Human TIMP-1 Antibody | R&D Systems AF970 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human TIMP-1 Antibody

catalog :

AF970

quantity :

100 ug (also 25 ug)

price :

489 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, neutralization, immunohistochemistry - paraffin section, proximity ligation assay

more info or order :

R&D Systems product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 1d	Wiley C, Liu S, Limbad C, Zawadzka A, Beck J, Demaria M, et al. SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells. Cell Rep. 2019;28:3329-3337.e5 pubmed publisher
western blot; human; 1:600; loading ...; fig 4	Nyberg M, Fiorenza M, Lund A, Christensen M, RÃ¸mer T, Piil P, et al. Adaptations to Speed Endurance Training in Highly Trained Soccer Players. Med Sci Sports Exerc. 2016;48:1355-64 pubmed publisher
	Nakamura K, Tsukasaki M, Tsunematsu T, Yan M, Ando Y, Huynh N, et al. The periosteum provides a stromal defence against cancer invasion into the bone. Nature. 2024;634:474-481 pubmed publisher
	Wittig F, Henkel L, Pr xfc ser J, Merkord J, Ramer R, Hinz B. Inhibition of Monoacylglycerol Lipase Decreases Angiogenic Features of Endothelial Cells via Release of Tissue Inhibitor of Metalloproteinase-1 from Lung Cancer Cells. Cells. 2023;12: pubmed publisher
	Ishihara R, Oda T, Murakami Y, Matsumura I, Watanabe S, Asao Y, et al. Myeloma Microenvironmental TIMP1 Induces the Invasive Phenotype in Fibroblasts to Modulate Disease Progression. Int J Mol Sci. 2023;24: pubmed publisher
	Kawai H, Bouchekioua Y, Nishitani N, Niitani K, Izumi S, Morishita H, et al. Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion. Nat Commun. 2022;13:7708 pubmed publisher
	Gerwinn T, Salemi S, Schori L, Planta D, Eberli D, Horst M. Improved contractile potential in detrusor microtissues from pediatric patients with end stage lower urinary tract dysfunction. Front Cell Dev Biol. 2022;10:1007265 pubmed publisher
	Theocharidis G, Thomas B, Sarkar D, Mumme H, Pilcher W, Dwivedi B, et al. Single cell transcriptomic landscape of diabetic foot ulcers. Nat Commun. 2022;13:181 pubmed publisher
	Kobayashi Y, Tokuda K, Yamashiro C, Higashijima F, Yoshimoto T, Ota M, et al. Inhibition of epithelial-mesenchymal transition in retinal pigment epithelial cells by a retinoic acid receptor-α agonist. Sci Rep. 2021;11:11842 pubmed publisher
	Li X, Niu N, Sun J, Mou Y, He X, Mei L. IL35 predicts prognosis in gastric cancer and is associated with angiogenesis by altering TIMP1, PAI1 and IGFBP1. FEBS Open Bio. 2020;10:2687-2701 pubmed publisher
	Taylor S, Whitfield M, Barratt J, Didangelos A. The Metalloproteinase ADAMTS5 Is Expressed by Interstitial Inflammatory Cells in IgA Nephropathy and Is Proteolytically Active on the Kidney Matrix. J Immunol. 2020;205:2243-2254 pubmed publisher
	Barbar L, Jain T, Zimmer M, Kruglikov I, Sadick J, Wang M, et al. CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes. Neuron. 2020;107:436-453.e12 pubmed publisher
	Abreu M, Cabezas Sainz P, Alonso Alconada L, Ferreirós A, Mondelo Macía P, Lago Lestón R, et al. Circulating Tumor Cells Characterization Revealed TIMP1 as a Potential Therapeutic Target in Ovarian Cancer. Cells. 2020;9: pubmed publisher
	Abreu M, Cabezas Sainz P, Pereira Veiga T, Falo C, Abalo A, Morilla I, et al. Looking for a Better Characterization of Triple-Negative Breast Cancer by Means of Circulating Tumor Cells. J Clin Med. 2020;9: pubmed publisher
	Cheng G, Fan X, Hao M, Wang J, Zhou X, Sun X. Higher levels of TIMP-1 expression are associated with a poor prognosis in triple-negative breast cancer. Mol Cancer. 2016;15:30 pubmed publisher
	Ding X, Yang D, Xia L, Chen B, Yu S, Niu Y, et al. Targeting TR4 nuclear receptor suppresses prostate cancer invasion via reduction of infiltrating macrophages with alteration of the TIMP-1/MMP2/MMP9 signals. Mol Cancer. 2015;14:16 pubmed publisher

product information

master code :

AF970

SKU :

AF970

product name :

Human TIMP-1 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human TIMP-1 Antibody from R&D Systems is a goat polyclonal antibody to TIMP-1. This antibody reacts with human,mouse,transgenic mouse. The Human TIMP-1 Antibody has been validated for the following applications: Neutralization,Immunohistochemistry,Proximity Ligation Assay (PLA),Western Blot,Immunohistochemistry-Paraffin,In vivo assay,Simple Western,Knockout Validated.

target :

TIMP-1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant human TIMP-1, Cys24-Ala207, Accession # Q6FGX5

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Transgenic Mouse

specificity :

Detects human TIMP-1 in direct ELISAs and Western blots. In direct ELISAs, approximately 20% cross-reactivity with recombinant mouse TIMP-1 and recombinant rat TIMP-1 is observed and less than 1% cross-reactivity with recombinant human (rh) TIMP-2, rhTIMP-3, and rhTIMP-4 is observed.

gene symbol :

TIMP1

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

Antibody validation :

Knockout/Knockdown

top caption :

Detection of Human TIMP-1 antibody by Western Blot.

accessionNumbers :

Q6FGX5

applications :

Immunohistochemistry,Proximity Ligation Assay (PLA),Western Blot,Neutralization,Immunohistochemistry-Paraffin,In vivo assay,Simple Western,Knockout Validated

USD :

489 USD

alt names :

CLGI, Collagenase inhibitor, collagenase inhibitor), EPATIMP-1, EPO, erythroid potentiating activity, Erythroid-potentiating activity, Fibroblast collagenase inhibitor, FLJ90373, HCI, metalloproteinase inhibitor 1, TIMP metallopeptidase inhibitor 1, TIMP1, TIMPtissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, Tissue inhibitor of metalloproteinases 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage