Mouse Gas6 Antibody | R&D Systems AF986 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse Gas6 Antibody

catalog :

AF986

quantity :

100 ug (also 25 ug)

price :

509 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:50; loading ...; fig 2a	Huang Y, Happonen K, Burrola P, O Connor C, Hah N, Huang L, et al. Microglia use TAM receptors to detect and engulf amyloid β plaques. Nat Immunol. 2021;22:586-594 pubmed publisher
	Nath S, Mart xed nez Santamar xed a J, Chu Y, Choi J, Conforti P, Lin J, et al. Interaction between subventricular zone microglia and neural stem cells impacts the neurogenic response in a mouse model of cortical ischemic stroke. Nat Commun. 2024;15:9095 pubmed publisher
	Tsugawa H, Ohki T, Tsubaki S, Tanaka R, Matsuzaki J, Suzuki H, et al. Gas6 ameliorates intestinal mucosal immunosenescence to prevent the translocation of a gut pathobiont, Klebsiella pneumoniae, to the liver. PLoS Pathog. 2023;19:e1011139 pubmed publisher
	Huang Y, Lemke G. Adaptable toolbox to characterize Alzheimer's disease pathology in mouse models. STAR Protoc. 2022;3:101891 pubmed publisher
	Roy E, Chiu G, Li S, Propson N, Kanchi R, Wang B, et al. Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques. Immunity. 2022;55:879-894.e6 pubmed publisher
	Owlett L, Karaahmet B, Le L, Belcher E, Dionisio Santos D, Olschowka J, et al. Gas6 induces inflammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP/PS1 model of Alzheimer's disease. J Neuroinflammation. 2022;19:38 pubmed publisher
	Tirado Gonzalez I, Descot A, Soetopo D, Nevmerzhitskaya A, Schaffer A, Kur I, et al. AXL Inhibition in Macrophages Stimulates Host-versus-Leukemia Immunity and Eradicates Naïve and Treatment-Resistant Leukemia. Cancer Discov. 2021;11:2924-2943 pubmed publisher
	Ibrahim A, Moss M, Gray Z, Rojo M, Burke C, Schwertfeger K, et al. Diverse Macrophage Populations Contribute to the Inflammatory Microenvironment in Premalignant Lesions During Localized Invasion. Front Oncol. 2020;10:569985 pubmed publisher
	Zag xf3 rska A, Trav xe9 s P, Jim xe9 nez Garc xed a L, Strickland J, Oh J, Tapia F, et al. Differential regulation of hepatic physiology and injury by the TAM receptors Axl and Mer. Life Sci Alliance. 2020;3: pubmed publisher
	Bordoloi J, Ozah D, Bora T, Kalita J, Manna P. Gamma-glutamyl carboxylated Gas6 mediates the beneficial effect of vitamin K on lowering hyperlipidemia via regulating the AMPK/SREBP1/PPARα signaling cascade of lipid metabolism. J Nutr Biochem. 2019;70:174-184 pubmed publisher
	Nassar M, Tabib Y, Capucha T, Mizraji G, Nir T, Pevsner Fischer M, et al. GAS6 is a key homeostatic immunological regulator of host-commensal interactions in the oral mucosa. Proc Natl Acad Sci U S A. 2017;114:E337-E346 pubmed publisher
	Fourgeaud L, Traves P, Tufail Y, Leal Bailey H, Lew E, Burrola P, et al. TAM receptors regulate multiple features of microglial physiology. Nature. 2016;532:240-244 pubmed publisher

product information

master code :

AF986

SKU :

AF986

product name :

Mouse Gas6 Antibody

unit size :

100 ug (also 25 ug)

description :

The Mouse Gas6 Antibody from R&D Systems is a goat polyclonal antibody to Gas6. This antibody reacts with mouse,transgenic mouse. The Mouse Gas6 Antibody has been validated for the following applications: Immunohistochemistry,Immunoprecipitation,Western Blot,Immunocytochemistry,ELISA Development,Immunohistochemistry-Frozen,ELISA Capture (Matched Antibody Pair).

target :

Gas6

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse Gas6 (R D Systems, Catalog # 986-GS), Asp115-Pro673, Accession # CAA42507

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Mouse

specificity :

Detects mouse Gas6 in ELISAs and Western blots. In sandwich immunoassays, less than 10% cross-reactivity with recombinant human Gas6 is observed and less than 1% cross-reactivity with recombinant mouse Gas1 is observed.

gene symbol :

GAS6

top caption :

Gas6 antibody in Mouse Intestine by Immunohistochemistry (IHC-P).

accessionNumbers :

CAA42507

applications :

Immunohistochemistry,Western Blot,ELISA Development,Immunoprecipitation,Immunohistochemistry-Frozen,ELISA Capture (Matched Antibody Pair)

USD :

509 USD

alt names :

AXLLG, AXLLGAXL stimulatory factor, AXSFAXL receptor tyrosine kinase ligand, DKFZp666G247, FLJ34709, GAS-6, growth arrest-specific 6, growth arrest-specific protein 6

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage