Human cIAP-1/HIAP-2 Antibody | R&D Systems AF8181 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human cIAP-1/HIAP-2 Antibody

catalog :

AF8181

quantity :

100 ug (also 25 ug)

price :

499 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, proximity ligation assay

more info or order :

R&D Systems product webpage

citations: 31

Reference
Tencer A, Yu Y, Causse S, Campbell G, Klein B, Xuan H, et al. Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2. Nat Struct Mol Biol. 2023;30:1265-1274 pubmed publisher
Orth He E, Huang H, Rao S, Wang Q, Chen Q, O Mara C, et al. Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation. Cell Rep. 2023;42:111965 pubmed publisher
Dum xe9 tier B, Zadoroznyj A, Berthelet J, Causse S, All xe8 gre J, Bourgeois P, et al. cIAP1/TRAF2 interplay promotes tumor growth through the activation of STAT3. Oncogene. 2023;42:198-208 pubmed publisher
Akizuki Y, Morita M, Mori Y, Kaiho Soma A, Dixit S, Endo A, et al. cIAP1-based degraders induce degradation via branched ubiquitin architectures. Nat Chem Biol. 2022;: pubmed publisher
Holmgren C, Sunstr xf6 m Th xf6 rnberg E, Granqvist V, Larsson C. Induction of Breast Cancer Cell Apoptosis by TRAIL and Smac Mimetics: Involvement of RIP1 and cFLIP. Curr Issues Mol Biol. 2022;44:4803-4821 pubmed publisher
Yin H, Karayel Ö, Chao Y, Seeholzer T, Hamp I, Plettenburg O, et al. A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells. Cell Mol Life Sci. 2022;79:112 pubmed publisher
Granqvist V, Holmgren C, Larsson C. Induction of interferon-β and interferon signaling by TRAIL and Smac mimetics via caspase-8 in breast cancer cells. PLoS ONE. 2021;16:e0248175 pubmed publisher
An Y, Jeon J, Sun L, Derakhshan A, Chen J, Carlson S, et al. Death agonist antibody against TRAILR2/DR5/TNFRSF10B enhances birinapant anti-tumor activity in HPV-positive head and neck squamous cell carcinomas. Sci Rep. 2021;11:6392 pubmed publisher
Liu Z, Nailwal H, Rector J, Rahman M, Sam R, McFadden G, et al. A class of viral inducer of degradation of the necroptosis adaptor RIPK3 regulates virus-induced inflammation. Immunity. 2021;54:247-258.e7 pubmed publisher
Pache L, Marsden M, Teriete P, Portillo A, Heimann D, Kim J, et al. Pharmacological Activation of Non-canonical NF-κB Signaling Activates Latent HIV-1 Reservoirs In Vivo. Cell Rep Med. 2020;1:100037 pubmed publisher
Muench D, Olsson A, Ferchen K, Pham G, Serafin R, Chutipongtanate S, et al. Mouse models of neutropenia reveal progenitor-stage-specific defects. Nature. 2020;582:109-114 pubmed publisher
Nixon C, Mavigner M, Sampey G, Brooks A, Spagnuolo R, Irlbeck D, et al. Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo. Nature. 2020;578:160-165 pubmed publisher
Dittmann J, Haydn T, Metzger P, Ward G, Boerries M, Vogler M, et al. Next-generation hypomethylating agent SGI-110 primes acute myeloid leukemia cells to IAP antagonist by activating extrinsic and intrinsic apoptosis pathways. Cell Death Differ. 2020;27:1878-1895 pubmed publisher
Lemos L, Longo G, Mendonça B, Robaina M, Brum M, Cirilo C, et al. The LQB-223 Compound Modulates Antiapoptotic Proteins and Impairs Breast Cancer Cell Growth and Migration. Int J Mol Sci. 2019;20: pubmed publisher
Xiao R, An Y, Ye W, Derakhshan A, Cheng H, Yang X, et al. Dual Antagonist of cIAP/XIAP ASTX660 Sensitizes HPV- and HPV+ Head and Neck Cancers to TNFα, TRAIL, and Radiation Therapy. Clin Cancer Res. 2019;25:6463-6474 pubmed publisher
Jeong Y, Lim J, Kim H. Lycopene Inhibits Reactive Oxygen Species-Mediated NF-κB Signaling and Induces Apoptosis in Pancreatic Cancer Cells. Nutrients. 2019;11: pubmed publisher
Lee S, Lee J, Lee E, Park S, Kang D, Min C, et al. Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-α-Induced Apoptosis via Different Routes. Cell Rep. 2019;26:2194-2211.e6 pubmed publisher
Ohoka N, Ujikawa O, Shimokawa K, Sameshima T, Shibata N, Hattori T, et al. Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER). Chem Pharm Bull (Tokyo). 2019;67:203-209 pubmed publisher
Allègre J, Cartier J, Glorian V, Droin N, Dumetier B, Kayaci C, et al. E2F1 binds to the peptide-binding groove within the BIR3 domain of cIAP1 and requires cIAP1 for chromatin binding. PLoS ONE. 2018;13:e0206253 pubmed publisher
Shibata N, Shimokawa K, Nagai K, Ohoka N, Hattori T, Miyamoto N, et al. Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase. Sci Rep. 2018;8:13549 pubmed publisher
Ward G, Lewis E, Ahn J, Johnson C, Lyons J, Martins V, et al. ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth. Mol Cancer Ther. 2018;17:1381-1391 pubmed publisher
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Shibata N, Miyamoto N, Nagai K, Shimokawa K, Sameshima T, Ohoka N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017;108:1657-1666 pubmed publisher
Glorian V, Allègre J, Berthelet J, Dumetier B, Boutanquoi P, Droin N, et al. DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues. Cell Death Dis. 2017;8:e2816 pubmed publisher
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product information

brand :

R&D Systems

master code :

AF8181

SKU :

AF8181

product name :

Human cIAP-1/HIAP-2 Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human cIAP-1/HIAP-2 Antibody from R&D Systems is a goat polyclonal antibody to cIAP-1/HIAP-2. This antibody reacts with feline,human,mouse. The Human cIAP-1/HIAP-2 Antibody has been validated for the following applications: Proximity Ligation Assay (PLA),Flow Cytometry,Immunoprecipitation,Western Blot,Immunohistochemistry,Immunocytochemistry,Simple Western,Knockout Validated.

target :

cIAP-1/HIAP-2

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 0.5 ug/mL, Simple Western 5 ug/mL, Immunohistochemistry 5-15 ug/mL, Knockout Validated

host :

Goat

immunogen :

E. coli -derived recombinant human cIAP-1/HIAP-2, His2-Ser618, Accession # Q13490

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Feline,Human,Mouse

specificity :

Detects human cIAP-1/HIAP-2. Does not cross-react with recombinant human cIAP-2 or XIAP.

gene symbol :

BIRC2

Antibody validation :

Knockout/Knockdown

top caption :

Detection of Human cIAP-1/HIAP-2 antibody by Western Blot.

accessionNumbers :

Q13490

applications :

Simple Western,Knockout Validated,Proximity Ligation Assay (PLA),Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunocytochemistry

USD :

499 USD

alt names :

API1Hiap-2, apoptosis inhibitor 1, baculoviral IAP repeat containing 2, baculoviral IAP repeat-containing 2, baculoviral IAP repeat-containing protein 2, BIRC2, cIAP1, C-IAP1, hIAP2, HIAP-2, IAP homolog B, IAP2, IAP-2, Inhibitor of apoptosis protein 2, MIHB, MIHBHIAP2, NFR2-TRAF signalling complex protein, RING finger protein 48, RNF48hiap-2, TNFR2-TRAF-signaling complex protein 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage