product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human TROP-2 Antibody
catalog :
AF650
quantity :
100 ug (also 25 ug)
price :
509 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
R&D Systems product webpage
citations: 20
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 4f
Chung V, Tan T, Tan M, Wong M, Kuay K, Yang Z, et al. GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification. Sci Rep. 2016;6:19943 pubmed publisher
Balinda H, Kelly W, Kaklamani V, Lathrop K, Canola M, Ghamasaee P, et al. Sacituzumab Govitecan in patients with breast cancer brain metastases and recurrent glioblastoma: a phase 0 window-of-opportunity trial. Nat Commun. 2024;15:6707 pubmed publisher
Tax G, Guay K, Sold xe0 T, Hitchman C, Hill J, Vasiljevi x107 S, et al. Rescue of secretion of a rare-disease associated mis-folded mutant glycoprotein in UGGT1 knock-out mammalian cells. bioRxiv. 2023;: pubmed publisher
Sperger J, Helzer K, Stahlfeld C, Jiang D, Singh A, Kaufmann K, et al. Expression and Therapeutic Targeting of TROP-2 in Treatment-Resistant Prostate Cancer. Clin Cancer Res. 2023;29:2324-2335 pubmed publisher
Hadefi A, Leprovots M, Thulliez M, Bastin O, Lefort A, Libert F, et al. Cold atmospheric plasma differentially affects cell renewal and differentiation of stem cells and APC-deficient-derived tumor cells in intestinal organoids. Cell Death Discov. 2022;8:66 pubmed publisher
Seok J, Fan X. TROP-2 and 5hmC expression in follicular-patterned thyroid neoplasm emphasizing tiny well-formed papillae. Ann Diagn Pathol. 2022;57:151903 pubmed publisher
Chen W, Li M, Younis M, Barnhart T, Jiang D, Sun T, et al. ImmunoPET of trophoblast cell-surface antigen 2 (Trop-2) expression in pancreatic cancer. Eur J Nucl Med Mol Imaging. 2022;49:861-870 pubmed publisher
Lee S, Jang B, Min J, Contreras Panta E, Presentation K, Delgado A, et al. Up-regulation of Aquaporin 5 Defines Spasmolytic Polypeptide-Expressing Metaplasia and Progression to Incomplete Intestinal Metaplasia. Cell Mol Gastroenterol Hepatol. 2022;13:199-217 pubmed publisher
Kamble P, Patkar S, Breed A, Pathak B. N-glycosylation status of Trop2 impacts its surface density, interaction with claudin-7 and exosomal release. Arch Biochem Biophys. 2021;714:109084 pubmed publisher
Trerotola M, Guerra E, Ali Z, Aloisi A, Ceci M, Simeone P, et al. Trop-2 cleavage by ADAM10 is an activator switch for cancer growth and metastasis. Neoplasia. 2021;23:415-428 pubmed publisher
Hao Y, Zhang D, Guo Y, Fu Z, Yu D, Guan G. miR-488-3p sponged by circ-0000495 and mediated upregulation of TROP2 in head and neck squamous cell carcinoma development. J Cancer. 2020;11:3375-3386 pubmed publisher
Zeybek B, Manzano A, Bianchi A, Bonazzoli E, Bellone S, Buza N, et al. Cervical carcinomas that overexpress human trophoblast cell-surface marker (Trop-2) are highly sensitive to the antibody-drug conjugate sacituzumab govitecan. Sci Rep. 2020;10:973 pubmed publisher
Kuai X, Jia L, Yang T, Huang X, Zhao W, Zhang M, et al. Trop2 Promotes Multidrug Resistance by Regulating Notch1 Signaling Pathway in Gastric Cancer Cells. Med Sci Monit. 2020;26:e919566 pubmed publisher
Han C, Perrone E, Zeybek B, Bellone S, Tymon Rosario J, Altwerger G, et al. In vitro and in vivo activity of sacituzumab govitecan, an antibody-drug conjugate targeting trophoblast cell-surface antigen 2 (Trop-2) in uterine serous carcinoma. Gynecol Oncol. 2020;156:430-438 pubmed publisher
Sin S, Li Y, Liu M, Ma S, Guan X. TROP-2 exhibits tumor suppressive functions in cervical cancer by dual inhibition of IGF-1R and ALK signaling. Gynecol Oncol. 2019;152:185-193 pubmed publisher
Vranic S, Palazzo J, Sanati S, Florento E, Contreras E, Xiu J, et al. Potential Novel Therapy Targets in Neuroendocrine Carcinomas of the Breast. Clin Breast Cancer. 2019;19:131-136 pubmed publisher
Zimmers S, Browne E, Williams K, Jawale R, Otis C, Schneider S, et al. TROP2 methylation and expression in tamoxifen-resistant breast cancer. Cancer Cell Int. 2018;18:94 pubmed publisher
Redlich N, Robinson A, Nickel K, Stein A, Wheeler D, Adkins D, et al. Anti-Trop2 blockade enhances the therapeutic efficacy of ErbB3 inhibition in head and neck squamous cell carcinoma. Cell Death Dis. 2018;9:5 pubmed publisher
Guan H, Guo Z, Liang W, Li H, Wei G, Xu L, et al. Trop2 enhances invasion of thyroid cancer by inducing MMP2 through ERK and JNK pathways. BMC Cancer. 2017;17:486 pubmed publisher
Starodub A, Ocean A, Shah M, Guarino M, Picozzi V, Vahdat L, et al. First-in-Human Trial of a Novel Anti-Trop-2 Antibody-SN-38 Conjugate, Sacituzumab Govitecan, for the Treatment of Diverse Metastatic Solid Tumors. Clin Cancer Res. 2015;21:3870-8 pubmed publisher
product information
master code :
AF650
SKU :
AF650
product name :
Human TROP-2 Antibody
unit size :
100 ug (also 25 ug)
description :
The Human TROP-2 Antibody from R&D Systems is a goat polyclonal antibody to TROP-2. This antibody reacts with human,mouse,transgenic mouse,xenograft. The Human TROP-2 Antibody has been validated for the following applications: Immunohistochemistry,Western Blot,Flow Cytometry,Immunoprecipitation,Neutralization,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,CyTOF-ready.
target :
TROP-2
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant human TROP-2, Thr88-Thr274, Accession # P09758
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse,Xenograft
specificity :
Detects human TROP-2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human (rh) MCAM, rhNCAM-L1, and rhBCAM is observed.
gene symbol :
TACSTD2
Antibody validation :
Knockout/Knockdown
top caption :
Detection of Human TROP-2 antibody by Western Blot.
accessionNumbers :
P09758
applications :
Western Blot,Immunohistochemistry,Flow Cytometry,Immunoprecipitation,Neutralization,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,CyTOF-ready
USD :
509 USD
alt names :
Cell surface glycoprotein Trop-2, EGP1, EGP-1, epithelial glycoprotein-1, GA733-1, GA733-1GP50, gastrointestinal tumor-associated antigen GA7331, gp50, M1S1cell surface glycoprotein TROP2, Membrane component chromosome 1 surface marker 1, membrane component, chromosome 1, surface marker 1, Pancreatic carcinoma marker protein GA733-1, pancreatic carcinoma marker protein GA7331,40kD glycoprotein, identified by monoclonal GA733, T16, TACSTD2, TROP2, TROP2GA7331, tumor-associated calcium signal transducer 2
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.