product summary
Loading...
company name :
R&D Systems
product type :
antibody
product name :
Mouse Axl Antibody
catalog :
AF854
quantity :
100 ug (also 25 ug)
price :
519 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section
more info or order :
citations: 42
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; human; 1:50; loading ...; fig 1a
Huang Y, Happonen K, Burrola P, O Connor C, Hah N, Huang L, et al. Microglia use TAM receptors to detect and engulf amyloid β plaques. Nat Immunol. 2021;22:586-594 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 4a
Safaiyan S, Besson Girard S, Kaya T, Cantuti Castelvetri L, Liu L, Ji H, et al. White matter aging drives microglial diversity. Neuron. 2021;109:1100-1117.e10 pubmed publisher
Tufan T, Cömertpay G, Villani A, Nelson G, Terekhova M, Kelley S, et al. Rapid unleashing of macrophage efferocytic capacity via transcriptional pause release. Nature. 2024;628:408-415 pubmed publisher
Nordb xf8 O, Landolt L, Eikrem x, Scherer A, Leh S, Furriol J, et al. Transcriptomic analysis reveals partial epithelial-mesenchymal transition and inflammation as common pathogenic mechanisms in hypertensive nephrosclerosis and Type 2 diabetic nephropathy. Physiol Rep. 2023;11:e15825 pubmed publisher
Di Carlo S, Raffenne J, Varet H, Ode A, Granados D, Stein M, et al. Depletion of slow-cycling PDGFRα+ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis. Nat Immunol. 2023;24:1867-1878 pubmed publisher
Gan S, Macalinao D, Shahoei S, Tian L, Jin X, Basnet H, et al. Distinct tumor architectures for metastatic colonization of the brain. bioRxiv. 2023;: pubmed publisher
Pop O, Geng A, Flint E, Singanayagam A, Ercan C, Possamai L, et al. AXL Expression on Homeostatic Resident Liver Macrophages Is Reduced in Cirrhosis Following GAS6 Production by Hepatic Stellate Cells. Cell Mol Gastroenterol Hepatol. 2023;16:17-37 pubmed publisher
van Lengerich B, Zhan L, Xia D, Chan D, Joy D, Park J, et al. A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models. Nat Neurosci. 2023;26:416-429 pubmed publisher
Hou J, Liang S, Xu C, Wei Y, Wang Y, Tan Y, et al. Single-cell CRISPR immune screens reveal immunological roles of tumor intrinsic factors. NAR Cancer. 2022;4:zcac038 pubmed publisher
Huang Y, Lemke G. Adaptable toolbox to characterize Alzheimer's disease pathology in mouse models. STAR Protoc. 2022;3:101891 pubmed publisher
Ko A, Hasanain M, Oh Y, D Angelo F, Sommer D, Frangaj B, et al. LZTR1 mutation mediates oncogenesis through stabilization of EGFR and AXL. Cancer Discov. 2022;: pubmed publisher
Shen Y, Zhu Q, Xiao M, Yin L, Feng W, Feng J, et al. Inhibitory effect of the novel tyrosine kinase inhibitor DCC-2036 on triple-negative breast cancer stem cells through AXL-KLF5 positive feedback loop. Cell Death Dis. 2022;13:749 pubmed publisher
Jung H, Lee S, Lim S, Choi H, Choi Y, Kim M, et al. Anti-inflammatory clearance of amyloid-β by a chimeric Gas6 fusion protein. Nat Med. 2022;28:1802-1812 pubmed publisher
Fane M, Chhabra Y, Alicea G, Maranto D, Douglass S, Webster M, et al. Stromal changes in the aged lung induce an emergence from melanoma dormancy. Nature. 2022;606:396-405 pubmed publisher
Roy E, Chiu G, Li S, Propson N, Kanchi R, Wang B, et al. Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques. Immunity. 2022;55:879-894.e6 pubmed publisher
Novoyatleva T, Rai N, Kojonazarov B, Veeroju S, Ben Batalla I, Caruso P, et al. Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2. Commun Biol. 2021;4:1002 pubmed publisher
Hohsfield L, Najafi A, Ghorbanian Y, Soni N, Crapser J, Figueroa Velez D, et al. Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave. elife. 2021;10: pubmed publisher
Tirado Gonzalez I, Descot A, Soetopo D, Nevmerzhitskaya A, Schaffer A, Kur I, et al. AXL Inhibition in Macrophages Stimulates Host-versus-Leukemia Immunity and Eradicates Naïve and Treatment-Resistant Leukemia. Cancer Discov. 2021;11:2924-2943 pubmed publisher
Wanke F, Gutbier S, Rümmelin A, Steinberg M, Hughes L, Koenen M, et al. Ligand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages. Cell Death Dis. 2021;12:538 pubmed publisher
Bosch Queralt M, Cantuti Castelvetri L, Damkou A, Schifferer M, Schlepckow K, Alexopoulos I, et al. Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination. Nat Metab. 2021;3:211-227 pubmed publisher
Chen C, Liu Y. MERTK Inhibition: Potential as a Treatment Strategy in EGFR Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer. Pharmaceuticals (Basel). 2021;14: pubmed publisher
Rosin J, Marsters C, Malik F, Far R, Adnani L, Schuurmans C, et al. Embryonic Microglia Interact with Hypothalamic Radial Glia during Development and Upregulate the TAM Receptors MERTK and AXL following an Insult. Cell Rep. 2021;34:108587 pubmed publisher
Madore C, Leyrolle Q, Morel L, Rossitto M, Greenhalgh A, Delpech J, et al. Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain. Nat Commun. 2020;11:6133 pubmed publisher
DuBois J, Ray A, Davies P, Shafit Zagardo B. Anti-Axl antibody treatment reduces the severity of experimental autoimmune encephalomyelitis. J Neuroinflammation. 2020;17:324 pubmed publisher
Konishi H, Okamoto T, Hara Y, Komine O, Tamada H, Maeda M, et al. Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction. EMBO J. 2020;39:e104464 pubmed publisher
Hohsfield L, Najafi A, Ghorbanian Y, Soni N, Hingco E, Kim S, et al. Effects of long-term and brain-wide colonization of peripheral bone marrow-derived myeloid cells in the CNS. J Neuroinflammation. 2020;17:279 pubmed publisher
King B, Araki J, Palm W, Thompson C. Yap/Taz promote the scavenging of extracellular nutrients through macropinocytosis. Genes Dev. 2020;34:1345-1358 pubmed publisher
Zag xf3 rska A, Trav xe9 s P, Jim xe9 nez Garc xed a L, Strickland J, Oh J, Tapia F, et al. Differential regulation of hepatic physiology and injury by the TAM receptors Axl and Mer. Life Sci Alliance. 2020;3: pubmed publisher
Eder N, Roncaroli F, Dolmart M, Horswell S, Andreiuolo F, Flynn H, et al. YAP1/TAZ drives ependymoma-like tumour formation in mice. Nat Commun. 2020;11:2380 pubmed publisher
Tutusaus A, de Gregorio E, Cucarull B, Cristóbal H, Aresté C, Graupera I, et al. A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target. Cell Mol Gastroenterol Hepatol. 2020;9:349-368 pubmed publisher
Dolan M, Mastri M, Tracz A, Christensen J, Chatta G, Ebos J. Enhanced efficacy of sitravatinib in metastatic models of antiangiogenic therapy resistance. PLoS ONE. 2019;14:e0220101 pubmed publisher
Fujino N, Brand O, Morgan D, Fujimori T, Grabiec A, Jagger C, et al. Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases. J Exp Med. 2019;216:2184-2201 pubmed publisher
Landolt L, Furriol J, Babickova J, Ahmed L, Eikrem x, Skogstrand T, et al. AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction. Physiol Rep. 2019;7:e14091 pubmed publisher
Cruz V, Arner E, Du W, Bremauntz A, Brekken R. Axl-mediated activation of TBK1 drives epithelial plasticity in pancreatic cancer. JCI Insight. 2019;5: pubmed publisher
Ayata P, Badimon A, Strasburger H, Duff M, Montgomery S, Loh Y, et al. Epigenetic regulation of brain region-specific microglia clearance activity. Nat Neurosci. 2018;21:1049-1060 pubmed publisher
Brosius Lutz A, Chung W, Sloan S, Carson G, Zhou L, Lovelett E, et al. Schwann cells use TAM receptor-mediated phagocytosis in addition to autophagy to clear myelin in a mouse model of nerve injury. Proc Natl Acad Sci U S A. 2017;114:E8072-E8080 pubmed publisher
Yanagihashi Y, Segawa K, Maeda R, Nabeshima Y, Nagata S. Mouse macrophages show different requirements for phosphatidylserine receptor Tim4 in efferocytosis. Proc Natl Acad Sci U S A. 2017;114:8800-8805 pubmed publisher
Kurowska Stolarska M, Alivernini S, Melchor E, Elmesmari A, Tolusso B, Tange C, et al. MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis. Nat Commun. 2017;8:15877 pubmed publisher
Voronova A, Yuzwa S, Wang B, Zahr S, Syal C, Wang J, et al. Migrating Interneurons Secrete Fractalkine to Promote Oligodendrocyte Formation in the Developing Mammalian Brain. Neuron. 2017;94:500-516.e9 pubmed publisher
Tufail Y, Cook D, Fourgeaud L, Powers C, Merten K, Clark C, et al. Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia. Neuron. 2017;93:574-586.e8 pubmed publisher
Zhen Y, Priest S, Shao W. Opposing Roles of Tyrosine Kinase Receptors Mer and Axl Determine Clinical Outcomes in Experimental Immune-Mediated Nephritis. J Immunol. 2016;197:2187-94 pubmed publisher
Fourgeaud L, Traves P, Tufail Y, Leal Bailey H, Lew E, Burrola P, et al. TAM receptors regulate multiple features of microglial physiology. Nature. 2016;532:240-244 pubmed publisher
product information
brand :
R&D Systems
master code :
AF854
SKU :
AF854
product name :
Mouse Axl Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Mouse Axl Antibody from R&D Systems is a goat polyclonal antibody to Axl. This antibody reacts with human,mouse,transgenic mouse. The Mouse Axl Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,Functional Assay,Flow Cytometry,Immunoprecipitation,Neutralization,Cell Culture,Immunohistochemistry-Frozen,In vivo assay,Immunocytochemistry.
target :
Axl
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 0.1 ug/mL, Immunohistochemistry 3-15 ug/mL
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse Axl, His20-Pro443, Accession # Q80YQ3
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse,Transgenic Mouse
specificity :
Detects mouse Axl in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 10% cross-reactivity with recombinant human Axl is observed.
gene symbol :
AXL
top caption :
Axl antibody in Mouse Kidney by Immunohistochemistry (IHC-P).
accessionNumbers :
Q80YQ3
applications :
Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Frozen,In vivo assay,Neutralization,Immunocytochemistry,Functional Assay,Cell Culture
USD :
519 USD
alt names :
AI323647, ARK, AXL oncogene, AXL receptor tyrosine kinase, AXL transforming sequence/gene, EC 2.7.10, EC 2.7.10.1, JTK11, Tyro7, tyrosine-protein kinase receptor UFO, UFO, UFOoncogene AXL
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.