product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human/Mouse RNF168 Antibody
catalog :
AF7217
quantity :
100 ug (also 25 ug)
price :
479 USD
clonality :
polyclonal
host :
domestic sheep
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunocytochemistry, immunohistochemistry - frozen section
more info or order :
R&D Systems product webpage
citations: 6
Reference
Longarini E, Dauben H, Locatelli C, Wondisford A, Smith R, Muench C, et al. Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling. Mol Cell. 2023;83:1743-1760.e11 pubmed publisher
Krais J, Wang Y, Patel P, Basu J, Bernhardy A, Johnson N. RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage. Nat Commun. 2021;12:5016 pubmed publisher
Patel P, Abraham K, Guturi K, Halaby M, Khan Z, Palomero L, et al. RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors. J Clin Invest. 2021;131: pubmed publisher
Krais J, Wang Y, Bernhardy A, Clausen E, Miller J, Cai K, et al. RNF168-Mediated Ubiquitin Signaling Inhibits the Viability of BRCA1-Null Cancers. Cancer Res. 2020;80:2848-2860 pubmed publisher
Callen E, Zong D, Wu W, Wong N, Stanlie A, Ishikawa M, et al. 53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination. Mol Cell. 2019;: pubmed publisher
Guturi K, Bohgaki M, Bohgaki T, Srikumar T, Ng D, Kumareswaran R, et al. RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation. Nat Commun. 2016;7:12638 pubmed publisher
product information
master code :
AF7217
SKU :
AF7217
product name :
Human/Mouse RNF168 Antibody
unit size :
100 ug (also 25 ug)
description :
The Human/Mouse RNF168 Antibody from R&D Systems is a sheep polyclonal antibody to RNF168. This antibody reacts with human,mouse. The Human/Mouse RNF168 Antibody has been validated for the following applications: Immunohistochemistry-Frozen,Western Blot,Immunocytochemistry.
target :
RNF168
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
host :
Sheep
immunogen :
E. coli -derived recombinant mouse RNF168, Asn423-Arg565, Accession # Q80XJ2
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse
specificity :
Detects recombinant mouse RNF168 and recombinant human RNF168 in direct ELISAs and Western blots.
gene symbol :
RNF168
top caption :
Detection of Mouse RNF168 antibody by Western Blot.
accessionNumbers :
Q80XJ2
applications :
Immunohistochemistry-Frozen,Western Blot,Immunocytochemistry
USD :
479 USD
alt names :
E3 ubiquitin-protein ligase RNF168, EC 6.3.2, EC 6.3.2.-, FLJ39749, ring finger protein 168FLJ35794
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.