product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human VE-Cadherin Antibody
catalog :
AF938
quantity :
100 ug (also 25 ug)
price :
559 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse, bovine, zebrafish
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section
more info or order :
citations: 54
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; 1:100; loading ...
Tacconi C, He Y, Ducoli L, Detmar M. Epigenetic regulation of the lineage specificity of primary human dermal lymphatic and blood vascular endothelial cells. Angiogenesis. 2020;: pubmed publisher
  • immunocytochemistry; human; 1:70; loading ...; fig 6c
Luxan G, Stewen J, Díaz N, Kato K, Maney S, Aravamudhan A, et al. Endothelial EphB4 maintains vascular integrity and transport function in adult heart. elife. 2019;8: pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig s1b
Ruan J, Hirai H, Yang D, Ma L, Hou X, Jiang H, et al. Efficient Gene Editing at Major CFTR Mutation Loci. Mol Ther Nucleic Acids. 2019;16:73-81 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:100; loading ...; fig s2e
  • immunocytochemistry; human; 1:100; loading ...; fig 2g
Sahara M, Santoro F, Sohlmér J, Zhou C, Witman N, Leung C, et al. Population and Single-Cell Analysis of Human Cardiogenesis Reveals Unique LGR5 Ventricular Progenitors in Embryonic Outflow Tract. Dev Cell. 2019;48:475-490.e7 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 1c
Gomi K, Tang Y, Arbelaez V, Crystal R, Walters M. Endothelial Cell Mediated Promotion of Ciliated Cell Differentiation of Human Airway Basal Cells via Insulin and Insulin-Like Growth Factor 1 Receptor Mediated Signaling. Stem Cell Rev. 2017;13:309-317 pubmed publisher
Johnson D, Colijn S, Richee J, Yano J, Burns M, Davis A, et al. Regulation of angiogenesis by endocytic trafficking mediated by cytoplasmic dynein 1 light intermediate chain 1. bioRxiv. 2024;: pubmed publisher
Essebier P, Keyser M, Yordanov T, Hill B, Yu A, Noordstra I, et al. c-Src-induced vascular malformations require localised matrix degradation at focal adhesions. J Cell Sci. 2024;137: pubmed publisher
Tian S, Ge J, Song Y, Yu X, Chen W, Chen Y, et al. A novel efficient strategy to generate liver sinusoidal endothelial cells from human pluripotent stem cells. Sci Rep. 2024;14:13831 pubmed publisher
El Bakkouri Y, Chidiac R, Delisle C, Corriveau J, Cagnone G, Gaonac h Lovejoy V, et al. ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis. Nat Commun. 2024;15:4405 pubmed publisher
Goeckel M, Lee J, Levitas A, Colijn S, Mun G, Burton Z, et al. CXCR3-CXCL11 signaling restricts angiogenesis and promotes pericyte recruitment. bioRxiv. 2023;: pubmed publisher
Stanton A, Bubnys A, Agbas E, James B, Park D, Jiang A, et al. Engineered 3D Immuno-Glial-Neurovascular Human Brain Model. bioRxiv. 2023;: pubmed publisher
Richards A, Khalil A, Friesen M, Whitfield T, Lungjangwa T, Gehrke L, et al. SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection. bioRxiv. 2023;: pubmed publisher
Choudhury A, Cady M, Lucas C, Najem H, Phillips J, Palikuqi B, et al. NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy. bioRxiv. 2023;: pubmed publisher
Kho J, Polak U, Jiang M, Odom J, Hunter J, Ali S, et al. Argininosuccinate lyase deficiency causes blood-brain barrier disruption via nitric oxide-mediated dysregulation of claudin expression. JCI Insight. 2023;8: pubmed publisher
Hong S, Ashby J, Kennelly J, Wu M, Chattopadhyay E, Foreman R, et al. Polarized Mechanosensitive Signaling Domains Protect Arterial Endothelial Cells Against Inflammation. bioRxiv. 2023;: pubmed publisher
Bosseboeuf E, Chikh A, Chaker A, Mitchell T, Vignaraja D, Rajendrakumar R, et al. Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow. Sci Signal. 2023;16:eabo4863 pubmed publisher
Acharya B, Fang J, Jeffery E, Chavkin N, Genet G, Vasavada H, et al. Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest. Life Sci Alliance. 2023;6: pubmed publisher
Bauer L, Rijsbergen L, Leijten L, Benavides F, Noack D, Lamers M, et al. The pro-inflammatory response to influenza A virus infection is fueled by endothelial cells. Life Sci Alliance. 2023;6: pubmed publisher
Liu M, Samant S, Vasa C, Pedrigi R, Oguz U, Ryu S, et al. Co-culture models of endothelial cells, macrophages, and vascular smooth muscle cells for the study of the natural history of atherosclerosis. PLoS ONE. 2023;18:e0280385 pubmed publisher
Gómez Salinero J, Itkin T, Houghton S, Badwe C, Lin Y, Kalna V, et al. Cooperative ETS Transcription Factors Enforce Adult Endothelial Cell Fate and Cardiovascular Homeostasis. Nat Cardiovasc Res. 2022;1:882-899 pubmed publisher
Ma B, Li T, Li W, Yang H, Zeng Q, Pan Z, et al. Patient-specific and gene-corrected induced pluripotent stem cell-derived endothelial cells elucidate single-cell phenotype of pulmonary veno-occlusive disease. Stem Cell Reports. 2022;17:2674-2689 pubmed publisher
Kim H, Leng K, Park J, Sorets A, Kim S, Shostak A, et al. Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin. Nat Commun. 2022;13:6581 pubmed publisher
Martins L, Brambilla I, Motta A, de Pretis S, Bhat G, Badaloni A, et al. Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity. Neuron. 2022;110:4090-4107.e11 pubmed publisher
SCHROEDER A, Nielsen T, Lynott M, Vogler G, Colas A, Bodmer R. Nascent polypeptide-Associated Complex and Signal Recognition Particle have cardiac-specific roles in heart development and remodeling. PLoS Genet. 2022;18:e1010448 pubmed publisher
Barbacena P, Dominguez Cejudo M, Fonseca C, G xf3 mez Gonz xe1 lez M, Faure L, Zarkada G, et al. Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina. Dev Cell. 2022;57:2321-2333.e9 pubmed publisher
Kuo A, Checa A, Niaudet C, Jung B, Fu Z, Wheelock C, et al. Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis. elife. 2022;11: pubmed publisher
Abello J, Raghavan S, Yien Y, Stratman A. Peristaltic pumps adapted for laminar flow experiments enhance in vitro modeling of vascular cell behavior. J Biol Chem. 2022;298:102404 pubmed publisher
Steffes L, Cheng P, Quertermous T, KUMAR M. von Willebrand Factor Is Produced Exclusively by Endothelium, Not Neointima, in Occlusive Vascular Lesions in Both Pulmonary Hypertension and Atherosclerosis. Circulation. 2022;146:429-431 pubmed publisher
G xf3 mez Salinero J, Izzo F, Lin Y, Houghton S, Itkin T, Geng F, et al. Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction. Cell Stem Cell. 2022;29:593-609.e7 pubmed publisher
Williams L, Fujimoto T, Weaver R, Logsdon A, Evitts K, Young J, et al. Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer's brain milieu. Fluids Barriers CNS. 2022;19:10 pubmed publisher
Facchinello N, Astone M, Audano M, Oberkersch R, Spizzotin M, Calura E, et al. Oxidative pentose phosphate pathway controls vascular mural cell coverage by regulating extracellular matrix composition. Nat Metab. 2022;4:123-140 pubmed publisher
Rosa A, Giese W, Meier K, Alt S, Klaus Bergmann A, Edgar L, et al. WASp controls oriented migration of endothelial cells to achieve functional vascular patterning. Development. 2022;149: pubmed publisher
Barak T, Ristori E, Ercan Sencicek A, Miyagishima D, Nelson Williams C, Dong W, et al. PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans. Nat Med. 2021;27:2165-2175 pubmed publisher
Le H, Liu C, Denaro P, Jousma J, Shao N, Rahman I, et al. Genome-wide differential expression profiling of lncRNAs and mRNAs in human induced pluripotent stem cell-derived endothelial cells exposed to e-cigarette extract. Stem Cell Res Ther. 2021;12:593 pubmed publisher
DeBari M, Ng W, Griffin M, Kokai L, Marra K, Rubin J, et al. Engineering a 3D Vascularized Adipose Tissue Construct Using a Decellularized Lung Matrix. Biomimetics (Basel). 2021;6: pubmed publisher
Saume A, Thiry M, Defourny J. LDLR expression in the cochlea suggests a role in endolymph homeostasis and cochlear amplification. Hear Res. 2021;409:108311 pubmed publisher
Gete Y, Koblan L, Mao X, Trappio M, Mahadik B, Fisher J, et al. Mechanisms of angiogenic incompetence in Hutchinson-Gilford progeria via downregulation of endothelial NOS. Aging Cell. 2021;20:e13388 pubmed publisher
Ziogas A, Sajib M, Lim J, Alves T, Das A, Witt A, et al. Glycolysis is integral to histamine-induced endothelial hyperpermeability. FASEB J. 2021;35:e21425 pubmed publisher
Mora P, Hollier P, Guimbal S, Abelanet A, Diop A, Cornuault L, et al. Blood-brain barrier genetic disruption leads to protective barrier formation at the Glia Limitans. PLoS Biol. 2020;18:e3000946 pubmed publisher
Propson N, Roy E, Litvinchuk A, Köhl J, Zheng H. Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging. J Clin Invest. 2021;131: pubmed publisher
Ohmes J, Xiao Y, Wang F, Mikkelsen M, Nguyen T, Schmidt H, et al. Effect of Enzymatically Extracted Fucoidans on Angiogenesis and Osteogenesis in Primary Cell Culture Systems Mimicking Bone Tissue Environment. Mar Drugs. 2020;18: pubmed publisher
Blanchard J, Bula M, Davila Velderrain J, Akay L, Zhu L, Frank A, et al. Reconstruction of the human blood-brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes. Nat Med. 2020;26:952-963 pubmed publisher
Brown J, Faley S, Shi Y, Hillgren K, Sawada G, Baker T, et al. Advances in blood-brain barrier modeling in microphysiological systems highlight critical differences in opioid transport due to cortisol exposure. Fluids Barriers CNS. 2020;17:38 pubmed publisher
Roudnicky F, Kim B, Lan Y, Schmucki R, Küppers V, Christensen K, et al. Identification of a combination of transcription factors that synergistically increases endothelial cell barrier resistance. Sci Rep. 2020;10:3886 pubmed publisher
Coleman P, Lay A, Ting K, Zhao Y, Li J, Jarrah S, et al. YAP and the RhoC regulator ARHGAP18, are required to mediate flow-dependent endothelial cell alignment. Cell Commun Signal. 2020;18:18 pubmed publisher
Carvalho J, Fortunato I, Fonseca C, Pezzarossa A, Barbacena P, Domínguez Cejudo M, et al. Non-canonical Wnt signaling regulates junctional mechanocoupling during angiogenic collective cell migration. elife. 2019;8: pubmed publisher
Brahmer A, Neuberger E, Esch Heisser L, Haller N, Jorgensen M, Baek R, et al. Platelets, endothelial cells and leukocytes contribute to the exercise-triggered release of extracellular vesicles into the circulation. J Extracell Vesicles. 2019;8:1615820 pubmed publisher
Kaushik G, Gil D, Torr E, Berge E, Soref C, Uhl P, et al. Quantitative Label-Free Imaging of 3D Vascular Networks Self-Assembled in Synthetic Hydrogels. Adv Healthc Mater. 2019;8:e1801186 pubmed publisher
Riddell M, Nakayama A, Hikita T, Mirzapourshafiyi F, Kawamura T, Pasha A, et al. aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability. Nat Commun. 2018;9:5357 pubmed publisher
Nonomura K, Lukacs V, Sweet D, Goddard L, Kanie A, Whitwam T, et al. Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation. Proc Natl Acad Sci U S A. 2018;115:12817-12822 pubmed publisher
Kho J, Tian X, Wong W, Bertin T, Jiang M, Chen S, et al. Argininosuccinate Lyase Deficiency Causes an Endothelial-Dependent Form of Hypertension. Am J Hum Genet. 2018;103:276-287 pubmed publisher
Cunningham T, YU M, McKeithan W, Spiering S, Carrette F, Huang C, et al. Id genes are essential for early heart formation. Genes Dev. 2017;31:1325-1338 pubmed publisher
Xu J, Liang J, Meng Y, Yan J, Yu X, Liu C, et al. Vascular CXCR4 Expression Promotes Vessel Sprouting and Sensitivity to Sorafenib Treatment in Hepatocellular Carcinoma. Clin Cancer Res. 2017;23:4482-4492 pubmed publisher
Klein S, Dieterich L, Mathelier A, Chong C, Sliwa Primorac A, Hong Y, et al. DeepCAGE transcriptomics identify HOXD10 as a transcription factor regulating lymphatic endothelial responses to VEGF-C. J Cell Sci. 2016;129:2573-85 pubmed publisher
product information
master code :
AF938
SKU :
AF938
product name :
Human VE-Cadherin Antibody
unit size :
100 ug (also 25 ug)
description :
The Human VE-Cadherin Antibody from R&D Systems is a goat polyclonal antibody to VE-Cadherin. This antibody reacts with bovine,human,mouse,zebrafish,fish - danio rerio (zebrafish). The Human VE-Cadherin Antibody has been validated for the following applications: Immunocytochemistry,ELISA Capture,Immunohistochemistry,Western Blot,IF/ICC,Westen Blot,Flow Cytometry,Immunohistochemistry-Frozen,RNAscope compatible,Immunocytochemistry/ Immunofluorescence,Simple Western,CyTOF-ready.
target :
VE-Cadherin
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant human VE-Cadherin, Asp48-Gln593, Accession # P33151
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Bovine,Human,Mouse,Zebrafish,Fish - Danio rerio (Zebrafish)
specificity :
Detects human VE-Cadherin in direct ELISAs and Western blots. In direct ELISAs, approximately 10% cross-reactivity with recombinant mouse VE-Cadherin is observed and less than 5% cross-reactivity with recombinant human E-Cadherin is observed.
gene symbol :
CDH5
top caption :
Detection of Human VE-Cadherin antibody by Western Blot.
accessionNumbers :
P33151
applications :
Immunocytochemistry,Immunohistochemistry,Western Blot,IF/ICC,Westen Blot,Flow Cytometry,Immunohistochemistry-Frozen,RNAscope compatible,Immunocytochemistry/ Immunofluorescence,Simple Western,CyTOF-ready
USD :
559 USD
alt names :
7B4, 7B4 antigen, cadherin 5, type 2 (vascular endothelium), cadherin 5, type 2, VE-cadherin (vascular epithelium), cadherin-5, CD144, CD144 antigen, CDH5, endothelial-specific cadherin, FLJ17376, Vascular endothelial cadherin, VE-cadherin, VECadherin
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.