Published Application/Species/Sample/Dilution | Reference |
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- immunohistochemistry; human; 1:50; loading ...; fig 1a
| Huang Y, Happonen K, Burrola P, O Connor C, Hah N, Huang L, et al. Microglia use TAM receptors to detect and engulf amyloid β plaques. Nat Immunol. 2021;22:586-594 pubmed publisher
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- immunohistochemistry - frozen section; mouse; loading ...; fig 4a
| Safaiyan S, Besson Girard S, Kaya T, Cantuti Castelvetri L, Liu L, Ji H, et al. White matter aging drives microglial diversity. Neuron. 2021;109:1100-1117.e10 pubmed publisher
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| Tufan T, Cömertpay G, Villani A, Nelson G, Terekhova M, Kelley S, et al. Rapid unleashing of macrophage efferocytic capacity via transcriptional pause release. Nature. 2024;628:408-415 pubmed publisher
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| Nordb xf8 O, Landolt L, Eikrem x, Scherer A, Leh S, Furriol J, et al. Transcriptomic analysis reveals partial epithelial-mesenchymal transition and inflammation as common pathogenic mechanisms in hypertensive nephrosclerosis and Type 2 diabetic nephropathy. Physiol Rep. 2023;11:e15825 pubmed publisher
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| Di Carlo S, Raffenne J, Varet H, Ode A, Granados D, Stein M, et al. Depletion of slow-cycling PDGFRα+ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis. Nat Immunol. 2023;24:1867-1878 pubmed publisher
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| Gan S, Macalinao D, Shahoei S, Tian L, Jin X, Basnet H, et al. Distinct tumor architectures for metastatic colonization of the brain. bioRxiv. 2023;: pubmed publisher
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| Pop O, Geng A, Flint E, Singanayagam A, Ercan C, Possamai L, et al. AXL Expression on Homeostatic Resident Liver Macrophages Is Reduced in Cirrhosis Following GAS6 Production by Hepatic Stellate Cells. Cell Mol Gastroenterol Hepatol. 2023;16:17-37 pubmed publisher
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| van Lengerich B, Zhan L, Xia D, Chan D, Joy D, Park J, et al. A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models. Nat Neurosci. 2023;26:416-429 pubmed publisher
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| Hou J, Liang S, Xu C, Wei Y, Wang Y, Tan Y, et al. Single-cell CRISPR immune screens reveal immunological roles of tumor intrinsic factors. NAR Cancer. 2022;4:zcac038 pubmed publisher
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| Huang Y, Lemke G. Adaptable toolbox to characterize Alzheimer's disease pathology in mouse models. STAR Protoc. 2022;3:101891 pubmed publisher
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| Ko A, Hasanain M, Oh Y, D Angelo F, Sommer D, Frangaj B, et al. LZTR1 mutation mediates oncogenesis through stabilization of EGFR and AXL. Cancer Discov. 2022;: pubmed publisher
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| Shen Y, Zhu Q, Xiao M, Yin L, Feng W, Feng J, et al. Inhibitory effect of the novel tyrosine kinase inhibitor DCC-2036 on triple-negative breast cancer stem cells through AXL-KLF5 positive feedback loop. Cell Death Dis. 2022;13:749 pubmed publisher
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| Jung H, Lee S, Lim S, Choi H, Choi Y, Kim M, et al. Anti-inflammatory clearance of amyloid-β by a chimeric Gas6 fusion protein. Nat Med. 2022;28:1802-1812 pubmed publisher
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| Fane M, Chhabra Y, Alicea G, Maranto D, Douglass S, Webster M, et al. Stromal changes in the aged lung induce an emergence from melanoma dormancy. Nature. 2022;606:396-405 pubmed publisher
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| Roy E, Chiu G, Li S, Propson N, Kanchi R, Wang B, et al. Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques. Immunity. 2022;55:879-894.e6 pubmed publisher
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| Novoyatleva T, Rai N, Kojonazarov B, Veeroju S, Ben Batalla I, Caruso P, et al. Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2. Commun Biol. 2021;4:1002 pubmed publisher
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| Hohsfield L, Najafi A, Ghorbanian Y, Soni N, Crapser J, Figueroa Velez D, et al. Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave. elife. 2021;10: pubmed publisher
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| Tirado Gonzalez I, Descot A, Soetopo D, Nevmerzhitskaya A, Schaffer A, Kur I, et al. AXL Inhibition in Macrophages Stimulates Host-versus-Leukemia Immunity and Eradicates Naïve and Treatment-Resistant Leukemia. Cancer Discov. 2021;11:2924-2943 pubmed publisher
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| Wanke F, Gutbier S, Rümmelin A, Steinberg M, Hughes L, Koenen M, et al. Ligand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages. Cell Death Dis. 2021;12:538 pubmed publisher
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| Bosch Queralt M, Cantuti Castelvetri L, Damkou A, Schifferer M, Schlepckow K, Alexopoulos I, et al. Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination. Nat Metab. 2021;3:211-227 pubmed publisher
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| Chen C, Liu Y. MERTK Inhibition: Potential as a Treatment Strategy in EGFR Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer. Pharmaceuticals (Basel). 2021;14: pubmed publisher
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| Rosin J, Marsters C, Malik F, Far R, Adnani L, Schuurmans C, et al. Embryonic Microglia Interact with Hypothalamic Radial Glia during Development and Upregulate the TAM Receptors MERTK and AXL following an Insult. Cell Rep. 2021;34:108587 pubmed publisher
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| Madore C, Leyrolle Q, Morel L, Rossitto M, Greenhalgh A, Delpech J, et al. Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain. Nat Commun. 2020;11:6133 pubmed publisher
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| DuBois J, Ray A, Davies P, Shafit Zagardo B. Anti-Axl antibody treatment reduces the severity of experimental autoimmune encephalomyelitis. J Neuroinflammation. 2020;17:324 pubmed publisher
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| Konishi H, Okamoto T, Hara Y, Komine O, Tamada H, Maeda M, et al. Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction. EMBO J. 2020;39:e104464 pubmed publisher
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| Hohsfield L, Najafi A, Ghorbanian Y, Soni N, Hingco E, Kim S, et al. Effects of long-term and brain-wide colonization of peripheral bone marrow-derived myeloid cells in the CNS. J Neuroinflammation. 2020;17:279 pubmed publisher
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| King B, Araki J, Palm W, Thompson C. Yap/Taz promote the scavenging of extracellular nutrients through macropinocytosis. Genes Dev. 2020;34:1345-1358 pubmed publisher
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| Zag xf3 rska A, Trav xe9 s P, Jim xe9 nez Garc xed a L, Strickland J, Oh J, Tapia F, et al. Differential regulation of hepatic physiology and injury by the TAM receptors Axl and Mer. Life Sci Alliance. 2020;3: pubmed publisher
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| Eder N, Roncaroli F, Dolmart M, Horswell S, Andreiuolo F, Flynn H, et al. YAP1/TAZ drives ependymoma-like tumour formation in mice. Nat Commun. 2020;11:2380 pubmed publisher
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| Tutusaus A, de Gregorio E, Cucarull B, Cristóbal H, Aresté C, Graupera I, et al. A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target. Cell Mol Gastroenterol Hepatol. 2020;9:349-368 pubmed publisher
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| Dolan M, Mastri M, Tracz A, Christensen J, Chatta G, Ebos J. Enhanced efficacy of sitravatinib in metastatic models of antiangiogenic therapy resistance. PLoS ONE. 2019;14:e0220101 pubmed publisher
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| Fujino N, Brand O, Morgan D, Fujimori T, Grabiec A, Jagger C, et al. Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases. J Exp Med. 2019;216:2184-2201 pubmed publisher
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| Landolt L, Furriol J, Babickova J, Ahmed L, Eikrem x, Skogstrand T, et al. AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction. Physiol Rep. 2019;7:e14091 pubmed publisher
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| Cruz V, Arner E, Du W, Bremauntz A, Brekken R. Axl-mediated activation of TBK1 drives epithelial plasticity in pancreatic cancer. JCI Insight. 2019;5: pubmed publisher
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| Ayata P, Badimon A, Strasburger H, Duff M, Montgomery S, Loh Y, et al. Epigenetic regulation of brain region-specific microglia clearance activity. Nat Neurosci. 2018;21:1049-1060 pubmed publisher
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| Brosius Lutz A, Chung W, Sloan S, Carson G, Zhou L, Lovelett E, et al. Schwann cells use TAM receptor-mediated phagocytosis in addition to autophagy to clear myelin in a mouse model of nerve injury. Proc Natl Acad Sci U S A. 2017;114:E8072-E8080 pubmed publisher
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| Yanagihashi Y, Segawa K, Maeda R, Nabeshima Y, Nagata S. Mouse macrophages show different requirements for phosphatidylserine receptor Tim4 in efferocytosis. Proc Natl Acad Sci U S A. 2017;114:8800-8805 pubmed publisher
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| Kurowska Stolarska M, Alivernini S, Melchor E, Elmesmari A, Tolusso B, Tange C, et al. MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis. Nat Commun. 2017;8:15877 pubmed publisher
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| Voronova A, Yuzwa S, Wang B, Zahr S, Syal C, Wang J, et al. Migrating Interneurons Secrete Fractalkine to Promote Oligodendrocyte Formation in the Developing Mammalian Brain. Neuron. 2017;94:500-516.e9 pubmed publisher
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| Tufail Y, Cook D, Fourgeaud L, Powers C, Merten K, Clark C, et al. Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia. Neuron. 2017;93:574-586.e8 pubmed publisher
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| Zhen Y, Priest S, Shao W. Opposing Roles of Tyrosine Kinase Receptors Mer and Axl Determine Clinical Outcomes in Experimental Immune-Mediated Nephritis. J Immunol. 2016;197:2187-94 pubmed publisher
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| Fourgeaud L, Traves P, Tufail Y, Leal Bailey H, Lew E, Burrola P, et al. TAM receptors regulate multiple features of microglial physiology. Nature. 2016;532:240-244 pubmed publisher
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