Human/Mouse Gremlin Antibody | R&D Systems AF956 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Mouse Gremlin Antibody

catalog :

AF956

quantity :

100 ug (also 25 ug)

price :

509 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, immunohistochemistry - paraffin section, western blot knockout validation

more info or order :

R&D Systems product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; mouse; 1:1000; fig 4a	Ichinose M, Suzuki N, Wang T, Kobayashi H, Vrbanac L, Ng J, et al. The BMP antagonist gremlin 1 contributes to the development of cortical excitatory neurons, motor balance and fear responses. Development. 2021;148: pubmed publisher
	Du X, Xin R, Chen X, Wang G, Huang C, Zhou K, et al. TAF15 regulates the BRD4/GREM1 axis and activates the gremlin-1-NF-κB pathway to promote OA progression. Regen Ther. 2023;24:227-236 pubmed publisher
	Wang Y, Lin W, Wu F, Luo C. Unveiling the transcriptomic landscape and the potential antagonist feedback mechanisms of TGF-β superfamily signaling module in bone and osteoporosis. Cell Commun Signal. 2022;20:190 pubmed publisher
	Vasquez E, Nasreddin N, Valbuena G, Mulholland E, Belnoue Davis H, Eggington H, et al. Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia. Cell Stem Cell. 2022;29:1213-1228.e8 pubmed publisher
	Yang Y, Zeng Q, Zou M, Zeng J, Nie J, Chen D, et al. Targeting Gremlin 1 Prevents Intestinal Fibrosis Progression by Inhibiting the Fatty Acid Oxidation of Fibroblast Cells. Front Pharmacol. 2021;12:663774 pubmed publisher
	Hong S, Yang M, Cho H, Park I, Bae H, Choe K, et al. Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi. Nat Commun. 2020;11:4102 pubmed publisher
	Meng L, Teng X, Liu Y, Yang C, Wang S, Yuan W, et al. Vital Roles of Gremlin-1 in Pulmonary Arterial Hypertension Induced by Systemic-to-Pulmonary Shunts. J Am Heart Assoc. 2020;9:e016586 pubmed publisher
	Dutton L, Hoare O, McCorry A, Redmond K, Adam N, Canamara S, et al. Fibroblast-derived Gremlin1 localises to epithelial cells at the base of the intestinal crypt. Oncotarget. 2019;10:4630-4639 pubmed publisher
	Chang S, Mori D, Kobayashi H, Mori Y, Nakamoto H, Okada K, et al. Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway. Nat Commun. 2019;10:1442 pubmed publisher
	Gamer L, Pregizer S, Gamer J, Feigenson M, Ionescu A, Li Q, et al. The Role of Bmp2 in the Maturation and Maintenance of the Murine Knee Joint. J Bone Miner Res. 2018;33:1708-1717 pubmed publisher
	Damioli V, Salvadori A, Beretta G, Ravelli C, Mitola S. Multi-physics interactions drive VEGFR2 relocation on endothelial cells. Sci Rep. 2017;7:16700 pubmed publisher

product information

master code :

AF956

SKU :

AF956

product name :

Human/Mouse Gremlin Antibody

unit size :

100 ug (also 25 ug)

description :

The Human/Mouse Gremlin Antibody from R&D Systems is a goat polyclonal antibody to Gremlin 1. This antibody reacts with bovine,human,mouse,rat,transgenic mouse. The Human/Mouse Gremlin Antibody has been validated for the following applications: Immunohistochemistry,Western Blot,Neutralization,Functional Assay,Immunohistochemistry-Paraffin,Immunocytochemistry,Blockade of Receptor-ligand Interaction.

target :

Gremlin

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse Gremlin, Lys25-Asp184, Accession # O70326

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Bovine,Human,Mouse,Rat,Transgenic Mouse

specificity :

Detects human and mouse Gremlin in direct ELISAs.

gene symbol :

GREM1

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Gremlin antibody in Human Breast Cancer Tissue by Immunohistochemistry (IHC-P).

accessionNumbers :

O70326

applications :

Immunohistochemistry,Western Blot,Neutralization,Functional Assay,Immunohistochemistry-Paraffin,Immunocytochemistry,Blockade of Receptor-ligand Interaction

USD :

509 USD

alt names :

Cell proliferation-inducing gene 2 protein, CKTSF1B1gremlin 1, cysteine knot superfamily, homolog, Cysteine knot superfamily 1, BMP antagonist 1gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis), DAN domain family member 2, DAND2, DAND2GREMLIN, Down-regulated in Mos-transformed cells protein, DRM, DRMMGC126660, GREM1, gremlin, gremlin 1, gremlin 1-like protein, gremlin-1, IHG-2, Increased in high glucose protein 2, increased in high glucose-2, proliferation-inducing gene 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage