product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human/Mouse/Rat/Hamster ACE-2 Antibody
catalog :
AF933
quantity :
100 ug (also 25 ug)
price :
499 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat, rhesus macaque
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, FACS, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, blocking or activating experiments
more info or order :
citations: 264
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; human; loading ...; fig 3e
Shen X, Geng R, Li Q, Chen Y, Li S, Wang Q, et al. ACE2-independent infection of T lymphocytes by SARS-CoV-2. Signal Transduct Target Ther. 2022;7:83 pubmed publisher
  • immunohistochemistry; human; 1:100; loading ...; fig 3b
Beumer J, Geurts M, Lamers M, Puschhof J, Zhang J, van der Vaart J, et al. A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses. Nat Commun. 2021;12:5498 pubmed publisher
  • immunohistochemistry; human; 1:100; loading ...; fig 2a
Li H, Liu C, Hsu T, Lin J, Hsu J, Li A, et al. Upregulation of ACE2 and TMPRSS2 by particulate matter and idiopathic pulmonary fibrosis: a potential role in severe COVID-19. Part Fibre Toxicol. 2021;18:11 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:200; fig 4a
Andrews M, Mukhtar T, Eze U, Simoneau C, Perez Y, Mostajo Radji M, et al. Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes. bioRxiv. 2021;: pubmed publisher
  • flow cytometry; human; loading ...; fig s2
Chu H, Hu B, Huang X, Chai Y, Zhou D, Wang Y, et al. Host and viral determinants for efficient SARS-CoV-2 infection of the human lung. Nat Commun. 2021;12:134 pubmed publisher
  • flow cytometry; human; loading ...; fig 6a, 6f
  • immunocytochemistry; human; loading ...; fig 6h
Daniloski Z, Jordan T, Wessels H, Hoagland D, Kasela S, Legut M, et al. Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells. Cell. 2021;184:92-105.e16 pubmed publisher
Coria L, Rodriguez J, Demaria A, Bruno L, Medrano M, Castro C, et al. A Gamma-adapted subunit vaccine induces broadly neutralizing antibodies against SARS-CoV-2 variants and protects mice from infection. Nat Commun. 2024;15:997 pubmed publisher
Puray Chavez M, Lapak K, Jasuja R, Pan J, Xu J, Eschbach J, et al. A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models. bioRxiv. 2024;: pubmed publisher
Hou J, Wei Y, Zou J, Jaffery R, Sun L, Liang S, et al. Integrated multi-omics analyses identify anti-viral host factors and pathways controlling SARS-CoV-2 infection. Nat Commun. 2024;15:109 pubmed publisher
Khan I, Li S, Tao L, Wang C, Ye B, Li H, et al. Tubeimosides are pan-coronavirus and filovirus inhibitors that can block their fusion protein binding to Niemann-Pick C1. Nat Commun. 2024;15:162 pubmed publisher
Loi L, Yang C, Lin Y, Su Y, Juan Y, Chen Y, et al. Decoy peptides effectively inhibit the binding of SARS-CoV-2 to ACE2 on oral epithelial cells. Heliyon. 2023;9:e22614 pubmed publisher
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Burke B, Rocha S, Zhan S, Eckley M, Reasoner C, Addetia A, et al. Regulatory T cell-like response to SARS-CoV-2 in Jamaican fruit bats (Artibeus jamaicensis) transduced with human ACE2. PLoS Pathog. 2023;19:e1011728 pubmed publisher
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Mohammad S, Wang Y, Cordero J, Watson C, MOLESTINA R, Rashid S, et al. Development and validation of a rapid and easy-to-perform point-of-care lateral flow immunoassay (LFIA) for the detection of SARS-CoV-2 spike protein. Front Immunol. 2023;14:1111644 pubmed publisher
McQuaid C, Solorzano A, Dickerson I, Deane R. Uptake of severe acute respiratory syndrome coronavirus 2 spike protein mediated by angiotensin converting enzyme 2 and ganglioside in human cerebrovascular cells. Front Neurosci. 2023;17:1117845 pubmed publisher
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product information
brand :
R&D Systems
master code :
AF933
SKU :
AF933
product name :
Human/Mouse/Rat/Hamster ACE-2 Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human/Mouse/Rat/Hamster ACE-2 Antibody from R&D Systems is a goat polyclonal antibody to ACE-2. This antibody reacts with bat,civet,hamster,hamster - mesocricetus auratus (golden hamster),human,mink,mouse,primate,primate - cercopithecus aethiops (african green monkey),primate - chlorocebus aethiops (african green monkey),primate - chlorocebus pygerythrus (vervet monkey),primate - macaca mulatta (rhesus macaque),rat,transgenic mouse. The Human/Mouse/Rat/Hamster ACE-2 Antibody has been validated for the following applications: Flow Cytometry,Western Blot,Immunohistochemistry,Neutralization,Immunocytochemistry,FACS,Simple Western,Co-Immunoprecipitation,Control,ELISA Capture,ELISA Detection,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunoprecipitation,Blockade of Receptor-ligand Interaction.
target :
ACE-2
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 1 ug/mL, Simple Western 10 ug/mL, Flow Cytometry 0.25 ug/10^6 cells, Immunohistochemistry 3-15 ug/mL, Immunoprecipitation 25 ug/mL, Blockade of Receptor-ligand Interaction
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant human ACE-2, Gln18-Ser740, Accession # Q9BYF1
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Bat,Civet,Hamster,Hamster - Mesocricetus auratus (Golden Hamster),Human,Mink,Mouse,Primate,Primate - Cercopithecus aethiops (African Green Monkey),Primate - Chlorocebus aethiops (African Green Monkey),Primate - Chlorocebus pygerythrus (Vervet Monkey),Primate - Macaca mulatta (Rhesus Macaque),Rat,Transgenic Mouse
specificity :
Detects human ACE-2 in direct ELISAs. Detects human, mouse, and rat ACE-2 in Western blots. Detects Hamster ACE-2 in immunohistochemistry.
gene symbol :
ACE2
top caption :
Detection of Human, Mouse, and Rat ACE-2 antibody by Western Blot.
accessionNumbers :
Q9BYF1
applications :
Immunoprecipitation,Blockade of Receptor-ligand Interaction,Co-Immunoprecipitation,FACS,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Simple Western,Control,Neutralization,Immunocytochemistry,ELISA Capture,ELISA Detection
USD :
499 USD
alt names :
ACE2, ACEH, ACEHangiotensin I converting enzyme 2, ACE-related carboxypeptidase, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, angiotensin-converting enzyme 2, Angiotensin-converting enzyme homolog, DKFZp434A014, EC 3.4.17, EC 3.4.17.23, Metalloprotease MPROT15
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.