product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human Survivin Antibody
catalog :
AF886
quantity :
100 ug (also 25 ug)
price :
409 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
more info or order :
citations: 31
Reference
Lin I, Lin Y, Chang Y, Kondapuram S, Lin K, Chen P, et al. The SMAC mimetic GDC-0152 is a direct ABCB1-ATPase activity modulator and BIRC5 expression suppressor in cancer cells. Toxicol Appl Pharmacol. 2024;485:116888 pubmed publisher
Delgado A, Griera R, Llor N, L xf3 pez Aguilar E, Busquets M, No xe9 V, et al. Trioleyl Pyridinium, a Cationic Transfection Agent for the Lipofection of Therapeutic Oligonucleotides into Mammalian Cells. Pharmaceutics. 2023;15: pubmed publisher
Carrasco N, Garrido M, Montenegro I, Madrid A, Hartley R, Gonz xe1 lez I, et al. Antitumoral Activity of Leptocarpha rivularis Flower Extracts against Gastric Cancer Cells. Int J Mol Sci. 2023;24: pubmed publisher
Woo S, Kim S, Seo S, Kim S, Park J, Kim G, et al. Inhibition of USP1 enhances anticancer drugs-induced cancer cell death through downregulation of survivin and miR-216a-5p-mediated upregulation of DR5. Cell Death Dis. 2022;13:821 pubmed publisher
Danielpour D, Corum S, Leahy P, Bangalore A. Jagged-1 is induced by mTOR inhibitors in renal cancer cells through an Akt/ALK5/Smad4-dependent mechanism. Curr Res Pharmacol Drug Discov. 2022;3:100117 pubmed publisher
Chang Y, Shieh M, Chang Y, Huang W, Su W, Cheng F, et al. Development of a cancer cells self‑activating and miR‑125a‑5p expressing poly‑pharmacological nanodrug for cancer treatment. Int J Mol Med. 2022;50: pubmed publisher
Mohammadhosseinpour S, Ho L, Fang L, Xu J, Medina Bolivar F. Arachidin-1, a Prenylated Stilbenoid from Peanut, Induces Apoptosis in Triple-Negative Breast Cancer Cells. Int J Mol Sci. 2022;23: pubmed publisher
Danielpour D, Corum S, Welford S, Shankar E. Hypoxia represses early responses of prostate and renal cancer cells to YM155 independent of HIF-1α and HIF-2α. Curr Res Pharmacol Drug Discov. 2022;3:100076 pubmed publisher
Aubets E, Chillon M, Ciudad C, Noe V. PolyPurine Reverse Hoogsteen Hairpins Work as RNA Species for Gene Silencing. Int J Mol Sci. 2021;22: pubmed publisher
Hakim S, Abou Gabal H. Diagnostic Utility of BAP1, EZH2 and Survivin in Differentiating Pleural Epithelioid Mesothelioma and Reactive Mesothelial Hyperplasia: Immunohistochemical Study. Pathol Oncol Res. 2021;27:600073 pubmed publisher
Jugel W, Aigner A, Michen S, Hagstotz A, Ewe A, Appelhans D, et al. Targeted RNAi of BIRC5/Survivin Using Antibody-Conjugated Poly(Propylene Imine)-Based Polyplexes Inhibits Growth of PSCA-Positive Tumors. Pharmaceutics. 2021;13: pubmed publisher
Ren Y, Wang X, Huang S, Xu Y, Weng G, Yu R. Alternol Sensitizes Renal Carcinoma Cells to TRAIL-Induced Apoptosis. Front Pharmacol. 2021;12:560903 pubmed publisher
Güllülü Ö, Hehlgans S, Mayer B, Gößner I, Petraki C, Hoffmann M, et al. A Spatial and Functional Interaction of a Heterotetramer Survivin-DNA-PKcs Complex in DNA Damage Response. Cancer Res. 2021;81:2304-2317 pubmed publisher
Rodrigues Moita A, Bandolik J, Hansen F, Kurz T, Hamacher A, Kassack M. Priming with HDAC Inhibitors Sensitizes Ovarian Cancer Cells to Treatment with Cisplatin and HSP90 Inhibitors. Int J Mol Sci. 2020;21: pubmed publisher
Garrido M, Salvatierra R, Valenzuela Valderrama M, Vallejos C, Bruneau N, Hernandez A, et al. Metformin Reduces NGF-Induced Tumour Promoter Effects in Epithelial Ovarian Cancer Cells. Pharmaceuticals (Basel). 2020;13: pubmed publisher
Schweitzer K, Jinawath N, Yonescu R, Ni K, Rush N, Charoensawan V, et al. IGSF3 mutation identified in patient with severe COPD alters cell function and motility. JCI Insight. 2020;5: pubmed publisher
Lee Y, Song S, Hong H, Oh B, Lee W, Cho Y. The FBW7-MCL-1 axis is key in M1 and M2 macrophage-related colon cancer cell progression: validating the immunotherapeutic value of targeting PI3Kγ. Exp Mol Med. 2020;52:815-831 pubmed publisher
Nishisaka F, Taniguchi K, Tsugane M, Hirata G, Takagi A, Asakawa N, et al. Antitumor activity of a novel oral signal transducer and activator of transcription 3 inhibitor YHO-1701. Cancer Sci. 2020;111:1774-1784 pubmed publisher
Garrido M, Hurtado I, Valenzuela Valderrama M, Salvatierra R, Hernandez A, Vega M, et al. NGF-Enhanced Vasculogenic Properties of Epithelial Ovarian Cancer Cells Is Reduced by Inhibition of the COX-2/PGE2 Signaling Axis. Cancers (Basel). 2019;11: pubmed publisher
Lin T, Chan H, Chen S, Sarvagalla S, Chen P, Coumar M, et al. BIRC5/Survivin is a novel ATG12-ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast cells. Autophagy. 2019;:1-18 pubmed publisher
Fitzpatrick C, Bendek M, Briones M, Farfan N, Silva V, Nardocci G, et al. Mitochondrial ncRNA targeting induces cell cycle arrest and tumor growth inhibition of MDA-MB-231 breast cancer cells through reduction of key cell cycle progression factors. Cell Death Dis. 2019;10:423 pubmed publisher
Tsai S, Chang Y, Sarvagalla S, Wang S, Coumar M, Cheung C. Cloning, expression, and purification of the recombinant pro-apoptotic dominant-negative survivin T34A-C84A protein in Escherichia coli. Protein Expr Purif. 2019;160:73-83 pubmed publisher
Ahmed R, Shaughnessy D, Knutson T, Vogel R, Ahmed K, Kren B, et al. CDK11 Loss Induces Cell Cycle Dysfunction and Death of BRAF and NRAS Melanoma Cells. Pharmaceuticals (Basel). 2019;12: pubmed publisher
Linder B, Wehle A, Hehlgans S, Bonn F, Dikic I, Rodel F, et al. Arsenic Trioxide and (-)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling. Cancers (Basel). 2019;11: pubmed publisher
Hehlgans S, Booms P, Güllülü Ö, Sader R, Rodel C, Balermpas P, et al. Radiation Sensitization of Basal Cell and Head and Neck Squamous Cell Carcinoma by the Hedgehog Pathway Inhibitor Vismodegib. Int J Mol Sci. 2018;19: pubmed publisher
Jiang X, Mak P, Mu H, Tao W, Mak D, Kornblau S, et al. Disruption of Wnt/β-Catenin Exerts Antileukemia Activity and Synergizes with FLT3 Inhibition in FLT3-Mutant Acute Myeloid Leukemia. Clin Cancer Res. 2018;24:2417-2429 pubmed publisher
Conde M, Michen S, Wiedemuth R, Klink B, Schrock E, Schackert G, et al. Chromosomal instability induced by increased BIRC5/Survivin levels affects tumorigenicity of glioma cells. BMC Cancer. 2017;17:889 pubmed publisher
Reich T, Switzeny O, Renovanz M, Sommer C, Kaina B, Christmann M, et al. Epigenetic silencing of XAF1 in high-grade gliomas is associated with IDH1 status and improved clinical outcome. Oncotarget. 2017;8:15071-15084 pubmed publisher
Mędra A, Witkowska M, Majchrzak A, Cebula Obrzut B, Bonner M, Robak T, et al. Pro-Apoptotic Activity of New Honokiol/Triphenylmethane Analogues in B-Cell Lymphoid Malignancies. Molecules. 2016;21: pubmed publisher
Engel K, Rudelius M, Slawska J, Jacobs L, Ahangarian Abhari B, Altmann B, et al. USP9X stabilizes XIAP to regulate mitotic cell death and chemoresistance in aggressive B-cell lymphoma. EMBO Mol Med. 2016;8:851-62 pubmed publisher
Lin K, Cheng S, Tsai S, Tsai J, Lin C, Cheung C. Delivery of a survivin promoter-driven antisense survivin-expressing plasmid DNA as a cancer therapeutic: a proof-of-concept study. Onco Targets Ther. 2016;9:2601-13 pubmed publisher
product information
brand :
R&D Systems
master code :
AF886
SKU :
AF886
product name :
Human Survivin Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human Survivin Antibody from R&D Systems is a rabbit polyclonal antibody to Survivin. This antibody reacts with human,mouse. The Human Survivin Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,Affinity Chromatography,Flow Cytometry,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunocytochemistry,Simple Western.
target :
Survivin
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 0.5 ug/mL, Simple Western 5 ug/mL, Immunohistochemistry 3-15 ug/mL
host :
Rabbit
immunogen :
E. coli -derived recombinant human Survivin, aa 1-142
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse
specificity :
Detects human Survivin. This antibody also detects an unidentified ~51 kDa protein band.
gene symbol :
BIRC5
top caption :
Detection of Human Survivin antibody by Western Blot.
applications :
Simple Western,Affinity Chromatography,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunocytochemistry
USD :
409 USD
alt names :
API4, apoptosis inhibitor 4, Apoptosis inhibitor survivin, baculoviral IAP repeat-containing 5, Baculoviral IAP Repeat-Containing Protein 5, BIRC5, EPR-1, IAP4, survivin variant 3 alpha
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.