Med Rep. 2019;19:2611-2619 pubmed publisher
Liu T, Jiang L, Tavana O, Gu W. The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11. Cancer Res. 2019;79:1913-1924 pubmed publisher
Murakami T, Kim J, Li Y, Green G, Shikanov A, Ono A. Secondary lymphoid organ fibroblastic reticular cells mediate trans-infection of HIV-1 via CD44-hyaluronan interactions. Nat Commun. 2018;9:2436 pubmed publisher
Donnelly C, Dykstra B, Mondal N, Huang J, Kaskow B, Griffin R, et al. Optimizing human Treg immunotherapy by Treg subset selection and E-selectin ligand expression. Sci Rep. 2018;8:420 pubmed publisher
Tsubouchi K, Minami K, Hayashi N, Yokoyama Y, Mori S, Yamamoto H, et al. The CD44 standard isoform contributes to radioresistance of pancreatic cancer cells. J Radiat Res. 2017;:1-11 pubmed publisher
Piyush T, Rhodes J, Yu L. MUC1 O-glycosylation contributes to anoikis resistance in epithelial cancer cells. Cell Death Discov. 2017;3:17044 pubmed publisher
Liu S, Cheng C. Akt Signaling Is Sustained by a CD44 Splice Isoform-Mediated Positive Feedback Loop. Cancer Res. 2017;77:3791-3801 pubmed publisher
Silva M, Fung R, Donnelly C, Videira P, Sackstein R. Cell-Specific Variation in E-Selectin Ligand Expression among Human Peripheral Blood Mononuclear Cells: Implications for Immunosurveillance and Pathobiology. J Immunol. 2017;198:3576-3587 pubmed publisher
Preca B, Bajdak K, Mock K, Lehmann W, Sundararajan V, Bronsert P, et al. A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer. Oncotarget. 2017;8:11530-11543 pubmed publisher
Bogachek M, Park J, De Andrade J, Lorenzen A, Kulak M, White J, et al. Inhibiting the SUMO Pathway Represses the Cancer Stem Cell Population in Breast and Colorectal Carcinomas. Stem Cell Reports. 2016;7:1140-1151 pubmed publisher
Dykstra B, Lee J, Mortensen L, Yu H, Wu Z, Lin C, et al. Glycoengineering of E-Selectin Ligands by Intracellular versus Extracellular Fucosylation Differentially Affects Osteotropism of Human Mesenchymal Stem Cells. Stem Cells. 2016;34:2501-2511 pubmed publisher
Inada E, Saitoh I, Watanabe S, Aoki R, Miura H, Ohtsuka M, et al. PiggyBac transposon-mediated gene delivery efficiently generates stable transfectants derived from cultured primary human deciduous tooth dental pulp cells (HDDPCs) and HDDPC-derived iPS cells. Int J Oral Sci. 2015;7:144-54 pubmed publisher
AbuSamra D, Al Kilani A, Hamdan S, Sakashita K, Gadhoum S, Merzaban J. Quantitative Characterization of E-selectin Interaction with Native CD44 and P-selectin Glycoprotein Ligand-1 (PSGL-1) Using a Real Time Immunoprecipitation-based Binding Assay. J Biol Chem. 2015;290:21213-30 pubmed publisher
Zhang P, Fu C, Hu Y, Dong C, Song Y, Song E. C6-ceramide nanoliposome suppresses tumor metastasis by eliciting PI3K and PKCζ tumor-suppressive activities and regulating integrin affinity modulation. Sci Rep. 2015;5:9275 pubmed publisher
Turtoi A, Blomme A, Bianchi E, Maris P, Vannozzi R, Naccarato A, et al. Accessibilome of human glioblastoma: collagen-VI-alpha-1 is a new target and a marker of poor outcome. J Proteome Res. 2014;13:5660-9 pubmed publisher
Zhao Q, Piyush T, Chen C, Hollingsworth M, Hilkens J, Rhodes J, et al. MUC1 extracellular domain confers resistance of epithelial cancer cells to anoikis. Cell Death Dis. 2014;5:e1438 pubmed publisher
Kultti A, Zhao C, Singha N, Zimmerman S, Osgood R, Symons R, et al. Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment. Biomed Res Int. 2014;2014:817613 pubmed publisher
DiCosmo Ponticello C, Hoover D, Coffman F, Cohen S, Cohen M. MIF inhibits monocytic movement through a non-canonical receptor and disruption of temporal Rho GTPase activities in U-937 cells. Cytokine. 2014;69:47-55 pubmed publisher
Okada T, Nakamura T, Watanabe T, Onoda N, Ashida A, Okuyama R, et al. Coexpression of EpCAM, CD44 variant isoforms and claudin-7 in anaplastic thyroid carcinoma. PLoS ONE. 2014;9:e94487 pubmed publisher
Havre P, Dang L, Ohnuma K, Iwata S, Morimoto C, Dang N. CD26 expression on T-anaplastic large cell lymphoma (ALCL) line Karpas 299 is associated with increased expression of versican and MT1-MMP and enhanced adhesion. BMC Cancer. 2013;13:517 pubmed publisher
Smith M, Russell A, Schiavinato A, Little C. A hexadecylamide derivative of hyaluronan (HYMOVIS®) has superior beneficial effects on human osteoarthritic chondrocytes and synoviocytes than unmodified hyaluronan. J Inflamm (Lond). 2013;10:26 pubmed publisher
Tian X, Azpurua J, Hine C, Vaidya A, MYAKISHEV REMPEL M, Ablaeva J, et al. High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat. Nature. 2013;499:346-9 pubmed publisher
Yakkundi A, McCallum L, O Kane A, Dyer H, Worthington J, McKeen H, et al. The anti-migratory effects of FKBPL and its peptide derivative, AD-01: regulation of CD44 and the cytoskeletal pathway. PLoS ONE. 2013;8:e55075 pubmed publisher
Duru N, Fan M, Candas D, Menaa C, Liu H, Nantajit D, et al. HER2-associated radioresistance of breast cancer stem cells isolated from HER2-negative breast cancer cells. Clin Cancer Res. 2012;18:6634-47 pubmed publisher
Kuras Z, Yun Y, Chimote A, Neumeier L, Conforti L. KCa3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells. PLoS ONE. 2012;7:e43859 pubmed publisher
Kure S, Matsuda Y, Hagio M, Ueda J, Naito Z, Ishiwata T. Expression of cancer stem cell markers in pancreatic intraepithelial neoplasias and pancreatic ductal adenocarcinomas. Int J Oncol. 2012;41:1314-24 pubmed publisher
Kolegraff K, Nava P, Helms M, Parkos C, Nusrat A. Loss of desmocollin-2 confers a tumorigenic phenotype to colonic epithelial cells through activation of Akt/?-catenin signaling. Mol Biol Cell. 2011;22:1121-34 pubmed publisher
Glynn S, Boersma B, Dorsey T, Yi M, Yfantis H, Ridnour L, et al. Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients. J Clin Invest. 2010;120:3843-54 pubmed publisher
Naka N, Takenaka S, Araki N, Miwa T, Hashimoto N, Yoshioka K, et al. Synovial sarcoma is a stem cell malignancy. Stem Cells. 2010;28:1119-31 pubmed publisher
Kohga K, Takehara T, Tatsumi T, Miyagi T, Ishida H, Ohkawa K, et al. Anticancer chemotherapy inhibits MHC class I-related chain a ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma. Cancer Res. 2009;69:8050-7 pubmed publisher
Kato N, Yuzawa Y, Kosugi T, Hobo A, Sato W, Miwa Y, et al. The E-selectin ligand basigin/CD147 is responsible for neutrophil recruitment in renal ischemia/reperfusion. J Am Soc Nephrol. 2009;20:1565-76 pubmed publisher
van Grevenstein W, Hofland L, van Rossen M, van Koetsveld P, Jeekel J, van Eijck C. Inflammatory cytokines stimulate the adhesion of colon carcinoma cells to mesothelial monolayers. Dig Dis Sci. 2007;52:2775-83 pubmed
Hill A, McFarlane S, Mulligan K, Gillespie H, Draffin J, Trimble A, et al. Cortactin underpins CD44-promoted invasion and adhesion of breast cancer cells to bone marrow endothelial cells. Oncogene. 2006;25:6079-91 pubmed
Draffin J, McFarlane S, Hill A, Johnston P, Waugh D. CD44 potentiates the adherence of metastatic prostate and breast cancer cells to bone marrow endothelial cells. Cancer Res. 2004;64:5702-11 pubmed
product information
brand :
R&D Systems
master code :
BBA10
SKU :
BBA10
product name :
Human CD44s Pan Specific Antibody
unit size :
200 ug
seo description :
The Human CD44s Pan Specific Antibody from R&D Systems is a mouse monoclonal antibody to CD44. This antibody reacts with human,mouse,rat. The Human CD44s Pan Specific Antibody has been validated for the following applications: Western Blot,Simple Western,Flow Cytometry,Immunoprecipitation,Surface Plasmon Resonance,Neutralization,Cell Culture,Immunohistochemistry,Immunocytochemistry,CyTOF-ready.
target :
CD44
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose.
clonality :
Monoclonal
clone :
2C5
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 2 ug/mL, Simple Western 20 ug/mL, Flow Cytometry 2.5 ug/10^6 cells, Immunohistochemistry 8-25 ug/mL, Immunoprecipitation, CyTOF-ready
host :
Mouse
immunogen :
Recombinant human CD44v3-10 (includes the invariant N-terminal exons and CD44v3-10 exons),
isotype :
IgG2a
purity :
Protein A or G purified from ascites
species :
Human,Mouse,Rat
specificity :
Detects human CD44s on a panel of CD44 transfected COS cells by flow cytometry (Fox, S.B. et al. (1994) Cancer Res . 54: 4539). This antibody recognizes an epitope in the invariant N-terminal region of all CD44 protein isoforms.
gene symbol :
CD44
top caption :
Detection of Human CD44 antibody by Western Blot.
applications :
CyTOF-ready,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Simple Western,Surface Plasmon Resonance,Neutralization,Immunocytochemistry,Cell Culture
USD :
479 USD
alt names :
CD44, CD44 antigen, CD44 molecule (Indian blood group), CD44R, CDw44, cell surface glycoprotein CD44, chondroitin sulfate proteoglycan 8, CSPG8, ECMR-III, Epican, Extracellular matrix receptor III, GP90 lymphocyte homing/adhesion receptor, HCAM, HCELL, hematopoietic cell E- and L-selectin ligand, Heparan sulfate proteoglycan, Hermes antigen, homing function and Indian blood group system, HUTCH-I, Hyaluronate receptor, IN, LHR, MC56, MDU2, MDU2CD44 antigen (homing function and Indian blood group system), MDU3, MDU3CDW44, MIC4, MIC4MGC10468, MUTCH-I, Pgp1, PGP-1, PGP-I, Phagocytic glycoprotein 1, Phagocytic glycoprotein I
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.