Mouse TREM2 Biotinylated Antibody | R&D Systems BAF1729 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse TREM2 Biotinylated Antibody

catalog :

BAF1729

quantity :

50 ug

price :

549 USD

clonality :

polyclonal

host :

domestic sheep

conjugate :

biotin

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry

more info or order :

R&D Systems product webpage

citations: 20

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:50; loading ...; fig 1d	Huang Y, Happonen K, Burrola P, O Connor C, Hah N, Huang L, et al. Microglia use TAM receptors to detect and engulf amyloid β plaques. Nat Immunol. 2021;22:586-594 pubmed publisher
ELISA; mouse; 1:3000; loading ...; fig 6b, s2b	Zhong L, Xu Y, Zhuo R, Wang T, Wang K, Huang R, et al. Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model. Nat Commun. 2019;10:1365 pubmed publisher
ELISA; mouse; loading ...; fig 1a	Brendel M, Kleinberger G, Probst F, Jaworska A, Overhoff F, Blume T, et al. Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis. Front Aging Neurosci. 2017;9:8 pubmed publisher
	Pierro E, Cottam M, An H, Lehmann B, Pietenpol J, Wellen K, et al. Trem2 deficiency attenuates breast cancer tumor growth in lean, but not obese or weight loss, mice and is associated with alterations of clonal T cell populations. bioRxiv. 2024;: pubmed publisher
	Yin T, D ADAMIO L. BRI2-mediated regulation of TREM2 processing in microglia and its potential implications for Alzheimer's disease and related dementias. bioRxiv. 2023;: pubmed publisher
	Shu X, Wei C, Tu W, Zhong K, Qi S, Wang A, et al. Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome. Cell Rep. 2023;42:112133 pubmed publisher
	You S, Brase L, Filipello F, Iyer A, Del Aguila J, He J, et al. MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state. medRxiv. 2023;: pubmed publisher
	Qiao W, Chen Y, Zhong J, Madden B, Charlesworth C, Martens Y, et al. Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology. Mol Neurodegener. 2023;18:8 pubmed publisher
	Rother C, Uhlmann R, M xfc ller S, Schelle J, Skodras A, Oberm xfc ller U, et al. Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae. Nat Commun. 2022;13:7333 pubmed publisher
	Roshanbin S, Julku U, Xiong M, Eriksson J, Masliah E, Hultqvist G, et al. Reduction of αSYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody. Pharmaceutics. 2022;14: pubmed publisher
	Xia D, Lianoglou S, Sandmann T, Calvert M, Suh J, Thomsen E, et al. Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia. Mol Neurodegener. 2022;17:41 pubmed publisher
	Logan T, Simon M, Rana A, Cherf G, Srivastava A, Davis S, et al. Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic. Cell. 2021;184:4651-4668.e25 pubmed publisher
	Biechele G, Wind K, Blume T, Sacher C, Beyer L, Eckenweber F, et al. Microglial activation in the right amygdala-entorhinal-hippocampal complex is associated with preserved spatial learning in AppNL-G-F mice. Neuroimage. 2021;230:117707 pubmed publisher
	Jadhav V, Lin P, Pennington T, Di Prisco G, Jannu A, Xu G, et al. Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice. Mol Neurodegener. 2020;15:62 pubmed publisher
	Liu W, Taso O, Wang R, Bayram S, Graham A, Garcia Reitboeck P, et al. Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions. Hum Mol Genet. 2020;29:3224-3248 pubmed publisher
	Schlepckow K, Monroe K, Kleinberger G, Cantuti Castelvetri L, Parhizkar S, Xia D, et al. Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region. EMBO Mol Med. 2020;12:e11227 pubmed publisher
	Reed Geaghan E, Croxford A, Becher B, Landreth G. Plaque-associated myeloid cells derive from resident microglia in an Alzheimer's disease model. J Exp Med. 2020;217: pubmed publisher
	Sacher C, Blume T, Beyer L, Peters F, Eckenweber F, Sgobio C, et al. Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second-Generation Amyloid-β Mouse Model. J Nucl Med. 2019;60:1787-1793 pubmed publisher
	Götzl J, Brendel M, Werner G, Parhizkar S, Sebastian Monasor L, Kleinberger G, et al. Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism. EMBO Mol Med. 2019;: pubmed publisher
	Kleinberger G, Brendel M, Mracskó É, Wefers B, Groeneweg L, Xiang X, et al. The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism. EMBO J. 2017;36:1837-1853 pubmed publisher

product information

master code :

BAF1729

SKU :

BAF1729

product name :

Mouse TREM2 Biotinylated Antibody

unit size :

50 ug

description :

The Mouse TREM2 Biotinylated Antibody from R&D Systems is a sheep polyclonal antibody to TREM2. This antibody reacts with mouse,n/a,transgenic mouse. The Mouse TREM2 Biotinylated Antibody has been validated for the following applications: ELISA Detection,Immunohistochemistry,ELISA Capture,ELISA Development,ELISA Development (Capture),ELISA Development (Detection),Flow Cytometry,Immunoprecipitation,Western Blot,ELISA,Immunocytochemistry.

target :

TREM2

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Biotin

host :

Sheep

immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse TREM2b, Leu19-Pro168, Accession # Q99NH8

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Mouse,N/A,Transgenic Mouse

specificity :

Detects mouse TREM2 in Western blots. In Western blots, approximately 5% cross-reactivity with recombinant human (rh) TREM2 is observed and less than 1% cross-reactivity with recombinant mouse (rm) TREM1 and rmTREM3 is observed.

gene symbol :

TREM2

top caption :

TREM-2 antibody in Mouse Splenocytes by Immunocytochemistry (ICC).

accessionNumbers :

Q99NH8

applications :

ELISA Detection,ELISA Development,ELISA Development (Capture),ELISA Development (Detection),Flow Cytometry,Immunoprecipitation,Western Blot,ELISA Capture,Immunohistochemistry,ELISA,Immunocytochemistry

USD :

549 USD

alt names :

PLOSL2, TREM-2, Trem2a, Trem2b, Trem2c, TREM-2triggering receptor expressed on myeloid cells 2a, Triggering receptor expressed on monocytes 2, triggering receptor expressed on myeloid cells 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage