Published Application/Species/Sample/Dilution | Reference |
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- western blot knockout validation; mouse; loading ...; fig 1a
| Iwama H, Mehanna S, Imasaka M, Hashidume S, Nishiura H, Yamamura K, et al. Cathepsin B and D deficiency in the mouse pancreas induces impaired autophagy and chronic pancreatitis. Sci Rep. 2021;11:6596 pubmed publisher
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- immunohistochemistry - frozen section; mouse; 10 ug/ml; loading ...; fig 2c, 2e
| Bando Y, Tokuda N, Ogasawara Y, Onozawa G, Nagasaka A, Sakiyama K, et al. Expression and enhancement of FABP4 in septoclasts of the growth plate in FABP5-deficient mouse tibiae. Histochem Cell Biol. 2021;155:439-449 pubmed publisher
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| Takahashi H, Bhagwagar S, Nies S, Ye H, Han X, Chiasseu M, et al. Reduced progranulin increases tau and α-synuclein inclusions and alters mouse tauopathy phenotypes via glucocerebrosidase. Nat Commun. 2024;15:1434 pubmed publisher
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| Do x11f ru A, Rehders M, Brix K. Investigations on Primary Cilia of Nthy-ori 3-1 Cells upon Cysteine Cathepsin Inhibition or Thyrotropin Stimulation. Int J Mol Sci. 2023;24: pubmed publisher
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| Zhang T, Pang W, Feng T, Guo J, Wu K, Nunez Santos M, et al. TMEM106B regulates microglial proliferation and survival in response to demyelination. Sci Adv. 2023;9:eadd2676 pubmed publisher
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| Hua J, Garcia de Paco E, Linck N, Maurice T, Desrumaux C, Manoury B, et al. Microglial P2X4 receptors promote ApoE degradation and contribute to memory deficits in Alzheimer's disease. Cell Mol Life Sci. 2023;80:138 pubmed publisher
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| Zhu X, Prakash S, McAuliffe G, Pan P. Synaptojanin1 Modifies Endolysosomal Parameters in Cultured Ventral Midbrain Neurons. Eneuro. 2023;10: pubmed publisher
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| Qiu Y, Shen X, Ravid O, Atrakchi D, Rand D, Wight A, et al. Definition of the contribution of an Osteopontin-producing CD11c+ microglial subset to Alzheimer's disease. Proc Natl Acad Sci U S A. 2023;120:e2218915120 pubmed publisher
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| Parchure A, Tian M, Stalder D, Boyer C, Bearrows S, Rohli K, et al. Liquid-liquid phase separation facilitates the biogenesis of secretory storage granules. J Cell Biol. 2022;221: pubmed publisher
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| Ratto E, Chowdhury S, Siefert N, Schneider M, Wittmann M, Helm D, et al. Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly. Nat Commun. 2022;13:4848 pubmed publisher
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| Feng T, Luan L, Katz I, Ullah M, Van Deerlin V, Trojanowski J, et al. TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss. Acta Neuropathol Commun. 2022;10:33 pubmed publisher
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| Uehara K, Koyanagi Aoi M, Koide T, Itoh T, Aoi T. Epithelial-derived factors induce muscularis mucosa of human induced pluripotent stem cell-derived gastric organoids. Stem Cell Reports. 2022;17:820-834 pubmed publisher
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| Sun J, Liu Y, Hao X, Lin W, Su W, Chiang E, et al. LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function. EMBO J. 2022;41:e108119 pubmed publisher
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| Dang T, Back S. Translation Inhibitors Activate Autophagy Master Regulators TFEB and TFE3. Int J Mol Sci. 2021;22: pubmed publisher
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| Roney J, Li S, Farfel Becker T, Huang N, Sun T, Xie Y, et al. Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C. Dev Cell. 2021;56:1452-1468.e8 pubmed publisher
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| Bonet Ponce L, Beilina A, Williamson C, Lindberg E, Kluss J, Saez Atienzar S, et al. LRRK2 mediates tubulation and vesicle sorting from lysosomes. Sci Adv. 2020;6: pubmed publisher
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| Yang C, Chen X, Li Z, Wu H, Jing K, Huang X, et al. SMAD3 promotes autophagy dysregulation by triggering lysosome depletion in tubular epithelial cells in diabetic nephropathy. Autophagy. 2020;:1-20 pubmed publisher
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| Huang M, Modeste E, Dammer E, Merino P, Taylor G, Duong D, et al. Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations. Acta Neuropathol Commun. 2020;8:163 pubmed publisher
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| Werner G, Damme M, Schludi M, Gn xf6 rich J, Wind K, Fellerer K, et al. Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice. EMBO Rep. 2020;21:e50241 pubmed publisher
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| Zhang J, Velmeshev D, Hashimoto K, Huang Y, Hofmann J, Shi X, et al. Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency. Nature. 2020;588:459-465 pubmed publisher
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| Feng T, Mai S, Roscoe J, Sheng R, Ullah M, Zhang J, et al. Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice. EMBO Rep. 2020;21:e50219 pubmed publisher
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| Ziros P, Renaud C, Chartoumpekis D, Bongiovanni M, Habeos I, Liao X, et al. Mice Hypomorphic for Keap1, a Negative Regulator of the Nrf2 Antioxidant Response, Show Age-Dependent Diffuse Goiter with Elevated Thyrotropin Levels. Thyroid. 2021;31:23-35 pubmed publisher
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| Selkrig J, Li N, Hausmann A, Mangan M, Zietek M, Mateus A, et al. Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection. Nat Microbiol. 2020;5:1119-1133 pubmed publisher
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| Cui W, Sathyanarayan A, Lopresti M, Aghajan M, Chen C, Mashek D. Lipophagy-derived fatty acids undergo extracellular efflux via lysosomal exocytosis. Autophagy. 2020;:1-16 pubmed publisher
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| Schwenck J, Maurer A, Fehrenbacher B, Mehling R, Knopf P, Mucha N, et al. Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions. Theranostics. 2019;9:3903-3917 pubmed publisher
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| Farfel Becker T, Roney J, Cheng X, Li S, Cuddy S, Sheng Z. Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity. Cell Rep. 2019;28:51-64.e4 pubmed publisher
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| Takagaki Y, Shi S, Katoh M, Kitada M, Kanasaki K, Koya D. Dipeptidyl peptidase-4 plays a pathogenic role in BSA-induced kidney injury in diabetic mice. Sci Rep. 2019;9:7519 pubmed publisher
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| Gabandé Rodríguez E, Pérez Cañamás A, Soto Huelin B, Mitroi D, Sánchez Redondo S, Martínez Sáez E, et al. Lipid-induced lysosomal damage after demyelination corrupts microglia protective function in lysosomal storage disorders. EMBO J. 2019;38: pubmed publisher
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| Götzl J, Colombo A, Fellerer K, Reifschneider A, Werner G, Tahirovic S, et al. Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice. Mol Neurodegener. 2018;13:48 pubmed publisher
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| Klein Z, Takahashi H, Ma M, Stagi M, Zhou M, Lam T, et al. Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice. Neuron. 2017;95:281-296.e6 pubmed publisher
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| Takahashi K, Mashima H, Miura K, Maeda D, Goto A, Goto T, et al. Disruption of Small GTPase Rab7 Exacerbates the Severity of Acute Pancreatitis in Experimental Mouse Models. Sci Rep. 2017;7:2817 pubmed publisher
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