Human Dystroglycan Antibody | R&D Systems AF6868 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Dystroglycan Antibody

catalog :

AF6868

quantity :

100 ug (also 25 ug)

price :

489 USD

clonality :

polyclonal

host :

domestic sheep

conjugate :

nonconjugated

reactivity :

human, mouse, dogs

application :

western blot, immunohistochemistry, flow cytometry

more info or order :

R&D Systems product webpage

citations: 19

Reference
Carr C, Crawford K, Murphy M, Galloway J, Haddox H, Matsen F, et al. Deep mutational scanning reveals functional constraints and antigenic variability of Lassa virus glycoprotein complex. bioRxiv. 2024;: pubmed publisher
Geoffroy M, Pili L, Buffa V, Caroff M, Bigot A, Gicquel E, et al. CRISPR-Cas9 KO Cell Line Generation and Development of a Cell-Based Potency Assay for rAAV-FKRP Gene Therapy. Cells. 2023;12: pubmed publisher
Chandel I, Campbell K. Identification of Matriglycan by Dual Exoglycosidase Digestion of α-Dystroglycan. Bio Protoc. 2023;13:e4827 pubmed publisher
Okuma H, Hord J, Chandel I, Venzke D, Anderson M, Walimbe A, et al. N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy. elife. 2023;12: pubmed publisher
Franzka P, Sch xfc ler S, Kentache T, Storm R, Bock A, Katona I, et al. Impact of Hypermannosylation on the Structure and Functionality of the ER and the Golgi Complex. Biomedicines. 2023;11: pubmed publisher
Shelton G, Minor K, Vieira N, Kunkel L, Friedenberg S, Cullen J, et al. Tandem duplication within the DMD gene in Labrador retrievers with a mild clinical phenotype. Neuromuscul Disord. 2022;32:836-841 pubmed publisher
Umezawa F, Natsume M, Fukusada S, Nakajima K, Yamasaki F, Kawashima H, et al. Cancer Malignancy Is Correlated with Upregulation of PCYT2-Mediated Glycerol Phosphate Modification of α-Dystroglycan. Int J Mol Sci. 2022;23: pubmed publisher
Yonekawa T, Rauckhorst A, El Hattab S, Cuellar M, Venzke D, Anderson M, et al. Large1 gene transfer in older myd mice with severe muscular dystrophy restores muscle function and greatly improves survival. Sci Adv. 2022;8:eabn0379 pubmed publisher
Shelton G, Minor K, Guo L, Friedenberg S, Cullen J, Hord J, et al. Muscular dystrophy-dystroglycanopathy in a family of Labrador retrievers with a LARGE1 mutation. Neuromuscul Disord. 2021;31:1169-1178 pubmed publisher
Packer D, Martin P. Micro-laminin gene therapy can function as an inhibitor of muscle disease in the dyW mouse model of MDC1A. Mol Ther Methods Clin Dev. 2021;21:274-287 pubmed publisher
Martin P, Zygmunt D, Ashbrook A, Hamilton S, Packer D, Birch S, et al. Short-term treatment of golden retriever muscular dystrophy (GRMD) dogs with rAAVrh74.MHCK7.GALGT2 induces muscle glycosylation and utrophin expression but has no significant effect on muscle strength. PLoS ONE. 2021;16:e0248721 pubmed publisher
Ortiz Cordero C, Magli A, Dhoke N, Kuebler T, Selvaraj S, Oliveira N, et al. NAD+ enhances ribitol and ribose rescue of α-dystroglycan functional glycosylation in human FKRP-mutant myotubes. elife. 2021;10: pubmed publisher
Walimbe A, Okuma H, Joseph S, Yang T, Yonekawa T, Hord J, et al. POMK regulates dystroglycan function via LARGE1-mediated elongation of matriglycan. elife. 2020;9: pubmed publisher
Lu P, Tucker J, Branch E, Guo F, Blaeser A, Lu Q. Ribitol enhances matriglycan of α-dystroglycan in breast cancer cells without affecting cell growth. Sci Rep. 2020;10:4935 pubmed publisher
Gumlaw N, Sevigny L, Zhao H, Luo Z, Bangari D, Masterjohn E, et al. biAb Mediated Restoration of the Linkage between Dystroglycan and Laminin-211 as a Therapeutic Approach for α-Dystroglycanopathies. Mol Ther. 2020;28:664-676 pubmed publisher
Kim J, Lana B, Torelli S, Ryan D, Catapano F, Ala P, et al. A new patient-derived iPSC model for dystroglycanopathies validates a compound that increases glycosylation of α-dystroglycan. EMBO Rep. 2019;20:e47967 pubmed publisher
Cataldi M, Lu P, Blaeser A, Lu Q. Ribitol restores functionally glycosylated α-dystroglycan and improves muscle function in dystrophic FKRP-mutant mice. Nat Commun. 2018;9:3448 pubmed publisher
Brouillette R, Phillips E, Patel R, Mahauad Fernandez W, Moller Tank S, Rogers K, et al. TIM-1 Mediates Dystroglycan-Independent Entry of Lassa Virus. J Virol. 2018;92: pubmed publisher
Briggs D, Yoshida Moriguchi T, Zheng T, Venzke D, Anderson M, Strazzulli A, et al. Structural basis of laminin binding to the LARGE glycans on dystroglycan. Nat Chem Biol. 2016;12:810-4 pubmed publisher

product information

master code :

AF6868

SKU :

AF6868

product name :

Human Dystroglycan Antibody

unit size :

100 ug (also 25 ug)

description :

The Human Dystroglycan Antibody from R&D Systems is a sheep polyclonal antibody to Dystroglycan. This antibody reacts with canine,human,mouse,rabbit,transgenic mouse. The Human Dystroglycan Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,Flow Cytometry,Knockout Validated.

target :

Dystroglycan

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Sheep

immunogen :

Mouse myeloma cell line NS0-derived recombinant human Dystroglycan, Gln28-Val749, Accession # Q14118

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Canine,Human,Mouse,Rabbit,Transgenic Mouse

specificity :

Detects human Dystroglycan in direct ELISAs and Western blots.

gene symbol :

DAG1

Antibody validation :

Knockout/Knockdown

top caption :

Detection of Human Dystroglycan antibody by Western Blot.

accessionNumbers :

Q14118

applications :

Western Blot,Immunohistochemistry,Flow Cytometry,Knockout Validated

USD :

489 USD

alt names :

A3a, AGRNR, Dag-1, DAG1, DAG156DAG, dystroglycan, dystroglycan 1 (dystrophin-associated glycoprotein 1), Dystrophin-associated glycoprotein 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage