This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
ELISA/assay
product name :
Proteome Profiler Human Phospho-Kinase Array Kit
catalog :
ARY003B
quantity :
1 Kit
price :
762 USD
citations: 224
Reference
Shahi Thakuri P, Gupta M, Singh S, Joshi R, Glasgow E, Lekan A, et al. Phytochemicals inhibit migration of triple negative breast cancer cells by targeting kinase signaling. BMC Cancer. 2020;20:4 pubmed publisher
Jo M, Jeong S, Yun H, Kim D, Kim B, Kim J, et al. Genipin induces mitochondrial dysfunction and apoptosis via downregulation of Stat3/mcl-1 pathway in gastric cancer. BMC Cancer. 2019;19:739 pubmed publisher
Menéndez Menéndez J, Hermida Prado F, Granda Díaz R, Gonzalez A, Garcia Pedrero J, Del Río Ibisate N, et al. Deciphering the Molecular Basis of Melatonin Protective Effects on Breast Cells Treated with Doxorubicin: TWIST1 a Transcription Factor Involved in EMT and Metastasis, a Novel Target of Melatonin. Cancers (Basel). 2019;11: pubmed publisher
Schepetkin I, Kirpotina L, Khlebnikov A, Balasubramanian N, Quinn M. Neutrophil Immunomodulatory Activity of Natural Organosulfur Compounds. Molecules. 2019;24: pubmed publisher
Chen J, Bell J, Lau B, Whittaker T, Stapleton D, Ji H. A functional CRISPR/Cas9 screen identifies kinases that modulate FGFR inhibitor response in gastric cancer. Oncogenesis. 2019;8:33 pubmed publisher
Xiao Z, Sperl B, Gartner S, Nedelko T, Stacher Priehse E, Ullrich A, et al. Lung cancer stem cells and their aggressive progeny, controlled by EGFR/MIG6 inverse expression, dictate a novel NSCLC treatment approach. Oncotarget. 2019;10:2546-2560 pubmed publisher
Yoo J, Brady S, Acosta Alvarez L, Rogers A, Peng J, Sorensen L, et al. The Small GTPase ARF6 Activates PI3K in Melanoma to Induce a Prometastatic State. Cancer Res. 2019;79:2892-2908 pubmed publisher
Hummitzsch L, Zitta K, Berndt R, Wong Y, Rusch R, Hess K, et al. Remote ischemic preconditioning attenuates intestinal mucosal damage: insight from a rat model of ischemia-reperfusion injury. J Transl Med. 2019;17:136 pubmed publisher
Pellizzari G, Hoskin C, Crescioli S, Mele S, Gotovina J, Chiaruttini G, et al. IgE re-programs alternatively-activated human macrophages towards pro-inflammatory anti-tumoural states. EBioMedicine. 2019;43:67-81 pubmed publisher
Ferraro D, Patella F, Zanivan S, Donato C, Aceto N, Giannotta M, et al. Endothelial cell-derived nidogen-1 inhibits migration of SK-BR-3 breast cancer cells. BMC Cancer. 2019;19:312 pubmed publisher
Bai Y, Liu X, Qi X, Liu X, Peng F, Li H, et al. PDIA6 modulates apoptosis and autophagy of non-small cell lung cancer cells via the MAP4K1/JNK signaling pathway. EBioMedicine. 2019;42:311-325 pubmed publisher
Kennedy S, Han J, Portman N, Nobis M, Hastings J, Murphy K, et al. Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer. Breast Cancer Res. 2019;21:43 pubmed publisher
Li L, Liu Y, Li S, Yang R, Zeng C, Rong W, et al. Signal regulatory protein α protects podocytes through promoting autophagic activity. JCI Insight. 2019;5: pubmed publisher
Jolly M, Ware K, Xu S, Gilja S, Shetler S, Yang Y, et al. E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms. Mol Cancer Res. 2019;17:1391-1402 pubmed publisher
Ko Y, Hu C, Liu Z, Tien H, Ou D, Chien H, et al. Cytarabine-Resistant FLT3-ITD Leukemia Cells are Associated with TP53 Mutation and Multiple Pathway Alterations-Possible Therapeutic Efficacy of Cabozantinib. Int J Mol Sci. 2019;20: pubmed publisher
Neelakantan D, Dogra S, Devapatla B, Jaiprasart P, Mukashyaka M, Janknecht R, et al. Multifunctional APJ Pathway Promotes Ovarian Cancer Progression and Metastasis. Mol Cancer Res. 2019;17:1378-1390 pubmed publisher
Ferro F, Spelat R, Shaw G, Duffy N, Islam M, O Shea P, et al. Survival/Adaptation of Bone Marrow-Derived Mesenchymal Stem Cells After Long-Term Starvation Through Selective Processes. Stem Cells. 2019;37:813-827 pubmed publisher
Martini G, Cardone C, Vitiello P, Belli V, Napolitano S, Troiani T, et al. EPHA2 Is a Predictive Biomarker of Resistance and a Potential Therapeutic Target for Improving Antiepidermal Growth Factor Receptor Therapy in Colorectal Cancer. Mol Cancer Ther. 2019;18:845-855 pubmed publisher
van Montfort T, van der Sluis R, Darcis G, Beaty D, Groen K, Pasternak A, et al. Dendritic cells potently purge latent HIV-1 beyond TCR-stimulation, activating the PI3K-Akt-mTOR pathway. EBioMedicine. 2019;42:97-108 pubmed publisher
Arora H, Wilcox S, Johnson L, Munro L, Eyford B, Pfeifer C, et al. The ATP-Binding Cassette Gene ABCF1 Functions as an E2 Ubiquitin-Conjugating Enzyme Controlling Macrophage Polarization to Dampen Lethal Septic Shock. Immunity. 2019;50:418-431.e6 pubmed publisher
Noh J, Kim K, Pandey P, Noren Hooten N, Munk R, Kundu G, et al. Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program. Nucleic Acids Res. 2019;47:2472-2486 pubmed publisher
Ashraf S, Bell S, O Leary C, Canning P, Micu I, Fernandez J, et al. CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularization. JCI Insight. 2019;4: pubmed publisher
Nickol M, Ciric J, Falcinelli S, Chertow D, Kindrachuk J. Characterization of Host and Bacterial Contributions to Lung Barrier Dysfunction Following Co-infection with 2009 Pandemic Influenza and Methicillin Resistant Staphylococcus aureus. Viruses. 2019;11: pubmed publisher
Zalfa C, Azmoon P, Mantuano E, Gonias S. Tissue-type plasminogen activator neutralizes LPS but not protease-activated receptor-mediated inflammatory responses to plasmin. J Leukoc Biol. 2019;105:729-740 pubmed publisher
Zhao Y, Huang W, Kim T, Jung Y, Menon L, Xing H, et al. MicroRNA-29a activates a multi-component growth and invasion program in glioblastoma. J Exp Clin Cancer Res. 2019;38:36 pubmed publisher
Kumar R, Njauw C, Reddy B, Ji Z, Rajadurai A, Klebanov N, et al. Growth suppression by dual BRAF(V600E) and NRAS(Q61) oncogene expression is mediated by SPRY4 in melanoma. Oncogene. 2019;38:3504-3520 pubmed publisher
Taniguchi H, Yamada T, Wang R, Tanimura K, Adachi Y, Nishiyama A, et al. AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells. Nat Commun. 2019;10:259 pubmed publisher
Cortés A, Díaz R, Hernandez Campo P, Gorrochategui J, Primo D, Robles A, et al. Ruxolitinib in combination with prednisone and nilotinib exhibit synergistic effects in human cells lines and primary cells from myeloproliferative neoplasms. Haematologica. 2019;104:937-946 pubmed publisher
Wang X, Ai J, Liu H, Peng X, Chen H, Chen Y, et al. The Secretome Engages STAT3 to Favor a Cytokine-rich Microenvironment in Mediating Acquired Resistance to FGFR Inhibitors. Mol Cancer Ther. 2019;18:667-679 pubmed publisher
Golec E, Lind L, Qayyum M, Blom A, King B. The Noncoding RNA nc886 Regulates PKR Signaling and Cytokine Production in Human Cells. J Immunol. 2019;202:131-141 pubmed publisher
Totiger T, Srinivasan S, Jala V, Lamichhane P, Dosch A, Gaidarski A, et al. Urolithin A, a Novel Natural Compound to Target PI3K/AKT/mTOR Pathway in Pancreatic Cancer. Mol Cancer Ther. 2019;18:301-311 pubmed publisher
Shimizu M, Tanaka N. IL-8-induced O-GlcNAc modification via GLUT3 and GFAT regulates cancer stem cell-like properties in colon and lung cancer cells. Oncogene. 2019;38:1520-1533 pubmed publisher
Kim J, Grotegut C, Wisler J, Li T, Mao L, Chen M, et al. β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility. Skelet Muscle. 2018;8:39 pubmed publisher
Tornillo G, Knowlson C, Kendrick H, Cooke J, Mirza H, Aurrekoetxea Rodríguez I, et al. Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells. Cell Rep. 2018;25:3674-3692.e10 pubmed publisher
Klein C, Roussel G, Brun S, Rusu C, Patte Mensah C, Maitre M, et al. 5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer's disease. Acta Neuropathol Commun. 2018;6:136 pubmed publisher
Kubala M, Punj V, Placencio Hickok V, Fang H, Fernandez G, Sposto R, et al. Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer. Cell Rep. 2018;25:2177-2191.e7 pubmed publisher
Deng L, Gao X, Liu B, He X, Xu J, Qiang J, et al. NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway. Cell Death Dis. 2018;9:1143 pubmed publisher
Narvi E, Vaparanta K, Karrila A, Chakroborty D, Knuutila S, Pulliainen A, et al. Different responses of colorectal cancer cells to alternative sequences of cetuximab and oxaliplatin. Sci Rep. 2018;8:16579 pubmed publisher
Miao W, Sakai K, Ozawa N, Nishiuchi T, Suzuki Y, Ito K, et al. Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist. Sci Rep. 2018;8:16492 pubmed publisher
Wong T, Juang W, Tsai C, Tseng C, Lee W, Chang S, et al. Mechanical Stretching Simulates Cardiac Physiology and Pathology through Mechanosensor Piezo1. J Clin Med. 2018;7: pubmed publisher
Taniuchi K, Furihata M, Naganuma S, Saibara T. WAVE2 is associated with poor prognosis in pancreatic cancers and promotes cell motility and invasiveness via binding to ACTN4. Cancer Med. 2018;7:5733-5751 pubmed publisher
Redaelli S, Ceccon M, Zappa M, Sharma G, Mastini C, Mauri M, et al. Lorlatinib Treatment Elicits Multiple On- and Off-Target Mechanisms of Resistance in ALK-Driven Cancer. Cancer Res. 2018;78:6866-6880 pubmed publisher
Pandey V, Wang B, Mohan C, Raquib A, Rangappa S, Srinivasa V, et al. Discovery of a small-molecule inhibitor of specific serine residue BAD phosphorylation. Proc Natl Acad Sci U S A. 2018;115:E10505-E10514 pubmed publisher
Zhang Y, Ji G, Han S, Shao Z, Lu Z, Huo L, et al. Tip60 Suppresses Cholangiocarcinoma Proliferation and Metastasis via PI3k-AKT. Cell Physiol Biochem. 2018;50:612-628 pubmed publisher
Gonçalves C, Vieira de Castro J, Pojo M, Martins E, Queirós S, Chautard E, et al. WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma. Theranostics. 2018;8:4805-4823 pubmed publisher
Chéret J, Bertolini M, Ponce L, Lehmann J, Tsai T, Alam M, et al. Olfactory receptor OR2AT4 regulates human hair growth. Nat Commun. 2018;9:3624 pubmed publisher
Choi B, Philips M, Chen Y, Lu L, Dai W. K-Ras Lys-42 is crucial for its signaling, cell migration, and invasion. J Biol Chem. 2018;293:17574-17581 pubmed publisher
Wagner T, Gschwandtner M, Strajeriu A, Elbe Bürger A, Grillari J, Grillari Voglauer R, et al. Establishment of keratinocyte cell lines from human hair follicles. Sci Rep. 2018;8:13434 pubmed publisher
Jiang Y, Jiang Y, Xie J, Mayakonda A, Hazawa M, Chen L, et al. Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression. Nat Commun. 2018;9:3619 pubmed publisher
Pareja F, Brandes A, Basili T, Selenica P, Geyer F, Fan D, et al. Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors. Nat Commun. 2018;9:3533 pubmed publisher
Vishwakarma V, New J, Kumar D, Snyder V, Arnold L, Nissen E, et al. Potent Antitumor Effects of a Combination of Three Nutraceutical Compounds. Sci Rep. 2018;8:12163 pubmed publisher
Urriola Muñoz P, Lagos Cabré R, Patiño Garcia D, Reyes J, Moreno R. Bisphenol-A and Nonylphenol Induce Apoptosis in Reproductive Tract Cancer Cell Lines by the Activation of ADAM17. Int J Mol Sci. 2018;19: pubmed publisher
Li W, Wong C, Zhang X, Kang W, Nakatsu G, Zhao Q, et al. CAB39L elicited an anti-Warburg effect via a LKB1-AMPK-PGC1α axis to inhibit gastric tumorigenesis. Oncogene. 2018;37:6383-6398 pubmed publisher
Gökyildirim M, Grandel U, Hattar K, Dahlem G, Schuetz E, Leinberger F, et al. Targeting CREB-binding protein overrides LPS induced radioresistance in non-small cell lung cancer cell lines. Oncotarget. 2018;9:28976-28988 pubmed publisher
Karthikeyan S, Russo A, DEAN M, Lantvit D, Endsley M, Burdette J. Prolactin signaling drives tumorigenesis in human high grade serous ovarian cancer cells and in a spontaneous fallopian tube derived model. Cancer Lett. 2018;433:221-231 pubmed publisher
Li C, Rezov V, Joensuu E, Vartiainen V, Rönty M, Yin M, et al. Pirfenidone decreases mesothelioma cell proliferation and migration via inhibition of ERK and AKT and regulates mesothelioma tumor microenvironment in vivo. Sci Rep. 2018;8:10070 pubmed publisher
Fang Z, Jung K, Yan H, Kim S, Rumman M, Park J, et al. Melatonin Synergizes with Sorafenib to Suppress Pancreatic Cancer via Melatonin Receptor and PDGFR-β/STAT3 Pathway. Cell Physiol Biochem. 2018;47:1751-1768 pubmed publisher
Chen W, Zebaze L, Dong J, Chézeau L, Inquimbert P, Hugel S, et al. WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3- cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling. Oncotarget. 2018;9:27197-27219 pubmed publisher
Fan P, Narzisi G, Jayaprakash A, Venturini E, Robine N, Smibert P, et al. YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics. Proc Natl Acad Sci U S A. 2018;115:E6030-E6038 pubmed publisher
Ruess D, Heynen G, Ciecielski K, Ai J, Berninger A, Kabacaoglu D, et al. Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase. Nat Med. 2018;24:954-960 pubmed publisher
Heger J, Bornbaum J, Würfel A, Hill C, Brockmann N, Gáspár R, et al. JDP2 overexpression provokes cardiac dysfunction in mice. Sci Rep. 2018;8:7647 pubmed publisher
Gong X, Smith J, Swanson H, Rubin L. Carotenoid Lutein Selectively Inhibits Breast Cancer Cell Growth and Potentiates the Effect of Chemotherapeutic Agents through ROS-Mediated Mechanisms. Molecules. 2018;23: pubmed publisher
Ku B, Choi M, Sun J, Lee S, Ahn J, Park K, et al. Acquired resistance to AZD9291 as an upfront treatment is dependent on ERK signaling in a preclinical model. PLoS ONE. 2018;13:e0194730 pubmed publisher
Taniuchi K, Furihata M, Naganuma S, Dabanaka K, Hanazaki K, Saibara T. BCL7B, a predictor of poor prognosis of pancreatic cancers, promotes cell motility and invasion by influencing CREB signaling. Am J Cancer Res. 2018;8:387-404 pubmed
Zhang X, Wang X, Xu R, Ji J, Xu Y, Han M, et al. YM155 decreases radiation-induced invasion and reverses epithelial-mesenchymal transition by targeting STAT3 in glioblastoma. J Transl Med. 2018;16:79 pubmed publisher
Hernandez C, Huebener P, Pradere J, Antoine D, Friedman R, Schwabe R. HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis. J Clin Invest. 2018;128:2436-2451 pubmed publisher
Zuo Q, Liu J, Huang L, Qin Y, Hawley T, Seo C, et al. AXL/AKT axis mediated-resistance to BRAF inhibitor depends on PTEN status in melanoma. Oncogene. 2018;37:3275-3289 pubmed publisher
Xiao G, Chan L, Klemm L, Braas D, Chen Z, Geng H, et al. B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies. Cell. 2018;173:470-484.e18 pubmed publisher
Huh S, Song H, Jeong G, Jang H, Seo N, Lee J, et al. Suppression of the ERK-SRF axis facilitates somatic cell reprogramming. Exp Mol Med. 2018;50:e448 pubmed publisher
Baumgartner U, Berger F, Hashemi Gheinani A, Burgener S, Monastyrskaya K, Vassella E. miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer. Mol Cancer. 2018;17:44 pubmed publisher
Yeo I, Lee Y, Song K, Jin H, Lee J, Kim D, et al. Low-molecular weight keratins with anti-skin aging activity produced by anaerobic digestion of poultry feathers with Fervidobacterium islandicum AW-1. J Biotechnol. 2018;271:17-25 pubmed publisher
Santiago O Farrill J, Kleinerman E, Hollomon M, Livingston A, Wang W, Tsai J, et al. Phosphorylated heat shock protein 27 as a potential biomarker to predict the role of chemotherapy-induced autophagy in osteosarcoma response to therapy. Oncotarget. 2018;9:1602-1616 pubmed publisher
Heavey S, Dowling P, Moore G, Barr M, Kelly N, Maher S, et al. Development and characterisation of a panel of phosphatidylinositide 3-kinase - mammalian target of rapamycin inhibitor resistant lung cancer cell lines. Sci Rep. 2018;8:1652 pubmed publisher
Wang J, Yang S, Ye F, Xia X, Shao X, Xia S, et al. Hypoxia-induced Rab11-family interacting protein 4 expression promotes migration and invasion of colon cancer and correlates with poor prognosis. Mol Med Rep. 2018;17:3797-3806 pubmed publisher
Wang D, Liu C, Wang J, Jia Y, Hu X, Jiang H, et al. Protein C receptor stimulates multiple signaling pathways in breast cancer cells. J Biol Chem. 2018;293:1413-1424 pubmed publisher
Kaittanis C, Andreou C, Hieronymus H, Mao N, Foss C, Eiber M, et al. Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors. J Exp Med. 2018;215:159-175 pubmed publisher
Zhou Z, Xu L, Sennepin A, Federici C, Ganor Y, Tudor D, et al. The HIV-1 viral synapse signals human foreskin keratinocytes to secrete thymic stromal lymphopoietin facilitating HIV-1 foreskin entry. Mucosal Immunol. 2018;11:158-171 pubmed publisher
Ribeiro J, Gaudet H, Khan M, Schorl C, James N, Oliver M, et al. Human Epididymis Protein 4 Promotes Events Associated with Metastatic Ovarian Cancer via Regulation of the Extracelluar Matrix. Front Oncol. 2017;7:332 pubmed publisher
Kuppusamy P, Nagalingam A, Muniraj N, Saxena N, Sharma D. Concomitant activation of ETS-like transcription factor-1 and Death Receptor-5 via extracellular signal-regulated kinase in withaferin A-mediated inhibition of hepatocarcinogenesis in mice. Sci Rep. 2017;7:17943 pubmed publisher
Álvarez Teijeiro S, Menendez S, Villaronga M, Rodrigo J, Manterola L, de Villalaín L, et al. Dysregulation of Mir-196b in Head and Neck Cancers Leads to Pleiotropic Effects in the Tumor Cells and Surrounding Stromal Fibroblasts. Sci Rep. 2017;7:17785 pubmed publisher
Keller S, Kneissl J, Grabher Meier V, Heindl S, Hasenauer J, Maier D, et al. Evaluation of epidermal growth factor receptor signaling effects in gastric cancer cell lines by detailed motility-focused phenotypic characterization linked with molecular analysis. BMC Cancer. 2017;17:845 pubmed publisher
Riera Borrull M, Cuevas V, Alonso B, Vega M, Joven J, Izquierdo E, et al. Palmitate Conditions Macrophages for Enhanced Responses toward Inflammatory Stimuli via JNK Activation. J Immunol. 2017;199:3858-3869 pubmed publisher
Owusu B, Thomas S, Venukadasula P, Han Z, Janetka J, Galemmo R, et al. Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation. Oncotarget. 2017;8:63014-63025 pubmed publisher
Tsuboi M, Taniuchi K, Shimizu T, Saito M, Saibara T. The transcription factor HOXB7 regulates ERK kinase activity and thereby stimulates the motility and invasiveness of pancreatic cancer cells. J Biol Chem. 2017;292:17681-17702 pubmed publisher
Curcic S, Holzer M, Pasterk L, Knuplez E, Eichmann T, Frank S, et al. Secretory phospholipase A2 modified HDL rapidly and potently suppresses platelet activation. Sci Rep. 2017;7:8030 pubmed publisher
Jayakar S, Loudig O, Brandwein Gensler M, Kim R, Ow T, Ustun B, et al. Apolipoprotein E Promotes Invasion in Oral Squamous Cell Carcinoma. Am J Pathol. 2017;187:2259-2272 pubmed publisher
Janczar S, Nautiyal J, Xiao Y, Curry E, Sun M, Zanini E, et al. WWOX sensitises ovarian cancer cells to paclitaxel via modulation of the ER stress response. Cell Death Dis. 2017;8:e2955 pubmed publisher
Shien K, Papadimitrakopoulou V, Ruder D, Behrens C, Shen L, Kalhor N, et al. JAK1/STAT3 Activation through a Proinflammatory Cytokine Pathway Leads to Resistance to Molecularly Targeted Therapy in Non-Small Cell Lung Cancer. Mol Cancer Ther. 2017;16:2234-2245 pubmed publisher
Chang C, Yen M, Liao S, Hsu Y, Lai C, Chang K, et al. Secreted Protein Acidic and Rich in Cysteine (SPARC) Enhances Cell Proliferation, Migration, and Epithelial Mesenchymal Transition, and SPARC Expression is Associated with Tumor Grade in Head and Neck Cancer. Int J Mol Sci. 2017;18: pubmed publisher
Ríos Luci C, García Alonso S, Díaz Rodríguez E, Nadal Serrano M, Arribas J, Ocaña A, et al. Resistance to the Antibody-Drug Conjugate T-DM1 Is Based in a Reduction in Lysosomal Proteolytic Activity. Cancer Res. 2017;77:4639-4651 pubmed publisher
Guo J, Jayaprakash P, Dan J, Wise P, Jang G, Liang C, et al. PRAS40 Connects Microenvironmental Stress Signaling to Exosome-Mediated Secretion. Mol Cell Biol. 2017;37: pubmed publisher
Sahu N, Chan E, Chu F, Pham T, Koeppen H, Forrest W, et al. Cotargeting of MEK and PDGFR/STAT3 Pathways to Treat Pancreatic Ductal Adenocarcinoma. Mol Cancer Ther. 2017;16:1729-1738 pubmed publisher
Islam S, Qi W, Morales C, Cooke L, Spier C, Weterings E, et al. Disruption of Aneuploidy and Senescence Induced by Aurora Inhibition Promotes Intrinsic Apoptosis in Double Hit or Double Expressor Diffuse Large B-cell Lymphomas. Mol Cancer Ther. 2017;16:2083-2093 pubmed publisher
Mustapic M, Eitan E, Werner J, Berkowitz S, Lazaropoulos M, Tran J, et al. Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes. Front Neurosci. 2017;11:278 pubmed publisher
Lee H, Baek S, Lee J, Kim C, Ko J, Lee S, et al. Isorhynchophylline, a Potent Plant Alkaloid, Induces Apoptotic and Anti-Metastatic Effects in Human Hepatocellular Carcinoma Cells through the Modulation of Diverse Cell Signaling Cascades. Int J Mol Sci. 2017;18: pubmed publisher
Pio G, Xia Y, Piaseczny M, Chu J, Allan A. Soluble bone-derived osteopontin promotes migration and stem-like behavior of breast cancer cells. PLoS ONE. 2017;12:e0177640 pubmed publisher
Crişan T, Cleophas M, Novakovic B, Erler K, van de Veerdonk F, Stunnenberg H, et al. Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway. Proc Natl Acad Sci U S A. 2017;114:5485-5490 pubmed publisher
Chen S, Tao J, Zhong F, Jiao Y, Xu J, Shen Q, et al. Polydatin down-regulates the phosphorylation level of Creb and induces apoptosis in human breast cancer cell. PLoS ONE. 2017;12:e0176501 pubmed publisher
Carriero M, Bifulco K, Ingangi V, Costantini S, Botti G, Ragone C, et al. Retro-inverso Urokinase Receptor Antagonists for the Treatment of Metastatic Sarcomas. Sci Rep. 2017;7:1312 pubmed publisher
Teixeira F, Manfiolli A, Vieira N, Medeiros A, Coelho P, Santiago Guimarães D, et al. FBXO25 regulates MAPK signaling pathway through inhibition of ERK1/2 phosphorylation. Arch Biochem Biophys. 2017;621:38-45 pubmed publisher
Boengler K, Bulić M, Schreckenberg R, Schluter K, Schulz R. The gap junction modifier ZP1609 decreases cardiomyocyte hypercontracture following ischaemia/reperfusion independent from mitochondrial connexin 43. Br J Pharmacol. 2017;174:2060-2073 pubmed publisher
Colomb F, Wang W, Simpson D, Zafar M, Beynon R, Rhodes J, et al. Galectin-3 interacts with the cell-surface glycoprotein CD146 (MCAM, MUC18) and induces secretion of metastasis-promoting cytokines from vascular endothelial cells. J Biol Chem. 2017;292:8381-8389 pubmed publisher
Kalyvianaki K, Gebhart V, Peroulis N, Panagiotopoulou C, Kiagiadaki F, Pediaditakis I, et al. Antagonizing effects of membrane-acting androgens on the eicosanoid receptor OXER1 in prostate cancer. Sci Rep. 2017;7:44418 pubmed publisher
Buchanan P, Boylan K, Walcheck B, Heinze R, Geller M, Argenta P, et al. Ectodomain shedding of the cell adhesion molecule Nectin-4 in ovarian cancer is mediated by ADAM10 and ADAM17. J Biol Chem. 2017;292:6339-6351 pubmed publisher
Mo Y, Lu Y, Wang P, Huang S, He L, Li D, et al. Long non-coding RNA XIST promotes cell growth by regulating miR-139-5p/PDK1/AKT axis in hepatocellular carcinoma. Tumour Biol. 2017;39:1010428317690999 pubmed publisher
Wladis E, Swamy S, Herrmann A, Yang J, Carlson J, Adam A. Activation of p38 and Erk Mitogen-Activated Protein Kinases Signaling in Ocular Rosacea. Invest Ophthalmol Vis Sci. 2017;58:843-848 pubmed publisher
Kuan I, Liang K, Wang Y, Kuo T, Meir Y, Wu S, et al. EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2α. Sci Rep. 2017;7:41852 pubmed publisher
Lee H, Cao Y, Pham V, Blackwood E, Wilson C, Evangelista M, et al. Ras-MEK Signaling Mediates a Critical Chk1-Dependent DNA Damage Response in Cancer Cells. Mol Cancer Ther. 2017;16:694-704 pubmed publisher
Yang P, Read C, Kuc R, Buonincontri G, Southwood M, Torella R, et al. Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension. Circulation. 2017;135:1160-1173 pubmed publisher
Bankó Z, Pozsgay J, Szili D, Toth M, Gati T, Nagy G, et al. Induction and Differentiation of IL-10-Producing Regulatory B Cells from Healthy Blood Donors and Rheumatoid Arthritis Patients. J Immunol. 2017;198:1512-1520 pubmed publisher
Nadeau S, An W, Mohapatra B, Mushtaq I, Bielecki T, Luan H, et al. Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene. J Biol Chem. 2017;292:3666-3682 pubmed publisher
Alaridah N, Lutay N, Tenland E, Rönnholm A, Hallgren O, Puthia M, et al. Mycobacteria Manipulate G-Protein-Coupled Receptors to Increase Mucosal Rac1 Expression in the Lungs. J Innate Immun. 2017;9:318-329 pubmed publisher
Kalbe B, Schulz V, Schlimm M, Philippou S, Jovancevic N, Jansen F, et al. Helional-induced activation of human olfactory receptor 2J3 promotes apoptosis and inhibits proliferation in a non-small-cell lung cancer cell line. Eur J Cell Biol. 2017;96:34-46 pubmed publisher
Fotouhi Ghiam A, Taeb S, Huang X, Huang V, Ray J, Scarcello S, et al. Long non-coding RNA urothelial carcinoma associated 1 (UCA1) mediates radiation response in prostate cancer. Oncotarget. 2017;8:4668-4689 pubmed publisher
Zhang S, Xu Y, Jin E, Zhu L, Xia B, Chen X, et al. Capilliposide from Lysimachia capillipes inhibits AKT activation and restores gefitinib sensitivity in human non-small cell lung cancer cells with acquired gefitinib resistance. Acta Pharmacol Sin. 2017;38:100-109 pubmed publisher
Sauer M, Schuldner M, Hoffmann N, Cetintas A, Reiners K, Shatnyeva O, et al. CBP/p300 acetyltransferases regulate the expression of NKG2D ligands on tumor cells. Oncogene. 2017;36:933-941 pubmed publisher
Tanouchi A, Taniuchi K, Furihata M, Naganuma S, Dabanaka K, Kimura M, et al. CCDC88A, a prognostic factor for human pancreatic cancers, promotes the motility and invasiveness of pancreatic cancer cells. J Exp Clin Cancer Res. 2016;35:190 pubmed
O Hara S, Garcea R. Murine Polyomavirus Cell Surface Receptors Activate Distinct Signaling Pathways Required for Infection. MBio. 2016;7: pubmed publisher
Escudero Esparza A, Bartoschek M, Gialeli C, Okroj M, Owen S, Jirström K, et al. Complement inhibitor CSMD1 acts as tumor suppressor in human breast cancer. Oncotarget. 2016;7:76920-76933 pubmed publisher
Warren K, Fang X, Gowda N, Thompson J, Heller N. The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2. J Biol Chem. 2016;291:24922-24930 pubmed
Satelli A, Hu J, Xia X, Li S. Potential Function of Exogenous Vimentin on the Activation of Wnt Signaling Pathway in Cancer Cells. J Cancer. 2016;7:1824-1832 pubmed
Patel A, Tsilioni I, Leeman S, Theoharides T. Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism. Proc Natl Acad Sci U S A. 2016;113:E7049-E7058 pubmed publisher
Bezzerri V, Vella A, Calcaterra E, Finotti A, Gasparello J, Gambari R, et al. New insights into the Shwachman-Diamond Syndrome-related haematological disorder: hyper-activation of mTOR and STAT3 in leukocytes. Sci Rep. 2016;6:33165 pubmed publisher
Chi M, Evans H, Gilchrist J, Mayhew J, Hoffman A, Pearsall E, et al. Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells. Sci Rep. 2016;6:33132 pubmed publisher
Kimani S, Kumar S, Davra V, Chang Y, Kasikara C, Geng K, et al. Normalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinase. Cell Commun Signal. 2016;14:19 pubmed publisher
Flegel C, Vogel F, Hofreuter A, Wojcik S, Schoeder C, Kiec Kononowicz K, et al. Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18. Sci Rep. 2016;6:32255 pubmed publisher
Barquilla A, Lamberto I, Noberini R, Heynen Genel S, Brill L, Pasquale E. Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation. Mol Biol Cell. 2016;27:2757-70 pubmed publisher
Gu Y, Helenius M, Väänänen K, Bulanova D, Saarela J, Sokolenko A, et al. BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine. Sci Rep. 2016;6:28217 pubmed publisher
Bullova P, Cougnoux A, Abunimer L, Kopacek J, Pastorekova S, Pacak K. Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models. Oncotarget. 2016;7:40531-40545 pubmed publisher
Raimondi C, Calleja V, Ferro R, Fantin A, Riley A, Potter B, et al. A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion. Sci Rep. 2016;6:26142 pubmed publisher
Derlet A, Rasper T, Roy Choudhury A, Bothur S, Rieger M, Namgaladze D, et al. Metabolism Regulates Cellular Functions of Bone Marrow-Derived Cells used for Cardiac Therapy. Stem Cells. 2016;34:2236-48 pubmed publisher
Ahn S, Park H, Ahn Y, Kim S, Cho M, Kang J, et al. Necrotic cells influence migration and invasion of glioblastoma via NF-?B/AP-1-mediated IL-8 regulation. Sci Rep. 2016;6:24552 pubmed publisher
Benard L, Oh J, Cacheux M, Lee A, Nonnenmacher M, Matasic D, et al. Cardiac Stim1 Silencing Impairs Adaptive Hypertrophy and Promotes Heart Failure Through Inactivation of mTORC2/Akt Signaling. Circulation. 2016;133:1458-71; discussion 1471 pubmed publisher
Sento S, Sasabe E, Yamamoto T. Application of a Persistent Heparin Treatment Inhibits the Malignant Potential of Oral Squamous Carcinoma Cells Induced by Tumor Cell-Derived Exosomes. PLoS ONE. 2016;11:e0148454 pubmed publisher
Skolekova S, Matuskova M, Bohac M, Toro L, Durinikova E, Tyciakova S, et al. Cisplatin-induced mesenchymal stromal cells-mediated mechanism contributing to decreased antitumor effect in breast cancer cells. Cell Commun Signal. 2016;14:4 pubmed publisher
Wculek S, Malanchi I. Neutrophils support lung colonization of metastasis-initiating breast cancer cells. Nature. 2015;528:413-7 pubmed publisher
Purushothaman A, Bandari S, Liu J, Mobley J, Brown E, Sanderson R. Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions. J Biol Chem. 2016;291:1652-63 pubmed publisher
Singh A, Ruan Y, Tippett T, Narendran A. Targeted inhibition of MEK1 by cobimetinib leads to differentiation and apoptosis in neuroblastoma cells. J Exp Clin Cancer Res. 2015;34:104 pubmed publisher
Yamada T, Amann J, Fukuda K, Takeuchi S, Fujita N, Uehara H, et al. Akt Kinase-Interacting Protein 1 Signals through CREB to Drive Diffuse Malignant Mesothelioma. Cancer Res. 2015;75:4188-97 pubmed publisher
Eggink L, Spyroulias G, Jones N, Hanson C, Hoober J. A Peptide Mimetic of 5-Acetylneuraminic Acid-Galactose Binds with High Avidity to Siglecs and NKG2D. PLoS ONE. 2015;10:e0130532 pubmed publisher
Paggetti J, Haderk F, Seiffert M, Janji B, Distler U, Ammerlaan W, et al. Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts. Blood. 2015;126:1106-17 pubmed publisher
Hansen F, Kalle Brune M, van der Plas M, Strömdahl A, Malmsten M, Mörgelin M, et al. The Thrombin-Derived Host Defense Peptide GKY25 Inhibits Endotoxin-Induced Responses through Interactions with Lipopolysaccharide and Macrophages/Monocytes. J Immunol. 2015;194:5397-406 pubmed publisher
Chang B, Johnson K, LaTocha D, Rowley J, Bryant J, Burke R, et al. YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway. J Hematol Oncol. 2015;8:39 pubmed publisher
Mailly L, Xiao F, Lupberger J, Wilson G, Aubert P, Duong F, et al. Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody. Nat Biotechnol. 2015;33:549-554 pubmed publisher
Laukkanen M, Cammarota F, Esposito T, Salvatore M, Castellone M. Extracellular superoxide dismutase regulates the expression of small gtpase regulatory proteins GEFs, GAPs, and GDI. PLoS ONE. 2015;10:e0121441 pubmed publisher
Man J, Shoemake J, Ma T, Rizzo A, Godley A, Wu Q, et al. Hyperthermia Sensitizes Glioma Stem-like Cells to Radiation by Inhibiting AKT Signaling. Cancer Res. 2015;75:1760-9 pubmed publisher
Zhao D, Besser A, Wander S, Sun J, Zhou W, Wang B, et al. Cytoplasmic p27 promotes epithelial-mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation. Oncogene. 2015;34:5447-59 pubmed publisher
Atefi M, Titz B, Avramis E, Ng C, Wong D, Lassen A, et al. Combination of pan-RAF and MEK inhibitors in NRAS mutant melanoma. Mol Cancer. 2015;14:27 pubmed publisher
Bruneau S, Néel M, Roumenina L, Frimat M, Laurent L, Frémeaux Bacchi V, et al. Loss of DGKε induces endothelial cell activation and death independently of complement activation. Blood. 2015;125:1038-46 pubmed publisher
Tseng P, Chen C, Shan Y, Chang W, Liu H, Hong T, et al. An increase in integrin-linked kinase non-canonically confers NF-κB-mediated growth advantages to gastric cancer cells by activating ERK1/2. Cell Commun Signal. 2014;12:69 pubmed publisher
Cho Y, Hur S, Kim J, Kim J, Lee D, Choe J, et al. Specific activation of insulin-like growth factor-1 receptor by ginsenoside Rg5 promotes angiogenesis and vasorelaxation. J Biol Chem. 2015;290:467-77 pubmed publisher
Iida M, Brand T, Starr M, Huppert E, Luthar N, Bahrar H, et al. Overcoming acquired resistance to cetuximab by dual targeting HER family receptors with antibody-based therapy. Mol Cancer. 2014;13:242 pubmed publisher
Ranayhossaini D, Lu J, Mabus J, Gervais A, Lingham R, Fursov N. EGF potentiation of VEGF production is cell density dependent in H292 EGFR wild type NSCLC cell line. Int J Mol Sci. 2014;15:17686-704 pubmed publisher
Lapeire L, Hendrix A, Lambein K, Van Bockstal M, Braems G, Van Den Broecke R, et al. Cancer-associated adipose tissue promotes breast cancer progression by paracrine oncostatin M and Jak/STAT3 signaling. Cancer Res. 2014;74:6806-19 pubmed publisher
Lee E, Fertig E, Jin K, Sukumar S, Pandey N, Popel A. Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis. Nat Commun. 2014;5:4715 pubmed publisher
Virtanen S, Kukkonen Macchi A, Vainio M, Elima K, Härkönen P, Jalkanen S, et al. Adenosine inhibits tumor cell invasion via receptor-independent mechanisms. Mol Cancer Res. 2014;12:1863-74 pubmed publisher
Sinkevicius K, Kriegel C, Bellaria K, Lee J, Lau A, Leeman K, et al. Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis. Proc Natl Acad Sci U S A. 2014;111:10299-304 pubmed publisher
Marra P, Mathew S, Grigoriadis A, Wu Y, Kyle Cezar F, Watkins J, et al. IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers. Cancer Res. 2014;74:4908-21 pubmed publisher
Large M, Wetendorf M, Lanz R, Hartig S, Creighton C, Mancini M, et al. The epidermal growth factor receptor critically regulates endometrial function during early pregnancy. PLoS Genet. 2014;10:e1004451 pubmed publisher
Naspi A, Panasiti V, Abbate F, Roberti V, Devirgiliis V, Curzio M, et al. Insulin-like-growth-factor-binding-protein-3 (IGFBP-3) contrasts melanoma progression in vitro and in vivo. PLoS ONE. 2014;9:e98641 pubmed publisher
Speakman C, Domke T, Wongpaiboonwattana W, Sanders K, Mudaliar M, van Aalten D, et al. Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ESC differentiation without affecting naïve to primed cell transition. Stem Cells. 2014;32:2605-15 pubmed publisher
Raimondi C, Fantin A, Lampropoulou A, Denti L, Chikh A, Ruhrberg C. Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. J Exp Med. 2014;211:1167-83 pubmed publisher
Jokela T, Kärnä R, Makkonen K, Laitinen J, Tammi R, Tammi M. Extracellular UDP-glucose activates P2Y14 Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr705 phosphorylation and binding to hyaluronan synthase 2 (HAS2) promoter, stimulating hyaluronan synthesis of keratinocytes. J Biol Chem. 2014;289:18569-81 pubmed publisher
Nagalingam A, Kuppusamy P, Singh S, Sharma D, Saxena N. Mechanistic elucidation of the antitumor properties of withaferin a in breast cancer. Cancer Res. 2014;74:2617-29 pubmed publisher
Li W, Liu J, Jackson K, Shi R, Zhao Y. Sensitizing the therapeutic efficacy of taxol with shikonin in human breast cancer cells. PLoS ONE. 2014;9:e94079 pubmed publisher
Golubkov V, Strongin A. Downstream signaling and genome-wide regulatory effects of PTK7 pseudokinase and its proteolytic fragments in cancer cells. Cell Commun Signal. 2014;12:15 pubmed publisher
Song W, Ma Y, Wang J, Brantley Sieders D, Chen J. JNK signaling mediates EPHA2-dependent tumor cell proliferation, motility, and cancer stem cell-like properties in non-small cell lung cancer. Cancer Res. 2014;74:2444-54 pubmed publisher
Spary L, Al Taei S, Salimu J, Cook A, Ager A, Watson H, et al. Enhancement of T cell responses as a result of synergy between lower doses of radiation and T cell stimulation. J Immunol. 2014;192:3101-10 pubmed publisher
Yang L, Murota H, Serada S, Fujimoto M, Kudo A, Naka T, et al. Histamine contributes to tissue remodeling via periostin expression. J Invest Dermatol. 2014;134:2105-2113 pubmed publisher
Kim J, Kim W, Sung Y, Kwack M, Song S, Choi J, et al. The molecular mechanism underlying the proliferating and preconditioning effect of vitamin C on adipose-derived stem cells. Stem Cells Dev. 2014;23:1364-76 pubmed publisher
Lutay N, Håkansson G, Alaridah N, Hallgren O, Westergren Thorsson G, Godaly G. Mycobacteria bypass mucosal NF-kB signalling to induce an epithelial anti-inflammatory IL-22 and IL-10 response. PLoS ONE. 2014;9:e86466 pubmed publisher
Bajpe P, Prahallad A, Horlings H, Nagtegaal I, Beijersbergen R, Bernards R. A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity. Oncogene. 2015;34:531-6 pubmed publisher
Lin Z, Zhang C, Zhang M, Xu D, Fang Y, Zhou Z, et al. Targeting cadherin-17 inactivates Ras/Raf/MEK/ERK signaling and inhibits cell proliferation in gastric cancer. PLoS ONE. 2014;9:e85296 pubmed publisher
Wang L, Chen P, Hsu L, Hsu W, Liu D, Chang C, et al. Concomitant induction of apoptosis and autophagy by prostate apoptosis response-4 in hypopharyngeal carcinoma cells. Am J Pathol. 2014;184:418-30 pubmed publisher
Victoni T, Gleonnec F, Lanzetti M, Tenor H, Valença S, Porto L, et al. Roflumilast N-oxide prevents cytokine secretion induced by cigarette smoke combined with LPS through JAK/STAT and ERK1/2 inhibition in airway epithelial cells. PLoS ONE. 2014;9:e85243 pubmed publisher
Lekawanvijit S, Kumfu S, Wang B, Manabe M, Nishijima F, Kelly D, et al. The uremic toxin adsorbent AST-120 abrogates cardiorenal injury following myocardial infarction. PLoS ONE. 2013;8:e83687 pubmed publisher
Davies K, Mahale S, Astling D, Aisner D, Le A, Hinz T, et al. Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer. PLoS ONE. 2013;8:e82236 pubmed publisher
Huck B, Duss S, Hausser A, Olayioye M. Elevated protein kinase D3 (PKD3) expression supports proliferation of triple-negative breast cancer cells and contributes to mTORC1-S6K1 pathway activation. J Biol Chem. 2014;289:3138-47 pubmed publisher
Gu Z, Liu F, Tonkova E, Lee S, Tschumperlin D, Brenner M. Soft matrix is a natural stimulator for cellular invasiveness. Mol Biol Cell. 2014;25:457-69 pubmed publisher
Drake J, Graham N, Lee J, Stoyanova T, Faltermeier C, Sud S, et al. Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets. Proc Natl Acad Sci U S A. 2013;110:E4762-9 pubmed publisher
Haas D, Bala K, Büsche G, Weidner Glunde M, Santag S, Kati S, et al. The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells. PLoS Pathog. 2013;9:e1003737 pubmed publisher
Kampen K, Ter Elst A, Mahmud H, Scherpen F, Diks S, Peppelenbosch M, et al. Insights in dynamic kinome reprogramming as a consequence of MEK inhibition in MLL-rearranged AML. Leukemia. 2014;28:589-99 pubmed publisher
Stegeman H, Kaanders J, Verheijen M, Peeters W, Wheeler D, Iida M, et al. Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines. Mol Cancer. 2013;12:133 pubmed publisher
Mir S, Schwarze S, Jin L, Zhang J, Friend W, Miriyala S, et al. Progesterone receptor membrane component 1/Sigma-2 receptor associates with MAP1LC3B and promotes autophagy. Autophagy. 2013;9:1566-78 pubmed publisher
Polajeva J, Bergström T, Edqvist P, Lundequist A, Sjösten A, Nilsson G, et al. Glioma-derived macrophage migration inhibitory factor (MIF) promotes mast cell recruitment in a STAT5-dependent manner. Mol Oncol. 2014;8:50-8 pubmed publisher
Szalmás A, Gyöngyösi E, Ferenczi A, László B, Karosi T, Csomor P, et al. Activation of Src, Fyn and Yes non-receptor tyrosine kinases in keratinocytes expressing human papillomavirus (HPV) type 16 E7 oncoprotein. Virol J. 2013;10:79 pubmed publisher
Weidenaar A, ter Elst A, Kampen K, Meeuwsen de Boer T, Kamps W, Schuringa J, et al. Impaired long-term expansion and self-renewal potential of pediatric acute myeloid leukemia-initiating cells by PTK787/ZK 222584. Mol Cancer Res. 2013;11:339-48 pubmed publisher
Liu K, Yu D, Cho Y, Bode A, Ma W, Yao K, et al. Sunlight UV-induced skin cancer relies upon activation of the p38? signaling pathway. Cancer Res. 2013;73:2181-8 pubmed publisher
Ray K, Moss M, Franklin J, Weaver C, Higginbotham J, Song Y, et al. Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia. Oncogene. 2014;33:823-31 pubmed publisher
Dreses Werringloer U, Vingtdeux V, Zhao H, Chandakkar P, Davies P, Marambaud P. CALHM1 controls the Ca²?-dependent MEK, ERK, RSK and MSK signaling cascade in neurons. J Cell Sci. 2013;126:1199-206 pubmed publisher
Shimizu A, Nakayama H, Wang P, König C, Akino T, Sandlund J, et al. Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein. J Biol Chem. 2013;288:2210-22 pubmed publisher
Joshi A, Loilome W, Siu I, Tyler B, Gallia G, Riggins G. Evaluation of tyrosine kinase inhibitor combinations for glioblastoma therapy. PLoS ONE. 2012;7:e44372 pubmed publisher
Cheng W, Chen L, Yang S, Han J, Zhai D, Ni J, et al. Puerarin suppresses proliferation of endometriotic stromal cells partly via the MAPK signaling pathway induced by 17ß-estradiol-BSA. PLoS ONE. 2012;7:e45529 pubmed publisher
Olszewski U, Deally A, Tacke M, Hamilton G. Alterations of phosphoproteins in NCI-H526 small cell lung cancer cells involved in cytotoxicity of cisplatin and titanocene Y. Neoplasia. 2012;14:813-22 pubmed
Jawad M, Yu N, Seedhouse C, Tandon K, Russell N, Pallis M. Targeting of CD34+CD38- cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in Acute Myeloid Leukaemia. BMC Cancer. 2012;12:431 pubmed publisher
Zhuang G, Wu X, Jiang Z, Kasman I, Yao J, Guan Y, et al. Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway. EMBO J. 2012;31:3513-23 pubmed publisher
Deharvengt S, Marmarelis M, Korc M. Concomitant targeting of EGF receptor, TGF-beta and SRC points to a novel therapeutic approach in pancreatic cancer. PLoS ONE. 2012;7:e39684 pubmed publisher
Dumitru C, Fechner M, Hoffmann T, Lang S, Brandau S. A novel p38-MAPK signaling axis modulates neutrophil biology in head and neck cancer. J Leukoc Biol. 2012;91:591-8 pubmed publisher
Maddigan A, Truitt L, Arsenault R, Freywald T, Allonby O, Dean J, et al. EphB receptors trigger Akt activation and suppress Fas receptor-induced apoptosis in malignant T lymphocytes. J Immunol. 2011;187:5983-94 pubmed publisher
Li J, Cho Y, Langfald A, Carper A, Lubet R, Grubbs C, et al. Lapatinib, a preventive/therapeutic agent against mammary cancer, suppresses RTK-mediated signaling through multiple signaling pathways. Cancer Prev Res (Phila). 2011;4:1190-7 pubmed publisher
Singhal G, Akhter M, Stern D, Gupta S, Ahuja A, Sharma U, et al. DNA triplex-mediated inhibition of MET leads to cell death and tumor regression in hepatoma. Cancer Gene Ther. 2011;18:520-30 pubmed publisher
Martins A, Ordóñez J, Amaral A, Prins F, Floris G, Debiec Rychter M, et al. IGF1R signaling in Ewing sarcoma is shaped by clathrin-/caveolin-dependent endocytosis. PLoS ONE. 2011;6:e19846 pubmed publisher
Ge Y, Bruno M, Wallace K, Winnik W, Prasad R. Proteome profiling reveals potential toxicity and detoxification pathways following exposure of BEAS-2B cells to engineered nanoparticle titanium dioxide. Proteomics. 2011;11:2406-22 pubmed publisher
Coeffier M, Claeyssens S, Bensifi M, Lecleire S, Boukhettala N, Maurer B, et al. Influence of leucine on protein metabolism, phosphokinase expression, and cell proliferation in human duodenum1,3. Am J Clin Nutr. 2011;93:1255-62 pubmed publisher
Wei Q, Jiang H, Xiao Z, Baker A, Young M, Veenstra T, et al. Sulfiredoxin-Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling. Proc Natl Acad Sci U S A. 2011;108:7004-9 pubmed publisher
Malik S, Orhon I, Morselli E, Criollo A, Shen S, Marino G, et al. BH3 mimetics activate multiple pro-autophagic pathways. Oncogene. 2011;30:3918-29 pubmed publisher
Li A, King J, Moro A, Sugi M, Dawson D, Kaplan J, et al. Overexpression of CXCL5 is associated with poor survival in patients with pancreatic cancer. Am J Pathol. 2011;178:1340-9 pubmed publisher
Chandarlapaty S, Sawai A, Scaltriti M, Rodrik Outmezguine V, Grbovic Huezo O, Serra V, et al. AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity. Cancer Cell. 2011;19:58-71 pubmed publisher
Chen P, Wakimoto H, Conner D, Araki T, Yuan T, Roberts A, et al. Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation. J Clin Invest. 2010;120:4353-65 pubmed publisher
Dunn E, Iida M, Myers R, Campbell D, Hintz K, Armstrong E, et al. Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab. Oncogene. 2011;30:561-74 pubmed publisher
Guo T, Lee S, Ng W, Zhu Y, Gan C, Zhu J, et al. Global molecular dysfunctions in gastric cancer revealed by an integrated analysis of the phosphoproteome and transcriptome. Cell Mol Life Sci. 2011;68:1983-2002 pubmed publisher
Shih Y, Tseng K, Lai H, Lin C, Lee O. Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells. J Bone Miner Res. 2011;26:730-8 pubmed publisher
Tomlinson D, Knowles M. Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer. Am J Pathol. 2010;177:2379-86 pubmed publisher
Vingtdeux V, Chandakkar P, Zhao H, d Abramo C, Davies P, Marambaud P. Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-? peptide degradation. FASEB J. 2011;25:219-31 pubmed publisher
Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villen J, et al. Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc Natl Acad Sci U S A. 2010;107:15299-304 pubmed publisher
Dewaele B, Floris G, Finalet Ferreiro J, Fletcher C, Coindre J, Guillou L, et al. Coactivated platelet-derived growth factor receptor {alpha} and epidermal growth factor receptor are potential therapeutic targets in intimal sarcoma. Cancer Res. 2010;70:7304-14 pubmed publisher
Carretero J, Shimamura T, Rikova K, Jackson A, Wilkerson M, Borgman C, et al. Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors. Cancer Cell. 2010;17:547-59 pubmed publisher
Fritz V, Benfodda Z, Rodier G, Henriquet C, Iborra F, Avances C, et al. Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice. Mol Cancer Ther. 2010;9:1740-54 pubmed publisher
Zhang H, Fagan D, Zeng X, Freeman K, Sachdev D, Yee D. Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation. Oncogene. 2010;29:2517-27 pubmed publisher
Vingtdeux V, Giliberto L, Zhao H, Chandakkar P, Wu Q, Simon J, et al. AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. J Biol Chem. 2010;285:9100-13 pubmed publisher
Roorda B, ter Elst A, Scherpen F, Meeuwsen de Boer T, Kamps W, de Bont E. VEGF-A promotes lymphoma tumour growth by activation of STAT proteins and inhibition of p27(KIP1) via paracrine mechanisms. Eur J Cancer. 2010;46:974-82 pubmed publisher
Cailleteau C, Liagre B, Beneytout J. A proteomic approach to the identification of molecular targets in subsequent apoptosis of HEL cells after diosgenin-induced megakaryocytic differentiation. J Cell Biochem. 2009;107:785-96 pubmed publisher
Smith N, Stoddart L, Devine N, Jenkins L, Milligan G. The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1. J Biol Chem. 2009;284:17527-39 pubmed publisher
Couty J, Lupu Meiri M, Oron Y, Gershengorn M. Kaposi's sarcoma-associated herpesvirus-G protein-coupled receptor-expressing endothelial cells exhibit reduced migration and stimulated chemotaxis by chemokine inverse agonists. J Pharmacol Exp Ther. 2009;329:1142-7 pubmed publisher
product information
SKU :
ARY003B
product name :
Proteome Profiler Human Phospho-Kinase Array Kit
unit size :
1 Kit
Description :
The Proteome Profiler Human Phospho-Kinase Array Kit from R D Systems Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 43 different kinases and 2 related total proteins.
target :
Kinase Assay Kits
category :
Proteome Profiler Antibody Arrays
species :
Human
catalog number base :
ARY003B
extended description :
Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 43 different kinases and 2 related total proteins
2020 Proposedprice USD :
762 USD
product details :
Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 43 different kinases and 2 related total proteins
storage :
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.