Human Cathepsin L Antibody | R&D Systems AF952 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Cathepsin L Antibody

catalog :

AF952

quantity :

100 ug (also 25 ug)

price :

509 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 18

Reference
Drobny A, Boros F, Balta D, Prieto Huarcaya S, Caylioglu D, Qazi N, et al. Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy models. Transl Neurodegener. 2023;12:31 pubmed publisher
Shah H, Stankov M, Panayotova Dimitrova D, Yazdi A, Budida R, Klusmann J, et al. Autolysosomal activation combined with lysosomal destabilization efficiently targets myeloid leukemia cells for cell death. Front Oncol. 2023;13:999738 pubmed publisher
Chan K, Farias A, Lee H, Guvenc F, Mero P, Brown K, et al. Survival-based CRISPR genetic screens across a panel of permissive cell lines identify common and cell-specific SARS-CoV-2 host factors. Heliyon. 2022;:e12744 pubmed publisher
Willett B, Grove J, MacLean O, Wilkie C, De Lorenzo G, Furnon W, et al. SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nat Microbiol. 2022;: pubmed publisher
Barral D, Staiano L, Guimas Almeida C, Cutler D, Eden E, Futter C, et al. Current methods to analyze lysosome morphology, positioning, motility and function. Traffic. 2022;23:238-269 pubmed publisher
Luke C, Markovina S, Good M, Wight I, Thomas B, Linneman J, et al. Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins. Commun Biol. 2022;5:47 pubmed publisher
Saidi A, Gaboriaud P, Lalmanach A, Vanderlynden L, Fessard A, Vettori P, et al. Upregulation of gut cathepsin L during Eimeria tenella infection. Res Vet Sci. 2021;140:109-116 pubmed publisher
Liu L, Doray B. Elevated mRNA expression and defective processing of cathepsin D in HeLa cells lacking the mannose 6-phosphate pathway. FEBS Open Bio. 2021;11:1695-1703 pubmed publisher
Benedetti L. Optogenetic Tools for Manipulating Protein Subcellular Localization and Intracellular Signaling at Organelle Contact Sites. Curr Protoc. 2021;1:e71 pubmed publisher
Mellott D, TSENG C, Drelich A, Fajtov xe1 P, Chenna B, Kostomiris D, et al. A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells. bioRxiv. 2020;: pubmed publisher
Oelschlaegel D, Weiss Sadan T, Salpeter S, Krug S, Blum G, Schmitz W, et al. Cathepsin Inhibition Modulates Metabolism and Polarization of Tumor-Associated Macrophages. Cancers (Basel). 2020;12: pubmed publisher
Wang K, Zhan Y, Chen B, Lu Y, Yin T, Zhou S, et al. Tubeimoside I-induced lung cancer cell death and the underlying crosstalk between lysosomes and mitochondria. Cell Death Dis. 2020;11:708 pubmed publisher
Kobylarz M, Goodwin J, Kang Z, Annand J, Hevi S, O Mahony E, et al. An iron-dependent metabolic vulnerability underlies VPS34-dependence in RKO cancer cells. PLoS ONE. 2020;15:e0235551 pubmed publisher
Kakimoto Y, Sasaki A, Niioka M, Kawabe N, Osawa M. Myocardial cathepsin D is downregulated in sudden cardiac death. PLoS ONE. 2020;15:e0230375 pubmed publisher
Flint M, Chatterjee P, Lin D, McMullan L, Shrivastava Ranjan P, Bergeron E, et al. A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus. Nat Commun. 2019;10:285 pubmed publisher
Lee C, Stankowski J, Chew J, Cook C, Lam Y, Almeida S, et al. The lysosomal protein cathepsin L is a progranulin protease. Mol Neurodegener. 2017;12:55 pubmed publisher
Bailleul G, Kravtzoff A, Joulin Giet A, Lecaille F, Labas V, Meudal H, et al. The Unusual Resistance of Avian Defensin AvBD7 to Proteolytic Enzymes Preserves Its Antibacterial Activity. PLoS ONE. 2016;11:e0161573 pubmed publisher
Hamon Y, Legowska M, HervÃ© V, Dallet Choisy S, Marchand Adam S, Vanderlynden L, et al. Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases. J Biol Chem. 2016;291:8486-99 pubmed publisher

product information

brand :

R&D Systems

master code :

AF952

SKU :

AF952

product name :

Human Cathepsin L Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human Cathepsin L Antibody from R&D Systems is a goat polyclonal antibody to Cathepsin L. This antibody reacts with avian - chicken,human,xenograft. The Human Cathepsin L Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry,Immunoprecipitation,ELISA Capture (Matched Antibody Pair).

target :

Cathepsin L

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 0.1 ug/mL, Immunohistochemistry 5-15 ug/mL, Immunoprecipitation 25 ug/mL, ELISA Capture (Matched Antibody Pair) 0.2-0.8 ug/mL

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant human Cathepsin L, Glu113-Val333, Accession # P07711

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Avian - Chicken,Human

specificity :

Detects human Cathepsin L in ELISAs and Western blots.

gene symbol :

CTSL1

top caption :

Detection of Recombinant Human Cathepsin L antibody by Western Blot.

accessionNumbers :

P07711

applications :

Immunoprecipitation,ELISA Capture (Matched Antibody Pair),Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunocytochemistry

USD :

509 USD

alt names :

cathepsin L, cathepsin L1, CATL, CTSL, CTSL1, CTSLEC 3.4.22.15, EC 3.4.22, FLJ31037, Major excreted protein, MEP

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage