Human STING/TMEM173 Antibody | R&D Systems AF6516 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human STING/TMEM173 Antibody

catalog :

AF6516

quantity :

100 ug (also 25 ug)

price :

489 USD

clonality :

polyclonal

host :

domestic sheep

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

more info or order :

R&D Systems product webpage

citations: 9

Reference
Kong L, Sui C, Chen T, Zhang L, Zhao W, Zheng Y, et al. The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus. Cell Rep. 2023;42:112306 pubmed publisher
Dixon C, Malik P, de las Heras J, Saiz Ros N, de Lima Alves F, Tingey M, et al. STING nuclear partners contribute to innate immune signaling responses. iScience. 2021;24:103055 pubmed publisher
Prabakaran T, Troldborg A, Kumpunya S, Alee I, Marinković E, Windross S, et al. A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology. EBioMedicine. 2021;66:103314 pubmed publisher
Zhang B, Nandakumar R, Reinert L, Huang J, Laustsen A, Gao Z, et al. STEEP mediates STING ER exit and activation of signaling. Nat Immunol. 2020;21:868-879 pubmed publisher
Kang L, Yu H, Yang X, Zhu Y, Bai X, Wang R, et al. Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke. Nat Commun. 2020;11:2488 pubmed publisher
Bodda C, Reinert L, Fruhwürth S, Richardo T, Sun C, Zhang B, et al. HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection. J Exp Med. 2020;217: pubmed publisher
Prabakaran T, Bodda C, Krapp C, Zhang B, Christensen M, Sun C, et al. Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1. EMBO J. 2018;37: pubmed publisher
Jønsson K, Laustsen A, Krapp C, Skipper K, Thavachelvam K, Hotter D, et al. IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP. Nat Commun. 2017;8:14391 pubmed publisher
Paijo J, Döring M, Spanier J, Grabski E, Nooruzzaman M, Schmidt T, et al. cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells. PLoS Pathog. 2016;12:e1005546 pubmed publisher

product information

master code :

AF6516

SKU :

AF6516

product name :

Human STING/TMEM173 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human STING/TMEM173 Antibody from R&D Systems is a sheep polyclonal antibody to STING/TMEM173. This antibody reacts with human,mouse. The Human STING/TMEM173 Antibody has been validated for the following applications: Western Blot,Immunocytochemistry,Co-Immunoprecipitation,Immunoprecipitation,Simple Western,Knockout Validated.

target :

STING/TMEM173

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Sheep

immunogen :

E. coli-derived recombinant human STING/TMEM173, Ala215-Ser379, Accession # Q86WV6

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse

specificity :

Detects human STING/TMEM173 in direct ELISAs and Western blots.

gene symbol :

TMEM173

Antibody validation :

Knockout/Knockdown

top caption :

Detection of Human STING/TMEM173 antibody by Western Blot.

accessionNumbers :

Q86WV6

applications :

Western Blot,Immunocytochemistry,Co-Immunoprecipitation,Immunoprecipitation,Simple Western,Knockout Validated

USD :

489 USD

alt names :

endoplasmic reticulum IFN stimulator, Endoplasmic reticulum interferon stimulator, ERIS, FLJ38577, hMITA, hSTING, Mediator of IRF3 activation, MITA, mitochondrial mediator of IRF3 activation, MPYS, NET23, N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner, SAVI, Stimulator of interferon genes protein, stimulator of interferon protein, sting, STING-beta, TMEM173, transmembrane protein 173

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage