product summary
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company name :
R&D Systems
product type :
ELISA/assay
product name :
Proteome Profiler Human Phospho-RTK Array Kit
catalog :
ARY001B
quantity :
1 Kit
price :
625 USD
more info or order :
citations: 274
Reference
Fukuda S, Suda K, Hamada A, Oiki H, Ohara S, Ito M, et al. Potential Utility of a 4th-Generation EGFR-TKI and Exploration of Resistance Mechanisms-An In Vitro Study. Biomedicines. 2024;12: pubmed publisher
Jang H, Min H, Kang Y, Boo H, Kim J, Ahn J, et al. Tobacco-induced hyperglycemia promotes lung cancer progression via cancer cell-macrophage interaction through paracrine IGF2/IR/NPM1-driven PD-L1 expression. Nat Commun. 2024;15:4909 pubmed publisher
Kim J, Koh D, Lee M, Park Y, Hong S, Shin J, et al. Targeting isoforms of RON kinase (MST1R) drives antitumor efficacy. Cell Death Differ. 2023;30:2491-2507 pubmed publisher
Qin H, Chen J, Bouchekioua Bouzaghou K, Meng Y, Griera J, Jiang X, et al. Immunization with a multi-antigen targeted DNA vaccine eliminates chemoresistant pancreatic cancer by disrupting tumor-stromal cell crosstalk. J Transl Med. 2023;21:702 pubmed publisher
Ando C, Ichihara E, Nishi T, Morita A, Hara N, Takada K, et al. Efficacy of gilteritinib in comparison with alectinib for the treatment of ALK-rearranged non-small cell lung cancer. Cancer Sci. 2023;114:4343-4354 pubmed publisher
Shen B, Shi J, Zhu Z, He Z, Liu S, Shi W, et al. EGFR Inhibition Overcomes Resistance to FGFR4 Inhibition and Potentiates FGFR4 Inhibitor Therapy in Hepatocellular Carcinoma. Mol Cancer Ther. 2023;22:1479-1492 pubmed publisher
Guan J, Boren xe4 s M, Xiong J, Lai W, Palmer R, Hallberg B. IGF1R Contributes to Cell Proliferation in ALK-Mutated Neuroblastoma with Preference for Activating the PI3K-AKT Signaling Pathway. Cancers (Basel). 2023;15: pubmed publisher
Meng M, Tan J, Chen H, Shi Z, Kwan H, Su T. Brevilin A exerts anti-colorectal cancer effects and potently inhibits STAT3 signaling invitro. Heliyon. 2023;9:e18488 pubmed publisher
Kuracha M, Govindarajan V, Loggie B, Tobi M, McVicker B. Pictilisib-Induced Resistance Is Mediated through FOXO1-Dependent Activation of Receptor Tyrosine Kinases in Mucinous Colorectal Adenocarcinoma Cells. Int J Mol Sci. 2023;24: pubmed publisher
Lee C, Yu C, Panda S, Chen K, Liang K, Huang W, et al. Epithelial cell adhesion molecule (EpCAM) regulates HGFR signaling to promote colon cancer progression and metastasis. J Transl Med. 2023;21:530 pubmed publisher
Siddique I, Kamble K, Gupta S, Solanki K, Bhola S, Ahsan N, et al. ARL6IP5 Ameliorates α-Synuclein Burden by Inducing Autophagy via Preventing Ubiquitination and Degradation of ATG12. Int J Mol Sci. 2023;24: pubmed publisher
Lee K, Lai T, Lee W, Chen Y, Ho K, Hung W, et al. Sustaining the Activation of EGFR Signal by Inflammatory Cytokine IL17A Prompts Cell Proliferation and EGFR-TKI Resistance in Lung Cancer. Cancers (Basel). 2023;15: pubmed publisher
Chen C, Wang S, Yang J, Huang C. Targeting Ras signaling excitability in cancer cells through combined inhibition of FAK and PI3K. bioRxiv. 2023;: pubmed publisher
Kim S, Carvajal R, Kim M, Yang H. Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma. Cell Rep. 2023;42:112570 pubmed publisher
Pillay V, Shukla L, Herle P, Maciburko S, Bandara N, Reid I, et al. Radiation therapy attenuates lymphatic vessel repair by reducing VEGFR-3 signalling. Front Pharmacol. 2023;14:1152314 pubmed publisher
Paassen I, Williams J, R xed os Arceo C, Ringnalda F, Mercer K, Buhl J, et al. Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities. Oncogene. 2023;42:1661-1671 pubmed publisher
Park J, Oh K, Lee G, Bang G, Park J, Kim H, et al. Defining regorafenib as a senomorphic drug: therapeutic potential in the age-related lung disease emphysema. Exp Mol Med. 2023;55:794-805 pubmed publisher
Tiedt R, King F, Stamm C, Niederst M, Delach S, Zumstein Mecker S, et al. Integrated CRISPR screening and drug profiling identifies combination opportunities for EGFR, ALK, and BRAF/MEK inhibitors. Cell Rep. 2023;42:112297 pubmed publisher
Lin W, Niu R, Park S, Zou Y, Kim S, Xia X, et al. IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis. Nat Commun. 2023;14:1578 pubmed publisher
Chang C, Lin B, Chen C, Nguyen N, Hsieh T, Su J, et al. Stellettin B Induces Cell Death in Bladder Cancer Via Activating the Autophagy/DAPK2/Apoptosis Signaling Cascade. Mar Drugs. 2023;21: pubmed publisher
Nakashima F, Gim xe9 nez Bastida J, Luis P, Presley S, Boer R, Chiusa M, et al. The 5-lipoxygenase/cyclooxygenase-2 cross-over metabolite, hemiketal E2, enhances VEGFR2 activation and promotes angiogenesis. J Biol Chem. 2023;299:103050 pubmed publisher
Shackleford T, Hariharan S, Vaseva A, Alagoa K, Espinoza M, Bid H, et al. Redundant Signaling as the Predominant Mechanism for Resistance to Antibodies Targeting the Type-I Insulin-Like Growth Factor Receptor in Cells Derived from Childhood Sarcoma. Mol Cancer Ther. 2023;22:539-550 pubmed publisher
Lin Z, Chung C, Liu Y, Chang C, Liu H, Liang Y, et al. EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression. elife. 2023;12: pubmed publisher
Park S, Yoon S, Choi S, Jung J, Park J, Park Y, et al. Particulate matter promotes cancer metastasis through increased HBEGF expression in macrophages. Exp Mol Med. 2022;54:1901-1912 pubmed publisher
Marques C, Po xe7 as J, Gomes C, Faria Ramos I, Reis C, Viv xe8 s R, et al. Glycosyltransferases EXTL2 and EXTL3 cellular balance dictates heparan sulfate biosynthesis and shapes gastric cancer cell motility and invasion. J Biol Chem. 2022;298:102546 pubmed publisher
Krchniakova M, Paukovcekova S, Chlapek P, Neradil J, Skoda J, Veselska R. Thiosemicarbazones and selected tyrosine kinase inhibitors synergize in pediatric solid tumors: NDRG1 upregulation and impaired prosurvival signaling in neuroblastoma cells. Front Pharmacol. 2022;13:976955 pubmed publisher
Kobayashi Y, Oxnard G, Cohen E, Mahadevan N, Alessi J, Hung Y, et al. Genomic and biological study of fusion genes as resistance mechanisms to EGFR inhibitors. Nat Commun. 2022;13:5614 pubmed publisher
Wang Y, Yu L, Hu Z, Fang Y, Shen Y, Song M, et al. Regulation of CCL2 by EZH2 affects tumor-associated macrophages polarization and infiltration in breast cancer. Cell Death Dis. 2022;13:748 pubmed publisher
Dieter S, Lovecchio D, Pataskar A, Zowada M, K xf6 rner P, Khalizieva A, et al. Suppression of heparan sulfation re-sensitizes YAP1-driven melanoma to MAPK pathway inhibitors. Oncogene. 2022;41:3953-3968 pubmed publisher
Ryan M, Coker O, Sorokin A, Fella K, Barnes H, Wong E, et al. KRASG12C-independent feedback activation of wild-type RAS constrains KRASG12C inhibitor efficacy. Cell Rep. 2022;39:110993 pubmed publisher
He X, Hikiba Y, Suzuki Y, Nakamori Y, Kanemaru Y, Sugimori M, et al. EGFR inhibition reverses resistance to lenvatinib in hepatocellular carcinoma cells. Sci Rep. 2022;12:8007 pubmed publisher
Gaiteiro C, Soares J, Relvas Santos M, Peixoto A, Ferreira D, Paulo P, et al. Glycoproteogenomics characterizes the CD44 splicing code associated with bladder cancer invasion. Theranostics. 2022;12:3150-3177 pubmed publisher
Weickhardt A, Lau D, Hodgson Garms M, Lavis A, Jenkins L, Vukelic N, et al. Dual targeting of FGFR3 and ERBB3 enhances the efficacy of FGFR inhibitors in FGFR3 fusion-driven bladder cancer. BMC Cancer. 2022;22:478 pubmed publisher
Song S, Yu Z, You Y, Liu C, Xie X, Lv H, et al. EGFR/MET promotes hepatocellular carcinoma metastasis by stabilizing tumor cells and resisting to RTKs inhibitors in circulating tumor microemboli. Cell Death Dis. 2022;13:351 pubmed publisher
Vannas C, Andersson L, Dolatabadi S, Ranji P, Lindén M, Jonasson E, et al. Different HSP90 Inhibitors Exert Divergent Effect on Myxoid Liposarcoma In Vitro and In Vivo. Biomedicines. 2022;10: pubmed publisher
Ueda T, Ito T, Inden M, Kurita H, Yamamoto A, Hozumi I. Stem Cells From Human Exfoliated Deciduous Teeth-Conditioned Medium (SHED-CM) is a Promising Treatment for Amyotrophic Lateral Sclerosis. Front Pharmacol. 2022;13:805379 pubmed publisher
Zhi J, Yi J, Hou X, Wang W, Yang W, Hu L, et al. Targeting SHP2 sensitizes differentiated thyroid carcinoma to the MEK inhibitor. Am J Cancer Res. 2022;12:247-264 pubmed
Scherschinski L, Prem M, Kremenetskaia I, Tinhofer I, Vajkoczy P, Karbe A, et al. Regulation of the Receptor Tyrosine Kinase AXL in Response to Therapy and Its Role in Therapy Resistance in Glioblastoma. Int J Mol Sci. 2022;23: pubmed publisher
Smith R, Odintsov I, Liu Z, Lui A, Hayashi T, Vojnic M, et al. Novel patient-derived models of desmoplastic small round cell tumor confirm a targetable dependency on ERBB signaling. Dis Model Mech. 2022;15: pubmed publisher
Patel H, Mishra R, Yacoub N, Alanazi S, Kilroy M, Garrett J. IGF1R/IR Mediates Resistance to BRAF and MEK Inhibitors in BRAF-Mutant Melanoma. Cancers (Basel). 2021;13: pubmed publisher
Mannsåker T, Hoang T, Aasen S, Bjørnstad O, Parajuli H, Sundstrøm T, et al. Cabozantinib Is Effective in Melanoma Brain Metastasis Cell Lines and Affects Key Signaling Pathways. Int J Mol Sci. 2021;22: pubmed publisher
Choi J, Kim T, Jeong B, Jeon H, Jeon S, Kang M, et al. ISL1 promotes enzalutamide resistance in castration-resistant prostate cancer (CRPC) through epithelial to mesenchymal transition (EMT). Sci Rep. 2021;11:21984 pubmed publisher
Sato T, Nakanishi H, Akao K, Okuda M, Mukai S, Kiyono T, et al. Three newly established immortalized mesothelial cell lines exhibit morphological phenotypes corresponding to malignant mesothelioma epithelioid, intermediate, and sarcomatoid types, respectively. Cancer Cell Int. 2021;21:546 pubmed publisher
Korec D, Louke D, Breitbach J, Geisler J, Husbands B, Fenger J. Characterization of receptor tyrosine kinase activation and biological activity of toceranib phosphate in canine urothelial carcinoma cell lines. BMC Vet Res. 2021;17:320 pubmed publisher
Chen P, Lin C, Yang S, Chang Y. Oral submucous fibrosis stimulates invasion and epithelial-mesenchymal transition in oral squamous cell carcinoma by activating MMP-2 and IGF-IR. J Cell Mol Med. 2021;25:9814-9825 pubmed publisher
Wang Y, Liu I, Chen K, Wu H. NOTCH1 signaling promotes protein stability of HER3 through the AKT pathway in squamous cell carcinoma of head and neck. Oncogenesis. 2021;10:59 pubmed publisher
Oh S, Noh K, Song K, Kim T. Interaction between SCP3 and JAB1 Confers Cancer Therapeutic Resistance and Stem-like Properties through EGF Expression. Int J Mol Sci. 2021;22: pubmed publisher
Nishii K, Ohashi K, Watanabe H, Makimoto G, Nakasuka T, Higo H, et al. Triple therapy with osimertinib, bevacizumab and cetuximab in EGFR-mutant lung cancer with HIF-1α/TGF-α expression. Oncol Lett. 2021;22:639 pubmed publisher
Ebner Peking P, Krisch L, Wolf M, Hochmann S, Höög A, Vári B, et al. Self-assembly of differentiated progenitor cells facilitates spheroid human skin organoid formation and planar skin regeneration. Theranostics. 2021;11:8430-8447 pubmed publisher
Mahdal M, Neradil J, Mudry P, Paukovcekova S, Staniczkova Zambo I, Urban J, et al. New Target for Precision Medicine Treatment of Giant-Cell Tumor of Bone: Sunitinib Is Effective in the Treatment of Neoplastic Stromal Cells with Activated PDGFRβ Signaling. Cancers (Basel). 2021;13: pubmed publisher
Harttrampf A, da Costa M, Renoult A, Daudigeos Dubus E, Geoerger B. Histone deacetylase inhibitor panobinostat induces antitumor activity in epithelioid sarcoma and rhabdoid tumor by growth factor receptor modulation. BMC Cancer. 2021;21:833 pubmed publisher
Lee S, Choi K, Bang G, Park S, Kim E, Choi J, et al. Identification of Nucleolin as a Novel AEG-1-Interacting Protein in Breast Cancer via Interactome Profiling. Cancers (Basel). 2021;13: pubmed publisher
Lee J, Chen R, Mohanakumar T, Bremner R, Mittal S, Fleming T. Identification of Phospho-Tyrosine Targets as a Strategy for the Treatment of Esophageal Adenocarcinoma Cells. Onco Targets Ther. 2021;14:3813-3820 pubmed publisher
Hafner S, Schmiech M, Lang S. The Cardenolide Glycoside Acovenoside A Interferes with Epidermal Growth Factor Receptor Trafficking in Non-Small Cell Lung Cancer Cells. Front Pharmacol. 2021;12:611657 pubmed publisher
Lee H, Wang Y, Yang W, Xia W, Wei Y, Chan L, et al. Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation. Nat Commun. 2021;12:2788 pubmed publisher
Lailler C, Lamuraglia M, Racine F, Louandre C, Godin C, Chauffert B, et al. DNA damage response- and JAK-dependent regulation of PD-L1 expression in head and neck squamous cell carcinoma (HNSCC) cells exposed to 5-fluorouracil (5-FU). Transl Oncol. 2021;14:101110 pubmed publisher
Billing O, Holmgren Y, Nosek D, Hedman H, Hemmingsson O. LRIG1 is a conserved EGFR regulator involved in melanoma development, survival and treatment resistance. Oncogene. 2021;40:3707-3718 pubmed publisher
Tsui J, Qi S, Perrino S, Leibovitch M, Brodt P. Identification of a Resistance Mechanism to IGF-IR Targeting in Human Triple Negative MDA-MB-231 Breast Cancer Cells. Biomolecules. 2021;11: pubmed publisher
Morishita A, Nomura K, Tani J, Fujita K, Iwama H, Takuma K, et al. Galectin‑9 suppresses the tumor growth of colon cancer in vitro and in vivo. Oncol Rep. 2021;45: pubmed publisher
Singh N, Frey N, Engels B, Barrett D, Shestova O, Ravikumar P, et al. Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells. Nat Med. 2021;27:842-850 pubmed publisher
Zhang P, Liu X, Guo P, Li X, He Z, Li Z, et al. Effect of cyclic mechanical loading on immunoinflammatory microenvironment in biofabricating hydroxyapatite scaffold for bone regeneration. Bioact Mater. 2021;6:3097-3108 pubmed publisher
Royer Pokora B, Busch M, Tenbusch S, Schmidt M, Beier M, Woods A, et al. Comprehensive Biology and Genetics Compendium of Wilms Tumor Cell Lines with Different WT1 Mutations. Cancers (Basel). 2020;13: pubmed publisher
H xfc ser L, Kokkaleniou M, Granados K, Dworacek J, Federico A, Vierthaler M, et al. HER3-Receptor-Mediated STAT3 Activation Plays a Central Role in Adaptive Resistance toward Vemurafenib in Melanoma. Cancers (Basel). 2020;12: pubmed publisher
Fuentes Baile M, Ventero M, Encinar J, Garcia Morales P, Poveda Deltell M, Pérez Valenciano E, et al. Differential Effects of IGF-1R Small Molecule Tyrosine Kinase Inhibitors BMS-754807 and OSI-906 on Human Cancer Cell Lines. Cancers (Basel). 2020;12: pubmed publisher
Pietrobono S, Anichini G, Sala C, Manetti F, Almada L, Pepe S, et al. ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL. Nat Commun. 2020;11:5865 pubmed publisher
Areeb Z, Stuart S, West A, Gomez J, Nguyen H, Paradiso L, et al. Reduced EGFR and increased miR-221 is associated with increased resistance to temozolomide and radiotherapy in glioblastoma. Sci Rep. 2020;10:17768 pubmed publisher
Zhou B, Liu J, Zeng L, Zhu S, Wang H, Billiar T, et al. Extracellular SQSTM1 mediates bacterial septic death in mice through insulin receptor signalling. Nat Microbiol. 2020;5:1576-1587 pubmed publisher
Hollosi P, Váncza L, Karaszi K, Dobos K, Péterfia B, Tátrai E, et al. Syndecan-1 Promotes Hepatocyte-Like Differentiation of Hepatoma Cells Targeting Ets-1 and AP-1. Biomolecules. 2020;10: pubmed publisher
Lee E, Lee E, Yoon J, Hong A, Nam S, Ko J. Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042. Mar Drugs. 2020;18: pubmed publisher
Roy S, Laroche Clary A, Verbeke S, Derieppe M, Italiano A. MDM2 Antagonists Induce a Paradoxical Activation of Erk1/2 through a P53-Dependent Mechanism in Dedifferentiated Liposarcomas: Implications for Combinatorial Strategies. Cancers (Basel). 2020;12: pubmed publisher
Kim S, Cho H, Hong S, Oh S, Lee H, Cho E, et al. LC3B upregulation by NANOG promotes immune resistance and stem-like property through hyperactivation of EGFR signaling in immune-refractory tumor cells. Autophagy. 2020;:1-20 pubmed publisher
Cheng C, Yang S, Lai C, Wang C, Chang C, Lin C, et al. CXCL14 Maintains hESC Self-Renewal through Binding to IGF-1R and Activation of the IGF-1R Pathway. Cells. 2020;9: pubmed publisher
Liao W, Liao C, Tseng T, Ho Y, Chen Y, Lin K, et al. Chondroitin sulfate synthase 1 enhances proliferation of glioblastoma by modulating PDGFRA stability. Oncogenesis. 2020;9:9 pubmed publisher
Lee P, Chen S, Kuo T, Lin T, Lin M, Huang J, et al. C1GALT1 is associated with poor survival and promotes soluble Ephrin A1-mediated cell migration through activation of EPHA2 in gastric cancer. Oncogene. 2020;39:2724-2740 pubmed publisher
Lee J, Lee J, Sim W, Kim J. Differential Dependency of Human Pancreatic Cancer Cells on Targeting PTEN via PLK 1 Expression. Cancers (Basel). 2020;12: pubmed publisher
Yanagitani N, Uchibori K, Koike S, Tsukahara M, Kitazono S, Yoshizawa T, et al. Drug resistance mechanisms in Japanese anaplastic lymphoma kinase-positive non-small cell lung cancer and the clinical responses based on the resistant mechanisms. Cancer Sci. 2020;111:932-939 pubmed publisher
Manabe T, Yasuda H, Terai H, Kagiwada H, Hamamoto J, Ebisudani T, et al. IGF2 Autocrine-Mediated IGF1R Activation Is a Clinically Relevant Mechanism of Osimertinib Resistance in Lung Cancer. Mol Cancer Res. 2020;18:549-559 pubmed publisher
Skoda J, Neradil J, Staniczkova Zambo I, Nunukova A, Macsek P, Borankova K, et al. Serial Xenotransplantation in NSG Mice Promotes a Hybrid Epithelial/Mesenchymal Gene Expression Signature and Stemness in Rhabdomyosarcoma Cells. Cancers (Basel). 2020;12: pubmed publisher
Kim J, Novak D, Sachpekidis C, Utikal J, Larribere L. STAT3 Relays a Differential Response to Melanoma-Associated NRAS Mutations. Cancers (Basel). 2020;12: pubmed publisher
Kuo M, Long Y, Tsai W, Li Y, Chen H, Feun L, et al. Collaboration Between RSK-EphA2 and Gas6-Axl RTK Signaling in Arginine Starvation Response That Confers Resistance to EGFR Inhibitors. Transl Oncol. 2020;13:355-364 pubmed publisher
MacFarland S, Naraparaju K, Iyer R, Guan P, Kolla V, Hu Y, et al. Mechanisms of Entrectinib Resistance in a Neuroblastoma Xenograft Model. Mol Cancer Ther. 2020;19:920-926 pubmed publisher
de Laat M, Spence R, Sillence M, Pollitt C. An investigation of the equine epidermal growth factor system during hyperinsulinemic laminitis. PLoS ONE. 2019;14:e0225843 pubmed publisher
Meng F, Wu L, Dong L, Mitchell A, James Block C, Liu J, et al. EGFL9 promotes breast cancer metastasis by inducing cMET activation and metabolic reprogramming. Nat Commun. 2019;10:5033 pubmed publisher
Zhang Q, Liu J, Liu J, Qi C, Yan L, Chen Y, et al. Activation and function of receptor tyrosine kinases in human clear cell renal cell carcinomas. BMC Cancer. 2019;19:1044 pubmed publisher
Nakai S, Yamada S, Outani H, Nakai T, Yasuda N, Mae H, et al. Establishment of a novel human CIC-DUX4 sarcoma cell line, Kitra-SRS, with autocrine IGF-1R activation and metastatic potential to the lungs. Sci Rep. 2019;9:15812 pubmed publisher
Sulahian R, Kwon J, Walsh K, Pailler E, Bosse T, Thaker M, et al. Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers. Cell Rep. 2019;29:118-134.e8 pubmed publisher
Sato T, Yoo S, Kong R, Sinha A, Chandramani Shivalingappa P, Patel A, et al. Epigenomic Profiling Discovers Trans-lineage SOX2 Partnerships Driving Tumor Heterogeneity in Lung Squamous Cell Carcinoma. Cancer Res. 2019;79:6084-6100 pubmed publisher
Lee N, Jang W, Seo J, Lee S, Jeong C. 2-Deoxy-d-Glucose-Induced Metabolic Alteration in Human Oral Squamous SCC15 Cells: Involvement of N-Glycosylation of Axl and Met. Metabolites. 2019;9: pubmed publisher
Njah K, Chakraborty S, Qiu B, Arumugam S, Raju A, Pobbati A, et al. A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis. Cell Rep. 2019;28:949-965.e7 pubmed publisher
Chen Y, Lv H, Shen N, Wang X, Tang S, Xiong B, et al. EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells. Acta Pharmacol Sin. 2019;: pubmed publisher
Horvath Z, Reszegi A, Szilak L, Dankó T, Kovalszky I, Baghy K. Tumor-specific inhibitory action of decorin on different hepatoma cell lines. Cell Signal. 2019;62:109354 pubmed publisher
Matsui T, Chiyo T, Kobara H, Fujihara S, Fujita K, Namima D, et al. Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo. Int J Mol Sci. 2019;20: pubmed publisher
Park S, Jo M, Kim B, Jeong Y, Na Y, Kim J, et al. Sonic hedgehog pathway activation is associated with cetuximab resistance and EPHB3 receptor induction in colorectal cancer. Theranostics. 2019;9:2235-2251 pubmed publisher
Xiao Z, Sperl B, Gartner S, Nedelko T, Stacher Priehse E, Ullrich A, et al. Lung cancer stem cells and their aggressive progeny, controlled by EGFR/MIG6 inverse expression, dictate a novel NSCLC treatment approach. Oncotarget. 2019;10:2546-2560 pubmed publisher
Kurimchak A, Shelton C, Herrera Montávez C, Duncan K, Chernoff J, Duncan J. Intrinsic Resistance to MEK Inhibition through BET Protein-Mediated Kinome Reprogramming in NF1-Deficient Ovarian Cancer. Mol Cancer Res. 2019;: pubmed publisher
Linkous A, Balamatsias D, Snuderl M, Edwards L, Miyaguchi K, MILNER T, et al. Modeling Patient-Derived Glioblastoma with Cerebral Organoids. Cell Rep. 2019;26:3203-3211.e5 pubmed publisher
Graves Deal R, Bogatcheva G, Rehman S, Lu Y, Higginbotham J, Singh B. Broad-spectrum receptor tyrosine kinase inhibitors overcome de novo and acquired modes of resistance to EGFR-targeted therapies in colorectal cancer. Oncotarget. 2019;10:1320-1333 pubmed publisher
Rao S, Du G, Hafner M, Subramanian K, Sorger P, Gray N. A multitargeted probe-based strategy to identify signaling vulnerabilities in cancers. J Biol Chem. 2019;294:8664-8673 pubmed publisher
He L, Gao L, Shay C, Lang L, Lv F, Teng Y. Histone deacetylase inhibitors suppress aggressiveness of head and neck squamous cell carcinoma via histone acetylation-independent blockade of the EGFR-Arf1 axis. J Exp Clin Cancer Res. 2019;38:84 pubmed publisher
Fukuda K, Takeuchi S, Arai S, Katayama R, Nanjo S, Tanimoto A, et al. Epithelial-to-Mesenchymal Transition Is a Mechanism of ALK Inhibitor Resistance in Lung Cancer Independent of ALK Mutation Status. Cancer Res. 2019;79:1658-1670 pubmed publisher
van der Waals L, Laoukili J, Jongen J, Raats D, Borel Rinkes I, Kranenburg O. Differential anti-tumour effects of MTH1 inhibitors in patient-derived 3D colorectal cancer cultures. Sci Rep. 2019;9:819 pubmed publisher
Ahmed T, Adamopoulos C, Karoulia Z, Wu X, Sachidanandam R, Aaronson S, et al. SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-Dependent Tumors. Cell Rep. 2019;26:65-78.e5 pubmed publisher
Wang X, Ai J, Liu H, Peng X, Chen H, Chen Y, et al. The Secretome Engages STAT3 to Favor a Cytokine-rich Microenvironment in Mediating Acquired Resistance to FGFR Inhibitors. Mol Cancer Ther. 2019;18:667-679 pubmed publisher
Choi S, Kim A, Nam J, Kim J, Kim J, Seo H, et al. Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization. Nat Commun. 2018;9:5108 pubmed publisher
Sin S, Li Y, Liu M, Ma S, Guan X. TROP-2 exhibits tumor suppressive functions in cervical cancer by dual inhibition of IGF-1R and ALK signaling. Gynecol Oncol. 2019;152:185-193 pubmed publisher
Jang W, Jung S, Vo T, Jeong C. Anticancer activity of paroxetine in human colon cancer cells: Involvement of MET and ERBB3. J Cell Mol Med. 2019;23:1106-1115 pubmed publisher
Painuly U, Ramakrishnan V, Kimlinger T, Wellik L, Haug J, Gonsalves W, et al. Aurora kinase and FGFR3 inhibition results in significant apoptosis in molecular subgroups of multiple myeloma. Oncotarget. 2018;9:34582-34594 pubmed publisher
Heliste J, Jokilammi A, Paatero I, Chakroborty D, Stark C, Savunen T, et al. Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target. BMC Cardiovasc Disord. 2018;18:196 pubmed publisher
Boichuk S, Galembikova A, Dunaev P, Micheeva E, Valeeva E, Novikova M, et al. Targeting of FGF-Signaling Re-Sensitizes Gastrointestinal Stromal Tumors (GIST) to Imatinib In Vitro and In Vivo. Molecules. 2018;23: pubmed publisher
Virzì A, Gentile A, Benvenuti S, Comoglio P. Reviving oncogenic addiction to MET bypassed by BRAF (G469A) mutation. Proc Natl Acad Sci U S A. 2018;115:10058-10063 pubmed publisher
Yángüez E, Hunziker A, Dobay M, Yildiz S, Schading S, Elshina E, et al. Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target. Nat Commun. 2018;9:3679 pubmed publisher
Sun S, Zhang Y, Zheng J, Duan B, Cui J, Chen Y, et al. HDAC6 inhibitor TST strengthens the antiproliferative effects of PI3K/mTOR inhibitor BEZ235 in breast cancer cells via suppressing RTK activation. Cell Death Dis. 2018;9:929 pubmed publisher
Srámek M, Neradil J, Macigova P, Mudry P, Polaskova K, Slaby O, et al. Effects of Sunitinib and Other Kinase Inhibitors on Cells Harboring a PDGFRB Mutation Associated with Infantile Myofibromatosis. Int J Mol Sci. 2018;19: pubmed publisher
Patwardhan P, Musi E, Schwartz G. Preclinical Evaluation of Nintedanib, a Triple Angiokinase Inhibitor, in Soft-tissue Sarcoma: Potential Therapeutic Implication for Synovial Sarcoma. Mol Cancer Ther. 2018;17:2329-2340 pubmed publisher
Chen S, Kuo T, Liao Y, Lin M, Tien Y, Huang M. Silencing of MUC20 suppresses the malignant character of pancreatic ductal adenocarcinoma cells through inhibition of the HGF/MET pathway. Oncogene. 2018;37:6041-6053 pubmed publisher
Fang Z, Jung K, Yan H, Kim S, Rumman M, Park J, et al. Melatonin Synergizes with Sorafenib to Suppress Pancreatic Cancer via Melatonin Receptor and PDGFR-β/STAT3 Pathway. Cell Physiol Biochem. 2018;47:1751-1768 pubmed publisher
Greenall S, Donoghue J, Johns T, Adams T. Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3. Transl Oncol. 2018;11:971-978 pubmed publisher
Donson A, Amani V, Warner E, Griesinger A, Witt D, Levy J, et al. Identification of FDA-Approved Oncology Drugs with Selective Potency in High-Risk Childhood Ependymoma. Mol Cancer Ther. 2018;17:1984-1994 pubmed publisher
Fan P, Narzisi G, Jayaprakash A, Venturini E, Robine N, Smibert P, et al. YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics. Proc Natl Acad Sci U S A. 2018;115:E6030-E6038 pubmed publisher
Daneshmanesh A, Hojjat Farsangi M, Ghaderi A, Moshfegh A, Hansson L, Schultz J, et al. A receptor tyrosine kinase ROR1 inhibitor (KAN0439834) induced significant apoptosis of pancreatic cells which was enhanced by erlotinib and ibrutinib. PLoS ONE. 2018;13:e0198038 pubmed publisher
Leonard B, Brand T, O Keefe R, Lee E, Zeng Y, Kemmer J, et al. BET Inhibition Overcomes Receptor Tyrosine Kinase-Mediated Cetuximab Resistance in HNSCC. Cancer Res. 2018;78:4331-4343 pubmed publisher
Haas B, Klinger V, Keksel C, Bonigut V, Kiefer D, Caspers J, et al. Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs. Cancer Cell Int. 2018;18:69 pubmed publisher
Jung S, Lim H, Liu L, Chang J, Lim Y, Rha K, et al. LAMB3 mediates metastatic tumor behavior in papillary thyroid cancer by regulating c-MET/Akt signals. Sci Rep. 2018;8:2718 pubmed publisher
Mao F, Holmlund C, Faraz M, Wang W, Bergenheim T, Kvarnbrink S, et al. Lrig1 is a haploinsufficient tumor suppressor gene in malignant glioma. Oncogenesis. 2018;7:13 pubmed publisher
Ninomiya K, Ohashi K, Makimoto G, Tomida S, Higo H, Kayatani H, et al. MET or NRAS amplification is an acquired resistance mechanism to the third-generation EGFR inhibitor naquotinib. Sci Rep. 2018;8:1955 pubmed publisher
Kotani H, Adachi Y, Kitai H, Tomida S, Bando H, Faber A, et al. Distinct dependencies on receptor tyrosine kinases in the regulation of MAPK signaling between BRAF V600E and non-V600E mutant lung cancers. Oncogene. 2018;37:1775-1787 pubmed publisher
Herr R, Halbach S, Heizmann M, Busch H, Boerries M, Brummer T. BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines. Oncogene. 2018;37:1576-1593 pubmed publisher
Wang D, Liu C, Wang J, Jia Y, Hu X, Jiang H, et al. Protein C receptor stimulates multiple signaling pathways in breast cancer cells. J Biol Chem. 2018;293:1413-1424 pubmed publisher
Noh K, Mangala L, Han H, Zhang N, Pradeep S, Wu S, et al. Differential Effects of EGFL6 on Tumor versus Wound Angiogenesis. Cell Rep. 2017;21:2785-2795 pubmed publisher
Chauvin C, Leruste A, Tauziède Espariat A, Andrianteranagna M, Surdez D, Lescure A, et al. High-Throughput Drug Screening Identifies Pazopanib and Clofilium Tosylate as Promising Treatments for Malignant Rhabdoid Tumors. Cell Rep. 2017;21:1737-1745 pubmed publisher
Pearson H, Iida M, Orbuch R, McDaniel N, Nickel K, Kimple R, et al. Overcoming Resistance to Cetuximab with Honokiol, A Small-Molecule Polyphenol. Mol Cancer Ther. 2018;17:204-214 pubmed publisher
Oura K, Tadokoro T, Fujihara S, Morishita A, Chiyo T, Samukawa E, et al. Telmisartan inhibits hepatocellular carcinoma cell proliferation in vitro by inducing cell cycle arrest. Oncol Rep. 2017;38:2825-2835 pubmed publisher
Adelaiye Ogala R, Budka J, Damayanti N, Arrington J, Ferris M, Hsu C, et al. EZH2 Modifies Sunitinib Resistance in Renal Cell Carcinoma by Kinome Reprogramming. Cancer Res. 2017;77:6651-6666 pubmed publisher
Owusu B, Thomas S, Venukadasula P, Han Z, Janetka J, Galemmo R, et al. Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation. Oncotarget. 2017;8:63014-63025 pubmed publisher
Lyons A, Coleman M, Riis S, Favre C, O Flanagan C, Zhdanov A, et al. Insulin-like growth factor 1 signaling is essential for mitochondrial biogenesis and mitophagy in cancer cells. J Biol Chem. 2017;292:16983-16998 pubmed publisher
Klameth L, Rath B, Hamilton G. In vitro Cytotoxic Activities of the Oral Platinum(IV) Prodrug Oxoplatin and HSP90 Inhibitor Ganetespib against a Panel of Gastric Cancer Cell Lines. J Cancer. 2017;8:1733-1743 pubmed publisher
Chen W, Kuang Y, Qiu H, Cao Z, Tu Y, Sheng Q, et al. Dual Targeting of Insulin Receptor and KIT in Imatinib-Resistant Gastrointestinal Stromal Tumors. Cancer Res. 2017;77:5107-5117 pubmed publisher
Hsu H, Lai M, Lee J, Yen M, Weng T, Chen W, et al. Mucin 2 silencing promotes colon cancer metastasis through interleukin-6 signaling. Sci Rep. 2017;7:5823 pubmed publisher
Aarnio Peterson M, Zhao P, Yu S, Christian C, Flanagan Steet H, Wells L, et al. Altered Met receptor phosphorylation and LRP1-mediated uptake in cells lacking carbohydrate-dependent lysosomal targeting. J Biol Chem. 2017;292:15094-15104 pubmed publisher
Mansouri R, Jouan Y, Hay E, Blin Wakkach C, Frain M, Ostertag A, et al. Osteoblastic heparan sulfate glycosaminoglycans control bone remodeling by regulating Wnt signaling and the crosstalk between bone surface and marrow cells. Cell Death Dis. 2017;8:e2902 pubmed publisher
Miyata K, Takemoto A, Okumura S, Nishio M, Fujita N. Podoplanin enhances lung cancer cell growth in vivo by inducing platelet aggregation. Sci Rep. 2017;7:4059 pubmed publisher
Malchers F, Ercanoglu M, Schütte D, Castiglione R, Tischler V, Michels S, et al. Mechanisms of Primary Drug Resistance in FGFR1-Amplified Lung Cancer. Clin Cancer Res. 2017;23:5527-5536 pubmed publisher
Lampada A, O Prey J, Szabadkai G, Ryan K, Hochhauser D, Salomoni P. mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism. Cell Death Differ. 2017;24:1045-1062 pubmed publisher
Jin H, Park J, Kim H, Chang Y, Hong Y, Park I, et al. Piperlongumine downregulates the expression of HER family in breast cancer cells. Biochem Biophys Res Commun. 2017;486:1083-1089 pubmed publisher
Xu L, Chen Y, Dutra Clarke M, Mayakonda A, Hazawa M, Savinoff S, et al. BCL6 promotes glioma and serves as a therapeutic target. Proc Natl Acad Sci U S A. 2017;114:3981-3986 pubmed publisher
Yadav S, Li J, Stockert J, Herzog B, O CONNOR J, Garzon Manco L, et al. Induction of Neuroendocrine Differentiation in Prostate Cancer Cells by Dovitinib (TKI-258) and its Therapeutic Implications. Transl Oncol. 2017;10:357-366 pubmed publisher
Li C, Singh B, Graves Deal R, Ma H, Starchenko A, Fry W, et al. Three-dimensional culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer. Proc Natl Acad Sci U S A. 2017;114:E2852-E2861 pubmed publisher
Buchanan P, Boylan K, Walcheck B, Heinze R, Geller M, Argenta P, et al. Ectodomain shedding of the cell adhesion molecule Nectin-4 in ovarian cancer is mediated by ADAM10 and ADAM17. J Biol Chem. 2017;292:6339-6351 pubmed publisher
Nukaga S, Yasuda H, Tsuchihara K, Hamamoto J, Masuzawa K, Kawada I, et al. Amplification of EGFR Wild-Type Alleles in Non-Small Cell Lung Cancer Cells Confers Acquired Resistance to Mutation-Selective EGFR Tyrosine Kinase Inhibitors. Cancer Res. 2017;77:2078-2089 pubmed publisher
Saintas E, Abrahams L, Ahmad G, Ajakaiye A, AlHumaidi A, Ashmore Harris C, et al. Acquired resistance to oxaliplatin is not directly associated with increased resistance to DNA damage in SK-N-ASrOXALI4000, a newly established oxaliplatin-resistant sub-line of the neuroblastoma cell line SK-N-AS. PLoS ONE. 2017;12:e0172140 pubmed publisher
Nanjo S, Arai S, Wang W, Takeuchi S, Yamada T, Hata A, et al. MET Copy Number Gain Is Associated with Gefitinib Resistance in Leptomeningeal Carcinomatosis of EGFR-mutant Lung Cancer. Mol Cancer Ther. 2017;16:506-515 pubmed publisher
Neill T, Buraschi S, Goyal A, Sharpe C, Natkanski E, Schaefer L, et al. EphA2 is a functional receptor for the growth factor progranulin. J Cell Biol. 2016;215:687-703 pubmed
Ciaglia E, Abate M, Laezza C, Pisanti S, Vitale M, Seneca V, et al. Antiglioma effects of N6-isopentenyladenosine, an endogenous isoprenoid end product, through the downregulation of epidermal growth factor receptor. Int J Cancer. 2017;140:959-972 pubmed publisher
Xu Y, Wang K, Yu Q. FRMD6 inhibits human glioblastoma growth and progression by negatively regulating activity of receptor tyrosine kinases. Oncotarget. 2016;7:70080-70091 pubmed publisher
Cassinelli G, Favini E, Dal Bo L, Tortoreto M, De Maglie M, Dagrada G, et al. Antitumor efficacy of the heparan sulfate mimic roneparstat (SST0001) against sarcoma models involves multi-target inhibition of receptor tyrosine kinases. Oncotarget. 2016;7:47848-47863 pubmed publisher
Aghajanian H, Cho Y, Manderfield L, Herling M, Gupta M, Ho V, et al. Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor. Nat Commun. 2016;7:12038 pubmed publisher
Brandt A, Löhers K, Beier M, Leube B, de Torres C, Mora J, et al. Establishment of a Conditionally Immortalized Wilms Tumor Cell Line with a Homozygous WT1 Deletion within a Heterozygous 11p13 Deletion and UPD Limited to 11p15. PLoS ONE. 2016;11:e0155561 pubmed publisher
Huang M, Liu T, Ma P, Mitteer R, Zhang Z, Kim H, et al. c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma. J Clin Invest. 2016;126:1801-14 pubmed publisher
Yoshida T, Song L, Bai Y, Kinose F, Li J, Ohaegbulam K, et al. ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer. PLoS ONE. 2016;11:e0147344 pubmed publisher
Yamaguchi T, Lu C, Ida L, Yanagisawa K, Usukura J, Cheng J, et al. ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1. Nat Commun. 2016;7:10060 pubmed publisher
Tani T, Yasuda H, Hamamoto J, Kuroda A, Arai D, Ishioka K, et al. Activation of EGFR Bypass Signaling by TGFα Overexpression Induces Acquired Resistance to Alectinib in ALK-Translocated Lung Cancer Cells. Mol Cancer Ther. 2016;15:162-71 pubmed publisher
Szymańska E, Skowronek A, Miaczynska M. Impaired dynamin 2 function leads to increased AP-1 transcriptional activity through the JNK/c-Jun pathway. Cell Signal. 2016;28:160-71 pubmed publisher
Heim E, Marston J, Federman R, Edwards A, Karabadzhak A, Petti L, et al. Biologically active LIL proteins built with minimal chemical diversity. Proc Natl Acad Sci U S A. 2015;112:E4717-25 pubmed publisher
Chung S, Dwabe S, Elshimali Y, Sukhija H, Aroh C, Vadgama J. Identification of Novel Biomarkers for Metastatic Colorectal Cancer Using Angiogenesis-Antibody Array and Intracellular Signaling Array. PLoS ONE. 2015;10:e0134948 pubmed publisher
Broecker Preuss M, Müller S, Britten M, Worm K, Schmid K, Mann K, et al. Sorafenib inhibits intracellular signaling pathways and induces cell cycle arrest and cell death in thyroid carcinoma cells irrespective of histological origin or BRAF mutational status. BMC Cancer. 2015;15:184 pubmed publisher
Cohen N, Zeng S, Seifert A, Kim T, Sorenson E, Greer J, et al. Pharmacological Inhibition of KIT Activates MET Signaling in Gastrointestinal Stromal Tumors. Cancer Res. 2015;75:2061-70 pubmed publisher
Ji Z, Erin Chen Y, Kumar R, Taylor M, Jenny Njauw C, Miao B, et al. MITF Modulates Therapeutic Resistance through EGFR Signaling. J Invest Dermatol. 2015;135:1863-1872 pubmed publisher
Ito K, Sakai K, Suzuki Y, Ozawa N, Hatta T, Natsume T, et al. Artificial human Met agonists based on macrocycle scaffolds. Nat Commun. 2015;6:6373 pubmed publisher
Laukkanen M, Cammarota F, Esposito T, Salvatore M, Castellone M. Extracellular superoxide dismutase regulates the expression of small gtpase regulatory proteins GEFs, GAPs, and GDI. PLoS ONE. 2015;10:e0121441 pubmed publisher
Song A, Kim T, Kim D, Kim S, Keam B, Lee S, et al. Molecular Changes Associated with Acquired Resistance to Crizotinib in ROS1-Rearranged Non-Small Cell Lung Cancer. Clin Cancer Res. 2015;21:2379-87 pubmed publisher
Wu J, Hu C, You R, Ma P, Pan S, Lee M, et al. Preclinical trials for prevention of tumor progression of hepatocellular carcinoma by LZ-8 targeting c-Met dependent and independent pathways. PLoS ONE. 2015;10:e0114495 pubmed publisher
Tworkoski K, Raab Traub N. LMP1 promotes expression of insulin-like growth factor 1 (IGF1) to selectively activate IGF1 receptor and drive cell proliferation. J Virol. 2015;89:2590-602 pubmed publisher
Zemskova M, Song J, Cen B, Cerda Infante J, Montecinos V, Kraft A. Regulation of prostate stromal fibroblasts by the PIM1 protein kinase. Cell Signal. 2015;27:135-46 pubmed publisher
Puzanov I, Lindsay C, Goff L, Sosman J, Gilbert J, Berlin J, et al. A phase I study of continuous oral dosing of OSI-906, a dual inhibitor of insulin-like growth factor-1 and insulin receptors, in patients with advanced solid tumors. Clin Cancer Res. 2015;21:701-11 pubmed publisher
Imura Y, Yasui H, Outani H, Wakamatsu T, Hamada K, Nakai T, et al. Combined targeting of mTOR and c-MET signaling pathways for effective management of epithelioid sarcoma. Mol Cancer. 2014;13:185 pubmed publisher
Shiono M, Kobayashi T, Takahashi R, Ueda M, Ishioka C, Hino O. Transgenic expression of the N525S-tuberin variant in Tsc2 mutant (Eker) rats causes dominant embryonic lethality. Sci Rep. 2014;4:5927 pubmed publisher
Outani H, Tanaka T, Wakamatsu T, Imura Y, Hamada K, Araki N, et al. Establishment of a novel clear cell sarcoma cell line (Hewga-CCS), and investigation of the antitumor effects of pazopanib on Hewga-CCS. BMC Cancer. 2014;14:455 pubmed publisher
Wang J, Mikse O, Liao R, Li Y, Tan L, Jänne P, et al. Ligand-associated ERBB2/3 activation confers acquired resistance to FGFR inhibition in FGFR3-dependent cancer cells. Oncogene. 2015;34:2167-77 pubmed publisher
Wang L, Hsiao T, Hong T, Chen H, Kao S, Wang W, et al. MicroRNA-133a suppresses multiple oncogenic membrane receptors and cell invasion in non-small cell lung carcinoma. PLoS ONE. 2014;9:e96765 pubmed publisher
Cuenca Lopez M, Montero J, Morales J, Prat A, Pandiella A, Ocana A. Phospho-kinase profile of triple negative breast cancer and androgen receptor signaling. BMC Cancer. 2014;14:302 pubmed publisher
Calero R, Morchon E, Johnsen J, Serrano R. Sunitinib suppress neuroblastoma growth through degradation of MYCN and inhibition of angiogenesis. PLoS ONE. 2014;9:e95628 pubmed publisher
Miyagawa Yamaguchi A, Kotani N, Honke K. Expressed glycosylphosphatidylinositol-anchored horseradish peroxidase identifies co-clustering molecules in individual lipid raft domains. PLoS ONE. 2014;9:e93054 pubmed publisher
Song W, Ma Y, Wang J, Brantley Sieders D, Chen J. JNK signaling mediates EPHA2-dependent tumor cell proliferation, motility, and cancer stem cell-like properties in non-small cell lung cancer. Cancer Res. 2014;74:2444-54 pubmed publisher
Banerjee J, Das Ghatak P, Roy S, Khanna S, Sequin E, Bellman K, et al. Improvement of human keratinocyte migration by a redox active bioelectric dressing. PLoS ONE. 2014;9:e89239 pubmed publisher
Camorani S, Esposito C, Rienzo A, Catuogno S, Iaboni M, Condorelli G, et al. Inhibition of receptor signaling and of glioblastoma-derived tumor growth by a novel PDGFR? aptamer. Mol Ther. 2014;22:828-41 pubmed publisher
Sakanyan V, Angelini M, Le Béchec M, Lecocq M, Benaiteau F, Rousseau B, et al. Screening and discovery of nitro-benzoxadiazole compounds activating epidermal growth factor receptor (EGFR) in cancer cells. Sci Rep. 2014;4:3977 pubmed publisher
Carlino M, Todd J, Gowrishankar K, Mijatov B, Pupo G, Fung C, et al. Differential activity of MEK and ERK inhibitors in BRAF inhibitor resistant melanoma. Mol Oncol. 2014;8:544-54 pubmed publisher
Lekawanvijit S, Kumfu S, Wang B, Manabe M, Nishijima F, Kelly D, et al. The uremic toxin adsorbent AST-120 abrogates cardiorenal injury following myocardial infarction. PLoS ONE. 2013;8:e83687 pubmed publisher
Davies K, Mahale S, Astling D, Aisner D, Le A, Hinz T, et al. Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer. PLoS ONE. 2013;8:e82236 pubmed publisher
Okon I, Coughlan K, Zou M. Liver kinase B1 expression promotes phosphatase activity and abrogation of receptor tyrosine kinase phosphorylation in human cancer cells. J Biol Chem. 2014;289:1639-48 pubmed publisher
de Freitas Junior J, Carvalho S, Dias A, Oliveira P, Cabral J, Seruca R, et al. Insulin/IGF-I signaling pathways enhances tumor cell invasion through bisecting GlcNAc N-glycans modulation. an interplay with E-cadherin. PLoS ONE. 2013;8:e81579 pubmed publisher
Skoda J, Neradil J, Zitterbart K, Sterba J, Veselska R. EGFR signaling in the HGG-02 glioblastoma cell line with an unusual loss of EGFR gene copy. Oncol Rep. 2014;31:480-7 pubmed publisher
Drake J, Graham N, Lee J, Stoyanova T, Faltermeier C, Sud S, et al. Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets. Proc Natl Acad Sci U S A. 2013;110:E4762-9 pubmed publisher
Son M, Seol B, Han Y, Cho Y. Comparative receptor tyrosine kinase profiling identifies a novel role for AXL in human stem cell pluripotency. Hum Mol Genet. 2014;23:1802-16 pubmed publisher
Lei H, Kazlauskas A. A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor ?. Mol Cell Biol. 2014;34:110-22 pubmed publisher
Ugurel S, Mentzel T, Utikal J, Helmbold P, Mohr P, Pföhler C, et al. Neoadjuvant imatinib in advanced primary or locally recurrent dermatofibrosarcoma protuberans: a multicenter phase II DeCOG trial with long-term follow-up. Clin Cancer Res. 2014;20:499-510 pubmed publisher
Li L, Chakraborty S, Yang C, Hatanpaa K, Cipher D, Puliyappadamba V, et al. An EGFR wild type-EGFRvIII-HB-EGF feed-forward loop regulates the activation of EGFRvIII. Oncogene. 2014;33:4253-64 pubmed publisher
Kwon H, Johnson T, Joe M, Abu Asab M, Zhang J, Chan C, et al. Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling. J Biol Chem. 2013;288:26357-71 pubmed publisher
Vultur A, Villanueva J, Krepler C, Rajan G, Chen Q, Xiao M, et al. MEK inhibition affects STAT3 signaling and invasion in human melanoma cell lines. Oncogene. 2014;33:1850-61 pubmed publisher
Krzyzaniak M, Zumstein M, Gerez J, Picotti P, Helenius A. Host cell entry of respiratory syncytial virus involves macropinocytosis followed by proteolytic activation of the F protein. PLoS Pathog. 2013;9:e1003309 pubmed publisher
Britschgi A, Bill A, Brinkhaus H, Rothwell C, Clay I, Duss S, et al. Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling. Proc Natl Acad Sci U S A. 2013;110:E1026-34 pubmed publisher
Lee H, Bennett A. Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migration. Mol Cell Biol. 2013;33:1430-41 pubmed publisher
Montero J, Esparis Ogando A, Re Louhau M, Seoane S, Abad M, Calero R, et al. Active kinase profiling, genetic and pharmacological data define mTOR as an important common target in triple-negative breast cancer. Oncogene. 2014;33:148-56 pubmed publisher
Lin S, Lee Y, Wang J, Miller S, Chiou S, Hung M, et al. Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27. PLoS ONE. 2012;7:e49605 pubmed publisher
Joshi A, Loilome W, Siu I, Tyler B, Gallia G, Riggins G. Evaluation of tyrosine kinase inhibitor combinations for glioblastoma therapy. PLoS ONE. 2012;7:e44372 pubmed publisher
Purushothaman A, Babitz S, Sanderson R. Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma. J Biol Chem. 2012;287:41288-96 pubmed publisher
Kotani N, Ishiura Y, Yamashita R, Ohnishi T, Honke K. Fibroblast growth factor receptor 3 (FGFR3) associated with the CD20 antigen regulates the rituximab-induced proliferation inhibition in B-cell lymphoma cells. J Biol Chem. 2012;287:37109-18 pubmed publisher
Davies K, Le A, Theodoro M, Skokan M, Aisner D, Berge E, et al. Identifying and targeting ROS1 gene fusions in non-small cell lung cancer. Clin Cancer Res. 2012;18:4570-9 pubmed publisher
Ganesh K, Das A, Dickerson R, Khanna S, Parinandi N, Gordillo G, et al. Prostaglandin E? induces oncostatin M expression in human chronic wound macrophages through Axl receptor tyrosine kinase pathway. J Immunol. 2012;189:2563-73 pubmed publisher
Ho A, Vasudeva S, Lae M, Saito T, Barbashina V, Antonescu C, et al. PDGF receptor alpha is an alternative mediator of rapamycin-induced Akt activation: implications for combination targeted therapy of synovial sarcoma. Cancer Res. 2012;72:4515-25 pubmed publisher
Duncan J, Whittle M, Nakamura K, Abell A, Midland A, Zawistowski J, et al. Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer. Cell. 2012;149:307-21 pubmed publisher
Oliveras Ferraros C, Cufí S, Queralt B, Vazquez Martin A, Martin Castillo B, de Llorens R, et al. Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cells. Br J Cancer. 2012;106:1406-14 pubmed publisher
Bai Y, Li J, Fang B, Edwards A, Zhang G, Bui M, et al. Phosphoproteomics identifies driver tyrosine kinases in sarcoma cell lines and tumors. Cancer Res. 2012;72:2501-11 pubmed publisher
Gowrishankar K, Snoyman S, Pupo G, Becker T, Kefford R, Rizos H. Acquired resistance to BRAF inhibition can confer cross-resistance to combined BRAF/MEK inhibition. J Invest Dermatol. 2012;132:1850-9 pubmed publisher
Ball S, Shuttleworth A, Kielty C. Inhibition of platelet-derived growth factor receptor signaling regulates Oct4 and Nanog expression, cell shape, and mesenchymal stem cell potency. Stem Cells. 2012;30:548-60 pubmed publisher
Poulikakos P, Persaud Y, Janakiraman M, Kong X, Ng C, Moriceau G, et al. RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature. 2011;480:387-90 pubmed publisher
Lorenzon E, Colladel R, Andreuzzi E, Marastoni S, Todaro F, Schiappacassi M, et al. MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway. Oncogene. 2012;31:3136-47 pubmed publisher
Tang W, Stitham J, Gleim S, Di Febbo C, Porreca E, Fava C, et al. Glucose and collagen regulate human platelet activity through aldose reductase induction of thromboxane. J Clin Invest. 2011;121:4462-76 pubmed publisher
Jiao Y, Ou W, Meng F, Zhou H, Wang A. Targeting HSP90 in ovarian cancers with multiple receptor tyrosine kinase coactivation. Mol Cancer. 2011;10:125 pubmed publisher
Tanizaki J, Okamoto I, Sakai K, Nakagawa K. Differential roles of trans-phosphorylated EGFR, HER2, HER3, and RET as heterodimerisation partners of MET in lung cancer with MET amplification. Br J Cancer. 2011;105:807-13 pubmed publisher
Lupberger J, Zeisel M, Xiao F, Thumann C, Fofana I, Zona L, et al. EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Nat Med. 2011;17:589-95 pubmed publisher
Tanabe H, Kuribayashi K, Tsuji N, Tanaka M, Kobayashi D, Watanabe N. Sesamin induces autophagy in colon cancer cells by reducing tyrosine phosphorylation of EphA1 and EphB2. Int J Oncol. 2011;39:33-40 pubmed publisher
Karki R, Lang S, Means R. The MARCH family E3 ubiquitin ligase K5 alters monocyte metabolism and proliferation through receptor tyrosine kinase modulation. PLoS Pathog. 2011;7:e1001331 pubmed publisher
Carrasco Garcia E, Saceda M, Grasso S, Rocamora Reverte L, Conde M, Gómez Martínez A, et al. Small tyrosine kinase inhibitors interrupt EGFR signaling by interacting with erbB3 and erbB4 in glioblastoma cell lines. Exp Cell Res. 2011;317:1476-89 pubmed publisher
Ding V, Boersema P, Foong L, Preisinger C, Koh G, Natarajan S, et al. Tyrosine phosphorylation profiling in FGF-2 stimulated human embryonic stem cells. PLoS ONE. 2011;6:e17538 pubmed publisher
Chakrabarty A, Sanchez V, Kuba M, Rinehart C, Arteaga C. Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors. Proc Natl Acad Sci U S A. 2012;109:2718-23 pubmed publisher
Henriksson M, Edin S, Dahlin A, Oldenborg P, Oberg A, Van Guelpen B, et al. Colorectal cancer cells activate adjacent fibroblasts resulting in FGF1/FGFR3 signaling and increased invasion. Am J Pathol. 2011;178:1387-94 pubmed publisher
McKinley E, Bugaj J, Zhao P, Guleryuz S, Mantis C, Gokhale P, et al. 18FDG-PET predicts pharmacodynamic response to OSI-906, a dual IGF-1R/IR inhibitor, in preclinical mouse models of lung cancer. Clin Cancer Res. 2011;17:3332-40 pubmed publisher
Ou W, Hubert C, Corson J, Bueno R, Flynn D, Sugarbaker D, et al. Targeted inhibition of multiple receptor tyrosine kinases in mesothelioma. Neoplasia. 2011;13:12-22 pubmed
Villanueva J, Vultur A, Lee J, Somasundaram R, Fukunaga Kalabis M, Cipolla A, et al. Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer Cell. 2010;18:683-95 pubmed publisher
Godshalk S, Paranjape T, Nallur S, Speed W, Chan E, Molinaro A, et al. A Variant in a MicroRNA complementary site in the 3' UTR of the KIT oncogene increases risk of acral melanoma. Oncogene. 2011;30:1542-50 pubmed publisher
Nazarian R, Shi H, Wang Q, Kong X, Koya R, Lee H, et al. Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature. 2010;468:973-7 pubmed publisher
Csepeggi C, Jiang M, Kojima F, Crofford L, Frolov A. Somatic cell plasticity and Niemann-Pick type C2 protein: fibroblast activation. J Biol Chem. 2011;286:2078-87 pubmed publisher
Suda K, Murakami I, Katayama T, Tomizawa K, Osada H, Sekido Y, et al. Reciprocal and complementary role of MET amplification and EGFR T790M mutation in acquired resistance to kinase inhibitors in lung cancer. Clin Cancer Res. 2010;16:5489-98 pubmed publisher
Flanigan S, Pitts T, Eckhardt S, Tentler J, Tan A, Thorburn A, et al. The insulin-like growth factor I receptor/insulin receptor tyrosine kinase inhibitor PQIP exhibits enhanced antitumor effects in combination with chemotherapy against colorectal cancer models. Clin Cancer Res. 2010;16:5436-46 pubmed publisher
Dewaele B, Floris G, Finalet Ferreiro J, Fletcher C, Coindre J, Guillou L, et al. Coactivated platelet-derived growth factor receptor {alpha} and epidermal growth factor receptor are potential therapeutic targets in intimal sarcoma. Cancer Res. 2010;70:7304-14 pubmed publisher
Oliveras Ferraros C, Vazquez Martin A, Martin Castillo B, Pérez Martínez M, Cufí S, del Barco S, et al. Pathway-focused proteomic signatures in HER2-overexpressing breast cancer with a basal-like phenotype: new insights into de novo resistance to trastuzumab (Herceptin). Int J Oncol. 2010;37:669-78 pubmed
Csepeggi C, Jiang M, Frolov A. Somatic cell plasticity and Niemann-pick type C2 protein: adipocyte differentiation and function. J Biol Chem. 2010;285:30347-54 pubmed publisher
Ding W, Knox T, Tschumper R, Wu W, Schwager S, Boysen J, et al. Platelet-derived growth factor (PDGF)-PDGF receptor interaction activates bone marrow-derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: implications for an angiogenic switch. Blood. 2010;116:2984-93 pubmed publisher
Strobel P, Bargou R, Wolff A, Spitzer D, Manegold C, Dimitrakopoulou Strauss A, et al. Sunitinib in metastatic thymic carcinomas: laboratory findings and initial clinical experience. Br J Cancer. 2010;103:196-200 pubmed publisher
Negri T, Virdis E, Brich S, Bozzi F, Tamborini E, Tarantino E, et al. Functional mapping of receptor tyrosine kinases in myxoid liposarcoma. Clin Cancer Res. 2010;16:3581-93 pubmed publisher
Stacchiotti S, Negri T, Palassini E, Conca E, Gronchi A, Morosi C, et al. Sunitinib malate and figitumumab in solitary fibrous tumor: patterns and molecular bases of tumor response. Mol Cancer Ther. 2010;9:1286-97 pubmed publisher
Kang H, Jenabi J, Liu X, Reynolds C, Triche T, Sorensen P. Inhibition of the insulin-like growth factor I receptor by epigallocatechin gallate blocks proliferation and induces the death of Ewing tumor cells. Mol Cancer Ther. 2010;9:1396-407 pubmed publisher
Roorda B, ter Elst A, Scherpen F, Meeuwsen de Boer T, Kamps W, de Bont E. VEGF-A promotes lymphoma tumour growth by activation of STAT proteins and inhibition of p27(KIP1) via paracrine mechanisms. Eur J Cancer. 2010;46:974-82 pubmed publisher
Franovic A, Holterman C, Payette J, Lee S. Human cancers converge at the HIF-2alpha oncogenic axis. Proc Natl Acad Sci U S A. 2009;106:21306-11 pubmed publisher
Cook S, Varela Carver A, Mongillo M, Kleinert C, Khan M, Leccisotti L, et al. Abnormal myocardial insulin signalling in type 2 diabetes and left-ventricular dysfunction. Eur Heart J. 2010;31:100-11 pubmed publisher
Yoon Y, Kim H, Han S, Hur H, Oh D, Im S, et al. Combination of EGFR and MEK1/2 inhibitor shows synergistic effects by suppressing EGFR/HER3-dependent AKT activation in human gastric cancer cells. Mol Cancer Ther. 2009;8:2526-36 pubmed publisher
Bax D, Gaspar N, Little S, Marshall L, Perryman L, Regairaz M, et al. EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines. Clin Cancer Res. 2009;15:5753-61 pubmed publisher
Eiselleova L, Matulka K, Kriz V, Kunova M, Schmidtova Z, Neradil J, et al. A complex role for FGF-2 in self-renewal, survival, and adhesion of human embryonic stem cells. Stem Cells. 2009;27:1847-57 pubmed publisher
Goldoni S, Humphries A, Nyström A, Sattar S, Owens R, McQuillan D, et al. Decorin is a novel antagonistic ligand of the Met receptor. J Cell Biol. 2009;185:743-54 pubmed publisher
Kawaguchi K, Murakami H, Taniguchi T, Fujii M, Kawata S, Fukui T, et al. Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells. Carcinogenesis. 2009;30:1097-105 pubmed publisher
Eckstein N, Servan K, Hildebrandt B, Pölitz A, von Jonquieres G, Wolf Kümmeth S, et al. Hyperactivation of the insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells. Cancer Res. 2009;69:2996-3003 pubmed publisher
Kobayashi T, Furukawa Y, Kikuchi J, Ito C, Miyata Y, Muto S, et al. Transactivation of RON receptor tyrosine kinase by interaction with PDGF receptor beta during steady-state growth of human mesangial cells. Kidney Int. 2009;75:1173-1183 pubmed publisher
Agarwal S, Zerillo C, Kolmakova J, Christensen J, Harris L, Rimm D, et al. Association of constitutively activated hepatocyte growth factor receptor (Met) with resistance to a dual EGFR/Her2 inhibitor in non-small-cell lung cancer cells. Br J Cancer. 2009;100:941-9 pubmed publisher
Kashiwagi K, Virgona N, Harada K, Kido W, Yano Y, Ando A, et al. A redox-silent analogue of tocotrienol acts as a potential cytotoxic agent against human mesothelioma cells. Life Sci. 2009;84:650-6 pubmed publisher
Stacchiotti S, Tamborini E, Marrari A, Brich S, Rota S, Orsenigo M, et al. Response to sunitinib malate in advanced alveolar soft part sarcoma. Clin Cancer Res. 2009;15:1096-104 pubmed publisher
Marston E, Weston V, Jesson J, Maina E, McConville C, Agathanggelou A, et al. Stratification of pediatric ALL by in vitro cellular responses to DNA double-strand breaks provides insight into the molecular mechanisms underlying clinical response. Blood. 2009;113:117-26 pubmed publisher
Buck E, Eyzaguirre A, Rosenfeld Franklin M, Thomson S, Mulvihill M, Barr S, et al. Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors. Cancer Res. 2008;68:8322-32 pubmed publisher
Shimamura T, Li D, Ji H, Haringsma H, Liniker E, Borgman C, et al. Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance. Cancer Res. 2008;68:5827-38 pubmed publisher
Koivunen J, Mermel C, Zejnullahu K, Murphy C, Lifshits E, Holmes A, et al. EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin Cancer Res. 2008;14:4275-83 pubmed publisher
Agaram N, Laquaglia M, Ustun B, Guo T, Wong G, Socci N, et al. Molecular characterization of pediatric gastrointestinal stromal tumors. Clin Cancer Res. 2008;14:3204-15 pubmed publisher
Mueller K, Hunter L, Ethier S, Boerner J. Met and c-Src cooperate to compensate for loss of epidermal growth factor receptor kinase activity in breast cancer cells. Cancer Res. 2008;68:3314-22 pubmed publisher
Kunii K, Davis L, Gorenstein J, Hatch H, Yashiro M, Di Bacco A, et al. FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival. Cancer Res. 2008;68:2340-8 pubmed publisher
Yu L, Saile K, Swartz C, He H, Zheng X, Kissling G, et al. Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas. Mol Med. 2008;14:264-75 pubmed publisher
Eckstein N, Servan K, Girard L, Cai D, von Jonquieres G, Jaehde U, et al. Epidermal growth factor receptor pathway analysis identifies amphiregulin as a key factor for cisplatin resistance of human breast cancer cells. J Biol Chem. 2008;283:739-50 pubmed
Stommel J, Kimmelman A, Ying H, Nabioullin R, Ponugoti A, Wiedemeyer R, et al. Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science. 2007;318:287-90 pubmed
Wang L, Schulz T, Sherrer E, Dauphin D, Shin S, Nelson A, et al. Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling. Blood. 2007;110:4111-9 pubmed
Lomas A, Mellody K, Freeman L, Bax D, Shuttleworth C, Kielty C. Fibulin-5 binds human smooth-muscle cells through alpha5beta1 and alpha4beta1 integrins, but does not support receptor activation. Biochem J. 2007;405:417-28 pubmed
Ball S, Shuttleworth C, Kielty C. Vascular endothelial growth factor can signal through platelet-derived growth factor receptors. J Cell Biol. 2007;177:489-500 pubmed
Engelman J, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park J, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science. 2007;316:1039-43 pubmed
Kang H, Jenabi J, Zhang J, Keshelava N, Shimada H, May W, et al. E-cadherin cell-cell adhesion in ewing tumor cells mediates suppression of anoikis through activation of the ErbB4 tyrosine kinase. Cancer Res. 2007;67:3094-105 pubmed
Fujikawa T, Shiraha H, Ueda N, Takaoka N, Nakanishi Y, Matsuo N, et al. Des-gamma-carboxyl prothrombin-promoted vascular endothelial cell proliferation and migration. J Biol Chem. 2007;282:8741-8 pubmed
Menendez J, Mehmi I, Lupu R. Trastuzumab in combination with heregulin-activated Her-2 (erbB-2) triggers a receptor-enhanced chemosensitivity effect in the absence of Her-2 overexpression. J Clin Oncol. 2006;24:3735-46 pubmed
Cohen E, Lingen M, Zhu B, Zhu H, Straza M, Pierce C, et al. Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase. Cancer Res. 2006;66:6296-303 pubmed
image
image 1 :
R&D Systems ARY001B image 1
Detection of Human Receptor Tyrosine Kinase Phosphorylation in KATO-III Cell Line.
product information
brand :
R&D Systems
master code :
ARY001B
SKU :
ARY001B
product name :
Proteome Profiler Human Phospho-RTK Array Kit
unit size :
1 Kit
seo description :
The Proteome Profiler Human Phospho-RTK Array Kit from R&D Systems Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies.
target :
RTK Assay Kits
category :
Proteome Profiler Antibody Arrays
species :
Human
top caption :
Detection of Human Receptor Tyrosine Kinase Phosphorylation in KATO-III Cell Line.
extended description :
Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
USD :
625 USD
product details :
Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
storage :
Store the unopened product at 2 - 8 ░C. Do not use past expiration date.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.