Argirova M, Cherneva E, Mihaylova R, Momekov G, Yancheva D. New metal complexes of 1H-benzimidazole-2-yl hydrazones: Cytostatic, proapoptotic and modulatory activity on kinase signaling pathways. Arch Biochem Biophys. 2025;764:110245 pubmed publisher

Mehta G, Horst E, Cotter L, Bonini M, Novak C, Treacher N, et al. Ascitic Shear Stress Activates GPCRs and Downregulates Mucin 15 to Promote OvarianCancer Malignancy. Res Sq. 2024;: pubmed

Jones K, Keddy C, Jenkins C, Nicholson K, Shinde U, Davare M. Novel insight into mechanisms of ROS1 catalytic activation via loss of the extracellular domain. Sci Rep. 2024;14:22191 pubmed publisher

Jimenez Macias J, Vaughn Beaucaire P, Bharati A, Xu Z, Forrest M, Hong J, et al. Modulation of blood-tumor barrier transcriptional programs improves intra-tumoral drug delivery and potentiates chemotherapy in GBM. bioRxiv. 2024;: pubmed publisher

Rodr xed guez Sarmiento D, Rond xf3 n Villarreal P, Scarpelli Pereira P, Bouvier M. Comprehensive Analysis of Kisspeptin Signaling: Effects on Cellular Dynamics in Cervical Cancer. Biomolecules. 2024;14: pubmed publisher

Ross M, Xie Y, Owyang R, Ye C, Zbihley O, Lyu R, et al. PTPN2 copper-sensing relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression. Nat Commun. 2024;15:6947 pubmed publisher

Di T, Luo Q, Song J, Yan X, Zhang L, Pan W, et al. APG-1252 combined with Cabozantinib inhibits hepatocellular carcinoma by suppressing MEK/ERK and CREB/Bcl-xl pathways. Int Immunopharmacol. 2024;139:112615 pubmed publisher

Yu L, Deng Y, Wang X, Santos C, Davis I, Earp H, et al. Co-targeting JAK1/STAT6/GAS6/TAM signaling improves chemotherapy efficacy in Ewing sarcoma. Nat Commun. 2024;15:5292 pubmed publisher

Standing D, Dandawate P, Gunewardena S, Covarrubias Zambrano O, Roby K, Khabele D, et al. Selective targeting of IRAK1 attenuates low molecular weight hyaluronic acid-induced stemness and non-canonical STAT3 activation in epithelial ovarian cancer. Cell Death Dis. 2024;15:362 pubmed publisher

Sidgwick G, Weston R, Mahmoud A, Schiro A, Serracino Inglott F, Tandel S, et al. Novel Glycomimetics Protect against Glycated Low-Density Lipoprotein-Induced Vascular Calcification In Vitro via Attenuation of the RAGE/ERK/CREB Pathway. Cells. 2024;13: pubmed publisher

Shumliakivska M, Lux xe1 n G, Hemmerling I, Scheller M, Li X, M xfc ller Tidow C, et al. DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblasts. Nat Commun. 2024;15:606 pubmed publisher

Lee M, Kang S, Um K, Lee S, Hwang H, Baek K, et al. Brain-targeted delivery of neuroprotective survival gene minimizing hematopoietic cell contamination: implications for Parkinson's disease treatment. J Transl Med. 2024;22:53 pubmed publisher

Soumoy L, Genbauffe A, Mouchart L, Sperone A, Trelcat A, Mukeba Harchies L, et al. ATP1A1 is a promising new target for melanoma treatment and can be inhibited by its physiological ligand bufalin to restore targeted therapy efficacy. Cancer Cell Int. 2024;24:8 pubmed publisher

Zhu G, Cai H, Xiao Q, Zeng S, Jiang X, Liu D. GRB7 plays a promoting role in the progression of gastric cancer. BMC Cancer. 2023;23:1262 pubmed publisher

Dernovics x, Sepr xe9 nyi G, R xe1 zga Z, Ayaydin F, Ver xe9 b Z, Megyeri K. Phenol-Soluble Modulin α3 Stimulates Autophagy in HaCaT Keratinocytes. Biomedicines. 2023;11: pubmed publisher

Gonzalez Suarez N, Fernández Marrero Y, H xe9 bert M, Roy M, Boudreau L, Annabi B. EGCG inhibits the inflammation and senescence inducing properties of MDA-MB-231 triple-negative breast cancer (TNBC) cells-derived extracellular vesicles in human adipose-derived mesenchymal stem cells. Cancer Cell Int. 2023;23:240 pubmed publisher

Pun S, O Neill K, Edgar K, Gill E, Moez A, Naderi Meshkin H, et al. PLAC8-Mediated Activation of NOX4 Signalling Restores Angiogenic Function of Endothelial Colony-Forming Cells in Experimental Hypoxia. Cells. 2023;12: pubmed publisher

Bassot A, Dragic H, Haddad S, Moindrot L, Odouard S, Corlazzoli F, et al. Identification of a miRNA multi-targeting therapeutic strategy in glioblastoma. Cell Death Dis. 2023;14:630 pubmed publisher

Ross M, Xie Y, Owyang R, Ye C, Zbihley O, Lyu R, et al. PTPN2 copper-sensing rapidly relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression. bioRxiv. 2023;: pubmed publisher

Pang L, Dunterman M, Guo S, Khan F, Liu Y, Taefi E, et al. Kunitz-type protease inhibitor TFPI2 remodels stemness and immunosuppressive tumor microenvironment in glioblastoma. Nat Immunol. 2023;24:1654-1670 pubmed publisher

Wang Y, Yang C, Wang Z, Wang Y, Yan Q, Feng Y, et al. Epithelial Galectin-3 Induced the Mitochondrial Complex Inhibition and Cell Cycle Arrest of CD8+ T Cells in Severe/Critical COVID-19. Int J Mol Sci. 2023;24: pubmed publisher

Wang Y, Vadhan A, Wu C, Hsu C, Chen Y, Chen Y, et al. Fumarate hydratase functions as a tumor suppressor in endometrial cancer by inactivating EGFR signaling. Oncol Rep. 2023;50: pubmed publisher

Jeon Y, Kim T, Kwon H, Kim J, Park Y, Ham J, et al. Cannabidiol Enhances Cabozantinib-Induced Apoptotic Cell Death via Phosphorylation of p53 Regulated by ER Stress in Hepatocellular Carcinoma. Cancers (Basel). 2023;15: pubmed publisher

Zhou Q, Peng Y, Ji F, Chen H, Kang W, Chan L, et al. Targeting of SLC25A22 boosts the immunotherapeutic response in KRAS-mutant colorectal cancer. Nat Commun. 2023;14:4677 pubmed publisher

Yuan S, Wang Y, Chan L, Hung A, Nguyen H, Chen Y, et al. IL-1RA promotes oral squamous cell carcinoma malignancy through mitochondrial metabolism-mediated EGFR/JNK/SOX2 pathway. J Transl Med. 2023;21:473 pubmed publisher

Choi D, Kang W, Park S, Son B, Park T. Identification of Glucocorticoid Receptor Target Genes That Potentially Inhibit Collagen Synthesis in Human Dermal Fibroblasts. Biomolecules. 2023;13: pubmed publisher

Wang J, Ding Z, Shu W, Zhuge Y. The role of KNTC1 in the regulation of proliferation, migration and tumorigenesis in colorectal cancer. Cell Signal. 2023;108:110728 pubmed publisher

Pirttiniemi A, Adeshara K, Happonen N, Einarsdottir E, Katayama S, Salmenkari H, et al. Long-chain polyphosphates inhibit type I interferon signaling and augment LPS-induced cytokine secretion in human leukocytes. J Leukoc Biol. 2023;114:250-265 pubmed publisher

Balasubramanian B, Yacqub Usman K, Venkatraman S, Myint K, Juengsamarn J, Sarkhampee P, et al. Targeting FGFRs Using PD173074 as a Novel Therapeutic Strategy in Cholangiocarcinoma. Cancers (Basel). 2023;15: pubmed publisher

Loda A, Calza S, Giacomini A, Ravelli C, Krishna Chandran A, Tobia C, et al. FGF-trapping hampers cancer stem-like cells in uveal melanoma. Cancer Cell Int. 2023;23:89 pubmed publisher

Li S, Pritchard D, Yu L. Galectin-3 promotes secretion of proteases that decrease epithelium integrity in human colon cancer cells. Cell Death Dis. 2023;14:268 pubmed publisher

Park J, Oh K, Lee G, Bang G, Park J, Kim H, et al. Defining regorafenib as a senomorphic drug: therapeutic potential in the age-related lung disease emphysema. Exp Mol Med. 2023;55:794-805 pubmed publisher

Lin W, Niu R, Park S, Zou Y, Kim S, Xia X, et al. IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis. Nat Commun. 2023;14:1578 pubmed publisher

Shah K, Al Ashiri L, Nasimian A, Ahmed M, Kazi J. Venetoclax-Resistant T-ALL Cells Display Distinct Cancer Stem Cell Signatures and Enrichment of Cytokine Signaling. Int J Mol Sci. 2023;24: pubmed publisher

Chang C, Lin B, Chen C, Nguyen N, Hsieh T, Su J, et al. Stellettin B Induces Cell Death in Bladder Cancer Via Activating the Autophagy/DAPK2/Apoptosis Signaling Cascade. Mar Drugs. 2023;21: pubmed publisher

Sar x131 yar E, Karpat O, Sezan S, Baylan S, K x131 p xe7 ak A, Guven K, et al. EGFR and Lyn inhibition augments regorafenib induced cell death in sorafenib resistant 3D tumor spheroid model. Cell Signal. 2023;105:110608 pubmed publisher

Guo C, Deshpande M, Niu Y, Kachwala I, Flores Bellver M, Megarity H, et al. HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease. Cell Rep. 2023;42:111976 pubmed publisher

Chu H, Kobayashi Y, Bui D, Yun Y, Nguyen L, Mitani A, et al. CCL4 Regulates Eosinophil Activation in Eosinophilic Airway Inflammation. Int J Mol Sci. 2022;23: pubmed publisher

Clemen R, Arlt K, Miebach L, von Woedtke T, Bekeschus S. Oxidized Proteins Differentially Affect Maturation and Activation of Human Monocyte-Derived Cells. Cells. 2022;11: pubmed publisher

SCHMITT M, Ceteci F, Gupta J, Pesic M, B xf6 ttger T, Nicolas A, et al. Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation. Nature. 2022;612:347-353 pubmed publisher

Takahashi H, K xfc htreiber W, Keefe R, Lee A, Aristarkhova A, Dias H, et al. BCG vaccinations drive epigenetic changes to the human T cell receptor: Restored expression in type 1 diabetes. Sci Adv. 2022;8:eabq7240 pubmed publisher

Chernova T, Grosso S, Sun X, Tenor A, Cabeza J, Craxton A, et al. Extracellular Vesicles Isolated from Malignant Mesothelioma Cancer-Associated Fibroblasts Induce Pro-Oncogenic Changes in Healthy Mesothelial Cells. Int J Mol Sci. 2022;23: pubmed publisher

Ablain J, Al Mahi A, Rothschild H, Prasad M, Aires S, Yang S, et al. Loss of NECTIN1 triggers melanoma dissemination upon local IGF1 depletion. Nat Genet. 2022;54:1839-1852 pubmed publisher

Fl xfc ck M, Vaughan D, Rittweger J, Giraud M. Post-translational dysregulation of glucose uptake during exhaustive cycling exercise in vastus lateralis muscle of healthy homozygous carriers of the ACE deletion allele. Front Physiol. 2022;13:933792 pubmed publisher

Barbolina M. Targeting Microtubule-Associated Protein Tau in Chemotherapy-Resistant Models of High-Grade Serous Ovarian Carcinoma. Cancers (Basel). 2022;14: pubmed publisher

Marona P, G xf3 rka J, Kwapisz O, Jura J, Rys J, Hoffman R, et al. Resistance to tyrosine kinase inhibitors promotes renal cancer progression through MCPIP1 tumor-suppressor downregulation and c-Met activation. Cell Death Dis. 2022;13:814 pubmed publisher

Xu C, Yan L, Guan X, Wang Z, Wu J, Lv A, et al. Tsp2 Facilitates Tumor-associated Fibroblasts Formation and Promotes Tumor Progression in Retroperitoneal Liposarcoma. Int J Biol Sci. 2022;18:5038-5055 pubmed publisher

Jiang W, Ma C, Bai J, Du X. Macrophage SAMSN1 protects against sepsis-induced acute lung injury in mice. Redox Biol. 2022;56:102432 pubmed publisher

Almutlaq M, Mansour F, Alghamdi J, Alhendi Y, Alamro A, Alghamdi A, et al. Angiotensin II Exaggerates SARS-CoV-2 Specific T-Cell Response in Convalescent Individuals following COVID-19. Int J Mol Sci. 2022;23: pubmed publisher

Jouida A, O Callaghan M, Mc Carthy C, Fabre A, Nadarajan P, Keane M. Exosomes from EGFR-Mutated Adenocarcinoma Induce a Hybrid EMT and MMP9-Dependant Tumor Invasion. Cancers (Basel). 2022;14: pubmed publisher

Peglion F, Capuana L, Perfettini I, Boucontet L, Braithwaite B, Colucci Guyon E, et al. PTEN inhibits AMPK to control collective migration. Nat Commun. 2022;13:4528 pubmed publisher

Pietrobono S, De Paolo R, Mangiameli D, Marranci A, Battisti I, Franchin C, et al. p38 MAPK-dependent phosphorylation of transcription factor SOX2 promotes an adaptive response to BRAF inhibitors in melanoma cells. J Biol Chem. 2022;298:102353 pubmed publisher

Stackhouse C, Anderson J, Yue Z, Nguyen T, Eustace N, Langford C, et al. An in vivo model of glioblastoma radiation resistance identifies long noncoding RNAs and targetable kinases. JCI Insight. 2022;7: pubmed publisher

xc1 vila Gonz xe1 lez D, Portillo W, Barrag xe1 n xc1 lvarez C, Hernández Montes G, Flores Garza E, Molina Hern xe1 ndez A, et al. The human amniotic epithelium confers a bias to differentiate toward the neuroectoderm lineage in human embryonic stem cells. elife. 2022;11: pubmed publisher

He C, Wang C, Liu H, Shan B. Kayadiol exerted anticancer effects through p53-mediated ferroptosis in NKTCL cells. BMC Cancer. 2022;22:724 pubmed publisher

Kamat K, Krishnan V, Dorigo O. Macrophage-derived CCL23 upregulates expression of T-cell exhaustion markers in ovarian cancer. Br J Cancer. 2022;127:1026-1033 pubmed publisher

Ding N, Jiang H, Thapa P, Hao Y, Alshahrani A, Allison D, et al. Peroxiredoxin IV plays a critical role in cancer cell growth and radioresistance through the activation of the Akt/GSK3 signaling pathways. J Biol Chem. 2022;298:102123 pubmed publisher

Alonso Gonz xe1 lez C, Gonz xe1 lez Abalde C, Men xe9 ndez Men xe9 ndez J, Gonz xe1 lez Gonz xe1 lez A, xc1 lvarez Garc xed a V, Gonz xe1 lez Cabeza A, et al. Melatonin Modulation of Radiation-Induced Molecular Changes in MCF-7 Human Breast Cancer Cells. Biomedicines. 2022;10: pubmed publisher

Zhao C, Yu H, Fan X, Niu W, Fan J, Sun S, et al. GSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2-STAT3 axis. Oncogenesis. 2022;11:28 pubmed publisher

Mamidi M, Mahmud H, Maiti G, Mendez M, Fernandes S, Vesely S, et al. Idelalisib activates AKT via increased recruitment of PI3Kδ/PI3Kβ to BCR signalosome while reducing PDK1 in post-therapy CLL cells. Leukemia. 2022;36:1806-1817 pubmed publisher

Lin J, Lian N, Gao Y, Zheng Q, Yang Y, Ma Y, et al. m6A methylation mediates LHPP acetylation as a tumour aerobic glycolysis suppressor to improve the prognosis of gastric cancer. Cell Death Dis. 2022;13:463 pubmed publisher

Kakarla M, Challasivakanaka S, Dufficy M, Gil V, Filipovich Y, Vickman R, et al. Ephrin B Activate Src Family Kinases in Fibroblasts Inducing Stromal Remodeling in Prostate Cancer. Cancers (Basel). 2022;14: pubmed publisher

Gaiteiro C, Soares J, Relvas Santos M, Peixoto A, Ferreira D, Paulo P, et al. Glycoproteogenomics characterizes the CD44 splicing code associated with bladder cancer invasion. Theranostics. 2022;12:3150-3177 pubmed publisher

Lim E, Kang J, Kim Y, Kim S, Lee S. ICAM-1 promotes cancer progression by regulating SRC activity as an adapter protein in colorectal cancer. Cell Death Dis. 2022;13:417 pubmed publisher

Bini S, Pecce V, Di Costanzo A, Polito L, Ghadiri A, Minicocci I, et al. The Fibrinogen-like Domain of ANGPTL3 Facilitates Lipolysis in 3T3-L1 Cells by Activating the Intracellular Erk Pathway. Biomolecules. 2022;12: pubmed publisher

Huang Y, Motta E, Nanvuma C, Kuhrt L, Yuan Y, Xia P, et al. Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model. Cell Rep. 2022;39:110670 pubmed publisher

Liu Z, Wang Q, Zhai G, Ke S, Yu X, Guo J. SLC4A4 promotes prostate cancer progression in vivo and in vitro via AKT-mediated signalling pathway. Cancer Cell Int. 2022;22:127 pubmed publisher

Mooz J, Riegel K, Ps H, Sadanandam A, Marini F, Klein M, et al. ARAF suppresses ERBB3 expression and metastasis in a subset of lung cancers. Sci Adv. 2022;8:eabk1538 pubmed publisher

Braun T, Stachelscheid J, Bley N, Oberbeck S, Otte M, Müller T, et al. Noncanonical Function of AGO2 Augments T-cell Receptor Signaling in T-cell Prolymphocytic Leukemia. Cancer Res. 2022;82:1818-1831 pubmed publisher

Zhang X, Hu Y, Pan Y, Xiong Y, Zhang Y, Han M, et al. DDR1 promotes hepatocellular carcinoma metastasis through recruiting PSD4 to ARF6. Oncogene. 2022;41:1821-1834 pubmed publisher

Shimada E, Matsumoto Y, Nakagawa M, Susuki Y, Endo M, Setsu N, et al. Methylation-mediated silencing of protein kinase C zeta induces apoptosis avoidance through ATM/CHK2 inactivation in dedifferentiated chondrosarcoma. Br J Cancer. 2022;126:1289-1300 pubmed publisher

Guney Eskiler G, Ozturk M. Therapeutic potential of the PI3K inhibitor LY294002 and PARP inhibitor Talazoparib combination in BRCA-deficient triple negative breast cancer cells. Cell Signal. 2022;91:110229 pubmed publisher

Berestjuk I, Lecacheur M, Carminati A, Diazzi S, Rovera C, Prod homme V, et al. Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix-mediated tumor cell adaptation and tolerance to BRAF-targeted therapy in melanoma. EMBO Mol Med. 2022;14:e11814 pubmed publisher

Borza C, Bolás G, Bock F, Zhang X, Akabogu F, Zhang M, et al. DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3. JCI Insight. 2022;7: pubmed publisher

Smith R, Odintsov I, Liu Z, Lui A, Hayashi T, Vojnic M, et al. Novel patient-derived models of desmoplastic small round cell tumor confirm a targetable dependency on ERBB signaling. Dis Model Mech. 2022;15: pubmed publisher

Mazzu Y, Liao Y, Nandakumar S, Jehane L, Koche R, Rajanala S, et al. Prognostic and therapeutic significance of COP9 signalosome subunit CSN5 in prostate cancer. Oncogene. 2022;41:671-682 pubmed publisher

Chauss D, Freiwald T, McGregor R, Yan B, Wang L, Nova Lamperti E, et al. Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells. Nat Immunol. 2022;23:62-74 pubmed publisher

Khayat M, Omar A, Ahmed F, Khan M, Ibrahim S, Muhammad Y, et al. Insights on Cancer Cell Inhibition, Subcellular Activities, and Kinase Profile of Phenylacetamides Pending 1H-Imidazol-5-One Variants. Front Pharmacol. 2021;12:794325 pubmed publisher

Marunaka K, Shu S, Kobayashi M, Goto M, Katsuta Y, Yoshino Y, et al. Elevation of Hyaluronan Synthase by Magnesium Supplementation Mediated through the Activation of GSK3 and CREB in Human Keratinocyte-Derived HaCaT Cells. Int J Mol Sci. 2021;23: pubmed publisher

Ahn H, Choi E, Kim Y. GPR87 Promotes Metastasis through the AKT-eNOS-NO Axis in Lung Adenocarcinoma. Cancers (Basel). 2021;14: pubmed publisher

Cha Y, Kim T, Jeon J, Jang Y, Kim P, Lopes C, et al. SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes. Cell Rep. 2021;37:110155 pubmed publisher

Ounoughene Y, Fourgous E, Boublik Y, Saland E, Guiraud N, Recher C, et al. SHED-Dependent Oncogenic Signaling of the PEAK3 Pseudo-Kinase. Cancers (Basel). 2021;13: pubmed publisher

Bakhshinyan D, Adile A, Liu J, Gwynne W, Suk Y, Custers S, et al. Temporal profiling of therapy resistance in human medulloblastoma identifies novel targetable drivers of recurrence. Sci Adv. 2021;7:eabi5568 pubmed publisher

Stoup N, Liberelle M, Schulz C, Cavdarli S, Vasseur R, Magnez R, et al. The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding Affinity and Promote Pancreatic Cancer Cell Tumorigenesis. Cancers (Basel). 2021;13: pubmed publisher

Al Luhaibi Z, Dernovics x, Sepr xe9 nyi G, Ayaydin F, Boldogk x151 i Z, Ver xe9 b Z, et al. IL-36α and Lipopolysaccharide Cooperatively Induce Autophagy by Triggering Pro-Autophagic Biased Signaling. Biomedicines. 2021;9: pubmed publisher

Yin L, Zeng Y, Zeng R, Chen Y, Wang T, Rodabaugh K, et al. Protein kinase RNA-activated controls mitotic progression and determines paclitaxel chemosensitivity through B-cell lymphoma 2 in ovarian cancer. Oncogene. 2021;40:6772-6785 pubmed publisher

Vorstandlechner V, Laggner M, Copic D, Klas K, Direder M, Chen Y, et al. The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation. Nat Commun. 2021;12:6242 pubmed publisher

Kim J, Jeon Y, Lim S, Ryu J, Lee J, Chang I, et al. Akt-mediated Ephexin1-Ras interaction promotes oncogenic Ras signaling and colorectal and lung cancer cell proliferation. Cell Death Dis. 2021;12:1013 pubmed publisher

Zalcman N, Gutreiman M, Shahar T, Weller M, Lavon I. Androgen Receptor Activation in Glioblastoma Can Be Achieved by Ligand-Independent Signaling through EGFR-A Potential Therapeutic Target. Int J Mol Sci. 2021;22: pubmed publisher

Pandey A, Tripathi S, Mai J, Hanash S, Shen H, Mitra S, et al. Combinatorial Effect of PLK1 Inhibition with Temozolomide and Radiation in Glioblastoma. Cancers (Basel). 2021;13: pubmed publisher

Quintanal Villalonga Á, Taniguchi H, Zhan Y, Hasan M, Chavan S, Meng F, et al. Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation. J Hematol Oncol. 2021;14:170 pubmed publisher

Roberts K, Cubitt M, Carlton T, Rodrigues Duarte L, Maggiore L, Chai R, et al. Preclinical development of a bispecific TNFα/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease. Sci Rep. 2021;11:19422 pubmed publisher

Barcus C, Hwang P, Morikis V, Brenot A, Pence P, Clarke M, et al. Tyrosine kinase-independent actions of DDR2 in tumor cells and cancer-associated fibroblasts influence tumor invasion, migration and metastasis. J Cell Sci. 2021;134: pubmed publisher

Ma S, Mangala L, Hu W, Bayaktar E, Yokoi A, Hu W, et al. CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance. Cell Rep. 2021;36:109549 pubmed publisher

Ebner Peking P, Krisch L, Wolf M, Hochmann S, Höög A, Vári B, et al. Self-assembly of differentiated progenitor cells facilitates spheroid human skin organoid formation and planar skin regeneration. Theranostics. 2021;11:8430-8447 pubmed publisher

Demirel E, Arnold C, Garg J, Jäger M, Sticht C, Li R, et al. RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells. Cells. 2021;10: pubmed publisher

Luo F, Lu F, Qiu M, Zhou T, Ma W, Luo M, et al. Gemcitabine and APG-1252, a novel small molecule inhibitor of BCL-2/BCL-XL, display a synergistic antitumor effect in nasopharyngeal carcinoma through the JAK-2/STAT3/MCL-1 signaling pathway. Cell Death Dis. 2021;12:772 pubmed publisher

Stecher C, Marinkov S, Mayr Harting L, Katic A, Kastner M, Rieder Rommer F, et al. Protein Phosphatase 1 Regulates Human Cytomegalovirus Protein Translation by Restraining AMPK Signaling. Front Microbiol. 2021;12:698603 pubmed publisher

Yoon C, Lu J, Ryeom S, Simon M, Yoon S. PIK3R3, part of the regulatory domain of PI3K, is upregulated in sarcoma stem-like cells and promotes invasion, migration, and chemotherapy resistance. Cell Death Dis. 2021;12:749 pubmed publisher

Mahdal M, Neradil J, Mudry P, Paukovcekova S, Staniczkova Zambo I, Urban J, et al. New Target for Precision Medicine Treatment of Giant-Cell Tumor of Bone: Sunitinib Is Effective in the Treatment of Neoplastic Stromal Cells with Activated PDGFRβ Signaling. Cancers (Basel). 2021;13: pubmed publisher

Durlanik S, Fundel Clemens K, Viollet C, Huber H, Lenter M, Kitt K, et al. CD276 is an important player in macrophage recruitment into the tumor and an upstream regulator for PAI-1. Sci Rep. 2021;11:14849 pubmed publisher

Xu J, Yang X, Deng Q, Yang C, Wang D, Jiang G, et al. TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer. Nat Commun. 2021;12:4413 pubmed publisher

Guo J, Zhong X, Tan Q, Yang S, Liao J, Zhuge J, et al. miR-301a-3p induced by endoplasmic reticulum stress mediates the occurrence and transmission of trastuzumab resistance in HER2-positive gastric cancer. Cell Death Dis. 2021;12:696 pubmed publisher

Sevim H, Celik H, Düşünceli L, Ceyhan C, Molotkova A, Nakazawa K, et al. Clofarabine induces ERK/MSK/CREB activation through inhibiting CD99 on Ewing sarcoma cells. PLoS ONE. 2021;16:e0253170 pubmed publisher

Andelid K, Öst K, Andersson A, Mohamed E, Jevnikar Z, Vanfleteren L, et al. Lung macrophages drive mucus production and steroid-resistant inflammation in chronic bronchitis. Respir Res. 2021;22:172 pubmed publisher

Lai Y, Chao C, Liao C, Lee T, Hsu J, Chou W, et al. Epithelial-mesenchymal transition induced by SARS-CoV-2 required transcriptional upregulation of Snail. Am J Cancer Res. 2021;11:2278-2290 pubmed

Gheysen L, Soumoy L, Trelcat A, Verset L, Journe F, Saussez S. New Treatment Strategy Targeting Galectin-1 against Thyroid Cancer. Cells. 2021;10: pubmed publisher

Jones T, Eddens L, Kupusarevic J, Simoes D, Furber M, Van Someren K, et al. Aerobic exercise intensity does not affect the anabolic signaling following resistance exercise in endurance athletes. Sci Rep. 2021;11:10785 pubmed publisher

Hafner S, Schmiech M, Lang S. The Cardenolide Glycoside Acovenoside A Interferes with Epidermal Growth Factor Receptor Trafficking in Non-Small Cell Lung Cancer Cells. Front Pharmacol. 2021;12:611657 pubmed publisher

Noor S, Hoffmann M, Rinis N, Bartels M, Winterhalter P, Hoelscher C, et al. Glycosyltransferase POMGNT1 deficiency strengthens N-cadherin-mediated cell-cell adhesion. J Biol Chem. 2021;296:100433 pubmed publisher

Yoon H, Tang C, Banerjee S, Delgado A, Yebra M, Davis J, et al. TGF-β1-mediated transition of resident fibroblasts to cancer-associated fibroblasts promotes cancer metastasis in gastrointestinal stromal tumor. Oncogenesis. 2021;10:13 pubmed publisher

Benedetti F, Curreli S, Gallo R, Zella D. Exogenous bacterial DnaK increases protein kinases activity in human cancer cell lines. J Transl Med. 2021;19:60 pubmed publisher

Chawsheen M, Dash P. mTOR modulates resistance to gemcitabine in lung cancer in an MTORC2 dependent mechanism. Cell Signal. 2021;81:109934 pubmed publisher

Shen W, Zhang X, Tang J, Zhang Z, Du R, Luo D, et al. CCL16 maintains stem cell-like properties in breast cancer by activating CCR2/GSK3β/β-catenin/OCT4 axis. Theranostics. 2021;11:2297-2317 pubmed publisher

Choi B, Kou Z, Colon T, Chen C, Chen Y, Dai W. Identification of Radil as a Ras binding partner and putative activator. J Biol Chem. 2021;296:100314 pubmed publisher

Jo S, Heo W, Son H, Quan M, Hong B, Kim J, et al. S100A8/A9 mediate the reprograming of normal mammary epithelial cells induced by dynamic cell-cell interactions with adjacent breast cancer cells. Sci Rep. 2021;11:1337 pubmed publisher

Jiao C, Feng Q, Li C, Wang D, Han S, Zhang Y, et al. BUB1B promotes extrahepatic cholangiocarcinoma progression via JNK/c-Jun pathways. Cell Death Dis. 2021;12:63 pubmed publisher

Wang J, Lv X, Guo X, Dong Y, Peng P, Huang F, et al. Feedback activation of STAT3 limits the response to PI3K/AKT/mTOR inhibitors in PTEN-deficient cancer cells. Oncogenesis. 2021;10:8 pubmed publisher

Weglage J, Wolters F, Hehr L, Lichtenberger J, Wulz C, Hempel F, et al. Schistosoma mansoni eggs induce Wnt/β-catenin signaling and activate the protooncogene c-Jun in human and hamster colon. Sci Rep. 2020;10:22373 pubmed publisher

Fuentes Baile M, Ventero M, Encinar J, Garcia Morales P, Poveda Deltell M, Pérez Valenciano E, et al. Differential Effects of IGF-1R Small Molecule Tyrosine Kinase Inhibitors BMS-754807 and OSI-906 on Human Cancer Cell Lines. Cancers (Basel). 2020;12: pubmed publisher

Willmann E, Pandurovic V, Jokinen A, Beckley D, Bohlson S. Extracellular signal-regulated kinase 1/2 is required for complement component C1q and fibronectin dependent enhancement of Fcγ- receptor mediated phagocytosis in mouse and human cells. BMC Immunol. 2020;21:61 pubmed publisher

Hao Q, Wang P, Dutta P, Chung S, Li Q, Wang K, et al. Comp34 displays potent preclinical antitumor efficacy in triple-negative breast cancer via inhibition of NUDT3-AS4, a novel oncogenic long noncoding RNA. Cell Death Dis. 2020;11:1052 pubmed publisher

Khattak M, Shanableh A, Hussain M, Khan A, Abdulwahab M, Radeef W, et al. Anticancer activities of selected Emirati Date (Phoenix dactylifera L.) varieties pits in human triple negative breast cancer MDA-MB-231 cells. Saudi J Biol Sci. 2020;27:3390-3396 pubmed publisher

Wantoch von Rekowski K, König P, Henze S, Schlesinger M, Zawierucha P, Januchowski R, et al. Insight into Cisplatin-Resistance Signaling of W1 Ovarian Cancer Cells Emerges mTOR and HSP27 as Targets for Sensitization Strategies. Int J Mol Sci. 2020;21: pubmed publisher

Wang Y, Chen H, Lo S, Chen Y, Huang Y, Hu S, et al. Visfatin Enhances Breast Cancer Progression through CXCL1 Induction in Tumor-Associated Macrophages. Cancers (Basel). 2020;12: pubmed publisher

Araldi R, de Melo T, Levy D, de Souza D, Maurício B, Colozza Gama G, et al. LIMD2 Regulates Key Steps of Metastasis Cascade in Papillary Thyroid Cancer Cells via MAPK Crosstalk. Cells. 2020;9: pubmed publisher

Alghamdi A, Aldossary W, Albahkali S, Alotaibi B, Alrfaei B. The loss of microglia activities facilitates glaucoma progression in association with CYP1B1 gene mutation (p.Gly61Glu). PLoS ONE. 2020;15:e0241902 pubmed publisher

Lee C, Hung P, Liu K, Chung H, Yang W, Hsu K, et al. LDOC1 Suppresses Microbe-Induced Production of IL-1β in Human Normal and Cancerous Oral Cells through the PI3K/Akt/GSK-3β Axis. Cancers (Basel). 2020;12: pubmed publisher

Zhou B, Liu J, Zeng L, Zhu S, Wang H, Billiar T, et al. Extracellular SQSTM1 mediates bacterial septic death in mice through insulin receptor signalling. Nat Microbiol. 2020;5:1576-1587 pubmed publisher

Szeliga M, Karpińska M, Rola R, Niewiadomy A. Design, synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as anti-glioblastoma agents targeting the AKT pathway. Bioorg Chem. 2020;105:104362 pubmed publisher

Ketterer S, Mitschke J, Ketscher A, Schlimpert M, Reichardt W, Baeuerle N, et al. Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling. Nat Commun. 2020;11:5133 pubmed publisher

Gao N, Yang F, Chen S, Wan H, Zhao X, Dong H. The role of TRPV1 ion channels in the suppression of gastric cancer development. J Exp Clin Cancer Res. 2020;39:206 pubmed publisher

Regan Fendt K, Li D, Reyes R, Yu L, Wani N, Hu P, et al. Transcriptomics-Based Drug Repurposing Approach Identifies Novel Drugs against Sorafenib-Resistant Hepatocellular Carcinoma. Cancers (Basel). 2020;12: pubmed publisher

Wang R, Yamada T, Kita K, Taniguchi H, Arai S, Fukuda K, et al. Transient IGF-1R inhibition combined with osimertinib eradicates AXL-low expressing EGFR mutated lung cancer. Nat Commun. 2020;11:4607 pubmed publisher

Gruber T, Kremenovic M, Sadozai H, Rombini N, Baeriswyl L, Maibach F, et al. IL-32γ potentiates tumor immunity in melanoma. JCI Insight. 2020;5: pubmed publisher

Reszegi A, Horvath Z, Karaszi K, Regős E, Postniková V, Tátrai P, et al. The Protective Role of Decorin in Hepatic Metastasis of Colorectal Carcinoma. Biomolecules. 2020;10: pubmed publisher

Bu S, Wang Q, Sun J, Li X, Gu T, Lai D. Melatonin suppresses chronic restraint stress-mediated metastasis of epithelial ovarian cancer via NE/AKT/β-catenin/SLUG axis. Cell Death Dis. 2020;11:644 pubmed publisher

Kim H, Bhattarai K, Junjappa R, Ahn J, Pagire S, Yoo H, et al. TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation. Nat Commun. 2020;11:4012 pubmed publisher

Zhang S, Yan L, Cui C, Wang Z, Wu J, Lv A, et al. Downregulation of RRM2 Attenuates Retroperitoneal Liposarcoma Progression via the Akt/mTOR/4EBP1 Pathway: Clinical, Biological, and Therapeutic Significance. Onco Targets Ther. 2020;13:6523-6537 pubmed publisher

Grandjean J, Madhavan A, Cech L, Seguinot B, Paxman R, Smith E, et al. Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming. Nat Chem Biol. 2020;16:1052-1061 pubmed publisher

Zhang X, Bandyopadhyay S, Araujo L, Tong K, Flores J, Laubitz D, et al. Elevating EGFR-MAPK program by a nonconventional Cdc42 enhances intestinal epithelial survival and regeneration. JCI Insight. 2020;5: pubmed publisher

Xie J, Huang X, Chen Q, Ma Y, Zhao Y, Liu L, et al. m6A modification-mediated BATF2 acts as a tumor suppressor in gastric cancer through inhibition of ERK signaling. Mol Cancer. 2020;19:114 pubmed publisher

Jen H, Gu D, Lang Y, Jou Y. PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility. Cells. 2020;9: pubmed publisher

Lang S, Schmiech M, Hafner S, Paetz C, Werner K, El Gaafary M, et al. Chrysosplenol d, a Flavonol from Artemisia annua, Induces ERK1/2-Mediated Apoptosis in Triple Negative Human Breast Cancer Cells. Int J Mol Sci. 2020;21: pubmed publisher

Nair V, Valo S, Peltomaki P, Bajbouj K, Abdel Rahman W. Oncogenic Potential of Bisphenol A and Common Environmental Contaminants in Human Mammary Epithelial Cells. Int J Mol Sci. 2020;21: pubmed publisher

Sheikh M, Henson S, Loiola R, Mercurio S, Colamatteo A, Maniscalco G, et al. Immuno-metabolic impact of the multiple sclerosis patients' sera on endothelial cells of the blood-brain barrier. J Neuroinflammation. 2020;17:153 pubmed publisher

Zhang J, Liu X, Li C, Wu X, Chen Y, Li W, et al. SNCG promotes the progression and metastasis of high-grade serous ovarian cancer via targeting the PI3K/AKT signaling pathway. J Exp Clin Cancer Res. 2020;39:79 pubmed publisher

Douida A, Batista F, Robaszkiewicz A, Boto P, Aladdin A, Szenykiv M, et al. The proteasome activator PA200 regulates expression of genes involved in cell survival upon selective mitochondrial inhibition in neuroblastoma cells. J Cell Mol Med. 2020;24:6716-6730 pubmed publisher

Tétu P, Delyon J, Andre J, Reger de Moura C, Sabbah M, Ghanem G, et al. FGF2 Induces Resistance to Nilotinib through MAPK Pathway Activation in KIT Mutated Melanoma. Cancers (Basel). 2020;12: pubmed publisher

Wang Y, Yao R, Zhang D, Chen R, Ren Z, Zhang L. Circulating Neutrophils Predict Poor Survival for HCC and Promote HCC Progression Through p53 and STAT3 Signaling Pathway. J Cancer. 2020;11:3736-3744 pubmed publisher

Kong L, Mohamed Salleh N, Ong R, Tan T, Syn N, Goh R, et al. A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma. Nat Commun. 2020;11:1556 pubmed publisher

Grassi E, Pantazopoulou V, Pietras A. Hypoxia-induced release, nuclear translocation, and signaling activity of a DLK1 intracellular fragment in glioma. Oncogene. 2020;39:4028-4044 pubmed publisher

Hurtz C, Wertheim G, Loftus J, Blumenthal D, Lehman A, Li Y, et al. Oncogene-independent BCR-like signaling adaptation confers drug resistance in Ph-like ALL. J Clin Invest. 2020;130:3637-3653 pubmed publisher

Bah A, Sanicas M, Nigou J, Guilhot C, Astarie Dequeker C, Vergne I. The Lipid Virulence Factors of Mycobacterium tuberculosis Exert Multilayered Control over Autophagy-Related Pathways in Infected Human Macrophages. Cells. 2020;9: pubmed publisher

Pruss M, Dwucet A, Tanriover M, Hlavac M, Kast R, Debatin K, et al. Dual metabolic reprogramming by ONC201/TIC10 and 2-Deoxyglucose induces energy depletion and synergistic anti-cancer activity in glioblastoma. Br J Cancer. 2020;122:1146-1157 pubmed publisher

Schwarz S, Gockel L, Naggi A, Barash U, Gobec M, Bendas G, et al. Glycosaminoglycans as Tools to Decipher the Platelet Tumor Cell Interaction: A Focus on P-Selectin. Molecules. 2020;25: pubmed publisher

Ronca R, Ghedini G, Maccarinelli F, Sacco A, Locatelli S, Foglio E, et al. FGF Trapping Inhibits Multiple Myeloma Growth through c-Myc Degradation-Induced Mitochondrial Oxidative Stress. Cancer Res. 2020;80:2340-2354 pubmed publisher

Bugueno I, Zobairi El Ghazouani F, Batool F, El Itawi H, Angles Cano E, Benkirane Jessel N, et al. Porphyromonas gingivalis triggers the shedding of inflammatory endothelial microvesicles that act as autocrine effectors of endothelial dysfunction. Sci Rep. 2020;10:1778 pubmed publisher

Oono K, Ohtake K, Watanabe C, Shiba S, Sekiya T, Kasono K. Contribution of Pyk2 pathway and reactive oxygen species (ROS) to the anti-cancer effects of eicosapentaenoic acid (EPA) in PC3 prostate cancer cells. Lipids Health Dis. 2020;19:15 pubmed publisher

Zhu Q, Zhong A, Hu H, Zhao J, Weng D, Tang Y, et al. Acylglycerol kinase promotes tumour growth and metastasis via activating the PI3K/AKT/GSK3β signalling pathway in renal cell carcinoma. J Hematol Oncol. 2020;13:2 pubmed publisher

Shahi Thakuri P, Gupta M, Singh S, Joshi R, Glasgow E, Lekan A, et al. Phytochemicals inhibit migration of triple negative breast cancer cells by targeting kinase signaling. BMC Cancer. 2020;20:4 pubmed publisher

Scarneo S, Eibschutz L, Bendele P, Yang K, Totzke J, Hughes P, et al. Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice. Arthritis Res Ther. 2019;21:292 pubmed publisher

Cook N, Pjanic M, Emmerich A, Rao A, Hetty S, Knowles J, et al. CRISPR-Cas9-mediated knockout of SPRY2 in human hepatocytes leads to increased glucose uptake and lipid droplet accumulation. BMC Endocr Disord. 2019;19:115 pubmed publisher

Xu R, Li Y, Yan H, Zhang E, Huang X, Chen Q, et al. CCL2 promotes macrophages-associated chemoresistance via MCPIP1 dual catalytic activities in multiple myeloma. Cell Death Dis. 2019;10:781 pubmed publisher

Kim J, Kim W, Park C. Interleukin-6 mediates resistance to PI3K-pathway-targeted therapy in lymphoma. BMC Cancer. 2019;19:936 pubmed publisher

Wurm J, Behringer S, Ravi V, Joseph K, Neidert N, Maier J, et al. Astrogliosis Releases Pro-Oncogenic Chitinase 3-Like 1 Causing MAPK Signaling in Glioblastoma. Cancers (Basel). 2019;11: pubmed publisher

Lin J, Xie X, Weng X, Qiu S, Yoon C, Lian N, et al. UFM1 suppresses invasive activities of gastric cancer cells by attenuating the expres7sion of PDK1 through PI3K/AKT signaling. J Exp Clin Cancer Res. 2019;38:410 pubmed publisher

Magni M, Biancon G, Rizzitano S, Cavanè A, Paolizzi C, Dugo M, et al. Tyrosine kinase inhibition to improve anthracycline-based chemotherapy efficacy in T-cell lymphoma. Br J Cancer. 2019;121:567-577 pubmed publisher

Jo M, Jeong S, Yun H, Kim D, Kim B, Kim J, et al. Genipin induces mitochondrial dysfunction and apoptosis via downregulation of Stat3/mcl-1 pathway in gastric cancer. BMC Cancer. 2019;19:739 pubmed publisher

Menéndez Menéndez J, Hermida Prado F, Granda Díaz R, Gonzalez A, Garcia Pedrero J, Del Río Ibisate N, et al. Deciphering the Molecular Basis of Melatonin Protective Effects on Breast Cells Treated with Doxorubicin: TWIST1 a Transcription Factor Involved in EMT and Metastasis, a Novel Target of Melatonin. Cancers (Basel). 2019;11: pubmed publisher

Chen Y, Lv H, Shen N, Wang X, Tang S, Xiong B, et al. EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells. Acta Pharmacol Sin. 2019;: pubmed publisher

de Boussac H, Bruyer A, Jourdan M, Maes A, Robert N, Gourzones C, et al. Kinome expression profiling to target new therapeutic avenues in multiple myeloma. Haematologica. 2020;105:784-795 pubmed publisher

Sun T, Ju M, Dai X, Dong H, Gu W, Gao Y, et al. Multilevel defects in the hematopoietic niche in essential thrombocythemia. Haematologica. 2020;105:661-673 pubmed publisher

Su P, Lai H, Huang R, Chen L, Wang Y, Wu T, et al. Paired Box-1 (PAX1) Activates Multiple Phosphatases and Inhibits Kinase Cascades in Cervical Cancer. Sci Rep. 2019;9:9195 pubmed publisher

Potthoff A, Heiland D, Evert B, Almeida F, Behringer S, Dolf A, et al. Inhibition of Gap Junctions Sensitizes Primary Glioblastoma Cells for Temozolomide. Cancers (Basel). 2019;11: pubmed publisher

Jeong S, Kim B, Kim D, Kim B, Kim J, Park S, et al. Cannabidiol Overcomes Oxaliplatin Resistance by Enhancing NOS3- and SOD2-Induced Autophagy in Human Colorectal Cancer Cells. Cancers (Basel). 2019;11: pubmed publisher

Offer S, Menard J, Pérez J, de Oliveira K, Chandran V, Johansson M, et al. Extracellular lipid loading augments hypoxic paracrine signaling and promotes glioma angiogenesis and macrophage infiltration. J Exp Clin Cancer Res. 2019;38:241 pubmed publisher

Schepetkin I, Kirpotina L, Khlebnikov A, Balasubramanian N, Quinn M. Neutrophil Immunomodulatory Activity of Natural Organosulfur Compounds. Molecules. 2019;24: pubmed publisher

Chen J, Bell J, Lau B, Whittaker T, Stapleton D, Ji H. A functional CRISPR/Cas9 screen identifies kinases that modulate FGFR inhibitor response in gastric cancer. Oncogenesis. 2019;8:33 pubmed publisher

Xiao Z, Sperl B, Gartner S, Nedelko T, Stacher Priehse E, Ullrich A, et al. Lung cancer stem cells and their aggressive progeny, controlled by EGFR/MIG6 inverse expression, dictate a novel NSCLC treatment approach. Oncotarget. 2019;10:2546-2560 pubmed publisher

Yoo J, Brady S, Acosta Alvarez L, Rogers A, Peng J, Sorensen L, et al. The Small GTPase ARF6 Activates PI3K in Melanoma to Induce a Prometastatic State. Cancer Res. 2019;79:2892-2908 pubmed publisher

Hummitzsch L, Zitta K, Berndt R, Wong Y, Rusch R, Hess K, et al. Remote ischemic preconditioning attenuates intestinal mucosal damage: insight from a rat model of ischemia-reperfusion injury. J Transl Med. 2019;17:136 pubmed publisher

Pellizzari G, Hoskin C, Crescioli S, Mele S, Gotovina J, Chiaruttini G, et al. IgE re-programs alternatively-activated human macrophages towards pro-inflammatory anti-tumoural states. EBioMedicine. 2019;43:67-81 pubmed publisher

Ferraro D, Patella F, Zanivan S, Donato C, Aceto N, Giannotta M, et al. Endothelial cell-derived nidogen-1 inhibits migration of SK-BR-3 breast cancer cells. BMC Cancer. 2019;19:312 pubmed publisher

Bai Y, Liu X, Qi X, Liu X, Peng F, Li H, et al. PDIA6 modulates apoptosis and autophagy of non-small cell lung cancer cells via the MAP4K1/JNK signaling pathway. EBioMedicine. 2019;42:311-325 pubmed publisher

Kennedy S, Han J, Portman N, Nobis M, Hastings J, Murphy K, et al. Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer. Breast Cancer Res. 2019;21:43 pubmed publisher

Li L, Liu Y, Li S, Yang R, Zeng C, Rong W, et al. Signal regulatory protein α protects podocytes through promoting autophagic activity. JCI Insight. 2019;5: pubmed publisher

Jolly M, Ware K, Xu S, Gilja S, Shetler S, Yang Y, et al. E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms. Mol Cancer Res. 2019;17:1391-1402 pubmed publisher

Ko Y, Hu C, Liu Z, Tien H, Ou D, Chien H, et al. Cytarabine-Resistant FLT3-ITD Leukemia Cells are Associated with TP53 Mutation and Multiple Pathway Alterations-Possible Therapeutic Efficacy of Cabozantinib. Int J Mol Sci. 2019;20: pubmed publisher

Neelakantan D, Dogra S, Devapatla B, Jaiprasart P, Mukashyaka M, Janknecht R, et al. Multifunctional APJ Pathway Promotes Ovarian Cancer Progression and Metastasis. Mol Cancer Res. 2019;17:1378-1390 pubmed publisher

Ferro F, Spelat R, Shaw G, Duffy N, Islam M, O Shea P, et al. Survival/Adaptation of Bone Marrow-Derived Mesenchymal Stem Cells After Long-Term Starvation Through Selective Processes. Stem Cells. 2019;37:813-827 pubmed publisher

Martini G, Cardone C, Vitiello P, Belli V, Napolitano S, Troiani T, et al. EPHA2 Is a Predictive Biomarker of Resistance and a Potential Therapeutic Target for Improving Antiepidermal Growth Factor Receptor Therapy in Colorectal Cancer. Mol Cancer Ther. 2019;18:845-855 pubmed publisher

van Montfort T, van der Sluis R, Darcis G, Beaty D, Groen K, Pasternak A, et al. Dendritic cells potently purge latent HIV-1 beyond TCR-stimulation, activating the PI3K-Akt-mTOR pathway. EBioMedicine. 2019;42:97-108 pubmed publisher

Noh J, Kim K, Pandey P, Noren Hooten N, Munk R, Kundu G, et al. Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program. Nucleic Acids Res. 2019;47:2472-2486 pubmed publisher

Ashraf S, Bell S, O Leary C, Canning P, Micu I, Fernandez J, et al. CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularization. JCI Insight. 2019;4: pubmed publisher

Nickol M, Ciric J, Falcinelli S, Chertow D, Kindrachuk J. Characterization of Host and Bacterial Contributions to Lung Barrier Dysfunction Following Co-infection with 2009 Pandemic Influenza and Methicillin Resistant Staphylococcus aureus. Viruses. 2019;11: pubmed publisher

Zalfa C, Azmoon P, Mantuano E, Gonias S. Tissue-type plasminogen activator neutralizes LPS but not protease-activated receptor-mediated inflammatory responses to plasmin. J Leukoc Biol. 2019;105:729-740 pubmed publisher

Zhao Y, Huang W, Kim T, Jung Y, Menon L, Xing H, et al. MicroRNA-29a activates a multi-component growth and invasion program in glioblastoma. J Exp Clin Cancer Res. 2019;38:36 pubmed publisher

Kumar R, Njauw C, Reddy B, Ji Z, Rajadurai A, Klebanov N, et al. Growth suppression by dual BRAF(V600E) and NRAS(Q61) oncogene expression is mediated by SPRY4 in melanoma. Oncogene. 2019;38:3504-3520 pubmed publisher

Taniguchi H, Yamada T, Wang R, Tanimura K, Adachi Y, Nishiyama A, et al. AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells. Nat Commun. 2019;10:259 pubmed publisher

Kim J, Grotegut C, Wisler J, Li T, Mao L, Chen M, et al. β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility. Skelet Muscle. 2018;8:39 pubmed publisher

Tornillo G, Knowlson C, Kendrick H, Cooke J, Mirza H, Aurrekoetxea Rodríguez I, et al. Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells. Cell Rep. 2018;25:3674-3692.e10 pubmed publisher

Cortés A, Díaz R, Hernandez Campo P, Gorrochategui J, Primo D, Robles A, et al. Ruxolitinib in combination with prednisone and nilotinib exhibit synergistic effects in human cells lines and primary cells from myeloproliferative neoplasms. Haematologica. 2019;104:937-946 pubmed publisher

Klein C, Roussel G, Brun S, Rusu C, Patte Mensah C, Maitre M, et al. 5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer's disease. Acta Neuropathol Commun. 2018;6:136 pubmed publisher

Wang X, Ai J, Liu H, Peng X, Chen H, Chen Y, et al. The Secretome Engages STAT3 to Favor a Cytokine-rich Microenvironment in Mediating Acquired Resistance to FGFR Inhibitors. Mol Cancer Ther. 2019;18:667-679 pubmed publisher

Golec E, Lind L, Qayyum M, Blom A, King B. The Noncoding RNA nc886 Regulates PKR Signaling and Cytokine Production in Human Cells. J Immunol. 2019;202:131-141 pubmed publisher

Kubala M, Punj V, Placencio Hickok V, Fang H, Fernandez G, Sposto R, et al. Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer. Cell Rep. 2018;25:2177-2191.e7 pubmed publisher

Deng L, Gao X, Liu B, He X, Xu J, Qiang J, et al. NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway. Cell Death Dis. 2018;9:1143 pubmed publisher

Narvi E, Vaparanta K, Karrila A, Chakroborty D, Knuutila S, Pulliainen A, et al. Different responses of colorectal cancer cells to alternative sequences of cetuximab and oxaliplatin. Sci Rep. 2018;8:16579 pubmed publisher

Miao W, Sakai K, Ozawa N, Nishiuchi T, Suzuki Y, Ito K, et al. Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist. Sci Rep. 2018;8:16492 pubmed publisher

Totiger T, Srinivasan S, Jala V, Lamichhane P, Dosch A, Gaidarski A, et al. Urolithin A, a Novel Natural Compound to Target PI3K/AKT/mTOR Pathway in Pancreatic Cancer. Mol Cancer Ther. 2019;18:301-311 pubmed publisher

Wong T, Juang W, Tsai C, Tseng C, Lee W, Chang S, et al. Mechanical Stretching Simulates Cardiac Physiology and Pathology through Mechanosensor Piezo1. J Clin Med. 2018;7: pubmed publisher

Taniuchi K, Furihata M, Naganuma S, Saibara T. WAVE2 is associated with poor prognosis in pancreatic cancers and promotes cell motility and invasiveness via binding to ACTN4. Cancer Med. 2018;7:5733-5751 pubmed publisher

Redaelli S, Ceccon M, Zappa M, Sharma G, Mastini C, Mauri M, et al. Lorlatinib Treatment Elicits Multiple On- and Off-Target Mechanisms of Resistance in ALK-Driven Cancer. Cancer Res. 2018;78:6866-6880 pubmed publisher

Pandey V, Wang B, Mohan C, Raquib A, Rangappa S, Srinivasa V, et al. Discovery of a small-molecule inhibitor of specific serine residue BAD phosphorylation. Proc Natl Acad Sci U S A. 2018;115:E10505-E10514 pubmed publisher

Zhang Y, Ji G, Han S, Shao Z, Lu Z, Huo L, et al. Tip60 Suppresses Cholangiocarcinoma Proliferation and Metastasis via PI3k-AKT. Cell Physiol Biochem. 2018;50:612-628 pubmed publisher

Shimizu M, Tanaka N. IL-8-induced O-GlcNAc modification via GLUT3 and GFAT regulates cancer stem cell-like properties in colon and lung cancer cells. Oncogene. 2019;38:1520-1533 pubmed publisher

Gonçalves C, Vieira de Castro J, Pojo M, Martins E, Queirós S, Chautard E, et al. WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma. Theranostics. 2018;8:4805-4823 pubmed publisher

Chéret J, Bertolini M, Ponce L, Lehmann J, Tsai T, Alam M, et al. Olfactory receptor OR2AT4 regulates human hair growth. Nat Commun. 2018;9:3624 pubmed publisher

Choi B, Philips M, Chen Y, Lu L, Dai W. K-Ras Lys-42 is crucial for its signaling, cell migration, and invasion. J Biol Chem. 2018;293:17574-17581 pubmed publisher

Wagner T, Gschwandtner M, Strajeriu A, Elbe Bürger A, Grillari J, Grillari Voglauer R, et al. Establishment of keratinocyte cell lines from human hair follicles. Sci Rep. 2018;8:13434 pubmed publisher

Jiang Y, Jiang Y, Xie J, Mayakonda A, Hazawa M, Chen L, et al. Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression. Nat Commun. 2018;9:3619 pubmed publisher

Pareja F, Brandes A, Basili T, Selenica P, Geyer F, Fan D, et al. Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors. Nat Commun. 2018;9:3533 pubmed publisher

Vishwakarma V, New J, Kumar D, Snyder V, Arnold L, Nissen E, et al. Potent Antitumor Effects of a Combination of Three Nutraceutical Compounds. Sci Rep. 2018;8:12163 pubmed publisher

Urriola Muñoz P, Lagos Cabré R, Patiño Garcia D, Reyes J, Moreno R. Bisphenol-A and Nonylphenol Induce Apoptosis in Reproductive Tract Cancer Cell Lines by the Activation of ADAM17. Int J Mol Sci. 2018;19: pubmed publisher

Li W, Wong C, Zhang X, Kang W, Nakatsu G, Zhao Q, et al. CAB39L elicited an anti-Warburg effect via a LKB1-AMPK-PGC1α axis to inhibit gastric tumorigenesis. Oncogene. 2018;37:6383-6398 pubmed publisher

Gökyildirim M, Grandel U, Hattar K, Dahlem G, Schuetz E, Leinberger F, et al. Targeting CREB-binding protein overrides LPS induced radioresistance in non-small cell lung cancer cell lines. Oncotarget. 2018;9:28976-28988 pubmed publisher

Li C, Rezov V, Joensuu E, Vartiainen V, Rönty M, Yin M, et al. Pirfenidone decreases mesothelioma cell proliferation and migration via inhibition of ERK and AKT and regulates mesothelioma tumor microenvironment in vivo. Sci Rep. 2018;8:10070 pubmed publisher

Fang Z, Jung K, Yan H, Kim S, Rumman M, Park J, et al. Melatonin Synergizes with Sorafenib to Suppress Pancreatic Cancer via Melatonin Receptor and PDGFR-β/STAT3 Pathway. Cell Physiol Biochem. 2018;47:1751-1768 pubmed publisher

Chen W, Zebaze L, Dong J, Chézeau L, Inquimbert P, Hugel S, et al. WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3- cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling. Oncotarget. 2018;9:27197-27219 pubmed publisher

Fan P, Narzisi G, Jayaprakash A, Venturini E, Robine N, Smibert P, et al. YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics. Proc Natl Acad Sci U S A. 2018;115:E6030-E6038 pubmed publisher

Heger J, Bornbaum J, Würfel A, Hill C, Brockmann N, Gáspár R, et al. JDP2 overexpression provokes cardiac dysfunction in mice. Sci Rep. 2018;8:7647 pubmed publisher

Gong X, Smith J, Swanson H, Rubin L. Carotenoid Lutein Selectively Inhibits Breast Cancer Cell Growth and Potentiates the Effect of Chemotherapeutic Agents through ROS-Mediated Mechanisms. Molecules. 2018;23: pubmed publisher

Ku B, Choi M, Sun J, Lee S, Ahn J, Park K, et al. Acquired resistance to AZD9291 as an upfront treatment is dependent on ERK signaling in a preclinical model. PLoS ONE. 2018;13:e0194730 pubmed publisher

Taniuchi K, Furihata M, Naganuma S, Dabanaka K, Hanazaki K, Saibara T. BCL7B, a predictor of poor prognosis of pancreatic cancers, promotes cell motility and invasion by influencing CREB signaling. Am J Cancer Res. 2018;8:387-404 pubmed

Zhang X, Wang X, Xu R, Ji J, Xu Y, Han M, et al. YM155 decreases radiation-induced invasion and reverses epithelial-mesenchymal transition by targeting STAT3 in glioblastoma. J Transl Med. 2018;16:79 pubmed publisher

Hernandez C, Huebener P, Pradere J, Antoine D, Friedman R, Schwabe R. HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis. J Clin Invest. 2018;128:2436-2451 pubmed publisher

Xiao G, Chan L, Klemm L, Braas D, Chen Z, Geng H, et al. B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies. Cell. 2018;173:470-484.e18 pubmed publisher

Huh S, Song H, Jeong G, Jang H, Seo N, Lee J, et al. Suppression of the ERK-SRF axis facilitates somatic cell reprogramming. Exp Mol Med. 2018;50:e448 pubmed publisher

Baumgartner U, Berger F, Hashemi Gheinani A, Burgener S, Monastyrskaya K, Vassella E. miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer. Mol Cancer. 2018;17:44 pubmed publisher

Yeo I, Lee Y, Song K, Jin H, Lee J, Kim D, et al. Low-molecular weight keratins with anti-skin aging activity produced by anaerobic digestion of poultry feathers with Fervidobacterium islandicum AW-1. J Biotechnol. 2018;271:17-25 pubmed publisher

Santiago O Farrill J, Kleinerman E, Hollomon M, Livingston A, Wang W, Tsai J, et al. Phosphorylated heat shock protein 27 as a potential biomarker to predict the role of chemotherapy-induced autophagy in osteosarcoma response to therapy. Oncotarget. 2018;9:1602-1616 pubmed publisher

Ribeiro J, Gaudet H, Khan M, Schorl C, James N, Oliver M, et al. Human Epididymis Protein 4 Promotes Events Associated with Metastatic Ovarian Cancer via Regulation of the Extracelluar Matrix. Front Oncol. 2017;7:332 pubmed publisher

Heavey S, Dowling P, Moore G, Barr M, Kelly N, Maher S, et al. Development and characterisation of a panel of phosphatidylinositide 3-kinase - mammalian target of rapamycin inhibitor resistant lung cancer cell lines. Sci Rep. 2018;8:1652 pubmed publisher

Kuppusamy P, Nagalingam A, Muniraj N, Saxena N, Sharma D. Concomitant activation of ETS-like transcription factor-1 and Death Receptor-5 via extracellular signal-regulated kinase in withaferin A-mediated inhibition of hepatocarcinogenesis in mice. Sci Rep. 2017;7:17943 pubmed publisher

Álvarez Teijeiro S, Menendez S, Villaronga M, Rodrigo J, Manterola L, de Villalaín L, et al. Dysregulation of Mir-196b in Head and Neck Cancers Leads to Pleiotropic Effects in the Tumor Cells and Surrounding Stromal Fibroblasts. Sci Rep. 2017;7:17785 pubmed publisher

Keller S, Kneissl J, Grabher Meier V, Heindl S, Hasenauer J, Maier D, et al. Evaluation of epidermal growth factor receptor signaling effects in gastric cancer cell lines by detailed motility-focused phenotypic characterization linked with molecular analysis. BMC Cancer. 2017;17:845 pubmed publisher

Wang D, Liu C, Wang J, Jia Y, Hu X, Jiang H, et al. Protein C receptor stimulates multiple signaling pathways in breast cancer cells. J Biol Chem. 2018;293:1413-1424 pubmed publisher

Kaittanis C, Andreou C, Hieronymus H, Mao N, Foss C, Eiber M, et al. Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors. J Exp Med. 2018;215:159-175 pubmed publisher

Riera Borrull M, Cuevas V, Alonso B, Vega M, Joven J, Izquierdo E, et al. Palmitate Conditions Macrophages for Enhanced Responses toward Inflammatory Stimuli via JNK Activation. J Immunol. 2017;199:3858-3869 pubmed publisher

Owusu B, Thomas S, Venukadasula P, Han Z, Janetka J, Galemmo R, et al. Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation. Oncotarget. 2017;8:63014-63025 pubmed publisher

Tsuboi M, Taniuchi K, Shimizu T, Saito M, Saibara T. The transcription factor HOXB7 regulates ERK kinase activity and thereby stimulates the motility and invasiveness of pancreatic cancer cells. J Biol Chem. 2017;292:17681-17702 pubmed publisher

Curcic S, Holzer M, Pasterk L, Knuplez E, Eichmann T, Frank S, et al. Secretory phospholipase A2 modified HDL rapidly and potently suppresses platelet activation. Sci Rep. 2017;7:8030 pubmed publisher

Janczar S, Nautiyal J, Xiao Y, Curry E, Sun M, Zanini E, et al. WWOX sensitises ovarian cancer cells to paclitaxel via modulation of the ER stress response. Cell Death Dis. 2017;8:e2955 pubmed publisher

Shien K, Papadimitrakopoulou V, Ruder D, Behrens C, Shen L, Kalhor N, et al. JAK1/STAT3 Activation through a Proinflammatory Cytokine Pathway Leads to Resistance to Molecularly Targeted Therapy in Non-Small Cell Lung Cancer. Mol Cancer Ther. 2017;16:2234-2245 pubmed publisher

Chang C, Yen M, Liao S, Hsu Y, Lai C, Chang K, et al. Secreted Protein Acidic and Rich in Cysteine (SPARC) Enhances Cell Proliferation, Migration, and Epithelial Mesenchymal Transition, and SPARC Expression is Associated with Tumor Grade in Head and Neck Cancer. Int J Mol Sci. 2017;18: pubmed publisher

Ríos Luci C, García Alonso S, Díaz Rodríguez E, Nadal Serrano M, Arribas J, Ocaña A, et al. Resistance to the Antibody-Drug Conjugate T-DM1 Is Based in a Reduction in Lysosomal Proteolytic Activity. Cancer Res. 2017;77:4639-4651 pubmed publisher

Sahu N, Chan E, Chu F, Pham T, Koeppen H, Forrest W, et al. Cotargeting of MEK and PDGFR/STAT3 Pathways to Treat Pancreatic Ductal Adenocarcinoma. Mol Cancer Ther. 2017;16:1729-1738 pubmed publisher

Islam S, Qi W, Morales C, Cooke L, Spier C, Weterings E, et al. Disruption of Aneuploidy and Senescence Induced by Aurora Inhibition Promotes Intrinsic Apoptosis in Double Hit or Double Expressor Diffuse Large B-cell Lymphomas. Mol Cancer Ther. 2017;16:2083-2093 pubmed publisher

Mustapic M, Eitan E, Werner J, Berkowitz S, Lazaropoulos M, Tran J, et al. Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes. Front Neurosci. 2017;11:278 pubmed publisher

Lee H, Baek S, Lee J, Kim C, Ko J, Lee S, et al. Isorhynchophylline, a Potent Plant Alkaloid, Induces Apoptotic and Anti-Metastatic Effects in Human Hepatocellular Carcinoma Cells through the Modulation of Diverse Cell Signaling Cascades. Int J Mol Sci. 2017;18: pubmed publisher

Pio G, Xia Y, Piaseczny M, Chu J, Allan A. Soluble bone-derived osteopontin promotes migration and stem-like behavior of breast cancer cells. PLoS ONE. 2017;12:e0177640 pubmed publisher

Crişan T, Cleophas M, Novakovic B, Erler K, van de Veerdonk F, Stunnenberg H, et al. Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway. Proc Natl Acad Sci U S A. 2017;114:5485-5490 pubmed publisher

Chen S, Tao J, Zhong F, Jiao Y, Xu J, Shen Q, et al. Polydatin down-regulates the phosphorylation level of Creb and induces apoptosis in human breast cancer cell. PLoS ONE. 2017;12:e0176501 pubmed publisher

Carriero M, Bifulco K, Ingangi V, Costantini S, Botti G, Ragone C, et al. Retro-inverso Urokinase Receptor Antagonists for the Treatment of Metastatic Sarcomas. Sci Rep. 2017;7:1312 pubmed publisher

Zhou Z, Xu L, Sennepin A, Federici C, Ganor Y, Tudor D, et al. The HIV-1 viral synapse signals human foreskin keratinocytes to secrete thymic stromal lymphopoietin facilitating HIV-1 foreskin entry. Mucosal Immunol. 2018;11:158-171 pubmed publisher

Teixeira F, Manfiolli A, Vieira N, Medeiros A, Coelho P, Santiago Guimarães D, et al. FBXO25 regulates MAPK signaling pathway through inhibition of ERK1/2 phosphorylation. Arch Biochem Biophys. 2017;621:38-45 pubmed publisher

Boengler K, Bulić M, Schreckenberg R, Schluter K, Schulz R. The gap junction modifier ZP1609 decreases cardiomyocyte hypercontracture following ischaemia/reperfusion independent from mitochondrial connexin 43. Br J Pharmacol. 2017;174:2060-2073 pubmed publisher

Colomb F, Wang W, Simpson D, Zafar M, Beynon R, Rhodes J, et al. Galectin-3 interacts with the cell-surface glycoprotein CD146 (MCAM, MUC18) and induces secretion of metastasis-promoting cytokines from vascular endothelial cells. J Biol Chem. 2017;292:8381-8389 pubmed publisher

Kalyvianaki K, Gebhart V, Peroulis N, Panagiotopoulou C, Kiagiadaki F, Pediaditakis I, et al. Antagonizing effects of membrane-acting androgens on the eicosanoid receptor OXER1 in prostate cancer. Sci Rep. 2017;7:44418 pubmed publisher

Buchanan P, Boylan K, Walcheck B, Heinze R, Geller M, Argenta P, et al. Ectodomain shedding of the cell adhesion molecule Nectin-4 in ovarian cancer is mediated by ADAM10 and ADAM17. J Biol Chem. 2017;292:6339-6351 pubmed publisher

Mo Y, Lu Y, Wang P, Huang S, He L, Li D, et al. Long non-coding RNA XIST promotes cell growth by regulating miR-139-5p/PDK1/AKT axis in hepatocellular carcinoma. Tumour Biol. 2017;39:1010428317690999 pubmed publisher

Wladis E, Swamy S, Herrmann A, Yang J, Carlson J, Adam A. Activation of p38 and Erk Mitogen-Activated Protein Kinases Signaling in Ocular Rosacea. Invest Ophthalmol Vis Sci. 2017;58:843-848 pubmed publisher

Kuan I, Liang K, Wang Y, Kuo T, Meir Y, Wu S, et al. EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2α. Sci Rep. 2017;7:41852 pubmed publisher

Lee H, Cao Y, Pham V, Blackwood E, Wilson C, Evangelista M, et al. Ras-MEK Signaling Mediates a Critical Chk1-Dependent DNA Damage Response in Cancer Cells. Mol Cancer Ther. 2017;16:694-704 pubmed publisher

Yang P, Read C, Kuc R, Buonincontri G, Southwood M, Torella R, et al. Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension. Circulation. 2017;135:1160-1173 pubmed publisher

Bankó Z, Pozsgay J, Szili D, Toth M, Gati T, Nagy G, et al. Induction and Differentiation of IL-10-Producing Regulatory B Cells from Healthy Blood Donors and Rheumatoid Arthritis Patients. J Immunol. 2017;198:1512-1520 pubmed publisher

Nadeau S, An W, Mohapatra B, Mushtaq I, Bielecki T, Luan H, et al. Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene. J Biol Chem. 2017;292:3666-3682 pubmed publisher

Alaridah N, Lutay N, Tenland E, Rönnholm A, Hallgren O, Puthia M, et al. Mycobacteria Manipulate G-Protein-Coupled Receptors to Increase Mucosal Rac1 Expression in the Lungs. J Innate Immun. 2017;9:318-329 pubmed publisher

Kalbe B, Schulz V, Schlimm M, Philippou S, Jovancevic N, Jansen F, et al. Helional-induced activation of human olfactory receptor 2J3 promotes apoptosis and inhibits proliferation in a non-small-cell lung cancer cell line. Eur J Cell Biol. 2017;96:34-46 pubmed publisher

Tanouchi A, Taniuchi K, Furihata M, Naganuma S, Dabanaka K, Kimura M, et al. CCDC88A, a prognostic factor for human pancreatic cancers, promotes the motility and invasiveness of pancreatic cancer cells. J Exp Clin Cancer Res. 2016;35:190 pubmed

Fotouhi Ghiam A, Taeb S, Huang X, Huang V, Ray J, Scarcello S, et al. Long non-coding RNA urothelial carcinoma associated 1 (UCA1) mediates radiation response in prostate cancer. Oncotarget. 2017;8:4668-4689 pubmed publisher

Zhang S, Xu Y, Jin E, Zhu L, Xia B, Chen X, et al. Capilliposide from Lysimachia capillipes inhibits AKT activation and restores gefitinib sensitivity in human non-small cell lung cancer cells with acquired gefitinib resistance. Acta Pharmacol Sin. 2017;38:100-109 pubmed publisher

O Hara S, Garcea R. Murine Polyomavirus Cell Surface Receptors Activate Distinct Signaling Pathways Required for Infection. MBio. 2016;7: pubmed publisher

Escudero Esparza A, Bartoschek M, Gialeli C, Okroj M, Owen S, Jirström K, et al. Complement inhibitor CSMD1 acts as tumor suppressor in human breast cancer. Oncotarget. 2016;7:76920-76933 pubmed publisher

Warren K, Fang X, Gowda N, Thompson J, Heller N. The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2. J Biol Chem. 2016;291:24922-24930 pubmed

Satelli A, Hu J, Xia X, Li S. Potential Function of Exogenous Vimentin on the Activation of Wnt Signaling Pathway in Cancer Cells. J Cancer. 2016;7:1824-1832 pubmed

Patel A, Tsilioni I, Leeman S, Theoharides T. Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism. Proc Natl Acad Sci U S A. 2016;113:E7049-E7058 pubmed publisher

Bezzerri V, Vella A, Calcaterra E, Finotti A, Gasparello J, Gambari R, et al. New insights into the Shwachman-Diamond Syndrome-related haematological disorder: hyper-activation of mTOR and STAT3 in leukocytes. Sci Rep. 2016;6:33165 pubmed publisher

Chi M, Evans H, Gilchrist J, Mayhew J, Hoffman A, Pearsall E, et al. Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells. Sci Rep. 2016;6:33132 pubmed publisher

Kimani S, Kumar S, Davra V, Chang Y, Kasikara C, Geng K, et al. Normalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinase. Cell Commun Signal. 2016;14:19 pubmed publisher

Flegel C, Vogel F, Hofreuter A, Wojcik S, Schoeder C, Kiec Kononowicz K, et al. Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18. Sci Rep. 2016;6:32255 pubmed publisher

Sauer M, Schuldner M, Hoffmann N, Cetintas A, Reiners K, Shatnyeva O, et al. CBP/p300 acetyltransferases regulate the expression of NKG2D ligands on tumor cells. Oncogene. 2017;36:933-941 pubmed publisher

Barquilla A, Lamberto I, Noberini R, Heynen Genel S, Brill L, Pasquale E. Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation. Mol Biol Cell. 2016;27:2757-70 pubmed publisher

Gu Y, Helenius M, Väänänen K, Bulanova D, Saarela J, Sokolenko A, et al. BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine. Sci Rep. 2016;6:28217 pubmed publisher

Bullova P, Cougnoux A, Abunimer L, Kopacek J, Pastorekova S, Pacak K. Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models. Oncotarget. 2016;7:40531-40545 pubmed publisher

Raimondi C, Calleja V, Ferro R, Fantin A, Riley A, Potter B, et al. A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion. Sci Rep. 2016;6:26142 pubmed publisher

Derlet A, Rasper T, Roy Choudhury A, Bothur S, Rieger M, Namgaladze D, et al. Metabolism Regulates Cellular Functions of Bone Marrow-Derived Cells used for Cardiac Therapy. Stem Cells. 2016;34:2236-48 pubmed publisher

Ahn S, Park H, Ahn Y, Kim S, Cho M, Kang J, et al. Necrotic cells influence migration and invasion of glioblastoma via NF-?B/AP-1-mediated IL-8 regulation. Sci Rep. 2016;6:24552 pubmed publisher

Benard L, Oh J, Cacheux M, Lee A, Nonnenmacher M, Matasic D, et al. Cardiac Stim1 Silencing Impairs Adaptive Hypertrophy and Promotes Heart Failure Through Inactivation of mTORC2/Akt Signaling. Circulation. 2016;133:1458-71; discussion 1471 pubmed publisher

Sento S, Sasabe E, Yamamoto T. Application of a Persistent Heparin Treatment Inhibits the Malignant Potential of Oral Squamous Carcinoma Cells Induced by Tumor Cell-Derived Exosomes. PLoS ONE. 2016;11:e0148454 pubmed publisher

Skolekova S, Matuskova M, Bohac M, Toro L, Durinikova E, Tyciakova S, et al. Cisplatin-induced mesenchymal stromal cells-mediated mechanism contributing to decreased antitumor effect in breast cancer cells. Cell Commun Signal. 2016;14:4 pubmed publisher

Wculek S, Malanchi I. Neutrophils support lung colonization of metastasis-initiating breast cancer cells. Nature. 2015;528:413-7 pubmed publisher

Purushothaman A, Bandari S, Liu J, Mobley J, Brown E, Sanderson R. Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions. J Biol Chem. 2016;291:1652-63 pubmed publisher

Singh A, Ruan Y, Tippett T, Narendran A. Targeted inhibition of MEK1 by cobimetinib leads to differentiation and apoptosis in neuroblastoma cells. J Exp Clin Cancer Res. 2015;34:104 pubmed publisher

Yamada T, Amann J, Fukuda K, Takeuchi S, Fujita N, Uehara H, et al. Akt Kinase-Interacting Protein 1 Signals through CREB to Drive Diffuse Malignant Mesothelioma. Cancer Res. 2015;75:4188-97 pubmed publisher

Eggink L, Spyroulias G, Jones N, Hanson C, Hoober J. A Peptide Mimetic of 5-Acetylneuraminic Acid-Galactose Binds with High Avidity to Siglecs and NKG2D. PLoS ONE. 2015;10:e0130532 pubmed publisher

Paggetti J, Haderk F, Seiffert M, Janji B, Distler U, Ammerlaan W, et al. Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts. Blood. 2015;126:1106-17 pubmed publisher

Hansen F, Kalle Brune M, van der Plas M, Strömdahl A, Malmsten M, Mörgelin M, et al. The Thrombin-Derived Host Defense Peptide GKY25 Inhibits Endotoxin-Induced Responses through Interactions with Lipopolysaccharide and Macrophages/Monocytes. J Immunol. 2015;194:5397-406 pubmed publisher

Chang B, Johnson K, LaTocha D, Rowley J, Bryant J, Burke R, et al. YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway. J Hematol Oncol. 2015;8:39 pubmed publisher

Mailly L, Xiao F, Lupberger J, Wilson G, Aubert P, Duong F, et al. Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody. Nat Biotechnol. 2015;33:549-554 pubmed publisher

Laukkanen M, Cammarota F, Esposito T, Salvatore M, Castellone M. Extracellular superoxide dismutase regulates the expression of small gtpase regulatory proteins GEFs, GAPs, and GDI. PLoS ONE. 2015;10:e0121441 pubmed publisher

Man J, Shoemake J, Ma T, Rizzo A, Godley A, Wu Q, et al. Hyperthermia Sensitizes Glioma Stem-like Cells to Radiation by Inhibiting AKT Signaling. Cancer Res. 2015;75:1760-9 pubmed publisher

Zhao D, Besser A, Wander S, Sun J, Zhou W, Wang B, et al. Cytoplasmic p27 promotes epithelial-mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation. Oncogene. 2015;34:5447-59 pubmed publisher

Atefi M, Titz B, Avramis E, Ng C, Wong D, Lassen A, et al. Combination of pan-RAF and MEK inhibitors in NRAS mutant melanoma. Mol Cancer. 2015;14:27 pubmed publisher

Bruneau S, Néel M, Roumenina L, Frimat M, Laurent L, Frémeaux Bacchi V, et al. Loss of DGKε induces endothelial cell activation and death independently of complement activation. Blood. 2015;125:1038-46 pubmed publisher

Tseng P, Chen C, Shan Y, Chang W, Liu H, Hong T, et al. An increase in integrin-linked kinase non-canonically confers NF-κB-mediated growth advantages to gastric cancer cells by activating ERK1/2. Cell Commun Signal. 2014;12:69 pubmed publisher

Cho Y, Hur S, Kim J, Kim J, Lee D, Choe J, et al. Specific activation of insulin-like growth factor-1 receptor by ginsenoside Rg5 promotes angiogenesis and vasorelaxation. J Biol Chem. 2015;290:467-77 pubmed publisher

Iida M, Brand T, Starr M, Huppert E, Luthar N, Bahrar H, et al. Overcoming acquired resistance to cetuximab by dual targeting HER family receptors with antibody-based therapy. Mol Cancer. 2014;13:242 pubmed publisher

Ranayhossaini D, Lu J, Mabus J, Gervais A, Lingham R, Fursov N. EGF potentiation of VEGF production is cell density dependent in H292 EGFR wild type NSCLC cell line. Int J Mol Sci. 2014;15:17686-704 pubmed publisher

Lapeire L, Hendrix A, Lambein K, Van Bockstal M, Braems G, Van Den Broecke R, et al. Cancer-associated adipose tissue promotes breast cancer progression by paracrine oncostatin M and Jak/STAT3 signaling. Cancer Res. 2014;74:6806-19 pubmed publisher

Lee E, Fertig E, Jin K, Sukumar S, Pandey N, Popel A. Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis. Nat Commun. 2014;5:4715 pubmed publisher

Virtanen S, Kukkonen Macchi A, Vainio M, Elima K, Härkönen P, Jalkanen S, et al. Adenosine inhibits tumor cell invasion via receptor-independent mechanisms. Mol Cancer Res. 2014;12:1863-74 pubmed publisher

Sinkevicius K, Kriegel C, Bellaria K, Lee J, Lau A, Leeman K, et al. Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis. Proc Natl Acad Sci U S A. 2014;111:10299-304 pubmed publisher

Marra P, Mathew S, Grigoriadis A, Wu Y, Kyle Cezar F, Watkins J, et al. IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers. Cancer Res. 2014;74:4908-21 pubmed publisher

Large M, Wetendorf M, Lanz R, Hartig S, Creighton C, Mancini M, et al. The epidermal growth factor receptor critically regulates endometrial function during early pregnancy. PLoS Genet. 2014;10:e1004451 pubmed publisher

Naspi A, Panasiti V, Abbate F, Roberti V, Devirgiliis V, Curzio M, et al. Insulin-like-growth-factor-binding-protein-3 (IGFBP-3) contrasts melanoma progression in vitro and in vivo. PLoS ONE. 2014;9:e98641 pubmed publisher

Speakman C, Domke T, Wongpaiboonwattana W, Sanders K, Mudaliar M, van Aalten D, et al. Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ESC differentiation without affecting naïve to primed cell transition. Stem Cells. 2014;32:2605-15 pubmed publisher

Raimondi C, Fantin A, Lampropoulou A, Denti L, Chikh A, Ruhrberg C. Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. J Exp Med. 2014;211:1167-83 pubmed publisher

Jokela T, Kärnä R, Makkonen K, Laitinen J, Tammi R, Tammi M. Extracellular UDP-glucose activates P2Y14 Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr705 phosphorylation and binding to hyaluronan synthase 2 (HAS2) promoter, stimulating hyaluronan synthesis of keratinocytes. J Biol Chem. 2014;289:18569-81 pubmed publisher

Nagalingam A, Kuppusamy P, Singh S, Sharma D, Saxena N. Mechanistic elucidation of the antitumor properties of withaferin a in breast cancer. Cancer Res. 2014;74:2617-29 pubmed publisher

Li W, Liu J, Jackson K, Shi R, Zhao Y. Sensitizing the therapeutic efficacy of taxol with shikonin in human breast cancer cells. PLoS ONE. 2014;9:e94079 pubmed publisher

Golubkov V, Strongin A. Downstream signaling and genome-wide regulatory effects of PTK7 pseudokinase and its proteolytic fragments in cancer cells. Cell Commun Signal. 2014;12:15 pubmed publisher

Song W, Ma Y, Wang J, Brantley Sieders D, Chen J. JNK signaling mediates EPHA2-dependent tumor cell proliferation, motility, and cancer stem cell-like properties in non-small cell lung cancer. Cancer Res. 2014;74:2444-54 pubmed publisher

Spary L, Al Taei S, Salimu J, Cook A, Ager A, Watson H, et al. Enhancement of T cell responses as a result of synergy between lower doses of radiation and T cell stimulation. J Immunol. 2014;192:3101-10 pubmed publisher

Yang L, Murota H, Serada S, Fujimoto M, Kudo A, Naka T, et al. Histamine contributes to tissue remodeling via periostin expression. J Invest Dermatol. 2014;134:2105-2113 pubmed publisher

Kim J, Kim W, Sung Y, Kwack M, Song S, Choi J, et al. The molecular mechanism underlying the proliferating and preconditioning effect of vitamin C on adipose-derived stem cells. Stem Cells Dev. 2014;23:1364-76 pubmed publisher

Lutay N, Håkansson G, Alaridah N, Hallgren O, Westergren Thorsson G, Godaly G. Mycobacteria bypass mucosal NF-kB signalling to induce an epithelial anti-inflammatory IL-22 and IL-10 response. PLoS ONE. 2014;9:e86466 pubmed publisher

Bajpe P, Prahallad A, Horlings H, Nagtegaal I, Beijersbergen R, Bernards R. A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity. Oncogene. 2015;34:531-6 pubmed publisher

Lin Z, Zhang C, Zhang M, Xu D, Fang Y, Zhou Z, et al. Targeting cadherin-17 inactivates Ras/Raf/MEK/ERK signaling and inhibits cell proliferation in gastric cancer. PLoS ONE. 2014;9:e85296 pubmed publisher

Wang L, Chen P, Hsu L, Hsu W, Liu D, Chang C, et al. Concomitant induction of apoptosis and autophagy by prostate apoptosis response-4 in hypopharyngeal carcinoma cells. Am J Pathol. 2014;184:418-30 pubmed publisher

Victoni T, Gleonnec F, Lanzetti M, Tenor H, Valença S, Porto L, et al. Roflumilast N-oxide prevents cytokine secretion induced by cigarette smoke combined with LPS through JAK/STAT and ERK1/2 inhibition in airway epithelial cells. PLoS ONE. 2014;9:e85243 pubmed publisher

Lekawanvijit S, Kumfu S, Wang B, Manabe M, Nishijima F, Kelly D, et al. The uremic toxin adsorbent AST-120 abrogates cardiorenal injury following myocardial infarction. PLoS ONE. 2013;8:e83687 pubmed publisher

Davies K, Mahale S, Astling D, Aisner D, Le A, Hinz T, et al. Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer. PLoS ONE. 2013;8:e82236 pubmed publisher

Huck B, Duss S, Hausser A, Olayioye M. Elevated protein kinase D3 (PKD3) expression supports proliferation of triple-negative breast cancer cells and contributes to mTORC1-S6K1 pathway activation. J Biol Chem. 2014;289:3138-47 pubmed publisher

Gu Z, Liu F, Tonkova E, Lee S, Tschumperlin D, Brenner M. Soft matrix is a natural stimulator for cellular invasiveness. Mol Biol Cell. 2014;25:457-69 pubmed publisher

Drake J, Graham N, Lee J, Stoyanova T, Faltermeier C, Sud S, et al. Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets. Proc Natl Acad Sci U S A. 2013;110:E4762-9 pubmed publisher

Haas D, Bala K, Büsche G, Weidner Glunde M, Santag S, Kati S, et al. The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells. PLoS Pathog. 2013;9:e1003737 pubmed publisher

Kampen K, Ter Elst A, Mahmud H, Scherpen F, Diks S, Peppelenbosch M, et al. Insights in dynamic kinome reprogramming as a consequence of MEK inhibition in MLL-rearranged AML. Leukemia. 2014;28:589-99 pubmed publisher

Stegeman H, Kaanders J, Verheijen M, Peeters W, Wheeler D, Iida M, et al. Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines. Mol Cancer. 2013;12:133 pubmed publisher

Mir S, Schwarze S, Jin L, Zhang J, Friend W, Miriyala S, et al. Progesterone receptor membrane component 1/Sigma-2 receptor associates with MAP1LC3B and promotes autophagy. Autophagy. 2013;9:1566-78 pubmed publisher

Polajeva J, Bergström T, Edqvist P, Lundequist A, Sjösten A, Nilsson G, et al. Glioma-derived macrophage migration inhibitory factor (MIF) promotes mast cell recruitment in a STAT5-dependent manner. Mol Oncol. 2014;8:50-8 pubmed publisher

Szalmás A, Gyöngyösi E, Ferenczi A, László B, Karosi T, Csomor P, et al. Activation of Src, Fyn and Yes non-receptor tyrosine kinases in keratinocytes expressing human papillomavirus (HPV) type 16 E7 oncoprotein. Virol J. 2013;10:79 pubmed publisher

Weidenaar A, ter Elst A, Kampen K, Meeuwsen de Boer T, Kamps W, Schuringa J, et al. Impaired long-term expansion and self-renewal potential of pediatric acute myeloid leukemia-initiating cells by PTK787/ZK 222584. Mol Cancer Res. 2013;11:339-48 pubmed publisher

Liu K, Yu D, Cho Y, Bode A, Ma W, Yao K, et al. Sunlight UV-induced skin cancer relies upon activation of the p38? signaling pathway. Cancer Res. 2013;73:2181-8 pubmed publisher

Ray K, Moss M, Franklin J, Weaver C, Higginbotham J, Song Y, et al. Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia. Oncogene. 2014;33:823-31 pubmed publisher

Dreses Werringloer U, Vingtdeux V, Zhao H, Chandakkar P, Davies P, Marambaud P. CALHM1 controls the Ca²?-dependent MEK, ERK, RSK and MSK signaling cascade in neurons. J Cell Sci. 2013;126:1199-206 pubmed publisher

Shimizu A, Nakayama H, Wang P, König C, Akino T, Sandlund J, et al. Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein. J Biol Chem. 2013;288:2210-22 pubmed publisher

Joshi A, Loilome W, Siu I, Tyler B, Gallia G, Riggins G. Evaluation of tyrosine kinase inhibitor combinations for glioblastoma therapy. PLoS ONE. 2012;7:e44372 pubmed publisher

Cheng W, Chen L, Yang S, Han J, Zhai D, Ni J, et al. Puerarin suppresses proliferation of endometriotic stromal cells partly via the MAPK signaling pathway induced by 17ß-estradiol-BSA. PLoS ONE. 2012;7:e45529 pubmed publisher

Olszewski U, Deally A, Tacke M, Hamilton G. Alterations of phosphoproteins in NCI-H526 small cell lung cancer cells involved in cytotoxicity of cisplatin and titanocene Y. Neoplasia. 2012;14:813-22 pubmed

Jawad M, Yu N, Seedhouse C, Tandon K, Russell N, Pallis M. Targeting of CD34+CD38- cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in Acute Myeloid Leukaemia. BMC Cancer. 2012;12:431 pubmed publisher

Zhuang G, Wu X, Jiang Z, Kasman I, Yao J, Guan Y, et al. Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway. EMBO J. 2012;31:3513-23 pubmed publisher

Deharvengt S, Marmarelis M, Korc M. Concomitant targeting of EGF receptor, TGF-beta and SRC points to a novel therapeutic approach in pancreatic cancer. PLoS ONE. 2012;7:e39684 pubmed publisher

Dumitru C, Fechner M, Hoffmann T, Lang S, Brandau S. A novel p38-MAPK signaling axis modulates neutrophil biology in head and neck cancer. J Leukoc Biol. 2012;91:591-8 pubmed publisher

Maddigan A, Truitt L, Arsenault R, Freywald T, Allonby O, Dean J, et al. EphB receptors trigger Akt activation and suppress Fas receptor-induced apoptosis in malignant T lymphocytes. J Immunol. 2011;187:5983-94 pubmed publisher

Li J, Cho Y, Langfald A, Carper A, Lubet R, Grubbs C, et al. Lapatinib, a preventive/therapeutic agent against mammary cancer, suppresses RTK-mediated signaling through multiple signaling pathways. Cancer Prev Res (Phila). 2011;4:1190-7 pubmed publisher

Singhal G, Akhter M, Stern D, Gupta S, Ahuja A, Sharma U, et al. DNA triplex-mediated inhibition of MET leads to cell death and tumor regression in hepatoma. Cancer Gene Ther. 2011;18:520-30 pubmed publisher

Martins A, Ordóñez J, Amaral A, Prins F, Floris G, Debiec Rychter M, et al. IGF1R signaling in Ewing sarcoma is shaped by clathrin-/caveolin-dependent endocytosis. PLoS ONE. 2011;6:e19846 pubmed publisher

Ge Y, Bruno M, Wallace K, Winnik W, Prasad R. Proteome profiling reveals potential toxicity and detoxification pathways following exposure of BEAS-2B cells to engineered nanoparticle titanium dioxide. Proteomics. 2011;11:2406-22 pubmed publisher

Coeffier M, Claeyssens S, Bensifi M, Lecleire S, Boukhettala N, Maurer B, et al. Influence of leucine on protein metabolism, phosphokinase expression, and cell proliferation in human duodenum1,3. Am J Clin Nutr. 2011;93:1255-62 pubmed publisher

Wei Q, Jiang H, Xiao Z, Baker A, Young M, Veenstra T, et al. Sulfiredoxin-Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling. Proc Natl Acad Sci U S A. 2011;108:7004-9 pubmed publisher

Malik S, Orhon I, Morselli E, Criollo A, Shen S, Marino G, et al. BH3 mimetics activate multiple pro-autophagic pathways. Oncogene. 2011;30:3918-29 pubmed publisher

Li A, King J, Moro A, Sugi M, Dawson D, Kaplan J, et al. Overexpression of CXCL5 is associated with poor survival in patients with pancreatic cancer. Am J Pathol. 2011;178:1340-9 pubmed publisher

Chandarlapaty S, Sawai A, Scaltriti M, Rodrik Outmezguine V, Grbovic Huezo O, Serra V, et al. AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity. Cancer Cell. 2011;19:58-71 pubmed publisher

Chen P, Wakimoto H, Conner D, Araki T, Yuan T, Roberts A, et al. Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation. J Clin Invest. 2010;120:4353-65 pubmed publisher

Dunn E, Iida M, Myers R, Campbell D, Hintz K, Armstrong E, et al. Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab. Oncogene. 2011;30:561-74 pubmed publisher

Guo T, Lee S, Ng W, Zhu Y, Gan C, Zhu J, et al. Global molecular dysfunctions in gastric cancer revealed by an integrated analysis of the phosphoproteome and transcriptome. Cell Mol Life Sci. 2011;68:1983-2002 pubmed publisher

Shih Y, Tseng K, Lai H, Lin C, Lee O. Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells. J Bone Miner Res. 2011;26:730-8 pubmed publisher

Tomlinson D, Knowles M. Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer. Am J Pathol. 2010;177:2379-86 pubmed publisher

Vingtdeux V, Chandakkar P, Zhao H, d Abramo C, Davies P, Marambaud P. Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-? peptide degradation. FASEB J. 2011;25:219-31 pubmed publisher

Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villen J, et al. Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc Natl Acad Sci U S A. 2010;107:15299-304 pubmed publisher

Dewaele B, Floris G, Finalet Ferreiro J, Fletcher C, Coindre J, Guillou L, et al. Coactivated platelet-derived growth factor receptor {alpha} and epidermal growth factor receptor are potential therapeutic targets in intimal sarcoma. Cancer Res. 2010;70:7304-14 pubmed publisher

Carretero J, Shimamura T, Rikova K, Jackson A, Wilkerson M, Borgman C, et al. Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors. Cancer Cell. 2010;17:547-59 pubmed publisher

Fritz V, Benfodda Z, Rodier G, Henriquet C, Iborra F, Avances C, et al. Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice. Mol Cancer Ther. 2010;9:1740-54 pubmed publisher

Zhang H, Fagan D, Zeng X, Freeman K, Sachdev D, Yee D. Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation. Oncogene. 2010;29:2517-27 pubmed publisher

Vingtdeux V, Giliberto L, Zhao H, Chandakkar P, Wu Q, Simon J, et al. AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. J Biol Chem. 2010;285:9100-13 pubmed publisher

Roorda B, ter Elst A, Scherpen F, Meeuwsen de Boer T, Kamps W, de Bont E. VEGF-A promotes lymphoma tumour growth by activation of STAT proteins and inhibition of p27(KIP1) via paracrine mechanisms. Eur J Cancer. 2010;46:974-82 pubmed publisher

Cailleteau C, Liagre B, Beneytout J. A proteomic approach to the identification of molecular targets in subsequent apoptosis of HEL cells after diosgenin-induced megakaryocytic differentiation. J Cell Biochem. 2009;107:785-96 pubmed publisher

Smith N, Stoddart L, Devine N, Jenkins L, Milligan G. The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1. J Biol Chem. 2009;284:17527-39 pubmed publisher

Couty J, Lupu Meiri M, Oron Y, Gershengorn M. Kaposi's sarcoma-associated herpesvirus-G protein-coupled receptor-expressing endothelial cells exhibit reduced migration and stimulated chemotaxis by chemokine inverse agonists. J Pharmacol Exp Ther. 2009;329:1142-7 pubmed publisher