product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human EGFR Isoform vIII Fc Avi-tag Protein, CF
catalog :
AVI10494-050
quantity :
50 ug
price :
599 USD
more info or order :
R&D Systems product webpage
citations: 2
Reference
Bagley S, Logun M, Fraietta J, Wang X, Desai A, Bagley L, et al. Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results. Nat Med. 2024;30:1320-1329 pubmed publisher
Sun R, Zhou Y, Han L, Pan Z, Chen J, Zong H, et al. A Rational Designed Novel Bispecific Antibody for the Treatment of GBM. Biomedicines. 2021;9: pubmed publisher
image
image 1 :
R&D Systems AVI10494-050 image 1
Recombinant Human EGFR Isoform vIII Fc Avi-tag Protein Binding Activity
product information
master code :
AVI10494
SKU :
AVI10494-050
product name :
Recombinant Human EGFR Isoform vIII Fc Avi-tag Protein, CF
unit size :
50 ug
description :
The Recombinant Human EGFR Isoform vIII Fc Avi-tag Protein, CF from R&D Systems is derived from CHO. The Recombinant Human EGFR Isoform vIII Fc Avi-tag Protein, CF has been validated for the following applications: Bioactivity.
target :
EGFR
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose.
conjugate :
Biotin
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
95-115 kDa, under reducing conditions
theoretical molecular weight :
67 kDa
details of functionality :
Measured by its binding ability in a functional ELISA. When Human EGFR Isoform vIII antibody (Novus Catalog # 50599 ) is immobilized at 0.1 ╡g/mL (100 ╡L/well), Biotinylated Recombinant Human EGFR Isoform vIII Fc Chimera Avi-tag (Catalog # AVI10494)binds with an ED50 of 25-150 ng/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Human EGFR Isoform vIII Fc Avi-tag Protein Binding Activity
accessionNumbers :
NP_001333870.1
applications :
Bioactivity
source long :
Chinese Hamster Ovary cell line, CHO-derived human EGFR protein Human EGFR Isoform vIII (Leu25-Ser378) Accession # NP_001333870.1 IEGRMD Human IgG1 (Pro100-Lys330) Avi-tag N-terminus C-terminus
source short :
CHO
extended description :
Biotinylated
USD :
599 USD
product details :
Biotinylated
alt names :
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, EC 2.7.10, EC 2.7.10.1, EGF R, epidermal growth factor receptor, epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b)oncogene homolog), ErbB, ErbB1, ERBB1PIG61, HER1, HER-1, mENA, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.