Human/Mouse/Rat Cathepsin X/Z/P Antibody | R&D Systems AF934 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Mouse/Rat Cathepsin X/Z/P Antibody

catalog :

AF934

quantity :

100 ug (also 25 ug)

price :

469 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 8

Reference
Calcagnì A, Staiano L, Zampelli N, Minopoli N, Herz N, Di Tullio G, et al. Loss of the batten disease protein CLN3 leads to mis-trafficking of M6PR and defective autophagic-lysosomal reformation. Nat Commun. 2023;14:3911 pubmed publisher
Hertel A, Alves L, Dutz H, Tascher G, Bonn F, Kaulich M, et al. USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction. Cell Rep. 2022;41:111653 pubmed publisher
Pi x161 lar A, Nedeljkovi x107 B, Peri x107 M, Jako x161 T, Zidar N, Kos J. Cysteine Peptidase Cathepsin X as a Therapeutic Target for Simultaneous TLR3/4-mediated Microglia Activation. Mol Neurobiol. 2022;59:2258-2276 pubmed publisher
Jako x161 T, Prunk M, Pi x161 lar A, Kos J. Cathepsin X Activity Does Not Affect NK-Target Cell Synapse but Is Rather Distributed to Cytotoxic Granules. Int J Mol Sci. 2021;22: pubmed publisher
Pi x161 lar A, Tratnjek L, Glavan G, Zidar N, x17d ivin M, Kos J. Neuroinflammation-Induced Upregulation of Glial Cathepsin X Expression and Activity in vivo. Front Mol Neurosci. 2020;13:575453 pubmed publisher
Davis O, Shin H, Lim C, Wu E, Kukurugya M, Maher C, et al. NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C. Dev Cell. 2021;56:260-276.e7 pubmed publisher
Aiba Y, Harada K, Ito M, Suematsu T, Aishima S, Hitomi Y, et al. Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis. Sci Rep. 2018;8:11808 pubmed publisher
Anja P, Anahid J, Janko K. Cysteine cathepsins: Their biological and molecular significance in cancer stem cells. Semin Cancer Biol. 2018;53:168-177 pubmed publisher

product information

brand :

R&D Systems

master code :

AF934

SKU :

AF934

product name :

Human/Mouse/Rat Cathepsin X/Z/P Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human/Mouse/Rat Cathepsin X/Z/P Antibody from R&D Systems is a goat polyclonal antibody to Cathepsin X/Z/P. This antibody reacts with human,mouse,rat,xenograft. The Human/Mouse/Rat Cathepsin X/Z/P Antibody has been validated for the following applications: Western Blot,ELISA Development,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,Immunoprecipitation,Simple Western.

target :

Cathepsin X/Z/P

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, Simple Western 5 ug/mL, Immunohistochemistry 3-15 ug/mL, Immunoprecipitation 25 ug/mL

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant human Cathepsin X/Z/P, Ala21-Val303 (Gly23Val, Ser48Thr), Accession # Q9UBR2

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Rat

specificity :

Detects human Cathepsin X/Z/P in direct ELISAs and Western blots.

gene symbol :

CTSZ

top caption :

Detection of Human, Mouse, and Rat Cathepsin X/Z/P antibody by Western Blot.

accessionNumbers :

Q9UBR2

applications :

Immunoprecipitation,Simple Western,ELISA Development,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry

USD :

469 USD

alt names :

Cathepsin P, Cathepsin Z, CTSX, CTSZ

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage