product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse ICAM-1/CD54 Antibody
catalog :
AF796
quantity :
100 ug (also 25 ug)
price :
509 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 49
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 5f
Jin Y, Liu Y, Xu L, Xu J, Xiong Y, Peng Y, et al. Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis. Cell Death Dis. 2022;13:512 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig s7a
Qin Z, Liu F, Blair R, Wang C, Yang H, Mudd J, et al. Endothelial cell infection and dysfunction, immune activation in severe COVID-19. Theranostics. 2021;11:8076-8091 pubmed publisher
Manandhar S, Gaddam R, Chambers S, Bhatia M. Kupffer Cell Inactivation Alters Endothelial Cell Adhesion Molecules in Cecal Ligation and Puncture-Induced Sepsis. Biomolecules. 2024;14: pubmed publisher
Yin D, Wang C, Qi Y, Wang Y, Hagemann N, Mohamud Yusuf A, et al. Neural precursor cell delivery induces acute post-ischemic cerebroprotection, but fails to promote long-term stroke recovery in hyperlipidemic mice due to mechanisms that include pro-inflammatory responses associated with brain hemorrhages. J Neuroinflammation. 2023;20:210 pubmed publisher
Manandhar S, Chambers S, Miller A, Ishii I, Bhatia M. Pharmacological Inhibition and Genetic Deletion of Cystathionine Gamma-Lyase in Mice Protects against Organ Injury in Sepsis: A Key Role of Adhesion Molecules on Endothelial Cells. Int J Mol Sci. 2023;24: pubmed publisher
Yu L, Xu L, Chu H, Peng J, Sacharidou A, Hsieh H, et al. Macrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice. Nat Commun. 2023;14:4101 pubmed publisher
Cerqueira A, Rodrigues L, Coavoy S xe1 nchez S, Teixeira S, Feitosa K, Taniguchi E, et al. Aedes aegypti salivary gland extract alleviates acute itching by blocking TRPA1 channels. Front Physiol. 2023;14:1055706 pubmed publisher
Cornuault L, H xe9 rion F, Bourguignon C, Rouault P, Foussard N, Alzieu P, et al. Partial Mural Cell Ablation Disrupts Coronary Vasculature Integrity and Induces Systolic Dysfunction. J Am Heart Assoc. 2023;12:e029279 pubmed publisher
Kim J, Yi M, Kim M, Choi J, Lee S, Yong T. Production of Dermatophagoides farinae Having Low Bacterial Content Using Ampicillin. J Immunol Res. 2023;2023:9024595 pubmed publisher
Patsouras M, Alexopoulou E, Foutadakis S, Tsiki E, Karagianni P, Agelopoulos M, et al. Antiphospholipid antibodies induce proinflammatory and procoagulant pathways in endothelial cells. J Transl Autoimmun. 2023;6:100202 pubmed publisher
Ma Z, Li W, Zhuang L, Wen T, Wang P, Yu H, et al. TMEM59 ablation leads to loss of olfactory sensory neurons and impairs olfactory functions via interaction with inflammation. Brain Behav Immun. 2023;111:151-168 pubmed publisher
An H, Gwon M, Gu H, Bae S, Leem J, Lee J, et al. STAT3/NF‑κB decoy oligodeoxynucleotides inhibit atherosclerosis through regulation of the STAT/NF‑κB signaling pathway in a mouse model of atherosclerosis. Int J Mol Med. 2023;51: pubmed publisher
Zhang Y, Liu T, Deng Z, Fang W, Zhang X, Zhang S, et al. Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils. Adv Sci (Weinh). 2023;10:e2206958 pubmed publisher
Uceda Castro R, Margarido A, Cornet L, Vegna S, Hahn K, Song J, et al. Re-purposing the pro-senescence properties of doxorubicin to introduce immunotherapy in breast cancer brain metastasis. Cell Rep Med. 2022;3:100821 pubmed publisher
Ren W, Ma Z, Wang L, Feng X, Yu H, Yu Y. Lgr5+ cells are required and dynamically participate in olfactory epithelium regeneration: a revisiting shows Lgr5 expression in multiple cell lineages. Theranostics. 2022;12:5631-5644 pubmed publisher
Liu L, Yang C, Lavayen B, Tishko R, LaRochelle J, Candelario Jalil E. Targeted BRD4 protein degradation by dBET1 ameliorates acute ischemic brain injury and improves functional outcomes associated with reduced neuroinflammation and oxidative stress and preservation of blood-brain barrier integrity. J Neuroinflammation. 2022;19:168 pubmed publisher
Asano H, Hasegawa Ishii S, Arae K, Obara A, Laumet G, Dantzer R, et al. Infiltration of peripheral immune cells into the olfactory bulb in a mouse model of acute nasal inflammation. J Neuroimmunol. 2022;368:577897 pubmed publisher
Choe Y, Yoon J, Joo J, Kim B, Hong S, Koh G, et al. Pericyte Loss Leads to Capillary Stalling Through Increased Leukocyte-Endothelial Cell Interaction in the Brain. Front Cell Neurosci. 2022;16:848764 pubmed publisher
Huisman C, Norgard M, Levasseur P, Krasnow S, van der Wijst M, Olson B, et al. Critical changes in hypothalamic gene networks in response to pancreatic cancer as found by single-cell RNA sequencing. Mol Metab. 2022;58:101441 pubmed publisher
Calvier L, Manouchehri N, Sacharidou A, Mineo C, Shaul P, Hui D, et al. Apolipoprotein E receptor 2 deficiency decreases endothelial adhesion of monocytes and protects against autoimmune encephalomyelitis. Sci Immunol. 2021;6: pubmed publisher
Calvier L, Xian X, Lee R, Sacharidou A, Mineo C, Shaul P, et al. Reelin Depletion Protects Against Atherosclerosis by Decreasing Vascular Adhesion of Leukocytes. Arterioscler Thromb Vasc Biol. 2021;41:1309-1318 pubmed publisher
Hagemann N, Mohamud Yusuf A, Martiny C, Zhang X, Kleinschnitz C, Gunzer M, et al. Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia. Basic Res Cardiol. 2020;115:64 pubmed publisher
Jeong S, Cho M, Ko N, Kim S, Jung I, Min J, et al. Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm. Exp Mol Med. 2020;52:1587-1601 pubmed publisher
Dufek B, Meehan D, Delimont D, Wilhelm K, Samuelson G, Coenen R, et al. RNA-seq analysis of gene expression profiles in isolated stria vascularis from wild-type and Alport mice reveals key pathways underling Alport strial pathogenesis. PLoS ONE. 2020;15:e0237907 pubmed publisher
Chen C, Wu M, Ho Y, Gung P, Tsai M, Orekhov A, et al. Exposure to Zinc Oxide Nanoparticles Disrupts Endothelial Tight and Adherens Junctions and Induces Pulmonary Inflammatory Cell Infiltration. Int J Mol Sci. 2020;21: pubmed publisher
Hsueh P, Ju Y, Vega A, Edman M, MacKay J, Hamm Alvarez S. A Multivalent ICAM-1 Binding Nanoparticle which Inhibits ICAM-1 and LFA-1 Interaction Represents a New Tool for the Investigation of Autoimmune-Mediated Dry Eye. Int J Mol Sci. 2020;21: pubmed publisher
Ruscetti M, Morris J, Mezzadra R, Russell J, Leibold J, Romesser P, et al. Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer. Cell. 2020;181:424-441.e21 pubmed publisher
Chao T, Gu S, Lin P, Chou Y, Ling T, Chang S. Characterization of Influenza A Virus Infection in Mouse Pulmonary Stem/Progenitor Cells. Front Microbiol. 2019;10:2942 pubmed publisher
Varga D, Menyhárt A, Pósfai B, Császár E, Lénárt N, Cserép C, et al. Microglia alter the threshold of spreading depolarization and related potassium uptake in the mouse brain. J Cereb Blood Flow Metab. 2020;40:S67-S80 pubmed publisher
Colijn S, Muthukumar V, Xie J, Gao S, Griffin C. Cell-specific and athero-protective roles for RIPK3 in a murine model of atherosclerosis. Dis Model Mech. 2020;13: pubmed publisher
Peng W, Pei G, Tang Y, Tan L, Qin W. IgA1 deposition may induce NLRP3 expression and macrophage transdifferentiation of podocyte in IgA nephropathy. J Transl Med. 2019;17:406 pubmed publisher
Salmeron K, Maniskas M, Edwards D, Wong R, Rajkovic I, Trout A, et al. Interleukin 1 alpha administration is neuroprotective and neuro-restorative following experimental ischemic stroke. J Neuroinflammation. 2019;16:222 pubmed publisher
Knackstedt S, Georgiadou A, Apel F, Abu Abed U, Moxon C, Cunnington A, et al. Neutrophil extracellular traps drive inflammatory pathogenesis in malaria. Sci Immunol. 2019;4: pubmed publisher
Riegler J, Gill H, Ogasawara A, Hedehus M, Javinal V, Oeh J, et al. VCAM-1 Density and Tumor Perfusion Predict T-cell Infiltration and Treatment Response in Preclinical Models. Neoplasia. 2019;21:1036-1050 pubmed publisher
Han I, Burnight E, Ulferts M, Worthington K, Russell S, Sohn E, et al. Helper-Dependent Adenovirus Transduces the Human and Rat Retina but Elicits an Inflammatory Reaction When Delivered Subretinally in Rats. Hum Gene Ther. 2019;30:1371-1384 pubmed publisher
Wilson M, Reske J, Holladay J, Wilber G, Rhodes M, Koeman J, et al. ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion. Nat Commun. 2019;10:3554 pubmed publisher
Guo X, Fereydooni A, Isaji T, Gorecka J, Liu S, Hu H, et al. Inhibition of the Akt1-mTORC1 Axis Alters Venous Remodeling to Improve Arteriovenous Fistula Patency. Sci Rep. 2019;9:11046 pubmed publisher
Liu X, Nemeth D, McKim D, Zhu L, DiSabato D, Berdysz O, et al. Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities. Immunity. 2019;50:317-333.e6 pubmed publisher
Wohlrab P, Soto Gonzales L, Benesch T, Winter M, Lang I, Markstaller K, et al. Intermittent Hypoxia Activates Duration-Dependent Protective and Injurious Mechanisms in Mouse Lung Endothelial Cells. Front Physiol. 2018;9:1754 pubmed publisher
Wong R, Lénárt N, Hill L, Toms L, Coutts G, Martinecz B, et al. Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons. Brain Behav Immun. 2019;76:126-138 pubmed publisher
Holler V, Buard V, Roque T, Squiban C, Benderitter M, Flamant S, et al. Early and Late Protective Effect of Bone Marrow Mononuclear Cell Transplantation on Radiation-Induced Vascular Dysfunction and Skin Lesions. Cell Transplant. 2019;28:116-128 pubmed publisher
Li Z, Luo T, Ning X, Xiong C, Wu A. Neurokinin-1 receptor antagonism improves postoperative neurocognitive disorder in mice. Neurosci Lett. 2018;687:189-195 pubmed publisher
Xiong C, Liu J, Lin D, Zhang J, Terrando N, Wu A. Complement activation contributes to perioperative neurocognitive disorders in mice. J Neuroinflammation. 2018;15:254 pubmed publisher
Niraula A, Wang Y, Godbout J, Sheridan J. Corticosterone Production during Repeated Social Defeat Causes Monocyte Mobilization from the Bone Marrow, Glucocorticoid Resistance, and Neurovascular Adhesion Molecule Expression. J Neurosci. 2018;38:2328-2340 pubmed publisher
Xu Y, Xu S, Liu P, Koroleva M, Zhang S, Si S, et al. Suberanilohydroxamic Acid as a Pharmacological Kruppel-Like Factor 2 Activator That Represses Vascular Inflammation and Atherosclerosis. J Am Heart Assoc. 2017;6: pubmed publisher
Meng Z, Klinngam W, Edman M, Hamm Alvarez S. Interferon-γ treatment in vitro elicits some of the changes in cathepsin S and antigen presentation characteristic of lacrimal glands and corneas from the NOD mouse model of Sjögren's Syndrome. PLoS ONE. 2017;12:e0184781 pubmed publisher
Wei C, Kong Y, Li G, Guan Y, Wang P, Miao C. Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway. Sci Rep. 2017;7:717 pubmed publisher
Gupta K, Donahue D, Sandoval Cooper M, Castellino F, Ploplis V. Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation. Sci Rep. 2017;7:365 pubmed publisher
Raguz J, Jerić I, Niault T, Nowacka J, Kuzet S, Rupp C, et al. Epidermal RAF prevents allergic skin disease. elife. 2016;5: pubmed publisher
product information
brand :
R&D Systems
master code :
AF796
SKU :
AF796
product name :
Mouse ICAM-1/CD54 Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Mouse ICAM-1/CD54 Antibody from R&D Systems is a goat polyclonal antibody to ICAM-1/CD54. This antibody reacts with hamster,human,mouse,transgenic mouse. The Mouse ICAM-1/CD54 Antibody has been validated for the following applications: Immunohistochemistry,Western Blot,Neutralization,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,Adhesion Blockade.
target :
ICAM-1/CD54
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 0.1 ug/mL, Immunohistochemistry 5-15 ug/mL, Adhesion Blockade
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse ICAM-1/CD54, Gln28-Asn485, Accession # Q3U8M7
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Hamster,Human,Mouse,Transgenic Mouse
specificity :
Detects mouse ICAM-1 in direct ELISAs and Western blots. In direct ELISAs, approximately 20% cross-reactivity with recombinant rat ICAM-1 is observed, approximately 5% cross-reactivity with recombinant human (rh) ICAM-1 and rhICAM-3 is observed, and less than 1% cross-reactivity with recombinant mouse ICAM-2 is observed.
gene symbol :
ICAM1
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
ICAM-1/CD54 antibody in Mouse Testis by Immunohistochemistry (IHC-Fr).
accessionNumbers :
Q3U8M7
applications :
Adhesion Blockade,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Neutralization,Immunocytochemistry
USD :
509 USD
alt names :
BB2, CD54, CD54 antigen, cell surface glycoprotein P3.58, human rhinovirus receptor, ICAM1, ICAM-1, intercellular adhesion molecule 1, intercellular adhesion molecule 1 (CD54), human rhinovirus receptor, Major group rhinovirus receptor, P3.58
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.