Human Mer Antibody | R&D Systems AF891 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Mer Antibody

catalog :

AF891

quantity :

100 ug (also 25 ug)

price :

549 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, neutralization, flow cytometry, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 12

Reference
Hayashi S, Craddock B, Miller W. Phosphorylation of Ack1 by the Receptor Tyrosine Kinase Mer. Kinases Phosphatases. 2023;1:167-180 pubmed publisher
Frey K, Goetze S, Rohrer L, von Eckardstein A, Wollscheid B. Decoding Functional High-Density Lipoprotein Particle Surfaceome Interactions. Int J Mol Sci. 2022;23: pubmed publisher
Jung H, Lee S, Lim S, Choi H, Choi Y, Kim M, et al. Anti-inflammatory clearance of amyloid-β by a chimeric Gas6 fusion protein. Nat Med. 2022;28:1802-1812 pubmed publisher
Wanke F, Gutbier S, Rümmelin A, Steinberg M, Hughes L, Koenen M, et al. Ligand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages. Cell Death Dis. 2021;12:538 pubmed publisher
Tutusaus A, de Gregorio E, Cucarull B, Cristóbal H, Aresté C, Graupera I, et al. A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target. Cell Mol Gastroenterol Hepatol. 2020;9:349-368 pubmed publisher
Brouillette R, Phillips E, Patel R, Mahauad Fernandez W, Moller Tank S, Rogers K, et al. TIM-1 Mediates Dystroglycan-Independent Entry of Lassa Virus. J Virol. 2018;92: pubmed publisher
Kumar A, Jovel J, López Orozco J, Limonta D, Airo A, Hou S, et al. Human Sertoli cells support high levels of Zika virus replication and persistence. Sci Rep. 2018;8:5477 pubmed publisher
Chua B, Ngo J, Situ K, Ramirez C, Nakano H, Morizono K. Protein S and Gas6 induce efferocytosis of HIV-1-infected cells. Virology. 2018;515:176-190 pubmed publisher
Dantas Barbosa C, Lesluyes T, Loarer F, Chibon F, Treilleux I, Coindre J, et al. Expression and role of TYRO3 and AXL as potential therapeutical targets in leiomyosarcoma. Br J Cancer. 2017;117:1787-1797 pubmed publisher
Cross S, Potter J, Aldo P, Kwon J, Pitruzzello M, Tong M, et al. Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation. J Immunol. 2017;199:2885-2895 pubmed publisher
Richard A, Shim B, Kwon Y, Zhang R, Otsuka Y, Schmitt K, et al. AXL-dependent infection of human fetal endothelial cells distinguishes Zika virus from other pathogenic flaviviruses. Proc Natl Acad Sci U S A. 2017;114:2024-2029 pubmed publisher
Cai B, Thorp E, Doran A, Subramanian M, Sansbury B, Lin C, et al. MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation. Proc Natl Acad Sci U S A. 2016;113:6526-31 pubmed publisher

product information

brand :

R&D Systems

master code :

AF891

SKU :

AF891

product name :

Human Mer Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human Mer Antibody from R&D Systems is a goat polyclonal antibody to Mer. This antibody reacts with human,mouse,n/a,primate. The Human Mer Antibody has been validated for the following applications: Flow Cytometry,Western Blot,Neutralization,Cell Culture,Immunohistochemistry,Immunohistochemistry-Frozen,CyTOF-ready,Knockout Validated.

target :

Mer

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, Flow Cytometry 0.25 ug/10^6 cells, CyTOF-ready, Knockout Validated

host :

Goat

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Mer, Arg26-Ala499, Accession # Q12866

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,N/A,Primate

specificity :

Detects human Mer in direct ELISAs and Western blots. In direct ELISAs, approximately 20% cross-reactivity with recombinant mouse Mer and less than 1% cross-reactivity with recombinant human (rh) Axl and rhDtk is observed.

gene symbol :

MERTK

Antibody validation :

Knockout/Knockdown

top caption :

Detection of Human Mer antibody by Western Blot.

accessionNumbers :

Q12866

applications :

CyTOF-ready,Knockout Validated,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Frozen,Neutralization,Cell Culture

USD :

549 USD

alt names :

c-Eyk, C-mer, c-mer proto-oncogene tyrosine kinase, EC 2.7.10, EC 2.7.10.1, MER, MER receptor tyrosine kinase, MerTK, MGC133349, Receptor tyrosine kinase MerTK, RP38Proto-oncogene c-Mer, STK kinase, tyrosine-protein kinase Mer

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage