Human NLRP1/NALP1 Antibody | R&D Systems AF6788 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human NLRP1/NALP1 Antibody

catalog :

AF6788

quantity :

100 ug (also 25 ug)

price :

489 USD

clonality :

polyclonal

host :

domestic sheep

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunoprecipitation

more info or order :

R&D Systems product webpage

citations: 10

Reference
Rodr xed guez Ruiz L, Lozano Gil J, Naranjo S xe1 nchez E, Mart xed nez Balsalobre E, Mart xed nez L xf3 pez A, Lachaud C, et al. ZAKα/P38 kinase signaling pathway regulates hematopoiesis by activating the NLRP1 inflammasome. EMBO Mol Med. 2023;15:e18142 pubmed publisher
Pinilla M, Mazars R, Verg xe9 R, Gorse L, Paradis M, Suire B, et al. EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption. J Exp Med. 2023;220: pubmed publisher
Orth He E, Huang H, Rao S, Wang Q, Chen Q, O Mara C, et al. Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation. Cell Rep. 2023;42:111965 pubmed publisher
Planès R, Pinilla M, Santoni K, Hessel A, Passemar C, Lay K, et al. Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells. Mol Cell. 2022;82:2385-2400.e9 pubmed publisher
Rao S, Chen Q, Wang Q, Orth He E, Saoi M, Griswold A, et al. M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome. Nat Chem Biol. 2022;18:565-574 pubmed publisher
Johnson D, Okondo M, Orth E, Rao S, Huang H, Ball D, et al. DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes. Cell Death Dis. 2020;11:628 pubmed publisher
Ball D, Taabazuing C, Griswold A, Orth E, Rao S, Kotliar I, et al. Caspase-1 interdomain linker cleavage is required for pyroptosis. Life Sci Alliance. 2020;3: pubmed publisher
Krześniak M, Zajkowicz A, Gdowicz Kłosok A, Głowala Kosińska M, Łasut Szyszka B, Rusin M. Synergistic activation of p53 by actinomycin D and nutlin-3a is associated with the upregulation of crucial regulators and effectors of innate immunity. Cell Signal. 2020;69:109552 pubmed publisher
DRUTMAN S, Haerynck F, Zhong F, Hum D, Hernandez N, Belkaya S, et al. Homozygous NLRP1 gain-of-function mutation in siblings with a syndromic form of recurrent respiratory papillomatosis. Proc Natl Acad Sci U S A. 2019;116:19055-19063 pubmed publisher
Johnson D, Taabazuing C, Okondo M, Chui A, Rao S, Brown F, et al. DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia. Nat Med. 2018;24:1151-1156 pubmed publisher

product information

master code :

AF6788

SKU :

AF6788

product name :

Human NLRP1/NALP1 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human NLRP1/NALP1 Antibody from R&D Systems is a sheep polyclonal antibody to NLRP1/NALP1. This antibody reacts with human. The Human NLRP1/NALP1 Antibody has been validated for the following applications: Immunoprecipitation,Western Blot.

target :

NLRP1/NALP1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Sheep

immunogen :

E. coli -derived recombinant human NLRP1/NALP1, Met1-Asp323 (Leu155His), Accession # Q9C000

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human

specificity :

Detects human NLRP1/NALP1 in direct ELISAs and Western blots. In direct ELISAs, less than 2% cross-reactivity with recombinant human (rh) NALP2 and rhNALP3 is observed.

gene symbol :

NLRP1

top caption :

Detection of Human NLRP1/NALP1 antibody by Western Blot.

accessionNumbers :

Q9C000

applications :

Immunoprecipitation,Western Blot

USD :

489 USD

alt names :

CARD7, CARD7SLEV1, Caspase recruitment domain-containing protein 7, CLR17.1, Death effector filament-forming ced-4-like apoptosis protein, DEFCAP, DEFCAPVAMAS1, DKFZp586O1822, KIAA0926DEFCAP-L/S, NACHT, leucine rich repeat and PYD (pyrin domain) containing 1, NACHT, leucine rich repeat and PYD containing 1, NACHT, LRR and PYD containing protein 1, NACHT, LRR and PYD domains-containing protein 1, NACPP1044, NALP1, NALP1caspase recruitment domain protein 7, NLR family, pyrin domain containing 1, Nucleotide-binding domain and caspase recruitment domain, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 1, PP1044, SLEV1, VAMAS1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage