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company name :
R&D Systems
product type :
antibody
product name :
Mouse Leptin R Biotinylated Antibody
catalog :
BAF497
quantity :
50 ug
price :
579 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
biotin
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section
more info or order :
citations: 32
Reference
Krepuska M, Mayer B, Vitale Cross L, Myneni V, Boyajian M, N xe9 meth K, et al. Bone marrow stromal cell-derived hepcidin has antimicrobial and immunomodulatory activities. Sci Rep. 2024;14:3986 pubmed publisher
Lin Y, Gu Q, Lu S, Pan Z, Yang Z, Li Y, et al. Ruxolitinib improves hematopoietic regeneration by restoring mesenchymal stromal cell function in acute graft-versus-host disease. J Clin Invest. 2023;133: pubmed publisher
Sorimachi Y, Kobayashi H, Shiozawa Y, Koide S, Nakato R, Shimizu Y, et al. Mesenchymal loss of p53 alters stem cell capacity and models human soft tissue sarcoma traits. Stem Cell Reports. 2023;18:1211-1226 pubmed publisher
Ramalingam P, Gutkin M, Poulos M, Tillery T, Doughty C, Winiarski A, et al. Restoring bone marrow niche function rejuvenates aged hematopoietic stem cells by reactivating the DNA Damage Response. Nat Commun. 2023;14:2018 pubmed publisher
Kawai H, Oo M, Takabatake K, Tosa I, Soe Y, Eain H, et al. Enzyme-Cleaved Bone Marrow Transplantation Improves the Engraftment of Bone Marrow Mesenchymal Stem Cells. JBMR Plus. 2023;7:e10722 pubmed publisher
Ernst M, Pronk E, van Dijk C, van Strien P, van Tienhoven T, Wevers M, et al. Hematopoietic Cell Autonomous Disruption of Hematopoiesis in a Germline Loss-of-function Mouse Model of RUNX1-FPD. Hemasphere. 2023;7:e824 pubmed publisher
Mitchell C, Verovskaya E, Calero Nieto F, Olson O, Swann J, Wang X, et al. Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing. Nat Cell Biol. 2023;25:30-41 pubmed publisher
Jeffery E, Mann T, Pool J, Zhao Z, Morrison S. Bone marrow and periosteal skeletal stem/progenitor cells make distinct contributions to bone maintenance and repair. Cell Stem Cell. 2022;29:1547-1561.e6 pubmed publisher
Boregowda S, Nanjappa M, Booker C, Strivelli J, Supper V, Cooke P, et al. Pharmacological Inhibition of Inositol Hexakisphosphate Kinase 1 Protects Mice against Obesity-Induced Bone Loss. Biology (Basel). 2022;11: pubmed publisher
Schloss M, Hulsmans M, Rohde D, Lee I, Severe N, Foy B, et al. B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis. Nat Immunol. 2022;23:605-618 pubmed publisher
Lee Y, Kim T, Kim Y, Kim S, Lee S, Seo S, et al. Microbiota-derived lactate promotes hematopoiesis and erythropoiesis by inducing stem cell factor production from leptin receptor+ niche cells. Exp Mol Med. 2021;53:1319-1331 pubmed publisher
Ambrosi T, Sinha R, Steininger H, Hoover M, Murphy M, Koepke L, et al. Distinct skeletal stem cell types orchestrate long bone skeletogenesis. elife. 2021;10: pubmed publisher
Shen B, Tasdogan A, Ubellacker J, Zhang J, Nosyreva E, Du L, et al. A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis. Nature. 2021;591:438-444 pubmed publisher
Mohrin M, Liu J, Zavala Solorio J, Bhargava S, Maxwell Trumble J, Brito A, et al. Inhibition of longevity regulator PAPP-A modulates tissue homeostasis via restraint of mesenchymal stromal cells. Aging Cell. 2021;20:e13313 pubmed publisher
Trinh T, Ropa J, Aljoufi A, Cooper S, Sinn A, Srour E, et al. Leptin receptor, a surface marker for a subset of highly engrafting long-term functional hematopoietic stem cells. Leukemia. 2021;35:2064-2075 pubmed publisher
Nosho S, Tosa I, Ono M, Hara E, Ishibashi K, Mikai A, et al. Distinct Osteogenic Potentials of BMP-2 and FGF-2 in Extramedullary and Medullary Microenvironments. Int J Mol Sci. 2020;21: pubmed publisher
van Gastel N, Spinelli J, Sharda A, Schajnovitz A, Baryawno N, Rhee C, et al. Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance. Cell Metab. 2020;32:391-403.e6 pubmed publisher
He D, Tang X, Dong W, Cui G, Peng G, Yin X, et al. C-KIT Expression Distinguishes Fetal from Postnatal Skeletal Progenitors. Stem Cell Reports. 2020;14:614-630 pubmed publisher
Gao B, Yin J, Xu X, Fan J, Wang D, Zheng C, et al. Leptin receptor-expressing cells represent a distinct subpopulation of notochord-derived cells and are essential for disc homoeostasis. J Orthop Translat. 2020;21:91-99 pubmed publisher
Rivadeneira D, DePeaux K, Wang Y, Kulkarni A, Tabib T, Menk A, et al. Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance. Immunity. 2019;51:548-560.e4 pubmed publisher
Severe N, Karabacak N, Gustafsson K, Baryawno N, Courties G, Kfoury Y, et al. Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping. Cell Stem Cell. 2019;25:570-583.e7 pubmed publisher
Zou W, Rohatgi N, Brestoff J, Zhang Y, Scheller E, Craft C, et al. Congenital lipodystrophy induces severe osteosclerosis. PLoS Genet. 2019;15:e1008244 pubmed publisher
Song J, Li J, Yang F, Ning G, Zhen L, Wu L, et al. Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow. Cell Death Dis. 2019;10:336 pubmed publisher
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product information
brand :
R&D Systems
master code :
BAF497
SKU :
BAF497
product name :
Mouse Leptin R Biotinylated Antibody
unit size :
50 ug
seo description :
The Mouse Leptin R Biotinylated Antibody from R&D Systems is a goat polyclonal antibody to Leptin R. This antibody reacts with human,mouse. The Mouse Leptin R Biotinylated Antibody has been validated for the following applications: Flow Cytometry,MACS,Western Blot,Cell Selection,Immunohistochemistry,Immunohistochemistry-Frozen,Immunocytochemistry,ELISA Detection (Matched Antibody Pair).
target :
Leptin R
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Biotin
dilution :
Western Blot 0.1 ug/mL, Flow Cytometry 0.25 ug/10^6 cells, ELISA Detection (Matched Antibody Pair) 0.1-0.4 ug/mL
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse Leptin R, Ala20-Gly839, Accession # Q3US58
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse
specificity :
Detects mouse Leptin R in ELISAs and Western blots.
gene symbol :
LEPR
accessionNumbers :
Q3US58
applications :
ELISA Detection (Matched Antibody Pair),MACS,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Frozen,Immunocytochemistry,Cell Selection
USD :
579 USD
alt names :
B219, CD295, CD295 antigen, DB, DKFZp686B1731, huB219, LEPR, LEP-R, leptin receptor, LeptinR, OB R, OB receptor, OB-R, OBRCD295
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.