This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse IL-18/IL-1F4 Protein
catalog :
B002-5
quantity :
25 ug
price :
588 USD
citations: 35
Reference
Yu J, Zhu H, Taheri S, Mondy W, Bonilha L, Magwood G, et al. Serum Amyloid A-Mediated Inflammasome Activation of Microglial Cells in Cerebral Ischemia. J Neurosci. 2019;39:9465-9476 pubmed publisher
Semper R, Vieth M, Gerhard M, Mejías Luque R. Helicobacter pylori Exploits the NLRC4 Inflammasome to Dampen Host Defenses. J Immunol. 2019;203:2183-2193 pubmed publisher
Lam V, Folkersen L, Aguilar O, Lanier L. KLF12 Regulates Mouse NK Cell Proliferation. J Immunol. 2019;203:981-989 pubmed publisher
Weizman O, Song E, Adams N, Hildreth A, Riggan L, Krishna C, et al. Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12. Nat Immunol. 2019;20:1004-1011 pubmed publisher
Mace T, Ware M, King S, Loftus S, Farren M, McMichael E, et al. Soy isoflavones and their metabolites modulate cytokine-induced natural killer cell function. Sci Rep. 2019;9:5068 pubmed publisher
Kumar P, Rajasekaran K, Nanbakhsh A, Gorski J, Thakar M, Malarkannan S. IL-27 promotes NK cell effector functions via Maf-Nrf2 pathway during influenza infection. Sci Rep. 2019;9:4984 pubmed publisher
Alhallaf R, Agha Z, Miller C, Robertson A, Sotillo J, Croese J, et al. The NLRP3 Inflammasome Suppresses Protective Immunity to Gastrointestinal Helminth Infection. Cell Rep. 2018;23:1085-1098 pubmed publisher
Nabekura T, Chen Z, Schroeder C, Park T, Vivier E, Lanier L, et al. Crk Adaptor Proteins Regulate NK Cell Expansion and Differentiation during Mouse Cytomegalovirus Infection. J Immunol. 2018;200:3420-3428 pubmed publisher
Wang Z, Liu Z, Wang L, Wang J, Chen L, Xie H, et al. Altered expression of IL-18 binding protein and IL-18 receptor in basophils and mast cells of asthma patients. Scand J Immunol. 2018;87:e12658 pubmed publisher
CASTILLO G, Nishimoto Ashfield A, Jones C, Kabirov K, Zakharov A, Lyubimov A. Protected graft copolymer-formulated fibroblast growth factors mitigate the lethality of partial body irradiation injury. PLoS ONE. 2017;12:e0171703 pubmed publisher
Ibiza S, García Cassani B, Ribeiro H, Carvalho T, Almeida L, Marques R, et al. Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence. Nature. 2016;535:440-443 pubmed publisher
Seregin S, Chen G, Laouar Y. Dissecting CD8+ NKT Cell Responses to Listeria Infection Reveals a Component of Innate Resistance. J Immunol. 2015;195:1112-20 pubmed publisher
Nabekura T, Girard J, Lanier L. IL-33 receptor ST2 amplifies the expansion of NK cells and enhances host defense during mouse cytomegalovirus infection. J Immunol. 2015;194:5948-52 pubmed publisher
Souza Fonseca Guimaraes F, Young A, Mittal D, Martinet L, Bruedigam C, Takeda K, et al. NK cells require IL-28R for optimal in vivo activity. Proc Natl Acad Sci U S A. 2015;112:E2376-84 pubmed publisher
Gandhapudi S, Tan C, Marino J, Taylor A, Pack C, Gaikwad J, et al. IL-18 acts in synergy with IL-7 to promote ex vivo expansion of T lymphoid progenitor cells. J Immunol. 2015;194:3820-8 pubmed publisher
Chen P, Aguilar O, Rahim M, Allan D, Fine J, Kirkham C, et al. Genetic investigation of MHC-independent missing-self recognition by mouse NK cells using an in vivo bone marrow transplantation model. J Immunol. 2015;194:2909-18 pubmed publisher
Oficjalska K, Raverdeau M, Aviello G, Wade S, Hickey A, Sheehan K, et al. Protective role for caspase-11 during acute experimental murine colitis. J Immunol. 2015;194:1252-60 pubmed publisher
Marcais A, Cherfils Vicini J, Viant C, Degouve S, Viel S, Fenis A, et al. The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells. Nat Immunol. 2014;15:749-757 pubmed publisher
Celis Gutierrez J, Boyron M, Walzer T, Pandolfi P, Jonjic S, Olive D, et al. Dok1 and Dok2 proteins regulate natural killer cell development and function. EMBO J. 2014;33:1928-40 pubmed publisher
He W, Yang C, Xia L, Zhao M, Ge R, Huang H, et al. CD4(+) T cells from food allergy model are resistant to TCR-dependent apoptotic induction. Cytokine. 2014;68:32-9 pubmed publisher
Freeman B, Meyer C, Slifka M. Anti-inflammatory cytokines directly inhibit innate but not adaptive CD8+ T cell functions. J Virol. 2014;88:7474-84 pubmed publisher
Chan C, Martinet L, Gilfillan S, Souza Fonseca Guimaraes F, Chow M, Town L, et al. The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions. Nat Immunol. 2014;15:431-8 pubmed publisher
Duong S, Condotta S, Rai D, Martin M, Griffith T, Badovinac V. Polymicrobial sepsis alters antigen-dependent and -independent memory CD8 T cell functions. J Immunol. 2014;192:3618-25 pubmed publisher
Tyznik A, Verma S, Wang Q, Kronenberg M, Benedict C. Distinct requirements for activation of NKT and NK cells during viral infection. J Immunol. 2014;192:3676-85 pubmed publisher
Jiang E, Perrard X, Yang D, Khan I, Perrard J, Smith C, et al. Essential role of CD11a in CD8+ T-cell accumulation and activation in adipose tissue. Arterioscler Thromb Vasc Biol. 2014;34:34-43 pubmed publisher
Valcarcel M, Carrascal T, Crende O, Vidal Vanaclocha F. IL-18 regulates melanoma VLA-4 integrin activation through a Hierarchized sequence of inflammatory factors. J Invest Dermatol. 2014;134:470-480 pubmed publisher
Wintges K, Beil F, Albers J, Jeschke A, Schweizer M, Claass B, et al. Impaired bone formation and increased osteoclastogenesis in mice lacking chemokine (C-C motif) ligand 5 (Ccl5). J Bone Miner Res. 2013;28:2070-80 pubmed publisher
Freeman B, Hammarlund E, Raué H, Slifka M. Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A. 2012;109:9971-6 pubmed publisher
Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, et al. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J Virol. 2010;84:12703-12 pubmed publisher
Wiener Z, Pocza P, Racz M, Nagy G, Tolgyesi G, Molnar V, et al. IL-18 induces a marked gene expression profile change and increased Ccl1 (I-309) production in mouse mucosal mast cell homologs. Int Immunol. 2008;20:1565-73 pubmed publisher
Chandrasekar B, Patel D, Mummidi S, Kim J, Clark R, Valente A. Interleukin-18 suppresses adiponectin expression in 3T3-L1 adipocytes via a novel signal transduction pathway involving ERK1/2-dependent NFATc4 phosphorylation. J Biol Chem. 2008;283:4200-9 pubmed
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French A, Sjölin H, Kim S, Koka R, Yang L, Young D, et al. DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections. J Immunol. 2006;177:4981-90 pubmed
Schleicher U, Mattner J, Blos M, Schindler H, Rollinghoff M, Karaghiosoff M, et al. Control of Leishmania major in the absence of Tyk2 kinase. Eur J Immunol. 2004;34:519-29 pubmed
product information
master code :
B002-5
SKU :
B002-5
product name :
Recombinant Mouse IL-18/IL-1F4 Protein
unit size :
25 ug
description :
The Recombinant Mouse IL-18/IL-1F4 Protein from R&D Systems is derived from E. coli.
target :
IL-18/IL-1F4
category :
Proteins and Enzymes
buffer :
25 ╡g in PBS containing 0.1% BSA and 1% sucrose.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie« Blue stain.
species :
Mouse
theoretical molecular weight :
18 kDa
gene symbol :
Il18
details of functionality :
Induction of IFN-gamma by Mouse IL-18 receptor transfected KG-1 cell [human myelomonocyte; ATCC CCL246] in response to the recombinant mouse IL-18 was measured using human IFN-gamma ELISA. The activity of lot 040 was as follows:IL-18 final concentration 5ng/mL; IFN-gamma induction 2863 IU/mL and IL-18 final concentration 10 ng/mL; IFN-gamma induction 7312 IU/mL.
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
source long :
E. coli -derived mouse IL-18/IL-1F4 protein 36-192 aa
source short :
E. coli
extended description :
A New rm IL-18 is Now Available! Competitively priced; Lower endotoxin specifications; Made in-house!
USD :
588 USD
product details :
A New rm IL-18 is Now Available! Competitively priced; Lower endotoxin specifications; Made in-house!
alt names :
Iboctadekin, IFN-gamma-inducing factor, IGIF, IGIFIL-1 gamma, IL18, IL-18MGC12320, IL-1F4, IL1F4iboctadekin, IL-1g, Interferon gamma-inducing factor, interleukin 18 (interferon-gamma-inducing factor), Interleukin-1 gamma, interleukin-18
storage :
Store the unopened product at -20 to -70 ░C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.