Recombinant Human IL-18/IL-1F4 Protein | R&D Systems B001-5 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-18/IL-1F4 Protein

catalog :

B001-5

quantity :

25 ug

price :

588 USD

more info or order :

R&D Systems product webpage

citations: 43

Reference
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Golden Mason L, McMahan R, Kriss M, Kilgore A, Cheng L, Dran R, et al. Early and late changes in natural killer cells in response to ledipasvir/sofosbuvir treatment. Hepatol Commun. 2018;2:364-375 pubmed publisher
Peppa D, Pedroza Pacheco I, Pellegrino P, Williams I, Maini M, Borrow P. Adaptive Reconfiguration of Natural Killer Cells in HIV-1 Infection. Front Immunol. 2018;9:474 pubmed publisher
van den Dries L, Claassen M, Groothuismink Z, van Gorp E, Boonstra A. Immune activation in prolonged cART-suppressed HIV patients is comparable to that of healthy controls. Virology. 2017;509:133-139 pubmed publisher
Dishon S, Cohen S, Cohen I, Nussbaum G. Inhibition of Myeloid Differentiation Factor 88 Reduces Human and Mouse T-Cell Interleukin-17 and IFNγ Production and Ameliorates Experimental Autoimmune Encephalomyelitis Induced in Mice. Front Immunol. 2017;8:615 pubmed publisher
Dai Z, Xing L, Cerise J, Wang E, Jabbari A, de Jong A, et al. CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata. J Immunol. 2016;197:1089-99 pubmed publisher
Jing Y, Ni Z, Wu J, Higgins L, Markowski T, Kaufman D, et al. Identification of an ADAM17 cleavage region in human CD16 (FcÎ³RIII) and the engineering of a non-cleavable version of the receptor in NK cells. PLoS ONE. 2015;10:e0121788 pubmed publisher
Tsai C, Liong K, Gunalan M, Li N, Lim D, Fisher D, et al. Type I IFNs and IL-18 regulate the antiviral response of primary human Î³Î´ T cells against dendritic cells infected with Dengue virus. J Immunol. 2015;194:3890-900 pubmed publisher
Dimova T, Brouwer M, Gosselin F, Tassignon J, Leo O, Donner C, et al. Effector VÎ³9VÎ´2 T cells dominate the human fetal Î³Î´ T-cell repertoire. Proc Natl Acad Sci U S A. 2015;112:E556-65 pubmed publisher
Presnell S, Al Attar A, Cichocki F, Miller J, Lutz C. Human natural killer cell microRNA: differential expression of MIR181A1B1 and MIR181A2B2 genes encoding identical mature microRNAs. Genes Immun. 2015;16:89-98 pubmed publisher
de Groen R, Boltjes A, Hou J, Liu B, McPhee F, Friborg J, et al. IFN-Î»-mediated IL-12 production in macrophages induces IFN-Î³ production in human NK cells. Eur J Immunol. 2015;45:250-9 pubmed publisher
Hedl M, Zheng S, Abraham C. The IL18RAP region disease polymorphism decreases IL-18RAP/IL-18R1/IL-1R1 expression and signaling through innate receptor-initiated pathways. J Immunol. 2014;192:5924-32 pubmed publisher
Luetke Eversloh M, Cicek B, Siracusa F, Thom J, Hamann A, Frischbutter S, et al. NK cells gain higher IFN-? competence during terminal differentiation. Eur J Immunol. 2014;44:2074-84 pubmed publisher
Mavropoulos A, Bogdanos D, Liaskos C, Orfanidou T, Simopoulou T, Zafiriou E, et al. Flow cytometric detection of p38 MAPK phosphorylation and intracellular cytokine expression in peripheral blood subpopulations from patients with autoimmune rheumatic diseases. J Immunol Res. 2014;2014:671431 pubmed publisher
Sun M, Yang P, Du L, Yang Y, Ye J. The role of interleukin-1 receptor-associated kinases in Vogt-Koyanagi-Harada disease. PLoS ONE. 2014;9:e93214 pubmed publisher
Teunissen M, Munneke J, Bernink J, Spuls P, Res P, te Velde A, et al. Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients. J Invest Dermatol. 2014;134:2351-2360 pubmed publisher
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Jitprasertwong P, Jaedicke K, Nile C, Preshaw P, Taylor J. Leptin enhances the secretion of interleukin (IL)-18, but not IL-1β, from human monocytes via activation of caspase-1. Cytokine. 2014;65:222-30 pubmed publisher
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product information

master code :

B001-5

SKU :

B001-5

product name :

Recombinant Human IL-18/IL-1F4 Protein

unit size :

25 ug

description :

The Recombinant Human IL-18/IL-1F4 Protein from R&D Systems is derived from E. coli. The Recombinant Human IL-18/IL-1F4 Protein has been validated for the following applications: Bioactivity.

target :

IL-18/IL-1F4

category :

Proteins and Enzymes

buffer :

25 ╡g in PBS containing 0.1% BSA and 1% sucrose.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie« Blue stain.

species :

Human

theoretical molecular weight :

18 kDa

gene symbol :

IL18

details of functionality :

Induction of IFN-gamma by KG-1 cell [human myelomonocyte; ATCC CCL246] in response to the recombinant human IL-18 was measured using human IFN-gamma ELISA. The activity of lot 111 was as follows: IL-18 final concentration 10 ng/mL; IFN-gamma induction 48.1 IU/mL and IL-18 final concentration 20 ng/mL; IFN-gamma induction 64.3 IU/mL.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

applications :

Bioactivity

source long :

E. coli -derived human IL-18/IL-1F4 protein 37-193 aa

source short :

E. coli

extended description :

A New rh IL-18 is Now Available! Competitively priced; Higher purity; Lower endotoxin; Manufactured in-house!

USD :

588 USD

product details :

A New rh IL-18 is Now Available! Competitively priced; Higher purity; Lower endotoxin; Manufactured in-house!

alt names :

Iboctadekin, IFN-gamma-inducing factor, IGIF, IGIFIL-1 gamma, IL18, IL-18MGC12320, IL-1F4, IL1F4iboctadekin, IL-1g, Interferon gamma-inducing factor, interleukin 18 (interferon-gamma-inducing factor), Interleukin-1 gamma, interleukin-18

storage :

Store the unopened product at -20 to -70 ░C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

R&D Systems product webpage