Human SREBP2 Antibody | R&D Systems AF7119 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human SREBP2 Antibody

catalog :

AF7119

quantity :

100 ug (also 25 ug)

price :

479 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunocytochemistry, chromatin immunoprecipitation

more info or order :

R&D Systems product webpage

citations: 7

Reference
Li D, Zhou J, Wang L, Gong Z, Le H, Huang Y, et al. Gut microbial metabolite deoxycholic acid facilitates Th17 differentiation through modulating cholesterol biosynthesis and participates in high-fat diet-associated colonic inflammation. Cell Biosci. 2023;13:186 pubmed publisher
Pan Y, Chen H, Zhang X, Liu W, Ding Y, Huang D, et al. METTL3 drives NAFLD-related hepatocellular carcinoma and is a therapeutic target for boosting immunotherapy. Cell Rep Med. 2023;4:101144 pubmed publisher
Firpo M, LoMascolo N, Petit M, Shah P, Mounce B. Polyamines and eIF5A hypusination facilitate SREBP2 synthesis and cholesterol production leading to enhanced enterovirus attachment and infection. PLoS Pathog. 2023;19:e1011317 pubmed publisher
Willemsen L, Prange K, Neele A, van Roomen C, Gijbels M, Griffith G, et al. DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability. Cell Rep. 2022;41:111703 pubmed publisher
Branche E, Wang Y, Viramontes K, Valls Cuevas J, Xie J, Ana Sosa Batiz F, et al. SREBP2-dependent lipid gene transcription enhances the infection of human dendritic cells by Zika virus. Nat Commun. 2022;13:5341 pubmed publisher
Volkmar N, Thezenas M, Louie S, Juszkiewicz S, Nomura D, Hegde R, et al. The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis. J Cell Sci. 2019;132: pubmed publisher
Zimmer M, Bista P, Benson E, Lee D, Liu F, Picarella D, et al. CAT-2003: A novel sterol regulatory element-binding protein inhibitor that reduces steatohepatitis, plasma lipids, and atherosclerosis in apolipoprotein E*3-Leiden mice. Hepatol Commun. 2017;1:311-325 pubmed publisher

product information

master code :

AF7119

SKU :

AF7119

product name :

Human SREBP2 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human SREBP2 Antibody from R&D Systems is a goat polyclonal antibody to SREBP2. This antibody reacts with human,mouse,transgenic mouse. The Human SREBP2 Antibody has been validated for the following applications: Western Blot,Chromatin Immunoprecipitation (ChIP),Chromatin Immunoprecipitation Sequencing,Immunocytochemistry.

target :

SREBP2

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

E. coli -derived recombinant human SREBP2, Leu242-Asp450, Accession # Q12772

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Transgenic Mouse

specificity :

Detects human SREBP2 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) SREBP1B and rhSREBP1C is observed.

gene symbol :

SREBF2

top caption :

Detection of Human SREBP2 antibody by Western Blot.

accessionNumbers :

Q12772

applications :

Western Blot,Chromatin Immunoprecipitation (ChIP),Chromatin Immunoprecipitation Sequencing,Immunocytochemistry

USD :

479 USD

alt names :

BHLHD2, bHLHd2sterol regulatory element-binding protein 2, Class D basic helix-loop-helix protein 2, SREBF2, SREBP2, SREBP2SREBP-2, sterol regulatory element binding transcription factor 2, Sterol regulatory element-binding transcription factor 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage