Human TREM2 Biotinylated Antibody | R&D Systems BAF1828 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human TREM2 Biotinylated Antibody

catalog :

BAF1828

quantity :

50 ug

price :

569 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

biotin

reactivity :

human, mouse

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation, flow cytometry

citations: 22

Published Application/Species/Sample/Dilution	Reference
ELISA; human; 1:3000; loading ...; fig 6b, s2b	Zhong L, Xu Y, Zhuo R, Wang T, Wang K, Huang R, et al. Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model. Nat Commun. 2019;10:1365 pubmed publisher
	Shanks H, Chen K, Reiman E, Blennow K, Cummings J, Massa S, et al. p75 neurotrophin receptor modulation in mild to moderate Alzheimer disease: a randomized, placebo-controlled phase 2a trial. Nat Med. 2024;30:1761-1770 pubmed publisher
	Qiang Q, Skudder Hill L, Toyota T, Huang Z, Wei W, Adachi H. CSF 14-3-3 zeta(ζ) isoform is associated with tau pathology and cognitive decline in Alzheimer's disease. J Neurol Sci. 2024;457:122861 pubmed publisher
	Fruhw xfc rth S, Reinert L, xd6 berg C, Sakr M, Henricsson M, Zetterberg H, et al. TREM2 is down-regulated by HSV1 in microglia and involved in antiviral defense in the brain. Sci Adv. 2023;9:eadf5808 pubmed publisher
	Filipello F, You S, Mirfakhar F, Mahali S, Bollman B, Acquarone M, et al. Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation. Acta Neuropathol. 2023;145:749-772 pubmed publisher
	Moutinho M, Coronel I, Tsai A, Di Prisco G, Pennington T, Atwood B, et al. TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation. Genome Med. 2023;15:11 pubmed publisher
	Woollacott I, Swift I, Sogorb Esteve A, Heller C, Knowles K, Bouzigues A, et al. CSF glial markers are elevated in a subset of patients with genetic frontotemporal dementia. Ann Clin Transl Neurol. 2022;9:1764-1777 pubmed publisher
	Obst J, Hall Roberts H, Smith T, Kreuzer M, Magno L, Di Daniel E, et al. PLCγ2 regulates TREM2 signalling and integrin-mediated adhesion and migration of human iPSC-derived macrophages. Sci Rep. 2021;11:19842 pubmed publisher
	Szykowska A, Chen Y, Smith T, Preger C, Yang J, Qian D, et al. Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain. Structure. 2021;: pubmed publisher
	Park S, Lee E, Kim H, Jo S, Lee S, Seo S, et al. The relationship of soluble TREM2 to other biomarkers of sporadic Alzheimer's disease. Sci Rep. 2021;11:13050 pubmed publisher
	Hall Roberts H, Agarwal D, Obst J, Smith T, Monzón Sandoval J, Di Daniel E, et al. TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages. Alzheimers Res Ther. 2020;12:151 pubmed publisher
	Huang F, Zhu Y, Hsiao Nakamoto J, Tang X, Dugas J, Moscovitch Lopatin M, et al. Longitudinal biomarkers in amyotrophic lateral sclerosis. Ann Clin Transl Neurol. 2020;7:1103-1116 pubmed publisher
	Banerjee G, Ambler G, Keshavan A, Paterson R, Foiani M, Toombs J, et al. Cerebrospinal Fluid Biomarkers in Cerebral Amyloid Angiopathy. J Alzheimers Dis. 2020;74:1189-1201 pubmed publisher
	Weber G, Koenig K, Khrestian M, Shao Y, Tuason E, Gramm M, et al. An Altered Relationship between Soluble TREM2 and Inflammatory Markers in Young Adults with Down Syndrome: A Preliminary Report. J Immunol. 2020;204:1111-1118 pubmed publisher
	Ashton N, Suarez Calvet M, Heslegrave A, Hye A, Razquin C, Pastor P, et al. Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriers. Alzheimers Res Ther. 2019;11:94 pubmed publisher
	Ewers M, Franzmeier N, Suarez Calvet M, Morenas Rodríguez E, Caballero M, Kleinberger G, et al. Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease. Sci Transl Med. 2019;11: pubmed publisher
	Jensen C, Bahl J, Østergaard L, Høgh P, Wermuth L, Heslegrave A, et al. Exercise as a potential modulator of inflammation in patients with Alzheimer's disease measured in cerebrospinal fluid and plasma. Exp Gerontol. 2019;121:91-98 pubmed publisher
	Suarez Calvet M, Capell A, Araque Caballero M, Morenas Rodríguez E, Fellerer K, Franzmeier N, et al. CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline. EMBO Mol Med. 2018;10: pubmed publisher
	Woollacott I, Nicholas J, Heslegrave A, Heller C, Foiani M, Dick K, et al. Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup. Alzheimers Res Ther. 2018;10:79 pubmed publisher
	Thornton P, Sevalle J, Deery M, Fraser G, Zhou Y, Ståhl S, et al. TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant. EMBO Mol Med. 2017;9:1366-1378 pubmed publisher
	Varnum M, Clayton K, Yoshii Kitahara A, Yonemoto G, Koro L, Ikezu S, et al. A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells. J Biol Chem. 2017;292:10651-10663 pubmed publisher
	Cooper Knock J, Green C, Altschuler G, Wei W, Bury J, Heath P, et al. A data-driven approach links microglia to pathology and prognosis in amyotrophic lateral sclerosis. Acta Neuropathol Commun. 2017;5:23 pubmed publisher

product information

brand :

R&D Systems

master code :

BAF1828

SKU :

BAF1828

product name :

Human TREM2 Biotinylated Antibody

unit size :

50 ug

seo description :

The Human TREM2 Biotinylated Antibody from R&D Systems is a goat polyclonal antibody to TREM2. This antibody reacts with human,mouse,transgenic mouse. The Human TREM2 Biotinylated Antibody has been validated for the following applications: ELISA Detection,ELISA Capture,ELISA Development,ELISA Development (Capture),ELISA Development (Detection),Immunoprecipitation,Functional Assay,Flow Cytometry,Western Blot,Immunocytochemistry.

target :

TREM2

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Biotin

dilution :

Western Blot 0.1 ug/mL, Flow Cytometry 0.25 ug/10^6 cells, Immunocytochemistry 5-15 ug/mL

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant human TREM2, His19-Ser174, Accession # Q9NZC2

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Transgenic Mouse

specificity :

Detects human TREM2 in Western blots. In Western blots, less than 1% cross-reactivity with recombinant human (rh) TREM2b, rhTREM1, and recombinant mouse TREM3 is observed.

gene symbol :

TREM2

top caption :

TREM2 antibody in Human PBMCs by Immunocytochemistry (ICC).

accessionNumbers :

Q9NZC2

applications :

Flow Cytometry,Western Blot,Immunocytochemistry,ELISA Development,ELISA Development (Capture),ELISA Development (Detection),Immunoprecipitation,Functional Assay,ELISA Capture,ELISA Detection

USD :

569 USD

alt names :

PLOSL2, TREM-2, Trem2a, Trem2b, Trem2c, TREM-2triggering receptor expressed on myeloid cells 2a, Triggering receptor expressed on monocytes 2, triggering receptor expressed on myeloid cells 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.